DRSC/TRiP Functional Genomics Resources

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Protein Alignment mld and ZNF782

DIOPT Version :9

Sequence 1:NP_001247289.1 Gene:mld / 2768685 FlyBaseID:FBgn0263490 Length:1965 Species:Drosophila melanogaster
Sequence 2:NP_001001662.1 Gene:ZNF782 / 158431 HGNCID:33110 Length:699 Species:Homo sapiens


Alignment Length:915 Identity:166/915 - (18%)
Similarity:267/915 - (29%) Gaps:396/915 - (43%)


- Green bases have known domain annotations that are detailed below.


  Fly  1048 LSVQSPQNHQPQ--VQSHDQSQMQHQIPPQIEPQIEVQNQEQNTLQLVPQAQH---------QVV 1101
            ||..||::.||.  .:...::|.:|.:      |:...|:...|.|.:....|         :::
Human    76 LSRNSPEDSQPDEISEKSPENQGKHLL------QVLFTNKLLTTEQEISGKPHNRDINIFRARMM 134

  Fly  1102 P--------HVQLQSQLVPHVQTQGTTTTVTYEQIYQQHIVQQ----------TVQQSSNKMQVI 1148
            |        ..|..|.:.||.|       .:.|:.:::::..:          ..|:.|.....|
Human   135 PCKCDIAGSACQGLSLMAPHCQ-------YSKEKAHERNVCDKWLISIKDGRTNTQEKSFAYSKI 192

  Fly  1149 SLPSAGSETTRQWQTQQSQQQQ-QVQWSSVGGLEAIKSAPVESVAPTTTTYYIS--ASDLYPQQT 1210
            .......|...|.||.|:..|. :...|....||........|..|...:|..:  ..:.|.:.|
Human   193 VKTLHHKEEVIQHQTIQTLGQDFEYNESRKAFLEKAALVTSNSTHPKGKSYNFNKFGENKYDKST 257

  Fly  1211 ETYTMLQPASNESYVIEQ-VNHQQQH--------CQQQI---------QMSQQQHQRQHQQQQAQ 1257
                         ::|.| :|.::.|        |..:|         ..||:.|.|:|.:    
Human   258 -------------FIIPQNMNPEKSHYEFNDTGNCFCRITHKTLTGGKSFSQKSHIREHHR---- 305

  Fly  1258 QQQQPIMILIQQPEIQQPVASASNPQQAPLHI----------YNAATSNDVHQMQHTQRQQIRQQ 1312
                                         :||          :|..::..|||..|..       
Human   306 -----------------------------VHIGVKPFEYGKSFNRNSTLPVHQRTHAT------- 334

  Fly  1313 YQHQQYQRLQQPQQTRVVQSHPVLGMPGATSISTKVTPIPVTAARGRPLTL-KCRFCHNGPRFSS 1376
               .:|.......:|...||        ..|:..||      ..|.:|... :|         ..
Human   335 ---DKYSDYHPCTETFSYQS--------TFSVHQKV------HIRAKPYEYNEC---------GK 373

  Fly  1377 SLEYSRHII---DLHPAVAPFNCPHCPMAFAGRTKRSQHILSHHVVQQYQCGQCSHVFPAQKALD 1438
            |...:.|:|   ..|....|:.||.|..||:.:::..:|..:|...:.|:|..|...|.|:..|.
Human   374 SCSMNSHLIWPQKSHTGEKPYECPECGKAFSEKSRLRKHQRTHTGEKPYKCDGCDKAFSAKSGLR 438

  Fly  1439 VHIQRFHMTLKTDPSGAVKVEDVQLQITSERRPRGRPYKPRLQLQQHQLQPQQKLQVQQHQQQQK 1503
            :| ||.|                    |.|     :|:                           
Human   439 IH-QRTH--------------------TGE-----KPF--------------------------- 450

  Fly  1504 ALQQLPQAQHHQQQQQPQLQQEVLQQVQQLQVQVQPQQHQ-----QHQQVLQVQQ---PQQQPLM 1560
                                                :.|:     .::.:|.|.|   ..::|. 
Human   451 ------------------------------------ECHECGKSFNYKSILIVHQRTHTGEKPF- 478

  Fly  1561 QPQSPHPSTVEMQASPTTPRKILCCPDCEDCTSGHSHANEQFEELQTLQAPPTVLTPPSTIVSVP 1625
                                      :|.:|....||                            
Human   479 --------------------------ECNECGKSFSH---------------------------- 489

  Fly  1626 SPQPMVYSQHITMPSPEQSEPDSTTTLRQYRKRGVIVGPQGPLHLATPVASPSPSSSPSSSTVDH 1690
                                   .:.||.:|:                                 
Human   490 -----------------------MSGLRNHRR--------------------------------- 498

  Fly  1691 IPPASPATPASPAPPPSPAVASTVQVSELRTSHHCLYCEERFTNEISLKKHHQLAHGALTTMPYV 1755
                   |.....|                  :.|..|.:.|..:..|:|||:...|   ..||.
Human   499 -------THTGERP------------------YKCDECGKAFKLKSGLRKHHRTHTG---EKPYK 535

  Fly  1756 CTICKRGYRMRTALHRHMESHDVEGRPYECNICRVRFPRPSQLTLHKITVHLLSKPHTCDECGKQ 1820
            |..|.:.:..::.|..|...|..| :||:||.|...|.:.|.|.:|..| |...||:.|:||||.
Human   536 CNQCGKAFGQKSQLRGHHRIHTGE-KPYKCNHCGEAFSQKSNLRVHHRT-HTGEKPYQCEECGKT 598

  Fly  1821 FGTESALKTHIKFH-GELGYQCDGCDRTFEYLKELRKHRRTHS-EMFYKCKFCPSSFMRFTNFRA 1883
            |..:|.|:.|.:.| ||..|:|:.|.:.|.....||||:|||: |..|.|..|..:|.:.:|.|.
Human   599 FRQKSNLRGHQRTHTGEKPYECNECGKAFSEKSVLRKHQRTHTGEKPYNCNQCGEAFSQKSNLRV 663

  Fly  1884 HMKTH 1888
            |.:||
Human   664 HQRTH 668

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
mldNP_001247289.1 zf-AD 186..255 CDD:214871
C2H2 Zn finger 1365..1388 CDD:275368 4/25 (16%)
C2H2 Zn finger 1396..1416 CDD:275368 6/19 (32%)
C2H2 Zn finger 1424..1445 CDD:275368 8/20 (40%)
C2H2 Zn finger 1725..1746 CDD:275368 7/20 (35%)
C2H2 Zn finger 1756..1776 CDD:275368 4/19 (21%)
C2H2 Zn finger 1785..1806 CDD:275368 8/20 (40%)
C2H2 Zn finger 1814..1834 CDD:275368 9/19 (47%)
zf-C2H2 1839..1861 CDD:278523 9/21 (43%)
C2H2 Zn finger 1841..1861 CDD:275368 8/19 (42%)
C2H2 Zn finger 1868..1888 CDD:275368 6/19 (32%)
ZNF782NP_001001662.1 KRAB 8..67 CDD:214630
KRAB 8..47 CDD:279668
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 75..95 6/18 (33%)
C2H2 Zn finger 291..307 CDD:275368 5/48 (10%)
C2H2 Zn finger 314..332 CDD:275368 4/17 (24%)
C2H2 Zn finger 343..360 CDD:275368 6/30 (20%)
C2H2 Zn finger 369..388 CDD:275368 4/27 (15%)
COG5048 392..697 CDD:227381 97/507 (19%)
C2H2 Zn finger 396..416 CDD:275368 6/19 (32%)
zf-H2C2_2 409..432 CDD:290200 5/22 (23%)
C2H2 Zn finger 424..444 CDD:275368 8/20 (40%)
zf-H2C2_2 437..461 CDD:290200 9/112 (8%)
C2H2 Zn finger 452..472 CDD:275368 4/19 (21%)
zf-H2C2_2 465..489 CDD:290200 6/50 (12%)
C2H2 Zn finger 480..500 CDD:275368 7/110 (6%)
zf-H2C2_2 493..516 CDD:290200 7/80 (9%)
C2H2 Zn finger 508..528 CDD:275368 7/19 (37%)
zf-H2C2_2 521..543 CDD:290200 9/24 (38%)
C2H2 Zn finger 536..556 CDD:275368 4/19 (21%)
zf-H2C2_2 549..573 CDD:290200 10/24 (42%)
C2H2 Zn finger 564..584 CDD:275368 8/20 (40%)
zf-H2C2_2 576..601 CDD:290200 12/25 (48%)
C2H2 Zn finger 592..612 CDD:275368 9/19 (47%)
zf-H2C2_2 604..628 CDD:290200 8/23 (35%)
C2H2 Zn finger 620..640 CDD:275368 8/19 (42%)
zf-H2C2_2 633..657 CDD:290200 12/23 (52%)
C2H2 Zn finger 648..668 CDD:275368 6/19 (32%)
zf-H2C2_2 660..685 CDD:290200 5/9 (56%)
C2H2 Zn finger 676..696 CDD:275368
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - O PTHR24376
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
11.100

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