DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment mld and Zfp52

DIOPT Version :9

Sequence 1:	NP_001247289.1	Gene:	mld / 2768685	FlyBaseID:	FBgn0263490	Length:	1965	Species:	Drosophila melanogaster
Sequence 2:	NP_653098.2	Gene:	Zfp52 / 22710	MGIID:	99199	Length:	724	Species:	Mus musculus

Alignment Length:	764	Identity:	155/764 - (20%)
Similarity:	249/764 - (32%)	Gaps:	199/764 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly  1152 SAGSETTRQWQTQQSQQQQQVQWSSVGGLEAIKSAPVESVAPTTTTYYISASDLYPQQTETYTML 1216
            |.|..|.|......||:    :|      |.:.||        ....||..      ..|.|:.|
Mouse     9 SQGLLTFRDVAVDFSQE----EW------ECLDSA--------QRALYIDV------MVENYSNL 49

  Fly  1217 QPASNESYVIEQVNHQQQHCQQQIQMSQQQHQRQHQQQQAQQQQQPIMILIQQPEIQQPVASAS- 1280
              .|.|:|.|....||....:::.....:.::..|:........            :.....||
Mouse    50 --VSVENYCICDTVHQPVRTEKESCPCNELNEMLHEPSNCALYN------------RSDTTEASN 100

  Fly  1281 -----NPQQAPLHIYNAATSNDVHQMQHTQRQQIRQQYQHQ----------QYQRLQQPQQTRVV 1330
                 |.:.|.:...||    |.|:..|...:...|....:          |||||...::....
Mouse   101 NYRCCNEKDASVDSSNA----DRHKSMHIGEEDTCQSKDCEKSFNLCSNIRQYQRLNTEKKEHKQ 161

  Fly  1331 QSHPVLGMPGATSISTKVTPIPVTAARGRPLTLKCRFCHNGPRFSSSLEYSRHIIDLHPAVAPFN 1395
            ..|                                     ...|||.....:..:|:..  .|:.
Mouse   162 DEH-------------------------------------DDHFSSLYSLMQETVDMEE--KPYQ 187

  Fly  1396 CPHCPMAFAGRTKRSQHILSHHVVQQYQCGQCSHVFPAQKALDVHIQRFHMT---LKTDPSGAVK 1457
            |.||...|:..:..|.|...|...:.|:|..|...|....:|... |..|..   .|....|.:.
Mouse   188 CGHCRKYFSTTSSLSIHQRIHTGEKPYKCNICGKSFNQWSSLKTD-QTLHTAKKPYKCKEGGKLL 251

  Fly  1458 VEDVQLQITSERRPRGRPYKPRLQLQQHQLQPQQKLQVQQHQQQQKALQQLPQAQHHQQQQQPQL 1522
            |:...|:....|....:|||                    .||..::.......:.||:...|::
Mouse   252 VQLSALKSHQRRHTGEKPYK--------------------CQQCDRSFAHCASLRWHQKIHSPEI 296

  Fly  1523 QQEVLQ------QVQQLQVQVQPQQHQQHQQVLQVQQPQQQPLMQPQSPHPSTVEMQASPTTPRK 1581
            ..|..:      ::..|         ::|.::...::|.:..:........||::......|..|
Mouse   297 HYECKECGKSCFELSHL---------KRHCRIHTAEKPYRYEVCDTSITVNSTLKTHHKIHTREK 352

  Fly  1582 ILCCPDCEDCTSGHSHANEQFEELQTLQAPPTVLTPPSTIVSVPSPQPMVYSQHITMPSPEQSEP 1646
            .....:|:...:..|:       |:|.|...|...|...     :.....:::|
Mouse   353 PYRYRECDKSITKCSY-------LRTYQRVHTGKRPYRC-----TECDKFFTKH----------- 394

  Fly  1647 DSTTTLRQYRKRGVIVGPQGPLHLATPVASPSPSSSPSSSTVDHIPPASPATPASPAPPPSPAVA 1711
               :.|||::|          :|....                  ||.......|.....|..:.
Mouse   395 ---SNLRQHQK----------IHTGEK------------------PPKCKDCDKSFLRISSVRIR 428

  Fly  1712 STVQVSELRTSHHCLYCEERFTNEISLKKHHQLAHGALTTMPYVCTICKRGYRMRTALHRHMESH 1776
            ..:...|.|  :.|..|...||...:|:.|.::..|   ..||.|..|.:.:...:.|..|.:.|
Mouse   429 QKIHAGERR--YRCKECGRSFTWFSNLRVHQRVHTG---ERPYRCKECGKSFTTGSNLRVHQKIH 488

  Fly  1777 DVEGRPYECNICRVRFPRPSQLTLHKITVHLLSKPHTCDECGKQFGTESALKTHIKFH-GELGYQ 1840
            ..| :||:|..|.:.|...|.|..|: .:|...||:.|.||.|.|...|.|:.|.|.| ||..|:
Mouse   489 TGE-KPYKCKDCDISFLWISNLRTHQ-KIHTGEKPYKCQECNKSFTRCSYLRDHQKIHTGEKLYK 551

  Fly  1841 CDGCDRTFEYLKELRKHRRTHS-EMFYKCKFCPSSFMRFTNFRAHMKTH 1888
            |..||.:|.::..||:|::.|: |..|||:.|..||.:.:..|.|.|.|
Mouse   552 CKDCDISFMWISSLRRHQKIHTGEKPYKCRGCEKSFTQCSTLRDHQKIH 600

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mld	NP_001247289.1	zf-AD	186..255	CDD:214871
		C2H2 Zn finger	1365..1388	CDD:275368	4/22 (18%)
		C2H2 Zn finger	1396..1416	CDD:275368	6/19 (32%)
		C2H2 Zn finger	1424..1445	CDD:275368	5/20 (25%)
		C2H2 Zn finger	1725..1746	CDD:275368	6/20 (30%)
		C2H2 Zn finger	1756..1776	CDD:275368	4/19 (21%)
		C2H2 Zn finger	1785..1806	CDD:275368	6/20 (30%)
		C2H2 Zn finger	1814..1834	CDD:275368	9/19 (47%)
		zf-C2H2	1839..1861	CDD:278523	8/21 (38%)
		C2H2 Zn finger	1841..1861	CDD:275368	7/19 (37%)
		C2H2 Zn finger	1868..1888	CDD:275368	7/19 (37%)
Zfp52	NP_653098.2	KRAB	12..52	CDD:366587	13/65 (20%)
		C2H2 Zn finger	134..153	CDD:275368	4/18 (22%)
		COG5048	184..615	CDD:227381	113/508 (22%)
		C2H2 Zn finger	188..208	CDD:275368	6/19 (32%)
		C2H2 Zn finger	216..264	CDD:275368	10/48 (21%)
		C2H2 Zn finger	244..259	CDD:275368	3/14 (21%)
		C2H2 Zn finger	272..292	CDD:275368	4/19 (21%)
		C2H2 Zn finger	300..320	CDD:275368	2/28 (7%)
		C2H2 Zn finger	329..348	CDD:275368	2/18 (11%)
		C2H2 Zn finger	357..376	CDD:275368	5/25 (20%)
		C2H2 Zn finger	384..404	CDD:275368	5/48 (10%)
		C2H2 Zn finger	412..432	CDD:275368	2/19 (11%)
		C2H2 Zn finger	440..460	CDD:275368	6/19 (32%)
		C2H2 Zn finger	468..488	CDD:275368	4/19 (21%)
		C2H2 Zn finger	496..516	CDD:275368	6/20 (30%)
		C2H2 Zn finger	524..544	CDD:275368	9/19 (47%)
		C2H2 Zn finger	552..572	CDD:275368	7/19 (37%)
		C2H2 Zn finger	580..600	CDD:275368	7/19 (37%)
		C2H2 Zn finger	608..628	CDD:275368
		zf-H2C2_2	620..643	CDD:372612
		C2H2 Zn finger	636..656	CDD:275368
		zf-H2C2_2	648..673	CDD:372612
		C2H2 Zn finger	664..684	CDD:275368
		zf-H2C2_5	690..714	CDD:372805
		C2H2 Zn finger	692..712	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24376
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.100