DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment mld and ZFP92

DIOPT Version :9

Sequence 1:NP_001247289.1 Gene:mld / 2768685 FlyBaseID:FBgn0263490 Length:1965 Species:Drosophila melanogaster
Sequence 2:NP_001129745.1 Gene:ZFP92 / 139735 HGNCID:12865 Length:416 Species:Homo sapiens


Alignment Length:234 Identity:70/234 - (29%)
Similarity:94/234 - (40%) Gaps:39/234 - (16%)


- Green bases have known domain annotations that are detailed below.


  Fly  1681 SSPSSSTVDH----IPPASP--------------------ATPASPAPPPSPAVASTVQVSELRT 1721
            |..|:||..|    :|.|.|                    ...:|.|.|..|..|      |.| 
Human    94 SKTSTSTQKHSGRQLPGADPQGGKEGQAARSSVLQRGAQGLGQSSAAGPQGPKGA------EKR- 151

  Fly  1722 SHHCLYCEERFTNEISLKKHHQLAHGALTTMPYVCTICKRGYRMRTALHRHMESHDVEGRPYECN 1786
             :.|..|.:.|:...:|.||..:..|   ..||.|..|.:.:|...||..|...|..| :||.|.
Human   152 -YLCQQCGKAFSRSSNLIKHRIIHSG---EKPYACPECGKLFRRSFALLEHQRIHSGE-KPYACP 211

  Fly  1787 ICRVRFPRPSQLTLHKITVHLLSKPHTCDECGKQFGTESALKTHIKFH-GELGYQCDGCDRTFEY 1850
            .|...|.|.|.|..|:: :|...:|..|.:|||.|....||..|.:.| ||..|.|..|.:.|..
Human   212 ECSKTFTRSSNLIKHQV-IHSGERPFACGDCGKLFRRSFALLEHARVHSGERPYACPECGKAFSR 275

  Fly  1851 LKELRKHRRTH-SEMFYKCKFCPSSFMRFTNFRAHMKTH 1888
            ...|.:|:||| .|..|.|..|..:|...:....|.::|
Human   276 SSNLIEHQRTHRGEKPYACGQCAKAFKGVSQLIHHQRSH 314

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
mldNP_001247289.1 zf-AD 186..255 CDD:214871
C2H2 Zn finger 1365..1388 CDD:275368
C2H2 Zn finger 1396..1416 CDD:275368
C2H2 Zn finger 1424..1445 CDD:275368
C2H2 Zn finger 1725..1746 CDD:275368 6/20 (30%)
C2H2 Zn finger 1756..1776 CDD:275368 6/19 (32%)
C2H2 Zn finger 1785..1806 CDD:275368 7/20 (35%)
C2H2 Zn finger 1814..1834 CDD:275368 8/19 (42%)
zf-C2H2 1839..1861 CDD:278523 7/21 (33%)
C2H2 Zn finger 1841..1861 CDD:275368 6/19 (32%)
C2H2 Zn finger 1868..1888 CDD:275368 4/19 (21%)
ZFP92NP_001129745.1 KRAB 14..74 CDD:214630
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 86..125 8/30 (27%)
COG5048 <145..286 CDD:227381 50/153 (33%)
C2H2 Zn finger 154..174 CDD:275368 6/19 (32%)
C2H2 Zn finger 182..202 CDD:275368 6/19 (32%)
C2H2 Zn finger 210..230 CDD:275368 7/20 (35%)
C2H2 Zn finger 238..258 CDD:275368 8/19 (42%)
COG5048 262..>315 CDD:227381 16/53 (30%)
C2H2 Zn finger 266..286 CDD:275368 6/19 (32%)
C2H2 Zn finger 294..314 CDD:275368 4/19 (21%)
C2H2 Zn finger 322..342 CDD:275368
zf-H2C2_2 335..359 CDD:404364
C2H2 Zn finger 350..370 CDD:275368
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 368..416
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C165142175
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.930

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