DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment mld and CTCFL

DIOPT Version :9

Sequence 1:	NP_001247289.1	Gene:	mld / 2768685	FlyBaseID:	FBgn0263490	Length:	1965	Species:	Drosophila melanogaster
Sequence 2:	NP_001255972.1	Gene:	CTCFL / 140690	HGNCID:	16234	Length:	700	Species:	Homo sapiens

Alignment Length:	488	Identity:	109/488 - (22%)
Similarity:	179/488 - (36%)	Gaps:	118/488 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly  1483 QQHQLQPQQKLQVQQHQQQQKALQQLPQAQHHQQQQQPQLQQEVLQQVQQ---LQVQVQ------ 1538
            |...|:.:.:|.:...::.:|.:..|...  |...:..:||...|..:||   :||.||
Human    57 QDSVLEEEVELVLAPSEESEKYILTLQTV--HFTSEAVELQDMSLLSIQQQEGVQVVVQQPGPGL 119

  Fly  1539 ------PQQHQQHQQVLQVQQ----PQQQPLMQPQSPHPSTVEMQASPTTPRKILCCPDCEDCTS 1593
                  |:|..|....:.:||    ||:..::|..:...:.  |.||..:...:....     |:
Human   120 LWLEEGPRQSLQQCVAISIQQELYSPQEMEVLQFHALEENV--MVASEDSKLAVSLAE-----TT 177

  Fly  1594 GHSHANEQFEELQTL------------------QAPPTVLTPPSTIVSVPSPQPMVYSQHITMPS 1640
            |.....|:.|:.|.|                  ::...|||..::.|.....|          |:
Human   178 GLIKLEEEQEKNQLLAERTKEQLFFVETMSGDERSDEIVLTVSNSNVEEQEDQ----------PT 232

  Fly  1641 PEQSEPDSTTTLRQYRKRGVIVGPQGPLHLATPVASPSPSSSPSSSTVDHIPPASPATPASPAPP 1705
            ..|::.:...:.:..||   ..|.:|..|....:.    :||..||...|:     .|..|..|.
Human   233 AGQADAEKAKSTKNQRK---TKGAKGTFHCDVCMF----TSSRMSSFNRHM-----KTHTSEKPH 285

  Fly  1706 PSPAVASTVQVSELRTSH----------HCLYCEERFTNEISLKKHHQLAHGALTTMPYVCTIC- 1759
            .......|.:...|..:|          .|..|...|.....|.:|.:..|  ....|:.|::|
Human   286 LCHLCLKTFRTVTLLRNHVNTHTGTRPYKCNDCNMAFVTSGELVRHRRYKH--THEKPFKCSMCK 348

  Fly  1760 ---------KRGYRMRTA------------------LHRHMESHDVEGRPYECNICRVRFPRPSQ 1797
                     ||..|..|.                  |.|||.:|..| :||||:||..||.:...
Human   349 YASVEASKLKRHVRSHTGERPFQCCQCSYASRDTYKLKRHMRTHSGE-KPYECHICHTRFTQSGT 412

  Fly  1798 LTLHKITVHLLSKP-HTCDECGKQFGTESALKTHIK-FH----GELGYQCDGCDRTFEYLKELRK 1856
            :.:|.:..|..:.| :.|..|......:|.|:.|:: .|    .||  :|..|...|.....|.:
Human   413 MKIHILQKHGENVPKYQCPHCATIIARKSDLRVHMRNLHAYSAAEL--KCRYCSAVFHERYALIQ 475

  Fly  1857 HRRTH-SEMFYKCKFCPSSFMRFTNFRAHMKTH 1888
            |::|| :|..:|||.|..:..:..:..||::||
Human   476 HQKTHKNEKRFKCKHCSYACKQERHMTAHIRTH 508

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mld	NP_001247289.1	zf-AD	186..255	CDD:214871
		C2H2 Zn finger	1365..1388	CDD:275368
		C2H2 Zn finger	1396..1416	CDD:275368
		C2H2 Zn finger	1424..1445	CDD:275368
		C2H2 Zn finger	1725..1746	CDD:275368	5/20 (25%)
		C2H2 Zn finger	1756..1776	CDD:275368	10/47 (21%)
		C2H2 Zn finger	1785..1806	CDD:275368	6/20 (30%)
		C2H2 Zn finger	1814..1834	CDD:275368	5/20 (25%)
		zf-C2H2	1839..1861	CDD:278523	5/21 (24%)
		C2H2 Zn finger	1841..1861	CDD:275368	5/19 (26%)
		C2H2 Zn finger	1868..1888	CDD:275368	5/19 (26%)
CTCFL	NP_001255972.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	24..55
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	221..250		6/41 (15%)
		COG5048	<259..403	CDD:227381	34/155 (22%)
		C2H2 Zn finger	259..279	CDD:275368	5/28 (18%)
		zf-H2C2_2	271..296	CDD:290200	6/29 (21%)
		C2H2 Zn finger	287..307	CDD:275368	3/19 (16%)
		zf-H2C2_2	300..324	CDD:290200	4/23 (17%)
		C2H2 Zn finger	315..333	CDD:275368	5/17 (29%)
		C2H2 Zn finger	344..364	CDD:275368	5/19 (26%)
		zf-H2C2_2	357..378	CDD:290200	4/20 (20%)
		C2H2 Zn finger	372..392	CDD:275368	4/19 (21%)
		zf-H2C2_2	385..409	CDD:290200	14/24 (58%)
		C2H2 Zn finger	400..417	CDD:275368	5/16 (31%)
		C2H2 Zn finger	430..448	CDD:275368	5/17 (29%)
		C2H2 Zn finger	460..480	CDD:275368	5/19 (26%)
		C2H2 Zn finger	488..508	CDD:275368	5/19 (26%)
		zf-H2C2_2	500..525	CDD:290200	4/9 (44%)
		C2H2 Zn finger	516..534	CDD:275368
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	569..630
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165142328
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.840