DRSC/TRiP Functional Genomics Resources

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Protein Alignment mld and ZNF497

DIOPT Version :9

Sequence 1:NP_001247289.1 Gene:mld / 2768685 FlyBaseID:FBgn0263490 Length:1965 Species:Drosophila melanogaster
Sequence 2:NP_001193938.1 Gene:ZNF497 / 162968 HGNCID:23714 Length:498 Species:Homo sapiens


Alignment Length:571 Identity:118/571 - (20%)
Similarity:168/571 - (29%) Gaps:237/571 - (41%)


- Green bases have known domain annotations that are detailed below.


  Fly  1355 AARGRPLTLK--CRFCHNGPRFSSS---LEYSRHIIDLHPAVAPFNCPHCPMAFAGRTKRSQHIL 1414
            |.|..||..:  ||....|..||..   |::.|    :|....|:.||.|..|||..:..|||..
Human    94 ALRPSPLPEEPGCRCGECGKAFSQGSYLLQHRR----VHTGEKPYTCPECGKAFAWSSNLSQHQR 154

  Fly  1415 SHHVVQQYQCGQCSHVFPAQKALDVHIQRFHMTLKTDPSGAVKVEDVQLQITSERRPRGRPYKPR 1479
            .|...:.|.|.:|...|.|...| :|.|..|..||     ..:..|.           |:.:...
Human   155 IHSGEKPYACRECGKAFRAHSQL-IHHQETHSGLK-----PFRCPDC-----------GKSFGRS 202

  Fly  1480 LQLQQHQLQPQQKLQVQQHQQQQKALQQLPQAQHHQQQQQPQLQQEVLQQVQQLQVQVQPQQHQQ 1544
            ..|.||:                                                        :.
Human   203 TTLVQHR--------------------------------------------------------RT 211

  Fly  1545 HQQVLQVQQPQQQPLMQPQSPHPSTVEMQASPTTPRKILCCPDCEDCTSGHSHANEQFEELQTLQ 1609
            |                                |..|...||:|....|.:|:            
Human   212 H--------------------------------TGEKPYECPECGKAFSWNSN------------ 232

  Fly  1610 APPTVLTPPSTIVSVPSPQPMVYSQHITMPSPEQSEPDSTTTLRQYRKRGVIVGPQGPLHLATPV 1674
                                  :.:|                      |.|..|       |.|.
Human   233 ----------------------FLEH----------------------RRVHTG-------ARPH 246

  Fly  1675 A--SPSPSSSPSSSTVDHIPPASPATPASPAPPPSPAVASTVQVSELRTSHHCLYCEERFTNEIS 1737
            |  ....:.|.||:..:|:...:.|.|                       |.|..|.:.|.....
Human   247 ACRDCGKAFSQSSNLAEHLKIHAGARP-----------------------HACPDCGKAFVRVAG 288

  Fly  1738 LKKHHQLAHGALTTMPYVCTICKRGYRMRTALHRHMESHDVEGRPYECNICRVRFPRPSQLTLHK 1802
            |::|.: .|.  :..|:.|..|.:.:|..:.|.:|..:|..| ||:||..|...|...|.|..|:
Human   289 LRQHRR-THS--SEKPFPCAECGKAFRESSQLLQHQRTHTGE-RPFECAECGQAFVMGSYLAEHR 349

  Fly  1803 ITVHLLSKPHTCDECGKQFGTESALKTHIKFH-----------------------------GELG 1838
             .||...|||.|.:|||.|...|.|.:|.:.|                             ||..
Human   350 -RVHTGEKPHACAQCGKAFSQRSNLLSHRRTHSGAKPFACADCGKAFRGSSGLAHHRLSHTGERP 413

  Fly  1839 YQCDGCDRTFEYLKELRKHRRTHS-EMFYKCKFCPSSFMRFTNFRAHMKTH 1888
            :.|..|.:.|....|||:|:|.|| |..:.|..|..:|:|.:...:|.:||
Human   414 FACAECGKAFRGSSELRQHQRLHSGERPFVCAHCSKAFVRKSELLSHRRTH 464

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
mldNP_001247289.1 zf-AD 186..255 CDD:214871
C2H2 Zn finger 1365..1388 CDD:275368 7/25 (28%)
C2H2 Zn finger 1396..1416 CDD:275368 9/19 (47%)
C2H2 Zn finger 1424..1445 CDD:275368 7/20 (35%)
C2H2 Zn finger 1725..1746 CDD:275368 5/20 (25%)
C2H2 Zn finger 1756..1776 CDD:275368 5/19 (26%)
C2H2 Zn finger 1785..1806 CDD:275368 6/20 (30%)
C2H2 Zn finger 1814..1834 CDD:275368 8/19 (42%)
zf-C2H2 1839..1861 CDD:278523 8/21 (38%)
C2H2 Zn finger 1841..1861 CDD:275368 8/19 (42%)
C2H2 Zn finger 1868..1888 CDD:275368 5/19 (26%)
ZNF497NP_001193938.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 30..104 4/9 (44%)
COG5048 107..492 CDD:227381 113/558 (20%)
C2H2 Zn finger 108..128 CDD:275368 5/23 (22%)
zf-H2C2_2 120..144 CDD:290200 8/27 (30%)
C2H2 Zn finger 136..156 CDD:275368 9/19 (47%)
zf-H2C2_2 148..171 CDD:290200 7/22 (32%)
C2H2 Zn finger 164..184 CDD:275368 7/20 (35%)
zf-C2H2 190..212 CDD:278523 5/88 (6%)
C2H2 Zn finger 192..212 CDD:275368 5/86 (6%)
zf-H2C2_2 205..228 CDD:290200 9/110 (8%)
C2H2 Zn finger 220..240 CDD:275368 7/75 (9%)
C2H2 Zn finger 248..268 CDD:275368 4/19 (21%)
C2H2 Zn finger 276..296 CDD:275368 5/20 (25%)
zf-H2C2_2 289..311 CDD:290200 6/24 (25%)
C2H2 Zn finger 304..324 CDD:275368 5/19 (26%)
zf-H2C2_2 317..340 CDD:290200 9/23 (39%)
C2H2 Zn finger 332..352 CDD:275368 6/20 (30%)
zf-H2C2_2 344..369 CDD:290200 12/25 (48%)
C2H2 Zn finger 360..380 CDD:275368 8/19 (42%)
C2H2 Zn finger 388..408 CDD:275368 0/19 (0%)
C2H2 Zn finger 416..436 CDD:275368 8/19 (42%)
zf-H2C2_2 428..453 CDD:290200 11/24 (46%)
C2H2 Zn finger 444..464 CDD:275368 5/19 (26%)
zf-H2C2_2 456..481 CDD:290200 3/9 (33%)
C2H2 Zn finger 472..492 CDD:275368
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C165142276
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.840

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