Protein Alignment mld and Zfp729a

DIOPT Version :10

• Sequence 1: NP_001247289.1
• Gene: mld / 2768685
• FlyBaseID: FBgn0263490
• Length: 1965
• Species: Drosophila melanogaster
• Sequence 2: NP_001388795.1
• Gene: Zfp729a / 212281
• MGIID: 3036250
• Length: 994
• Species: Mus musculus
• Alignment Length: 542
• Identity: 127/542 - (23%)
• Similarity: 182/542 - (33%)
• Gaps: 171/542 - (31%)

  Fly  1364 KCRFCHNGPRFSSSLEYSRHIIDLHPAVAPFNCPHCPMAFAGRTKRSQHILSHHVVQQYQCGQCS 1428
            :|..|.....|.|||...:.|   |....|:.|..|..||...:..|:|...|...:.|:|.:|.
Mouse   505 QCEVCGKAFCFPSSLSKHKRI---HTGEKPYKCKECGKAFRSLSSLSKHKRIHTGEKPYKCEECG 566

  Fly  1429 HVFPAQKAL---------------DVHIQRFHMTLKTDPSGAVKVEDVQLQITSERRPRGRPYKP 1478
            ..|.....|               ||..|.||:     ||   |:...::..|.|     :|||.
Mouse   567 KAFHYPSLLSKHKIIHTEEKPYKCDVCGQAFHV-----PS---KLSHHKIIHTGE-----KPYKC 618

  Fly  1479 R---------LQLQQHQLQPQQKLQVQQHQQQQKALQQLPQAQHHQQQQQPQLQQEVLQQVQQLQ 1534
            .         |.|.:|:         :.|..:.....|:..                       :
Mouse   619 EVCGKAFCIPLLLSKHK---------RVHTGENPYNSQVCS-----------------------K 651

  Fly  1535 VQVQPQQHQQHQQVLQVQQPQQQPLMQPQSPHPSTVEMQASPTTPRKILCCP-DCEDCTSGHSHA 1598
            ..|.|.:..:|::|...::|.:..:.......||.:.:.....|..|    | .||||.....:
Mouse   652 AFVYPSKLSKHKKVRTKEKPYKCEVCGKAFRFPSLLLIHKGMHTGEK----PYKCEDCGKAFHY- 711

  Fly  1599 NEQFEELQTLQAPPTVLTPPSTIVSVPSPQPMVYSQH---ITMPSPEQSEPDSTTTLRQYRKRGV 1660
                                          |.:.|:|   .|...|.|.|
Mouse   712 ------------------------------PSLLSKHKRIHTGEKPYQCE--------------- 731

  Fly  1661 IVGPQGPLHLATPVASPSPSSSPSSSTVDHIPPASPATPASPAPPPSPAVASTVQVSELRTSHHC 1725
            :.|..  .|:         |||.|...:.|       |...|                    :.|
Mouse   732 VCGKD--FHV---------SSSLSKHRIIH-------TGEKP--------------------YKC 758

  Fly  1726 LYCEERFTNEISLKKHHQLAHGALTTMPYVCTICKRGYRMRTALHRHMESHDVEGRPYECNICRV 1790
            ..|.:.|....||.||.:...|   ..||.|..|.:.:...:.|.:|..||..| :||.|::|..
Mouse   759 EICGKTFRFSSSLSKHKRNHTG---KKPYKCEECGKAFHFPSILAKHKISHTGE-KPYNCDLCGK 819

  Fly  1791 RFPRPSQLTLHKITVHLLSKPHTCDECGKQFGTESALKTHIKFH-GELGYQCDGCDRTFEYLKEL 1854
            .|...|.|:.||: :|...|||.||.|||.|...|.|..|.|.| ||..|:|:.|...|.:...|
Mouse   820 AFHYASLLSKHKM-IHTGEKPHKCDICGKAFHYPSKLSNHKKIHTGEKPYKCEVCGNVFCFASSL 883

  Fly  1855 RKHRRTHS-EMFYKCKFCPSSF 1875
            .||:|.|: |..|||:.|..:|
Mouse   884 SKHKRIHTGENPYKCEVCGKAF 905

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
mld	NP_001247289.1	zf-AD	186..255	CDD:214871
		PAT1	<959..>1109	CDD:401645
		C2H2 Zn finger	1365..1388	CDD:275368	7/22 (32%)
		C2H2 Zn finger	1396..1416	CDD:275368	6/19 (32%)
		C2H2 Zn finger	1424..1445	CDD:275368	7/35 (20%)
		C2H2 Zn finger	1725..1746	CDD:275368	7/20 (35%)
		C2H2 Zn finger	1756..1776	CDD:275368	4/19 (21%)
		C2H2 Zn finger	1785..1806	CDD:275368	7/20 (35%)
		zf-C2H2	1812..1834	CDD:395048	11/21 (52%)
		C2H2 Zn finger	1814..1834	CDD:275368	10/19 (53%)
		zf-C2H2	1839..1861	CDD:395048	8/21 (38%)
		C2H2 Zn finger	1841..1861	CDD:275368	7/19 (37%)
		zf-C2H2	1866..1888	CDD:395048	5/10 (50%)
		C2H2 Zn finger	1868..1888	CDD:275368	3/8 (38%)
Zfp729a	NP_001388795.1	KRAB	36..94	CDD:214630
		C2H2 Zn finger	114..131	CDD:275368
		C2H2 Zn finger	142..162	CDD:275368
		SFP1	<164..233	CDD:227516
		C2H2 Zn finger	170..190	CDD:275368
		C2H2 Zn finger	198..218	CDD:275368
		C2H2 Zn finger	226..246	CDD:275368
		COG5048	250..691	CDD:227381	46/233 (20%)
		C2H2 Zn finger	254..274	CDD:275368
		C2H2 Zn finger	282..302	CDD:275368
		C2H2 Zn finger	310..330	CDD:275368
		C2H2 Zn finger	338..358	CDD:275368
		C2H2 Zn finger	366..386	CDD:275368
		C2H2 Zn finger	394..414	CDD:275368
		C2H2 Zn finger	425..442	CDD:275368
		C2H2 Zn finger	450..470	CDD:275368
		C2H2 Zn finger	478..498	CDD:275368
		C2H2 Zn finger	506..526	CDD:275368	7/22 (32%)
		COG5048	530..972	CDD:227381	119/514 (23%)
		C2H2 Zn finger	534..554	CDD:275368	6/19 (32%)
		C2H2 Zn finger	562..582	CDD:275368	4/19 (21%)
		C2H2 Zn finger	590..610	CDD:275368	8/27 (30%)
		C2H2 Zn finger	618..638	CDD:275368	3/28 (11%)
		C2H2 Zn finger	647..666	CDD:275368	4/41 (10%)
		C2H2 Zn finger	674..694	CDD:275368	2/19 (11%)
		C2H2 Zn finger	702..722	CDD:275368	7/50 (14%)
		C2H2 Zn finger	730..750	CDD:275368	7/45 (16%)
		C2H2 Zn finger	758..778	CDD:275368	7/19 (37%)
		C2H2 Zn finger	786..806	CDD:275368	4/19 (21%)
		C2H2 Zn finger	814..834	CDD:275368	7/20 (35%)
		C2H2 Zn finger	842..862	CDD:275368	10/19 (53%)
		C2H2 Zn finger	870..890	CDD:275368	7/19 (37%)
		C2H2 Zn finger	898..918	CDD:275368	3/8 (38%)
		C2H2 Zn finger	926..946	CDD:275368
		C2H2 Zn finger	954..974	CDD:275368