DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment mld and ZNF267

DIOPT Version :9

Sequence 1:	NP_001247289.1	Gene:	mld / 2768685	FlyBaseID:	FBgn0263490	Length:	1965	Species:	Drosophila melanogaster
Sequence 2:	NP_003405.4	Gene:	ZNF267 / 10308	HGNCID:	13060	Length:	743	Species:	Homo sapiens

Alignment Length:	825	Identity:	158/825 - (19%)
Similarity:	271/825 - (32%)	Gaps:	277/825 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly  1122 TVTYEQIYQQHIVQQTVQQSSNKMQVIS--LPSAGSETTRQWQTQQS--QQQQQVQWSSVGGLEA 1182
            |..|:| :.:..|:....|     |::|  ..|...:..|:..|..|  .||:::   .:.|...
Human   133 TFKYDQ-FDESSVESLFHQ-----QILSSCAKSYNFDQYRKVFTHSSLLNQQEEI---DIWGKHH 188

  Fly  1183 I--KSAPVESVAPTTTTY---YISASDLYPQQTETYTMLQPAS----NESYVIEQVNHQQQHCQQ 1238
            |  |::.:.....|..:|   :|...:.:...:|. |:.|.:|    .|:|.:|    :|..|::
Human   189 IYDKTSVLFRQVSTLNSYRNVFIGEKNYHCNNSEK-TLNQSSSPKNHQENYFLE----KQYKCKE 248

  Fly  1239 QIQMSQQQHQRQHQQQQAQQQQQPIMILIQQPEIQQPVASASNPQQAPLHIYNAATSNDVHQMQH 1303
            ..::..|....|.:|:|:.:..:.:.:..|         |..:.|...:||...:.|.:.:....
Human   249 FEEVFLQSMHGQEKQEQSYKCNKCVEVCTQ---------SLKHIQHQTIHIRENSYSYNKYDKDL 304

  Fly  1304 TQRQQIRQQYQHQQYQRLQQPQQTRV----------VQSHPVLGMPGATSISTKVTPIPVTAARG 1358
            :|...:|:|..|.:    ::|.:...          :..|.:        |.|:..|...... |
Human   305 SQSSNLRKQIIHNE----EKPYKCEKCGDSLNHSLHLTQHQI--------IPTEEKPCKWKEC-G 356

  Fly  1359 RPLTL-------------------KCRFCHNGPRFSSSLEYSRHIIDLHPAVAPFNCPHCPMAFA 1404
            :...|                   ||:.|......||:|...:.|   |....|:.|..|..||.
Human   357 KVFNLNCSLYLTKQQQIDTGENLYKCKACSKSFTRSSNLIVHQRI---HTGEKPYKCKECGKAFR 418

  Fly  1405 GRTKRSQHILSHHVVQQYQCGQCSHVFPAQKALDVHIQRFHMTLKTDPSGAVKVEDVQLQITSER 1469
            ..:..::|...|...:.|:|.:|...|.....|..| |..|                    |.|:
Human   419 CSSYLTKHKRIHTGEKPYKCKECGKAFNRSSCLTQH-QTTH--------------------TGEK 462

  Fly  1470 RPRGRPYKPRLQLQQHQLQPQQKLQVQQHQQQQKALQQLPQAQHHQQQQQPQLQQEVLQQVQQLQ 1534
            .     ||             .|:..:.:.:....:
Human   463 L-----YK-------------CKVCSKSYARSSNLI----------------------------- 480

  Fly  1535 VQVQPQQHQQHQQVLQVQQPQQQPLMQPQSPHPSTVEMQASPTTPRKILCCPDC------EDCTS 1593
                     .||:|...::|.:                            |.:|      ..|.:
Human   481 ---------MHQRVHTGEKPYK----------------------------CKECGKVFSRSSCLT 508

  Fly  1594 GHS--HANEQFEELQTLQAPPTVLTPPSTIVSVPSPQPMVYSQHITMPSPEQSE------PDSTT 1650
            .|.  |..|...:.:....|.|..   |.::        |:.:..|...|.:.:      |.|:.
Human   509 QHRKIHTGENLYKCKVCAKPFTCF---SNLI--------VHERIHTGEKPYKCKECGKAFPYSSH 562

  Fly  1651 TLRQYRKRGVIVGPQGPLHLATPVASPSPSSSPSSSTVDHIPPASPATPASPAPPPSPAVASTVQ 1715
            .:|.:|           :|                            |...|
Human   563 LIRHHR-----------IH----------------------------TGEKP------------- 575

  Fly  1716 VSELRTSHHCLYCEERFTNEISLKKHHQLAHGALTTMPYVCTICKRGYRMRTALHRHMESHDVEG 1780
                   :.|..|.:.|::...|..|.:...|   ..||.|..|.:.:...:.:.:|...|..:
Human   576 -------YKCKACSKSFSDSSGLTVHRRTHTG---EKPYTCKECGKAFSYSSDVIQHRRIHTGQ- 629

  Fly  1781 RPYECNICRVRFPRPSQLTLHKITVHLLSKPHTCDECGKQFGTESALKTHIKFH-GELGYQCDGC 1844
            |||:|..|...|...|.||.|:.: |...:|:.|:||||.|.:.|.|.||.:.| ||..|:||.|
Human   630 RPYKCEECGKAFNYRSYLTTHQRS-HTGERPYKCEECGKAFNSRSYLTTHRRRHTGERPYKCDEC 693

  Fly  1845 DRTFEYLKELRKHRRTHS-EMFYKCKFCPSSFMRFTNFRAHMKTH 1888
            .:.|.|...|..|||:|| |..|||:.|..:|...:...||.::|
Human   694 GKAFSYRSYLTTHRRSHSGERPYKCEECGKAFNSRSYLIAHQRSH 738

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mld	NP_001247289.1	zf-AD	186..255	CDD:214871
		C2H2 Zn finger	1365..1388	CDD:275368	6/22 (27%)
		C2H2 Zn finger	1396..1416	CDD:275368	5/19 (26%)
		C2H2 Zn finger	1424..1445	CDD:275368	6/20 (30%)
		C2H2 Zn finger	1725..1746	CDD:275368	5/20 (25%)
		C2H2 Zn finger	1756..1776	CDD:275368	3/19 (16%)
		C2H2 Zn finger	1785..1806	CDD:275368	7/20 (35%)
		C2H2 Zn finger	1814..1834	CDD:275368	10/19 (53%)
		zf-C2H2	1839..1861	CDD:278523	10/21 (48%)
		C2H2 Zn finger	1841..1861	CDD:275368	9/19 (47%)
		C2H2 Zn finger	1868..1888	CDD:275368	5/19 (26%)
ZNF267	NP_003405.4	KRAB	4..64	CDD:214630
		C2H2 Zn finger	269..289	CDD:275368	3/28 (11%)
		C2H2 Zn finger	297..316	CDD:275368	3/18 (17%)
		C2H2 Zn finger	324..341	CDD:275368	0/16 (0%)
		C2H2 Zn finger	353..374	CDD:275368	2/21 (10%)
		COG5048	364..730	CDD:227381	106/548 (19%)
		C2H2 Zn finger	382..402	CDD:275368	6/22 (27%)
		C2H2 Zn finger	410..430	CDD:275368	5/19 (26%)
		C2H2 Zn finger	438..458	CDD:275368	6/20 (30%)
		C2H2 Zn finger	466..486	CDD:275368	3/57 (5%)
		C2H2 Zn finger	494..514	CDD:275368	4/19 (21%)
		C2H2 Zn finger	522..542	CDD:275368	4/30 (13%)
		C2H2 Zn finger	550..570	CDD:275368	4/30 (13%)
		C2H2 Zn finger	578..598	CDD:275368	5/19 (26%)
		C2H2 Zn finger	606..626	CDD:275368	3/19 (16%)
		C2H2 Zn finger	634..654	CDD:275368	7/20 (35%)
		C2H2 Zn finger	662..682	CDD:275368	10/19 (53%)
		C2H2 Zn finger	690..710	CDD:275368	9/19 (47%)
		C2H2 Zn finger	718..738	CDD:275368	5/19 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24376
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.100