DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment mld and Zfp160

DIOPT Version :9

Sequence 1:	NP_001247289.1	Gene:	mld / 2768685	FlyBaseID:	FBgn0263490	Length:	1965	Species:	Drosophila melanogaster
Sequence 2:	NP_663458.2	Gene:	Zfp160 / 224585	MGIID:	108187	Length:	650	Species:	Mus musculus

Alignment Length:	558	Identity:	133/558 - (23%)
Similarity:	195/558 - (34%)	Gaps:	147/558 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly  1364 KCRFCHNGPRFS--SSLEYSRHIIDLHPAVAPFNCPHCPMAFAGRTKRSQHILSHHVVQQYQCGQ 1426
            ||..|  |..||  |.|:..|.|   |....||.|.||..||:.|:..:.|.:.|...:.|:|.:
Mouse   203 KCNEC--GKVFSQNSHLKSHRRI---HTGEKPFKCNHCGKAFSVRSNLTHHQVIHTGDKPYKCNE 262

  Fly  1427 CSHVFPAQKALDVHIQRFHMTLKTDPSGAVKVEDVQLQITSERRPR----GRPYKPRLQLQQHQL 1487
            |..||....:|.:| :|.|                    |.|:..|    |:.:.....|..|
Mouse   263 CGKVFSQTSSLTIH-RRTH--------------------TGEKPYRCNECGKVFSSHSNLNTH-- 304

  Fly  1488 QPQQKLQVQQHQQQQKALQQLPQAQHHQQQQQPQLQQEVLQQVQQLQVQVQPQQHQQHQQVLQVQ 1552
                                  ||.|  ..::|....|.      .:|..|......|.::...:
Mouse   305 ----------------------QAIH--TGEKPYKCSEC------GKVFTQNSHLANHWRIHTGE 339

  Fly  1553 QPQQQPLMQPQSPHPSTVEMQASPTTPRKILCCPDCEDCTSGHSHANEQFEELQTLQAPPT---- 1613
            :|.:                               |.:|....|    .:..|.|.||..|
Mouse   340 KPYK-------------------------------CNECGKAFS----VYSSLTTHQAIHTGEKP 369

  Fly  1614 --------VLTPPSTIVSVPSPQPMVYSQHITMPSPEQSEPDSTTT--LRQYRKRGVIVGPQGPL 1668
                    |.|..|.:.|    ...|:|........|..:..|.|:  .|.:|   |..| :.|.
Mouse   370 YKCNECGKVFTQNSHLAS----HRGVHSGEKPYKCEECGKLFSQTSNLARHWR---VHTG-EKPY 426

  Fly  1669 HLATPVASPSPSSSPSSSTVDHIPPASPATPASP----------APPPSPAVASTVQVSELRTSH 1723
            ..:....:.|..||..:..|.|       |...|          :...|.::...:...|  ..:
Mouse   427 KCSECGKAFSVRSSLIAHQVIH-------TGEKPYKCTECGKVFSQTSSLSIHQRIHTGE--KPY 482

  Fly  1724 HCLYCEERFTNEISLKKHHQLAHGALTTMPYVCTICKRGYRMRTALHRHMESHDVEGRPYECNIC 1788
            .|..|.:.|.:..:|..|..:..|   ..||.|..|.:.:...:.|..|..:|..| :||:||.|
Mouse   483 RCNECGKAFNSHSNLNTHQVIHTG---QKPYKCMQCGKVFTQNSHLANHQRTHTGE-KPYKCNEC 543

  Fly  1789 RVRFPRPSQLTLHKITVHLLSKPHTCDECGKQFGTESALKTHIKFH-GELGYQCDGCDRTFEYLK 1852
            ...|...|.||.|: .:|...||:.|:||||.|...|.|.:|.:.| ||..|||:.||:.|....
Mouse   544 GKAFSVYSSLTTHQ-AIHTGEKPYKCNECGKVFTQNSHLASHRRTHTGEKPYQCNKCDKAFSVRS 607

  Fly  1853 ELRKHRRTHS-EMFYKCKFCPSSFMRFTNFRAHMKTHL 1889
            .|..|:..|: |..|.|..|...|.|.:|..:|.:.|:
Mouse   608 SLTTHQAIHTGEKPYTCSECGKVFSRSSNLTSHQRLHV 645

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mld	NP_001247289.1	zf-AD	186..255	CDD:214871
		C2H2 Zn finger	1365..1388	CDD:275368	9/24 (38%)
		C2H2 Zn finger	1396..1416	CDD:275368	7/19 (37%)
		C2H2 Zn finger	1424..1445	CDD:275368	7/20 (35%)
		C2H2 Zn finger	1725..1746	CDD:275368	5/20 (25%)
		C2H2 Zn finger	1756..1776	CDD:275368	4/19 (21%)
		C2H2 Zn finger	1785..1806	CDD:275368	8/20 (40%)
		C2H2 Zn finger	1814..1834	CDD:275368	9/19 (47%)
		zf-C2H2	1839..1861	CDD:278523	8/21 (38%)
		C2H2 Zn finger	1841..1861	CDD:275368	6/19 (32%)
		C2H2 Zn finger	1868..1888	CDD:275368	6/19 (32%)
Zfp160	NP_663458.2	KRAB	8..68	CDD:214630
		KRAB	8..47	CDD:279668
		C2H2 Zn finger	148..168	CDD:275368
		C2H2 Zn finger	176..196	CDD:275368
		zf-H2C2_2	188..213	CDD:290200	5/11 (45%)
		COG5048	200..635	CDD:227381	130/546 (24%)
		zf-C2H2	202..224	CDD:278523	10/25 (40%)
		C2H2 Zn finger	204..224	CDD:275368	9/24 (38%)
		zf-H2C2_2	216..240	CDD:290200	10/26 (38%)
		C2H2 Zn finger	232..252	CDD:275368	7/19 (37%)
		zf-H2C2_2	244..269	CDD:290200	7/24 (29%)
		C2H2 Zn finger	260..280	CDD:275368	7/20 (35%)
		zf-H2C2_2	272..297	CDD:290200	8/45 (18%)
		C2H2 Zn finger	288..308	CDD:275368	5/43 (12%)
		zf-H2C2_2	300..325	CDD:290200	8/56 (14%)
		C2H2 Zn finger	316..336	CDD:275368	4/25 (16%)
		C2H2 Zn finger	344..364	CDD:275368	7/23 (30%)
		zf-H2C2_2	356..381	CDD:290200	6/24 (25%)
		C2H2 Zn finger	372..392	CDD:275368	4/23 (17%)
		zf-H2C2_2	384..409	CDD:290200	4/28 (14%)
		C2H2 Zn finger	400..420	CDD:275368	5/22 (23%)
		zf-H2C2_2	412..436	CDD:290200	5/27 (19%)
		C2H2 Zn finger	428..448	CDD:275368	4/19 (21%)
		zf-H2C2_2	440..465	CDD:290200	5/31 (16%)
		C2H2 Zn finger	456..476	CDD:275368	1/19 (5%)
		zf-H2C2_2	468..493	CDD:290200	5/26 (19%)
		C2H2 Zn finger	484..504	CDD:275368	5/19 (26%)
		zf-H2C2_2	496..521	CDD:290200	7/27 (26%)
		C2H2 Zn finger	512..532	CDD:275368	4/19 (21%)
		zf-H2C2_2	524..548	CDD:290200	9/24 (38%)
		C2H2 Zn finger	540..560	CDD:275368	8/20 (40%)
		zf-H2C2_2	552..577	CDD:290200	12/25 (48%)
		C2H2 Zn finger	568..588	CDD:275368	9/19 (47%)
		zf-H2C2_2	580..604	CDD:290200	10/23 (43%)
		C2H2 Zn finger	596..616	CDD:275368	6/19 (32%)
		zf-H2C2_2	608..633	CDD:290200	8/24 (33%)
		C2H2 Zn finger	624..644	CDD:275368	6/19 (32%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167832260
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.930