Protein Alignment mld and Zfp27

DIOPT Version :10

• Sequence 1: NP_001247289.1
• Gene: mld / 2768685
• FlyBaseID: FBgn0263490
• Length: 1965
• Species: Drosophila melanogaster
• Sequence 2: NP_001408747.1
• Gene: Zfp27 / 22689
• MGIID: 99174
• Length: 848
• Species: Mus musculus
• Alignment Length: 940
• Identity: 183/940 - (19%)
• Similarity: 307/940 - (32%)
• Gaps: 249/940 - (26%)

  Fly  1065 QSQMQHQIPPQIEPQIEVQNQEQNTLQLVPQAQ--------HQVVPHVQLQSQLVPHVQTQGTTT 1121
            :.:.||..|.|.....:|..:..:.|:.|.:.|        :|.:.|......:.       .|.
Mouse    38 REEWQHLDPAQRSLYRDVVQETYSHLRSVEELQQIGDQKKTYQQIGHKSASDMVF-------ITK 95

  Fly  1122 TVTYEQIYQQHIVQQTVQQSSNKMQVISLPSAGSETTRQWQTQQSQQQQ----QVQWSSVGGLEA 1182
            |:..|..:....|::.:..:|    .|.||   .:..|.|...:.:.:.    |....|.|....
Mouse    96 TLGAESCHDYSGVRKVIHVNS----YIVLP---PKRPRHWDPPEDEPKHSSDLQTHDESNGLKRT 153

  Fly  1183 IKSAPVESVAPTTTTYYISASDLYPQQTETYTMLQPASNESYVIEQVNHQQQHCQQQIQMSQQQH 1247
            .:......::....|.:|...:..|...:...:|             .::|..|         |:
Mouse   154 KRITEYGKISSCINTEHILTGEKLPDHNQCGKVL-------------GYKQIPC---------QY 196

  Fly  1248 QRQHQQQQAQQQQQPIMILIQQPEIQQPVASASNPQQAPLHIY----NAATSND---VHQMQHTQ 1305
            |:.|..:::.:..:...|..|:.:::..|.|   |....|::.    .|.:...   .||..||:
Mouse   197 QKIHTGEKSYECAEFGKIFTQKSQLRVHVTS---PTGEKLYVCVECGKACSQTSEFLTHQKTHTR 258

  Fly  1306 RQ------------QIRQQYQHQQYQRLQQPQQTRVVQSHPVLGMPGATSISTKVTPIPVTAARG 1358
            .:            |:...::|::                          |.|           |
Mouse   259 EKPYKCGDCGKSFFQVSSLFRHRR--------------------------IHT-----------G 286

  Fly  1359 RPLTLKCRFCHNGPRFSSSLEYSRHIIDLHPAVAPFNCPHCPMAFAGRTKRSQHILSHHVVQQYQ 1423
            ..| ..|..|..|..::|.|...:.|   |.......|..|..||..::....|...|...:.|.
Mouse   287 EKL-YDCSHCGKGFSYNSDLRIHQKI---HTGEKRHGCVDCGKAFTQKSTLRMHQKIHTGERAYV 347

  Fly  1424 CGQCSHVFPAQKALDVHIQRFHMTLK---TDPSGAVKVEDVQL----QITSERRP-----RGRPY 1476
            |.:|...|..:..|..| :|.|...|   .|..|...:...||    :|.|..||     |.:|:
Mouse   348 CIECGQAFIQKTHLVAH-RRIHTGEKPYACDGCGKAFLSKSQLLVHQRIHSRVRPCVSLDRAKPF 411

  Fly  1477 KPRLQLQQHQLQPQQKLQVQQHQ----QQQKALQQLPQAQHHQQQQQPQLQQE------VLQQVQ 1531
            .     ....|.|::|:|:::..    :..||.....:...||:....:...:      ...|..
Mouse   412 S-----SAPNLLPRKKVQMREKSSICAECGKAFTYRSELIIHQRTHTGEKPYQCGDCGKAFTQKS 471

  Fly  1532 QLQVQ-------------------VQPQQHQQHQQVLQVQQPQQQPLMQPQSPHPSTVEMQASPT 1577
            .|.|.                   ||......||.:...::|.|...........|.:.:.....
Mouse   472 ALTVHRRIHTGEKSYVCVKCGLAFVQRAHLDAHQVIHTGEKPYQCGHCGKFFTSKSQLHVHKRIH 536

  Fly  1578 TPRKILCCPDCEDCTSGHSHANEQFEELQTLQAPPT------------VLTPPSTIVSVPSPQPM 1630
            |..|...|.:|     |.:.||.  ..|.|.|...|            ..|..|.:|:
Mouse   537 TGEKPYVCSNC-----GKAFANR--SNLITHQKTHTGEKAYVCARCGKAFTQRSDLVT------- 587

  Fly  1631 VYSQHITMPSPEQSEPDST------------------TTLRQY---------RKRGVIVGPQGPL 1668
                |..:.:.|:....||                  |..|||         .::.:::..| .:
Mouse   588 ----HQRIHTGEKPYGCSTCGKAFTQKSHLSIHEKIHTGERQYGCRDCGKAFNQKSILIVHQ-KI 647

  Fly  1669 HLATP---VASPSPSSSPSSSTVDHIPPASPATPASPAPPPSPAVASTVQVSELRTSHHCLYCEE 1730
            |....   .|....:....|:.:.|                     ..:...|  ..:.|..|.:
Mouse   648 HTGEKPHVCAECGRAFIRKSNFITH---------------------QRIHTGE--KPYGCTDCGK 689

  Fly  1731 RFTNEISLKKHHQLAHGALTTMPYVCTICKRGYRMRTALHRHMESHDVEGRPYECNICRVRFPRP 1795
            .||::..|..|..:..|   ..||||..|.:.:..|:.|.:|.::|..| :||.|:.|...|.:.
Mouse   690 SFTSKSQLLVHRPIHTG---EKPYVCAECGKAFSGRSNLSKHQKTHTGE-KPYACSECGKSFRQK 750

  Fly  1796 SQLTLHKITVHLLSKPHTCDECGKQFGTESALKTHIKFH-GELGYQCDGCDRTFEYLKELRKHRR 1859
            |:|..|. .:|...||:.|.:|||.|..:|.|:.|.:.| ||..|:|..|.:.|.....|.||:.
Mouse   751 SELITHH-RIHTGEKPYDCGDCGKSFTKKSQLQVHQRIHTGEKPYRCAECGKAFTDRSNLNKHQT 814

  Fly  1860 THS-EMFYKCKFCPSSFMRFTNFRAHMKTH 1888
            ||: |..|||..|...|::.:....|...|
Mouse   815 THTGEKPYKCVVCGKGFVQKSVLSIHENVH 844

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
mld	NP_001247289.1	zf-AD	186..255	CDD:214871
		PAT1	<959..>1109	CDD:401645	10/51 (20%)
		C2H2 Zn finger	1365..1388	CDD:275368	6/22 (27%)
		C2H2 Zn finger	1396..1416	CDD:275368	5/19 (26%)
		C2H2 Zn finger	1424..1445	CDD:275368	6/20 (30%)
		C2H2 Zn finger	1725..1746	CDD:275368	6/20 (30%)
		C2H2 Zn finger	1756..1776	CDD:275368	5/19 (26%)
		C2H2 Zn finger	1785..1806	CDD:275368	6/20 (30%)
		zf-C2H2	1812..1834	CDD:395048	8/21 (38%)
		C2H2 Zn finger	1814..1834	CDD:275368	8/19 (42%)
		zf-C2H2	1839..1861	CDD:395048	7/21 (33%)
		C2H2 Zn finger	1841..1861	CDD:275368	6/19 (32%)
		zf-C2H2	1866..1888	CDD:395048	6/21 (29%)
		C2H2 Zn finger	1868..1888	CDD:275368	4/19 (21%)
Zfp27	NP_001408747.1	KRAB	27..>67	CDD:214630	6/28 (21%)
		C2H2 Zn finger	181..200	CDD:275370	5/40 (13%)
		C2H2 Zn finger	208..228	CDD:275368	4/22 (18%)
		C2H2 Zn finger	236..256	CDD:275368	3/19 (16%)
		COG5048	<241..401	CDD:227381	39/201 (19%)
		C2H2 Zn finger	264..284	CDD:275368	2/45 (4%)
		C2H2 Zn finger	292..312	CDD:275368	6/22 (27%)
		C2H2 Zn finger	320..340	CDD:275368	5/19 (26%)
		COG5048	346..775	CDD:227381	97/481 (20%)
		C2H2 Zn finger	348..368	CDD:275368	6/20 (30%)
		C2H2 Zn finger	376..396	CDD:275368	4/19 (21%)
		C2H2 Zn finger	432..452	CDD:275368	4/19 (21%)
		C2H2 Zn finger	460..480	CDD:275368	3/19 (16%)
		C2H2 Zn finger	488..508	CDD:275368	4/19 (21%)
		C2H2 Zn finger	516..536	CDD:275368	1/19 (5%)
		C2H2 Zn finger	544..564	CDD:275368	8/26 (31%)
		C2H2 Zn finger	572..592	CDD:275368	4/30 (13%)
		C2H2 Zn finger	600..620	CDD:275368	2/19 (11%)
		C2H2 Zn finger	628..648	CDD:275368	1/20 (5%)
		C2H2 Zn finger	656..676	CDD:275368	3/40 (8%)
		C2H2 Zn finger	684..704	CDD:275368	6/19 (32%)
		C2H2 Zn finger	712..732	CDD:275368	5/19 (26%)
		C2H2 Zn finger	740..760	CDD:275368	6/20 (30%)
		C2H2 Zn finger	768..788	CDD:275368	8/19 (42%)
		zf-H2C2_2	781..804	CDD:463886	8/22 (36%)
		zf-C2H2	794..816	CDD:395048	7/21 (33%)
		C2H2 Zn finger	796..816	CDD:275368	6/19 (32%)
		C2H2 Zn finger	824..844	CDD:275368	4/19 (21%)