DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment mld and ZNF48

DIOPT Version :9

Sequence 1:	NP_001247289.1	Gene:	mld / 2768685	FlyBaseID:	FBgn0263490	Length:	1965	Species:	Drosophila melanogaster
Sequence 2:	NP_001201835.1	Gene:	ZNF48 / 197407	HGNCID:	13114	Length:	618	Species:	Homo sapiens

Alignment Length:	697	Identity:	119/697 - (17%)
Similarity:	180/697 - (25%)	Gaps:	322/697 - (46%)

- Green bases have known domain annotations that are detailed below.

  Fly  1229 VNHQQQHCQQQ------------IQMSQQQHQRQHQQQQAQQQQQPIMILIQQPEIQQPVASASN 1281
            |.||:.|..::            ...::.:|||.|..::..:.:.|                |..
Human   128 VKHQRTHTGEKPYKCGVCGKGFGDSSARIKHQRTHSGEKPYRARPP----------------AQG 176

  Fly  1282 PQQAPLHIYNAA--------------TSNDV--HQMQHTQRQQIR------------QQYQHQQY 1318
            |.:.|.....|.              .|:|:  ||..||..:..:            .:.:||:.
Human   177 PPKIPRSRIPAGERPTICGECGKSFRQSSDLVKHQRTHTGEKPYKCGICGKGFGDSSARIKHQRT 241

  Fly  1319 QRLQQPQQTRVVQSHPVLGMPGATSISTKVTPIP-VTAARGRPLTLKCRF-----CHNGPR---- 1373
            .|.:||.:..|.:..|......||. ..|....| :....|:...|.|..     .|.||:
Human   242 HRGEQPPRPVVPRRQPSRAATAATQ-GPKAQDKPYICTDCGKRFVLSCSLLSHQRSHLGPKPFGC 305

  Fly  1374 ------FSSSLEYSRHIIDLHPAVAPFNCPHCPMAFAGRTKRSQHILSHHVVQQYQCGQCSHVFP 1432
                  |:...:..:| :.:|....|:.||.|...||..:.|.:|:.:|...:.:.|.:|...|.
Human   306 DVCGKEFARGSDLVKH-LRVHTGEKPYLCPECGKGFADSSARVKHLRTHSGERPHACPECDRTFS 369

  Fly  1433 AQKALDVHIQRFHMTLKTDPSGAVKVEDVQLQITSERRPRGRPYKPRLQLQQHQLQPQQKLQVQQ 1497
            ....|
Human   370 LSSTL------------------------------------------------------------ 374

  Fly  1498 HQQQQKALQQLPQAQHHQQQQQPQLQQEVLQQVQQLQVQVQPQQHQQHQQVLQVQQPQQQPLMQP 1562
                         .:|.....:|                                    |....|
Human   375 -------------LRHRLTHMEP------------------------------------QDFSFP 390

  Fly  1563 QSPHPSTVEMQASPTTPRKILCCPDCEDCTSGHSHANEQFEELQTLQAPPTVLTPPSTIVSVPSP 1627
            ..|.|:.:     |:.|                              .||...:||.|
Human   391 GYPLPALI-----PSPP------------------------------PPPLGTSPPLT------- 413

  Fly  1628 QPMVYSQHITMPSPEQSEPDSTTTLRQYRKRGVIVGPQGPLHLATPVASPSPSSSPSSSTVDHIP 1692
                                                |:.|.|...|...|.            :.
Human   414 ------------------------------------PRSPSHSGEPFGLPG------------LE 430

  Fly  1693 PASPATPASPAPPPSPAVASTVQVSELRTSHHCLYCEERFTNEISLKKHHQLAHGALTTMPYVCT 1757
            | .|..|.:..||| |....        ..|.|..|.:.|.....|.|||::..|   ..||:|.
Human   431 P-EPGGPQAGEPPP-PLAGD--------KPHKCPECGKGFRRSSDLVKHHRVHTG---EKPYLCP 482

  Fly  1758 ICKRGYRMRTALHRHMESHDVE-----------------------------------GRPYECNI 1787
            .|.:|:...:|..:|:.:|..|                                   .:|:.|..
Human   483 ECGKGFADSSARVKHLRTHRGERARPPPPSTLLRPHNPPGPVPMAPRPRVRAQPSGPSQPHVCGF 547

  Fly  1788 CRVRFPRPSQLTLHKITVHLLSKPHTCDECGKQFGTESALKTHIKFH 1834
            |...|||.|.|..|:.| |...||:.|.||||.||..||...|.:.|
Human   548 CGKEFPRSSDLVKHRRT-HTGEKPYKCAECGKGFGDSSARIKHQRGH 593

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mld	NP_001247289.1	zf-AD	186..255	CDD:214871
		C2H2 Zn finger	1365..1388	CDD:275368	6/37 (16%)
		C2H2 Zn finger	1396..1416	CDD:275368	7/19 (37%)
		C2H2 Zn finger	1424..1445	CDD:275368	4/20 (20%)
		C2H2 Zn finger	1725..1746	CDD:275368	7/20 (35%)
		C2H2 Zn finger	1756..1776	CDD:275368	5/19 (26%)
		C2H2 Zn finger	1785..1806	CDD:275368	9/20 (45%)
		C2H2 Zn finger	1814..1834	CDD:275368	10/19 (53%)
		zf-C2H2	1839..1861	CDD:278523
		C2H2 Zn finger	1841..1861	CDD:275368
		C2H2 Zn finger	1868..1888	CDD:275368
ZNF48	NP_001201835.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..51
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	78..109
		zf-C2H2	113..134	CDD:278523	3/5 (60%)
		COG5048	114..499	CDD:227381	93/600 (16%)
		C2H2 Zn finger	114..134	CDD:275368	3/5 (60%)
		zf-H2C2_2	126..149	CDD:290200	4/20 (20%)
		C2H2 Zn finger	142..162	CDD:275368	3/19 (16%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	157..189		9/47 (19%)
		C2H2 Zn finger	194..214	CDD:275368	4/19 (21%)
		zf-C2H2	194..214	CDD:278523	4/19 (21%)
		zf-H2C2_2	206..229	CDD:290200	5/22 (23%)
		C2H2 Zn finger	222..242	CDD:275368	2/19 (11%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	235..271		10/36 (28%)
		C2H2 Zn finger	277..297	CDD:275368	3/19 (16%)
		C2H2 Zn finger	305..325	CDD:275368	2/20 (10%)
		zf-H2C2_2	317..341	CDD:290200	6/24 (25%)
		C2H2 Zn finger	333..353	CDD:275368	7/19 (37%)
		zf-H2C2_2	348..369	CDD:290200	4/20 (20%)
		C2H2 Zn finger	361..381	CDD:275368	5/92 (5%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	392..457		23/164 (14%)
		zf-C2H2	451..473	CDD:278523	8/21 (38%)
		C2H2 Zn finger	453..473	CDD:275368	7/19 (37%)
		zf-H2C2_2	465..489	CDD:290200	10/26 (38%)
		C2H2 Zn finger	481..501	CDD:275368	5/19 (26%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	500..540		2/39 (5%)
		COG5048	524..>591	CDD:227381	23/67 (34%)
		zf-C2H2	543..565	CDD:278523	9/22 (41%)
		C2H2 Zn finger	545..565	CDD:275368	9/20 (45%)
		zf-H2C2_2	557..580	CDD:290200	11/23 (48%)
		C2H2 Zn finger	573..593	CDD:275370	10/19 (53%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165142329
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24376
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	2.030