DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment mld and LOC103691005

DIOPT Version :9

Sequence 1:	NP_001247289.1	Gene:	mld / 2768685	FlyBaseID:	FBgn0263490	Length:	1965	Species:	Drosophila melanogaster
Sequence 2:	XP_038956093.1	Gene:	LOC103691005 / 103691005	RGDID:	9163837	Length:	764	Species:	Rattus norvegicus

Alignment Length:	747	Identity:	149/747 - (19%)
Similarity:	267/747 - (35%)	Gaps:	137/747 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly  1189 ESVAPTTTTYYISASDLYPQQTETYTMLQPASNESYVIEQVNHQQQHCQQQI--------QMSQQ 1245
            |.:..|....||..      ..|.|..|  .|.|:|.|....:|.....::.        .:.:.
  Rat    49 ECLDSTQRALYIDV------MLENYRNL--VSVENYCICDATYQHVKTDKESHHFNEFGEMLPEP 105

  Fly  1246 QHQRQHQQQQAQQ--------QQQPIMILIQQPEIQQPVASASNPQQAPLHIYNAATSNDVHQMQ 1302
            .|...::...|.:        :::...:.:...:..:...:...|.::..:..:....:.:.|.|
  Rat   106 SHSALYKTSDATETSNNYTCCKERDASVCLSNRDSHKSAPTGEEPCESKDYEKSLTLCSVISQDQ 170

  Fly  1303 H------TQRQQIRQQYQHQQYQRLQQPQQTRVVQSHP-VLGMPG-ATSISTKVTPIPVTAARGR 1359
            .      .|||::...|....|..:   |||..::..| ..|..| ..|.|:.:|.......|.:
  Rat   171 RLYTAKKEQRQEVYDDYFSSAYSLM---QQTVYIKEKPHQCGKCGKCFSTSSSLTVHQRIHTREK 232

  Fly  1360 PLTLKCRFCHNGPRFSSSLEYSRHIIDLHPAVAPFNCPHCPMAFAGRTKRSQHILSHHVVQQYQC 1424
            |  .||..|.......:.|:..:.   .|....|:.|..|..:|...:....|...|...:.|:|
  Rat   233 P--YKCNICDKSFTQCTHLKIHQR---RHTGEKPYKCKECEKSFVQLSALKSHQKLHTGEKPYKC 292

  Fly  1425 GQCSHVFPAQKALDVHIQRFHMTLKTDPSGAVKVEDVQLQITSERR---PR-GRPYKPRLQLQQH 1485
            .:|...|........| |:.|                    |||..   |. ||.:        |
  Rat   293 KECDKSFAHYPNFRTH-QKIH--------------------TSEEHCSCPECGREF--------H 328

  Fly  1486 QLQPQQKLQVQQHQQQQ--------KALQQLPQAQHHQQQQQPQLQQEVLQQVQQLQVQVQPQQH 1542
            ||...:| ..:.|..::        ::.......:.||:...|::..|..:..:..   ::....
  Rat   329 QLSHFRK-HYRLHTGEKPYKCNECGRSFTHYASLRWHQKTHSPEMHHECKECGKAF---IELSHL 389

  Fly  1543 QQHQQVLQVQQPQQQPLMQPQSPHPSTVEMQASPTTPRKILCCPDCEDCTSGHSHANEQFEELQT 1607
            ::|.::...::|.:..:........:|::......|..|...|.:| |.:..||....:.:.:.|
  Rat   390 KRHYRIHTGEKPYKCEICDKSFTTTTTLKTHQKIHTGEKPYKCREC-DKSFIHSSHLRRHQSIHT 453

  Fly  1608 LQAPPTVLTPPSTIVSVPSPQPMVYSQHITMPSPEQSEPDSTTTL-----RQYRKRGVIVGPQGP 1667
            .:.|........:           :.::.|:...|:|..:..|..     :.:.:|..:......
  Rat   454 GERPYKCKECDKS-----------FRENSTLREHEKSHTEEKTYKCRECDKSFTQRAYLRNHHNR 507

  Fly  1668 LHLATPVASPSPSSSPSSSTVDHIPPASPATPASPAPPPSPAVASTVQVSEL----RTSHHCLYC 1728
            :|..   ..|........|.:                     ..||:::.:.    :..:.|:.|
  Rat   508 VHTG---ERPYECKECGKSFI---------------------TCSTLKIHQTIHTGKKPYKCMEC 548

  Fly  1729 EERFTNEISLKKHHQLAHGALTTMPYVCTICKRGYRMRTALHRHMESHDVEGRPYECNICRVRFP 1793
            |:.||:...|:.|.::..|   ..||.|..|.:.:...:.|..|...|..| :||:|..|...|.
  Rat   549 EKSFTHNSYLRTHQKVHTG---ERPYKCKECDKSFTSCSTLKAHQNIHSGE-KPYKCIECDKSFT 609

  Fly  1794 RPSQLTLHKITVHLLSKPHTCDECGKQFGTESALKTHIKFH-GELGYQCDGCDRTFEYLKELRKH 1857
            :.|.|..|: .||...:|:.|.||.|.|...|.|:.|.|.| ||..|:|..||.:|..:..||:|
  Rat   610 QASHLRTHQ-RVHTGERPYRCIECDKSFTRYSHLREHQKIHSGEKPYKCRDCDISFNQISNLRRH 673

  Fly  1858 RRTHS-EMFYKCKFCPSSFMRFTNFRAHMKTH 1888
            ::.|: |..|||..|..||...:|||.|.:||
  Rat   674 QKLHTGEKPYKCMKCDKSFTHNSNFRTHQRTH 705

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mld	NP_001247289.1	zf-AD	186..255	CDD:214871
		C2H2 Zn finger	1365..1388	CDD:275368	3/22 (14%)
		C2H2 Zn finger	1396..1416	CDD:275368	4/19 (21%)
		C2H2 Zn finger	1424..1445	CDD:275368	5/20 (25%)
		C2H2 Zn finger	1725..1746	CDD:275368	7/20 (35%)
		C2H2 Zn finger	1756..1776	CDD:275368	4/19 (21%)
		C2H2 Zn finger	1785..1806	CDD:275368	6/20 (30%)
		C2H2 Zn finger	1814..1834	CDD:275368	9/19 (47%)
		zf-C2H2	1839..1861	CDD:278523	8/21 (38%)
		C2H2 Zn finger	1841..1861	CDD:275368	7/19 (37%)
		C2H2 Zn finger	1868..1888	CDD:275368	8/19 (42%)
LOC103691005	XP_038956093.1	KRAB	33..73	CDD:396083	7/31 (23%)
		COG5048	140..526	CDD:227381	72/462 (16%)
		C2H2 Zn finger	208..228	CDD:275368	5/19 (26%)
		C2H2 Zn finger	236..256	CDD:275368	3/22 (14%)
		C2H2 Zn finger	264..284	CDD:275368	4/19 (21%)
		C2H2 Zn finger	292..312	CDD:275368	5/20 (25%)
		C2H2 Zn finger	348..368	CDD:275368	2/19 (11%)
		COG5048	374..734	CDD:227381	84/376 (22%)
		C2H2 Zn finger	376..396	CDD:275368	1/22 (5%)
		C2H2 Zn finger	404..424	CDD:275368	1/19 (5%)
		C2H2 Zn finger	432..452	CDD:275368	5/20 (25%)
		C2H2 Zn finger	460..480	CDD:275368	2/30 (7%)
		C2H2 Zn finger	488..509	CDD:275368	1/20 (5%)
		C2H2 Zn finger	517..537	CDD:275368	3/40 (8%)
		C2H2 Zn finger	545..565	CDD:275368	7/19 (37%)
		C2H2 Zn finger	573..593	CDD:275368	4/19 (21%)
		C2H2 Zn finger	601..621	CDD:275368	6/20 (30%)
		C2H2 Zn finger	629..649	CDD:275368	9/19 (47%)
		C2H2 Zn finger	657..677	CDD:275368	7/19 (37%)
		C2H2 Zn finger	685..705	CDD:275368	8/19 (42%)
		C2H2 Zn finger	713..733	CDD:275368
		C2H2 Zn finger	741..761	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24376
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.100