DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment mld and Zfp27

DIOPT Version :9

Sequence 1:	NP_001247289.1	Gene:	mld / 2768685	FlyBaseID:	FBgn0263490	Length:	1965	Species:	Drosophila melanogaster
Sequence 2:	NP_001032796.1	Gene:	Zfp27 / 22689	MGIID:	99174	Length:	819	Species:	Mus musculus

Alignment Length:	940	Identity:	183/940 - (19%)
Similarity:	307/940 - (32%)	Gaps:	249/940 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly  1065 QSQMQHQIPPQIEPQIEVQNQEQNTLQLVPQAQ--------HQVVPHVQLQSQLVPHVQTQGTTT 1121
            :.:.||..|.|.....:|..:..:.|:.|.:.|        :|.:.|......:.       .|.
Mouse     9 REEWQHLDPAQRSLYRDVVQETYSHLRSVEELQQIGDQKKTYQQIGHKSASDMVF-------ITK 66

  Fly  1122 TVTYEQIYQQHIVQQTVQQSSNKMQVISLPSAGSETTRQWQTQQSQQQQ----QVQWSSVGGLEA 1182
            |:..|..:....|::.:..:|    .|.||   .:..|.|...:.:.:.    |....|.|....
Mouse    67 TLGAESCHDYSGVRKVIHVNS----YIVLP---PKRPRHWDPPEDEPKHSSDLQTHDESNGLKRT 124

  Fly  1183 IKSAPVESVAPTTTTYYISASDLYPQQTETYTMLQPASNESYVIEQVNHQQQHCQQQIQMSQQQH 1247
            .:......::....|.:|...:..|...:...:|             .::|..|         |:
Mouse   125 KRITEYGKISSCINTEHILTGEKLPDHNQCGKVL-------------GYKQIPC---------QY 167

  Fly  1248 QRQHQQQQAQQQQQPIMILIQQPEIQQPVASASNPQQAPLHIY----NAATSND---VHQMQHTQ 1305
            |:.|..:::.:..:...|..|:.:::..|.|   |....|::.    .|.:...   .||..||:
Mouse   168 QKIHTGEKSYECAEFGKIFTQKSQLRVHVTS---PTGEKLYVCVECGKACSQTSEFLTHQKTHTR 229

  Fly  1306 RQ------------QIRQQYQHQQYQRLQQPQQTRVVQSHPVLGMPGATSISTKVTPIPVTAARG 1358
            .:            |:...::|::                          |.|           |
Mouse   230 EKPYKCGDCGKSFFQVSSLFRHRR--------------------------IHT-----------G 257

  Fly  1359 RPLTLKCRFCHNGPRFSSSLEYSRHIIDLHPAVAPFNCPHCPMAFAGRTKRSQHILSHHVVQQYQ 1423
            ..| ..|..|..|..::|.|...:.|   |.......|..|..||..::....|...|...:.|.
Mouse   258 EKL-YDCSHCGKGFSYNSDLRIHQKI---HTGEKRHGCVDCGKAFTQKSTLRMHQKIHTGERAYV 318

  Fly  1424 CGQCSHVFPAQKALDVHIQRFHMTLK---TDPSGAVKVEDVQL----QITSERRP-----RGRPY 1476
            |.:|...|..:..|..| :|.|...|   .|..|...:...||    :|.|..||     |.:|:
Mouse   319 CIECGQAFIQKTHLVAH-RRIHTGEKPYACDGCGKAFLSKSQLLVHQRIHSRVRPCVSLDRAKPF 382

  Fly  1477 KPRLQLQQHQLQPQQKLQVQQHQ----QQQKALQQLPQAQHHQQQQQPQLQQE------VLQQVQ 1531
            .     ....|.|::|:|:::..    :..||.....:...||:....:...:      ...|..
Mouse   383 S-----SAPNLLPRKKVQMREKSSICAECGKAFTYRSELIIHQRTHTGEKPYQCGDCGKAFTQKS 442

  Fly  1532 QLQVQ-------------------VQPQQHQQHQQVLQVQQPQQQPLMQPQSPHPSTVEMQASPT 1577
            .|.|.                   ||......||.:...::|.|...........|.:.:.....
Mouse   443 ALTVHRRIHTGEKSYVCVKCGLAFVQRAHLDAHQVIHTGEKPYQCGHCGKFFTSKSQLHVHKRIH 507

  Fly  1578 TPRKILCCPDCEDCTSGHSHANEQFEELQTLQAPPT------------VLTPPSTIVSVPSPQPM 1630
            |..|...|.:|     |.:.||.  ..|.|.|...|            ..|..|.:|:
Mouse   508 TGEKPYVCSNC-----GKAFANR--SNLITHQKTHTGEKAYVCARCGKAFTQRSDLVT------- 558

  Fly  1631 VYSQHITMPSPEQSEPDST------------------TTLRQY---------RKRGVIVGPQGPL 1668
                |..:.:.|:....||                  |..|||         .::.:::..| .:
Mouse   559 ----HQRIHTGEKPYGCSTCGKAFTQKSHLSIHEKIHTGERQYGCRDCGKAFNQKSILIVHQ-KI 618

  Fly  1669 HLATP---VASPSPSSSPSSSTVDHIPPASPATPASPAPPPSPAVASTVQVSELRTSHHCLYCEE 1730
            |....   .|....:....|:.:.|                     ..:...|  ..:.|..|.:
Mouse   619 HTGEKPHVCAECGRAFIRKSNFITH---------------------QRIHTGE--KPYGCTDCGK 660

  Fly  1731 RFTNEISLKKHHQLAHGALTTMPYVCTICKRGYRMRTALHRHMESHDVEGRPYECNICRVRFPRP 1795
            .||::..|..|..:..|   ..||||..|.:.:..|:.|.:|.::|..| :||.|:.|...|.:.
Mouse   661 SFTSKSQLLVHRPIHTG---EKPYVCAECGKAFSGRSNLSKHQKTHTGE-KPYACSECGKSFRQK 721

  Fly  1796 SQLTLHKITVHLLSKPHTCDECGKQFGTESALKTHIKFH-GELGYQCDGCDRTFEYLKELRKHRR 1859
            |:|..|. .:|...||:.|.:|||.|..:|.|:.|.:.| ||..|:|..|.:.|.....|.||:.
Mouse   722 SELITHH-RIHTGEKPYDCGDCGKSFTKKSQLQVHQRIHTGEKPYRCAECGKAFTDRSNLNKHQT 785

  Fly  1860 THS-EMFYKCKFCPSSFMRFTNFRAHMKTH 1888
            ||: |..|||..|...|::.:....|...|
Mouse   786 THTGEKPYKCVVCGKGFVQKSVLSIHENVH 815

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mld	NP_001247289.1	zf-AD	186..255	CDD:214871
		C2H2 Zn finger	1365..1388	CDD:275368	6/22 (27%)
		C2H2 Zn finger	1396..1416	CDD:275368	5/19 (26%)
		C2H2 Zn finger	1424..1445	CDD:275368	6/20 (30%)
		C2H2 Zn finger	1725..1746	CDD:275368	6/20 (30%)
		C2H2 Zn finger	1756..1776	CDD:275368	5/19 (26%)
		C2H2 Zn finger	1785..1806	CDD:275368	6/20 (30%)
		C2H2 Zn finger	1814..1834	CDD:275368	8/19 (42%)
		zf-C2H2	1839..1861	CDD:278523	7/21 (33%)
		C2H2 Zn finger	1841..1861	CDD:275368	6/19 (32%)
		C2H2 Zn finger	1868..1888	CDD:275368	4/19 (21%)
Zfp27	NP_001032796.1	KRAB	2..37	CDD:366587	6/27 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	93..123		5/29 (17%)
		C2H2 Zn finger	152..171	CDD:275370	5/40 (13%)
		C2H2 Zn finger	179..199	CDD:275368	4/22 (18%)
		C2H2 Zn finger	207..227	CDD:275368	3/19 (16%)
		COG5048	<212..372	CDD:227381	39/201 (19%)
		C2H2 Zn finger	235..255	CDD:275368	2/45 (4%)
		C2H2 Zn finger	263..283	CDD:275368	6/22 (27%)
		C2H2 Zn finger	291..311	CDD:275368	5/19 (26%)
		COG5048	317..746	CDD:227381	97/481 (20%)
		C2H2 Zn finger	319..339	CDD:275368	6/20 (30%)
		C2H2 Zn finger	347..367	CDD:275368	4/19 (21%)
		C2H2 Zn finger	403..423	CDD:275368	4/19 (21%)
		C2H2 Zn finger	431..451	CDD:275368	3/19 (16%)
		C2H2 Zn finger	459..479	CDD:275368	4/19 (21%)
		C2H2 Zn finger	487..507	CDD:275368	1/19 (5%)
		C2H2 Zn finger	515..535	CDD:275368	8/26 (31%)
		C2H2 Zn finger	543..563	CDD:275368	4/30 (13%)
		C2H2 Zn finger	571..591	CDD:275368	2/19 (11%)
		C2H2 Zn finger	599..619	CDD:275368	1/20 (5%)
		C2H2 Zn finger	627..647	CDD:275368	3/40 (8%)
		C2H2 Zn finger	655..675	CDD:275368	6/19 (32%)
		C2H2 Zn finger	683..703	CDD:275368	5/19 (26%)
		C2H2 Zn finger	711..731	CDD:275368	6/20 (30%)
		C2H2 Zn finger	739..759	CDD:275368	8/19 (42%)
		zf-H2C2_2	752..775	CDD:372612	8/22 (36%)
		C2H2 Zn finger	767..787	CDD:275368	6/19 (32%)
		zf-H2C2_2	779..804	CDD:372612	11/24 (46%)
		C2H2 Zn finger	795..815	CDD:275368	4/19 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24376
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.100