DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment mld and LOC102551340

DIOPT Version :9

Sequence 1:	NP_001247289.1	Gene:	mld / 2768685	FlyBaseID:	FBgn0263490	Length:	1965	Species:	Drosophila melanogaster
Sequence 2:	XP_038955362.1	Gene:	LOC102551340 / 102551340	RGDID:	7697243	Length:	948	Species:	Rattus norvegicus

Alignment Length:	601	Identity:	140/601 - (23%)
Similarity:	211/601 - (35%)	Gaps:	182/601 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly  1364 KCRFCHNGPRFSSSLEYSRHIIDLHPAVAPFNCPHCPMAFAGRTKRSQHILSHHVVQQYQCGQCS 1428
            ||:.|....|..|||...|.|   |....|:.|..|..||...:..|:|.::|...:.|:|..|.
  Rat   499 KCKECDKAFRSLSSLSKHRRI---HTGEKPYKCEVCGKAFHYPSLLSKHKITHTEEKPYKCEVCG 560

  Fly  1429 HVFPAQKALDVHIQRFHMTLKTDPSGAVKVEDVQLQITSERRPRGRPYKPR---------LQLQQ 1484
                         |.||:     ||   |:...::..|.|     .|||..         |.|.:
  Rat   561 -------------QGFHV-----PS---KLSHHKIIHTGE-----SPYKCEVCGKAFCIPLLLSK 599

  Fly  1485 HQLQPQQKLQVQQHQQQQKALQQLPQAQHHQQQQQPQLQQEVLQQVQQLQVQVQPQQHQQHQQVL 1549
            |::         .|..:..:..||.:                       :..:.|.:..:|:::.
  Rat   600 HKI---------SHTGENHSNSQLSK-----------------------KAFIYPSRLSKHKKIH 632

  Fly  1550 QVQQPQQQPLMQPQSPHPSTVEMQASPTTPRKILCCP-DCEDCTSGHSHANEQFEELQTLQAPPT 1613
            :..:|.:..:.......||.:.:.....|..|    | .||:|.....:
  Rat   633 KRVKPYKCEVCGKAFRFPSLLLIHKGIHTGEK----PYKCEECGKAFYY---------------- 677

  Fly  1614 VLTPPSTIVSVPSPQPMVYSQH---ITMPSPEQSEPDSTTTLRQYRKRGVIVGPQGPLHLATPVA 1675
                           |.:.|:|   .|...|.|.|                |..:| .|:
  Rat   678 ---------------PSLLSKHKRVHTGEKPYQCE----------------VCGKG-FHV----- 705

  Fly  1676 SPSPSSSPSSSTVDHIPPASPATPASPAPPPSPAVASTVQVSELRTSHHCLYCEERFTNEISLKK 1740
                |||.|...:.|       |...|                    :.|..||:.|....||.|
  Rat   706 ----SSSLSKHRIIH-------TGEKP--------------------YKCEVCEKAFRFSSSLSK 739

  Fly  1741 HHQLAHGALTTMPYVCTICKRGYRMRTALHRHMESHDVEGRPYECNICRVRFPRPSQLTLHKITV 1805
            |.::..|   ..||.|..|.:.:...:.|.:|..||..| :||.|::|...|..||.|:.||: :
  Rat   740 HKRIHTG---KKPYKCEECGKAFHFPSLLSKHKISHTGE-KPYNCDLCGKAFYYPSLLSKHKM-I 799

  Fly  1806 HLLSKPHTCDECGKQFGTESALKTHIKFH-GELGYQCDGCDRTFEYLKELRKHRRTHS-EMFYKC 1868
            |...|||.||.|||.|...|.|..|.|.| ||..|:|:.|...|.:...|.||:|.|: |..|||
  Rat   800 HTGEKPHKCDICGKAFHYPSKLSNHKKIHTGEKPYKCEVCGNVFCFASSLSKHKRIHTGENPYKC 864

  Fly  1869 KFCPSSFMRFTNFRAHMK-THLPLGVFRNE--DAASKSPSNNNSHASSDKLENPATPIEETPLTP 1930
            ..|..:|. :.:...|.| .|.....::.|  ..|...||..:.|....:..||      |.:..
  Rat   865 DVCGKAFY-YPSLLCHHKIIHTGEKPYKCEVCGKAFHYPSLLSKHKIIHQERNP------TSVKY 922

  Fly  1931 MSSGGHLYHSPDEYPN 1946
            ::....::|   ::||
  Rat   923 VAKPSIIHH---DFPN 935

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mld	NP_001247289.1	zf-AD	186..255	CDD:214871
		C2H2 Zn finger	1365..1388	CDD:275368	8/22 (36%)
		C2H2 Zn finger	1396..1416	CDD:275368	6/19 (32%)
		C2H2 Zn finger	1424..1445	CDD:275368	3/20 (15%)
		C2H2 Zn finger	1725..1746	CDD:275368	8/20 (40%)
		C2H2 Zn finger	1756..1776	CDD:275368	4/19 (21%)
		C2H2 Zn finger	1785..1806	CDD:275368	8/20 (40%)
		C2H2 Zn finger	1814..1834	CDD:275368	10/19 (53%)
		zf-C2H2	1839..1861	CDD:278523	8/21 (38%)
		C2H2 Zn finger	1841..1861	CDD:275368	7/19 (37%)
		C2H2 Zn finger	1868..1888	CDD:275368	5/20 (25%)
LOC102551340	XP_038955362.1	KRAB	2..60	CDD:214630
		C2H2 Zn finger	108..128	CDD:275368
		SFP1	<131..199	CDD:227516
		C2H2 Zn finger	136..156	CDD:275368
		C2H2 Zn finger	164..184	CDD:275368
		C2H2 Zn finger	192..212	CDD:275368
		COG5048	216..657	CDD:227381	43/218 (20%)
		C2H2 Zn finger	220..240	CDD:275368
		C2H2 Zn finger	248..268	CDD:275368
		C2H2 Zn finger	276..296	CDD:275368
		C2H2 Zn finger	304..324	CDD:275368
		C2H2 Zn finger	332..352	CDD:275368
		C2H2 Zn finger	360..380	CDD:275368
		C2H2 Zn finger	389..408	CDD:275370
		C2H2 Zn finger	416..436	CDD:275368
		C2H2 Zn finger	444..464	CDD:275368
		COG5048	468..910	CDD:227381	134/565 (24%)
		C2H2 Zn finger	472..492	CDD:275368
		C2H2 Zn finger	500..520	CDD:275368	8/22 (36%)
		C2H2 Zn finger	528..548	CDD:275368	6/19 (32%)
		C2H2 Zn finger	556..576	CDD:275368	8/40 (20%)
		C2H2 Zn finger	584..604	CDD:275368	3/28 (11%)
		C2H2 Zn finger	640..660	CDD:275368	2/19 (11%)
		C2H2 Zn finger	668..688	CDD:275368	6/50 (12%)
		C2H2 Zn finger	696..716	CDD:275368	8/45 (18%)
		C2H2 Zn finger	724..744	CDD:275368	8/19 (42%)
		C2H2 Zn finger	752..772	CDD:275368	4/19 (21%)
		C2H2 Zn finger	780..800	CDD:275368	8/20 (40%)
		C2H2 Zn finger	808..828	CDD:275368	10/19 (53%)
		C2H2 Zn finger	836..856	CDD:275368	7/19 (37%)
		C2H2 Zn finger	864..884	CDD:275368	5/20 (25%)
		C2H2 Zn finger	892..912	CDD:275368	5/19 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24376
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.100