DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment mld and Zfp40

DIOPT Version :9

Sequence 1:	NP_001247289.1	Gene:	mld / 2768685	FlyBaseID:	FBgn0263490	Length:	1965	Species:	Drosophila melanogaster
Sequence 2:	NP_001344626.1	Gene:	Zfp40 / 22700	MGIID:	99185	Length:	796	Species:	Mus musculus

Alignment Length:	875	Identity:	159/875 - (18%)
Similarity:	278/875 - (31%)	Gaps:	307/875 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly  1096 AQHQVVPHVQLQSQLVPHVQTQGTTTTVTYEQIYQQHIVQQTVQQSSNKMQVISLPSAGSETTRQ 1160
            :.|.:..|..::                  |:.|:.|.:.:.:.:||.     |.|...|:||..
Mouse    99 SNHIIYQHANIE------------------EKSYKYHELDKMLYESSQ-----STPYNTSDTTEN 140

  Fly  1161 WQTQQSQQQQQVQWSSVGGLEAIKSAPVESVAPTTTTYYISASDLYPQQTETYTMLQPASNESYV 1225
            .:...|..|......|: .|:|.||...|.........|::...:    ..:||.:.....|..:
Mouse   141 CKMYGSDNQWDPSNESL-NLKAHKSRSTEEEEYKDYREYLNLCSI----IGSYTQMDTRKKEHKI 200

  Fly  1226 IE-------------------QVNHQQQHCQQ--QIQMSQQQHQRQHQQQQAQQQQQPIMILIQQ 1269
            .|                   :..:|.:.|.:  :...|..:|:|.|
Mouse   201 TEHDKFFDSKHKLMIKRMCSGEKPYQCRKCGKCFRTYSSLYRHRRTH------------------ 247

  Fly  1270 PEIQQPVASASNPQQAPLHIYNAATS------NDVHQMQHTQRQQIR-----QQYQHQQYQ---R 1320
                        |.:.|..:.....|      :.||...|...:..:     :.|.|..::   |
Mouse   248 ------------PGEKPYKLTECNKSILYLSHHKVHYNIHYGEKPYKCIECGKCYYHSSFEKHYR 300

  Fly  1321 LQQPQQTRVVQSHPVLGMPGATSISTKVTPIPVTAARGRPLTLKCRFCHNGPRFSSSLEYSRHII 1385
            :...::                                   :.||..|...  |...|...|| .
Mouse   301 IHSEEE-----------------------------------SYKCNDCRKS--FICCLGLKRH-H 327

  Fly  1386 DLHPAVAPFNCPHCPMAFAGRTKRSQHILSH---HVVQQYQCGQCSHVFPAQKALDVHIQRFHMT 1447
            .:|....|:.|..|..:|    ..|.|:.:|   |..:.::|.:|.....:...|..| ||.|..
Mouse   328 KIHGGERPYECKQCSKSF----YTSSHLENHYRTHRRKLHRCNECGKSLSSSSGLQRH-QRIHRG 387

  Fly  1448 LKTDPSGAVKVEDVQLQITSERRPRGRPYKPRLQLQQHQLQPQQKLQVQQHQQQ----QKALQQL 1508
            .|.             .|.:|..        :..:|:.||:..|::...:...:    :|:....
Mouse   388 EKA-------------YICAECN--------KCFIQKSQLKTHQRIHTGEKSYKCSECEKSFTVG 431

  Fly  1509 PQAQHHQQ---QQQPQLQQEVLQ-QVQQLQVQVQPQQHQQHQQVLQVQQPQQQPLMQPQSPHPST 1569
            ...:.||:   .::|....|..: .:||..:       ::||::...::|.:....:......|.
Mouse   432 SSLRIHQRIHTGEKPYKCSECHKCFIQQAHL-------RRHQKIHTGEKPYKCSECEKSFTVGSD 489

  Fly  1570 VEMQASPTTPRKILCCPDCEDCTSGHSHANEQFEELQTLQAPPTVLTPPSTIVSVPSPQPMVYSQ 1634
            :.|.....|..|...|.||:.|....:.. ::.:.:.|.:.|                    |
Mouse   490 LRMHQKIHTGEKPYKCSDCDKCFIQKAKL-KKHQRIHTGEKP--------------------Y-- 531

  Fly  1635 HITMPSPEQSEPDSTTTLRQYRKRGVIVGPQGPLHLATPVASPSPSSSPSSSTVDHIPPASPATP 1699
                   :.||.:...|:
Mouse   532 -------KCSECEKCFTV----------------------------------------------- 542

  Fly  1700 ASPAPPPSPAVASTVQVSELRT---------SHHCLYCEERFTNEISLKKHHQL----------- 1744
                            ||:|||         .:.|..|::.|..:.:|::||::
Mouse   543 ----------------VSDLRTHQKIHTGEKPYKCSECDKCFIRKANLRRHHRIHTGEKPYKCSD 591

  Fly  1745 ------------AHGALTT--MPYVCTICKRGYRMRTALHRHMESHDVEGRPYECNICRVRFPRP 1795
                        .|..:.|  .||.|. |.:.:.:.:.|.:|.:.|..| :||:|:.|...|.|.
Mouse   592 CGKCFIQKANLRTHERIHTGEKPYKCE-CGKSFTVGSDLRKHQKCHTGE-KPYKCSECNKCFIRK 654

  Fly  1796 SQLTLHKITVHLLSKPHTCDECGKQFGTESALKTHIKFH-GELGYQCDGCDRTFEYLKELRKHRR 1859
            :.|..|: .:|...||:.|.:|||.|..::.|:||.|.| ||..|:|..||:.|.....||.|:|
Mouse   655 AHLRRHQ-RIHTGEKPYKCSDCGKCFIQKANLRTHQKIHTGEKPYKCSECDKCFIQKDHLRTHQR 718

  Fly  1860 THS-EMFYKCKFCPSSFMRFTNFRAHMKTH 1888
            .|: |..|||..|..||...:..|.|.|.|
Mouse   719 LHTGEKPYKCSECEKSFTGGSVLRKHQKIH 748

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mld	NP_001247289.1	zf-AD	186..255	CDD:214871
		C2H2 Zn finger	1365..1388	CDD:275368	6/22 (27%)
		C2H2 Zn finger	1396..1416	CDD:275368	5/19 (26%)
		C2H2 Zn finger	1424..1445	CDD:275368	6/20 (30%)
		C2H2 Zn finger	1725..1746	CDD:275368	6/43 (14%)
		C2H2 Zn finger	1756..1776	CDD:275368	4/19 (21%)
		C2H2 Zn finger	1785..1806	CDD:275368	6/20 (30%)
		C2H2 Zn finger	1814..1834	CDD:275368	9/19 (47%)
		zf-C2H2	1839..1861	CDD:278523	9/21 (43%)
		C2H2 Zn finger	1841..1861	CDD:275368	8/19 (42%)
		C2H2 Zn finger	1868..1888	CDD:275368	7/19 (37%)
Zfp40	NP_001344626.1	KRAB	42..82	CDD:307490
		C2H2 Zn finger	227..247	CDD:275368	4/19 (21%)
		C2H2 Zn finger	255..275	CDD:275368	3/19 (16%)
		COG5048	279..677	CDD:227381	91/564 (16%)
		C2H2 Zn finger	283..302	CDD:275368	3/18 (17%)
		C2H2 Zn finger	310..330	CDD:275368	6/22 (27%)
		C2H2 Zn finger	338..358	CDD:275368	6/23 (26%)
		C2H2 Zn finger	365..385	CDD:275368	6/20 (30%)
		C2H2 Zn finger	393..413	CDD:275368	5/27 (19%)
		C2H2 Zn finger	421..441	CDD:275368	3/19 (16%)
		C2H2 Zn finger	449..469	CDD:275368	5/26 (19%)
		C2H2 Zn finger	477..497	CDD:275368	2/19 (11%)
		C2H2 Zn finger	505..525	CDD:275368	4/20 (20%)
		C2H2 Zn finger	533..553	CDD:275368	8/82 (10%)
		C2H2 Zn finger	561..581	CDD:275368	6/19 (32%)
		C2H2 Zn finger	589..609	CDD:275368	1/19 (5%)
		C2H2 Zn finger	618..636	CDD:275368	3/18 (17%)
		C2H2 Zn finger	644..664	CDD:275368	6/20 (30%)
		C2H2 Zn finger	672..692	CDD:275368	9/19 (47%)
		zf-H2C2_2	684..709	CDD:316026	12/24 (50%)
		C2H2 Zn finger	700..720	CDD:275368	8/19 (42%)
		C2H2 Zn finger	728..748	CDD:275368	7/19 (37%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24376
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.100