DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment mld and Zfp11

DIOPT Version :9

Sequence 1:	NP_001247289.1	Gene:	mld / 2768685	FlyBaseID:	FBgn0263490	Length:	1965	Species:	Drosophila melanogaster
Sequence 2:	NP_766050.1	Gene:	Zfp11 / 22648	MGIID:	99156	Length:	647	Species:	Mus musculus

Alignment Length:	694	Identity:	141/694 - (20%)
Similarity:	242/694 - (34%)	Gaps:	181/694 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly  1234 QHCQQQIQMSQQ--QHQRQHQQQQAQQQQQ------PIMILIQQPEIQQPVASASNPQQAPLHI- 1289
            :.|.:..:.|:.  |||..|::::..:.::      .:.:|.|.        ..::..:.|...
Mouse    88 KECGKAFKRSRNLAQHQVTHKREKPHKCEECGRAFSALSVLTQH--------RITHTGEKPFKCK 144

  Fly  1290 -------YNAATSNDVHQMQHTQRQQIRQQYQHQQYQRLQQPQQTRVV----QSHPVLGMPGATS 1343
                   ||:..:.  |::.||:.:..|.|...:.::|.....|.:|:    :.|.......|.|
Mouse   145 ECGRAFKYNSTLTQ--HEVIHTEAKPYRCQECGKAFKRSHTLSQHQVIHKGEKPHKCDECGRAFS 207

  Fly  1344 ISTKVTPIPVTAARGRPLTLKCRFCHNGPRFSSSLEYSRHIIDLHPAVAPFNCPHCPMAFAGRTK 1408
            ..:.:|...|.....:|  .:||.|....|:.|:|  :||.| :|....|:.||.|..||...:.
Mouse   208 KHSSLTQHQVIHTGEKP--YQCRECGKAFRYQSTL--TRHHI-VHTGAKPYKCPECDKAFNNSST 267

  Fly  1409 RSQHILSHHVVQQYQCGQCSHVFPAQKALDVHIQRFHMTLKTDPSGAVKVEDVQLQITSERRPRG 1473
            .|:|.:.|...:.|:|.:|...|.....|..|::             :..|::..:.    |..|
Mouse   268 LSRHQIIHTGEKPYKCQECGRAFYCSSFLIQHMK-------------IHFEEMPYRC----RECG 315

  Fly  1474 RPYKPRLQLQQHQLQPQQKLQVQQHQQQQKALQQLPQAQHHQQQQQPQLQQEVLQQVQQLQVQVQ 1538
            :|::...||.:|                          |.....::|.:.:|..:..:.
Mouse   316 KPFRLSSQLIRH--------------------------QRIHTGEEPYICRECGKTFKY------ 348

  Fly  1539 PQQHQQHQQVLQV-QQPQQQPLMQPQSPHPSTVEMQASPTTPRKILCCPDCED---CTSG-HSHA 1598
             |.:....|:|.. .:|.:.|.......:.||:.......|..|...|.:|..   |:|. ..|.
Mouse   349 -QSNLTRHQILHTGAKPYKCPECGKAFNNSSTLTRHQIIHTGEKPYKCQECSKAFYCSSYLIQHM 412

  Fly  1599 NEQFEELQTLQAPPTVLTPPSTIVSVPSPQPMVYSQHITMPSPEQSEP--DSTTTLRQYRKRGVI 1661
            ...|||                               |.....|..:|  .|:..:|..|
Mouse   413 KIHFEE-------------------------------IPYRCKECGKPFKCSSQLIRHQR----- 441

  Fly  1662 VGPQGPLHLATPVASPSPSSSPSSSTVDHIPPASPATPASPAPPPSPAVASTVQVSELRTSHH-- 1724
                  :|                              :...|............:...|.|.
Mouse   442 ------IH------------------------------SGEKPYICKECGKAFNCTSYLTKHQRI 470

  Fly  1725 --------CLYCEERFTNEISLKKHHQLAHGALTTMPYVCTICKRGYRMRTALHRHMESHDVEGR 1781
                    |..|.:.|.....|.||.::..|   ...|.|..|.:.|...:.|:||...|..| :
Mouse   471 HTGEKPYVCQECGKAFNCSSYLSKHQRIHIG---DRLYKCKECGKAYYFSSQLNRHQRIHTGE-K 531

  Fly  1782 PYECNICRVRFPRPSQLTLHKITVHLLSKPHTCDECGKQFGTESALKTHIKFH-GELGYQCDGCD 1845
            ||.|..|...|...|.||.|: .:|::.||:.|.||.|.|...|.|..|.:.| |:..|:|..|.
Mouse   532 PYVCQECGKAFNCSSYLTKHQ-RIHIVEKPYVCKECSKAFSCSSYLTKHQRIHAGDRLYKCTECG 595

  Fly  1846 RTFEYLKELRKHRRTHS-EMFYKCKFCPSSFMRFTNFRAHMKTH 1888
            :.:.:..:|.:|:|.|: |..|:||.|..:|:..:..:.|.:||
Mouse   596 KAYCFSSQLNRHQRIHTRERPYRCKECGKAFITSSCLKRHQETH 639

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mld	NP_001247289.1	zf-AD	186..255	CDD:214871
		C2H2 Zn finger	1365..1388	CDD:275368	9/22 (41%)
		C2H2 Zn finger	1396..1416	CDD:275368	7/19 (37%)
		C2H2 Zn finger	1424..1445	CDD:275368	5/20 (25%)
		C2H2 Zn finger	1725..1746	CDD:275368	6/20 (30%)
		C2H2 Zn finger	1756..1776	CDD:275368	6/19 (32%)
		C2H2 Zn finger	1785..1806	CDD:275368	7/20 (35%)
		C2H2 Zn finger	1814..1834	CDD:275368	8/19 (42%)
		zf-C2H2	1839..1861	CDD:278523	6/21 (29%)
		C2H2 Zn finger	1841..1861	CDD:275368	5/19 (26%)
		C2H2 Zn finger	1868..1888	CDD:275368	5/19 (26%)
Zfp11	NP_766050.1	C2H2 Zn finger	59..79	CDD:275368
		COG5048	83..460	CDD:227381	85/508 (17%)
		C2H2 Zn finger	87..107	CDD:275368	5/18 (28%)
		C2H2 Zn finger	115..135	CDD:275368	2/27 (7%)
		zf-H2C2_2	128..152	CDD:290200	3/31 (10%)
		C2H2 Zn finger	143..163	CDD:275368	3/21 (14%)
		C2H2 Zn finger	171..191	CDD:275368	4/19 (21%)
		C2H2 Zn finger	199..219	CDD:275368	4/19 (21%)
		C2H2 Zn finger	227..247	CDD:275368	9/22 (41%)
		C2H2 Zn finger	255..275	CDD:275368	7/19 (37%)
		C2H2 Zn finger	283..303	CDD:275368	5/32 (16%)
		DUF45	<308..349	CDD:302795	9/77 (12%)
		C2H2 Zn finger	311..331	CDD:275368	7/49 (14%)
		COG5048	335..>645	CDD:227381	83/389 (21%)
		C2H2 Zn finger	339..359	CDD:275368	3/26 (12%)
		C2H2 Zn finger	367..387	CDD:275368	3/19 (16%)
		C2H2 Zn finger	395..415	CDD:275368	5/19 (26%)
		C2H2 Zn finger	423..443	CDD:275368	5/30 (17%)
		C2H2 Zn finger	451..471	CDD:275368	2/19 (11%)
		zf-H2C2_2	463..488	CDD:290200	5/24 (21%)
		C2H2 Zn finger	479..499	CDD:275368	6/19 (32%)
		C2H2 Zn finger	507..527	CDD:275368	6/19 (32%)
		zf-H2C2_2	520..544	CDD:290200	10/24 (42%)
		C2H2 Zn finger	535..555	CDD:275368	7/20 (35%)
		C2H2 Zn finger	563..583	CDD:275368	8/19 (42%)
		C2H2 Zn finger	591..611	CDD:275368	5/19 (26%)
		zf-H2C2_2	604..628	CDD:290200	10/23 (43%)
		C2H2 Zn finger	619..639	CDD:275368	5/19 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24376
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.100