DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment mld and Zfp658

DIOPT Version :9

Sequence 1:	NP_001247289.1	Gene:	mld / 2768685	FlyBaseID:	FBgn0263490	Length:	1965	Species:	Drosophila melanogaster
Sequence 2:	NP_001008549.1	Gene:	Zfp658 / 210104	MGIID:	2652821	Length:	887	Species:	Mus musculus

Alignment Length:	832	Identity:	157/832 - (18%)
Similarity:	250/832 - (30%)	Gaps:	329/832 - (39%)

- Green bases have known domain annotations that are detailed below.

  Fly  1152 SAGSETTRQ----------WQ----TQQSQQQQQVQWSSVGGLEAIKSAPVES----VAPTTTTY 1198
            |..|..||.          ||    .|:..|.|...||....|.. |:|..:.    ..|..||.
Mouse   117 SKASAVTRHGLWCSILEELWQDPDPAQRDGQNQIPPWSPGASLNK-KTARADRDCGWKEPGKTTP 180

  Fly  1199 YIS-------------ASDLYPQ------------------QTETYTMLQPASNESYVI------ 1226
            :::             |..|.|.                  .|..:.:.|.:||.:..|
Mouse   181 FVANLFSTQKGAPRLLAKRLNPNLEANGEEQGSVTKQLNGLVTSAHLLPQDSSNANCTILRETWN 245

  Fly  1227 -------------EQVNHQQQHCQQQIQMSQQ------------QHQRQHQQQQAQQQQQPIMIL 1266
                         :|:..::.|.::::....:            :||..|..:......:.....
Mouse   246 PCKGNQCRKVPTHKQLTEKEAHSREKLDEGTECRKVFYDESAFCKHQAAHAGEGPFVCHKCGEAF 310

  Fly  1267 IQQPEIQQPVASASNPQQAPLHIYN--------AATSN-DVHQMQHTQRQQIRQQYQHQQYQRLQ 1322
            :|:.|.      ||:.:..|...|.        :.||| .||...||.                :
Mouse   311 LQKTEF------ASHQETHPEKPYECPDCGKSFSRTSNLQVHHRIHTG----------------E 353

  Fly  1323 QPQQTRVVQSHPVLGMPGATSISTKVTPIPVTAARGRPLTLKCRFCHNGPRFSSSLEYSRHIIDL 1387
            :|.:                                      ||.|  |..|:::.:...| ..:
Mouse   354 KPYE--------------------------------------CRDC--GKSFNNTSQLKVH-YRI 377

  Fly  1388 HPAVAPFNCPHCPMAFAGRTKRSQHILSHHVVQQYQCGQCSHVFPAQKALDVHIQRFHMTLKTDP 1452
            |....|:.||.|..||..::..|.|...|...:.|:|..|..:|.....|.||.| .||..|...
Mouse   378 HTGERPYVCPVCGKAFKQKSILSTHETIHTGEKPYKCTVCGKLFSCTSRLKVHYQ-IHMKEKPYE 441

  Fly  1453 SGAVKVEDVQLQITSERRPRGRPYKPRLQLQQHQLQPQQKLQVQQ--HQQQQ--KALQQLPQAQH 1513
            .|..                |:.:|.:..|..|     ||:.::|  |:..:  |...|..:...
Mouse   442 CGDC----------------GKAFKRKSSLTVH-----QKIHIRQTHHECSECGKTFNQKSELST 485

  Fly  1514 HQQQQQPQLQQEVLQQVQQLQVQVQPQQHQQHQQVLQVQQPQQQPLMQPQSPHPSTVEMQASPTT 1578
            ||                  ::.:....|:
Mouse   486 HQ------------------RLHLGKNSHR----------------------------------- 497

  Fly  1579 PRKILCCPDCEDCTSGHSHANEQFEELQTLQAPPTVLTPPSTIVSVPSPQPMVYSQHITMPSPEQ 1643
                     |.||....::|::       |:....|.|...........:...||
Mouse   498 ---------CSDCGKSFTYASQ-------LKMHRRVHTGEKPYKCRDCGKSFTYS---------- 536

  Fly  1644 SEPDSTTTLRQYRKRGVIVGPQGPLHLATPVASPSPSSSPSSSTVDHIPPASPATPASPAPPPSP 1708
                  .||..:|:
Mouse   537 ------FTLNVHRR--------------------------------------------------- 544

  Fly  1709 AVASTVQVSELRTSHHCLYCEERFTNEISLKKHHQLAHGALTTMPYVCTICKRGYRMRTALHRHM 1773
                   :.::...|.|..|.:...::..|::|.::..|   ..|||||.|.:|:..|:...||.
Mouse   545 -------IHKVEKPHKCSICGKALASKYQLEEHERIHTG---EKPYVCTECGKGFHGRSGFLRHQ 599

  Fly  1774 ESHDVEGRPYECNICRVRFPRPSQLTLHKITVHLLSKPHTCDECGKQFGTESALKTHIKFH-GEL 1837
            .:| ...:|:.|:.|...|.:.||||.|:.| |...||:||..|||.|...|.|..|.:.| ||.
Mouse   600 ITH-TRDKPFVCHKCGKAFFQRSQLTSHQQT-HTGEKPYTCHYCGKSFSHTSQLTVHHRIHTGER 662

  Fly  1838 GYQCDGCDRTFEYLKELRKHRRTHS-EMFYKCKFCPSSFMRFTNFRAHMKTH 1888
            .|:||.|.::|....:|::|.|.|: |..|.|..|..:|.|.::...|.|.|
Mouse   663 PYKCDYCAKSFSNSSQLKEHLRIHTGETPYACSECGKAFSRRSSLNLHTKIH 714

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mld	NP_001247289.1	zf-AD	186..255	CDD:214871
		C2H2 Zn finger	1365..1388	CDD:275368	6/22 (27%)
		C2H2 Zn finger	1396..1416	CDD:275368	7/19 (37%)
		C2H2 Zn finger	1424..1445	CDD:275368	7/20 (35%)
		C2H2 Zn finger	1725..1746	CDD:275368	4/20 (20%)
		C2H2 Zn finger	1756..1776	CDD:275368	7/19 (37%)
		C2H2 Zn finger	1785..1806	CDD:275368	9/20 (45%)
		C2H2 Zn finger	1814..1834	CDD:275368	8/19 (42%)
		zf-C2H2	1839..1861	CDD:278523	8/21 (38%)
		C2H2 Zn finger	1841..1861	CDD:275368	7/19 (37%)
		C2H2 Zn finger	1868..1888	CDD:275368	6/19 (32%)
Zfp658	NP_001008549.1	KRAB	23..80	CDD:214630
		C2H2 Zn finger	275..295	CDD:275368	2/19 (11%)
		COG5048	300..684	CDD:227381	116/616 (19%)
		C2H2 Zn finger	303..323	CDD:275368	4/25 (16%)
		C2H2 Zn finger	330..350	CDD:275368	5/19 (26%)
		C2H2 Zn finger	358..378	CDD:275368	6/22 (27%)
		C2H2 Zn finger	386..406	CDD:275368	7/19 (37%)
		C2H2 Zn finger	414..434	CDD:275368	7/20 (35%)
		C2H2 Zn finger	442..462	CDD:275368	7/40 (18%)
		C2H2 Zn finger	470..490	CDD:275368	4/37 (11%)
		COG5048	493..887	CDD:227381	73/352 (21%)
		C2H2 Zn finger	498..518	CDD:275368	5/26 (19%)
		C2H2 Zn finger	526..546	CDD:275368	5/93 (5%)
		C2H2 Zn finger	554..574	CDD:275368	4/19 (21%)
		C2H2 Zn finger	582..602	CDD:275368	7/19 (37%)
		C2H2 Zn finger	610..630	CDD:275368	9/20 (45%)
		C2H2 Zn finger	638..658	CDD:275368	8/19 (42%)
		C2H2 Zn finger	666..686	CDD:275368	7/19 (37%)
		C2H2 Zn finger	694..714	CDD:275368	6/19 (32%)
		C2H2 Zn finger	722..742	CDD:275368
		C2H2 Zn finger	750..770	CDD:275368
		C2H2 Zn finger	778..798	CDD:275368
		C2H2 Zn finger	806..826	CDD:275368
		C2H2 Zn finger	834..854	CDD:275368
		C2H2 Zn finger	862..882	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24376
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.100