DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment mld and ZNF197

DIOPT Version :9

Sequence 1:	NP_001247289.1	Gene:	mld / 2768685	FlyBaseID:	FBgn0263490	Length:	1965	Species:	Drosophila melanogaster
Sequence 2:	NP_001310222.1	Gene:	ZNF197 / 10168	HGNCID:	12988	Length:	1029	Species:	Homo sapiens

Alignment Length:	1106	Identity:	203/1106 - (18%)
Similarity:	341/1106 - (30%)	Gaps:	376/1106 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly   949 LELTQFLRDLQPSQ-------SDPPAGEQ----VEKIEMETQPSTVQMDVQSNLPVQAADTQPQN 1002
            |.|.||| .:.|.:       ..|.:||:    ||:::.:.....:|:.|.    |:..||
Human    85 LVLEQFL-SILPGEIRTWVQLHHPGSGEEAVALVEELQKDLDGPAIQVPVL----VKDQDT---- 140

  Fly  1003 ESANHSPFESPISSPQVQ-------SQIELQMEPQIETQMQPQIETRMQHDVLSVQSPQNHQPQV 1060
                   .:..:|:|...       |.|..::.|...|.:.          ..::|.||:..|..
Human   141 -------LQKVVSAPGTTLPPVLPGSHIAAEICPHPPTDLV----------AFNLQDPQHDSPAP 188

  Fly  1061 QSHDQSQMQHQIPPQIEPQIEVQNQEQNTLQLVPQAQHQVV-----------------PHVQLQS 1108
            ::...||.::.           :||....:.|..|.|..|:                 |   :|.
Human   189 EASALSQEENP-----------RNQLMALMLLTAQPQELVMFEEVSVCFTSEEWACLGP---IQR 239

  Fly  1109 QLVPHV--QTQGTTTTVTYEQIYQQHIVQQTVQQS---------SNKMQVISLPSA-GSETTRQW 1161
            .|...|  :..|..|::.:|.:.:...|......|         |.::|. |:|.. ..|...:|
Human   240 ALYWDVMLENYGNVTSLEWETMTENEEVTSKPSSSQRADSHKGTSKRLQG-SVPQVLDFEEECEW 303

  Fly  1162 QTQQSQ----------------------------QQQQVQWSSVGGLEAIKSAPVESVAPTTTTY 1198
            |...||                            ::|..:|..:|......||..||:..|
Human   304 QVLASQWGNETDERADTVKKVSLCERDKKKRTPPEKQGQKWKELGDSLTFGSAISESLIGT---- 364

  Fly  1199 YISASDLYPQQTETYTMLQPASNESYVIEQVNHQQQHCQQQ-----------IQMSQ-QQHQRQH 1251
                     :..:.|.......:.:.:...:||::.|..::           ||.|. ..|.|.|
Human   365 ---------EGKKFYKCDMCCKHFNKISHLINHRRIHTGEKPHKCKECGKGFIQRSSLLMHLRNH 420

  Fly  1252 QQQQAQQQQQPIMILIQQPEI--QQPVASASNP---QQAPLHIYNAATSNDVHQ--MQHTQRQQI 1309
            ..::..:..:......|...:  .|.:.:...|   ::.....|.       |.  :.|.:|...
Human   421 SGEKPYKCNECGKAFSQSAYLLNHQRIHTGEKPYKCKECGKGFYR-------HSGLIIHLRRHSG 478

  Fly  1310 RQQYQ----------------HQQYQRLQQPQQTRVVQSHPVLGMPGATSISTKVTPIPVTAARG 1358
            .:.|:                ||:..:.::|
Human   479 ERPYKCNECGKVFSQNAYLIDHQRLHKGEEP---------------------------------- 509

  Fly  1359 RPLTLKCRFCHNGPRFSSSLEYSRHIIDLHPAVAPFNCPHCPMAFAGRTKRSQHILSHHVVQQYQ 1423
                .||..|........||...:.|   |....|:.|..|...||..|....|...|.....|:
Human   510 ----YKCNKCQKAFILKKSLILHQRI---HSGEKPYKCDECGKTFAQTTYLIDHQRLHSAENPYK 567

  Fly  1424 CGQCSHVFPAQKALDVHIQRFHMTLKTDPSGAVKVEDVQLQITSERRPRGRPYKPRLQLQQHQLQ 1488
            |.:|..||...|:|.:| ||.|...||  .|..|.              |:.:..:.....|:
Human   568 CKECGKVFIRSKSLLLH-QRVHTEKKT--FGCKKC--------------GKIFSSKSNFIDHK-- 613

  Fly  1489 PQQKLQVQQHQQQQ--------KALQQLPQAQHHQQQQQPQLQQEVLQQVQQLQVQVQPQQHQQ- 1544
                   :.|.:::        ||..|......||:....:...|..:..:...::.....||:
Human   614 -------RMHSREKPYKCTECGKAFTQSAYLFDHQRLHNGEKPYECNECGKVFILKKSLILHQRF 671

  Fly  1545 ------------------------HQQVLQVQQPQQ-----------QPLMQPQSPHPSTVEMQA 1574
                                    |:::...::|.:           :..|..|..|
Human   672 HTGENLYECKDCGKVFGSNRNLIDHERLHNGEKPYECRECGKTFIMSKSFMVHQKLH-------- 728

  Fly  1575 SPTTPRKILCCPDCEDCTSGHS--------HANEQ-FEELQTLQAPPTVLTPPSTIVSVPSPQPM 1630
               |..|...|.||....|.:|        |..|: ||..:..:|             ..|.:.:
Human   729 ---TQEKAYKCEDCGKAFSYNSSLLVHRRIHTGEKPFECSECGRA-------------FSSNRNL 777

  Fly  1631 VYSQHITMPSPEQS-EPDSTTTLRQYRKRGVIVGPQGPLHLATPVASPSPSSSPSSSTVDHIPPA 1694
            :  :|..:.|.|:. |.|........:|.  ::|.|
Human   778 I--EHKRIHSGEKPYECDECGKCFILKKS--LIGHQ----------------------------- 809

  Fly  1695 SPATPASPAPPPSPAVASTVQVSELRTSHHCLYCEERFTNEISLKKHHQLAHGALTTMPYVCTIC 1759
                                ::.....|:.|..|.:.|:...:|..|.::..|   ..||.|:.|
Human   810 --------------------RIHTREKSYKCNDCGKVFSYRSNLIAHQRIHTG---EKPYACSEC 851

  Fly  1760 KRGYRMRTALHRHMESHDVEGRPYECNICRVRFPRPSQLTLHKITVHLLSKPHTCDECGKQFGTE 1824
            .:|:.....|..|...|..| :.|||::||........|.:|: .:|...||:.|:||||.|...
Human   852 GKGFTYNRNLIEHQRIHSGE-KTYECHVCRKVLTSSRNLMVHQ-RIHTGEKPYKCNECGKDFSQN 914

  Fly  1825 SALKTHIKFH-GELGYQCDGCDRTFEYLKELRKHRRTHS-EMFYKCKFCPSSFMRFTNFRAHMKT 1887
            ..|..|.:.| ||..|:||.|.::|...:.|..|:|.|: |..|.|..|...|.:..|...|.|.
Human   915 KNLVVHQRMHTGEKPYECDKCRKSFTSKRNLVGHQRIHTGEKPYGCNDCSKVFRQRKNLTVHQKI 979

  Fly  1888 H 1888
            |
Human   980 H 980

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mld	NP_001247289.1	zf-AD	186..255	CDD:214871
		C2H2 Zn finger	1365..1388	CDD:275368	5/22 (23%)
		C2H2 Zn finger	1396..1416	CDD:275368	6/19 (32%)
		C2H2 Zn finger	1424..1445	CDD:275368	9/20 (45%)
		C2H2 Zn finger	1725..1746	CDD:275368	5/20 (25%)
		C2H2 Zn finger	1756..1776	CDD:275368	5/19 (26%)
		C2H2 Zn finger	1785..1806	CDD:275368	5/20 (25%)
		C2H2 Zn finger	1814..1834	CDD:275368	8/19 (42%)
		zf-C2H2	1839..1861	CDD:278523	8/21 (38%)
		C2H2 Zn finger	1841..1861	CDD:275368	7/19 (37%)
		C2H2 Zn finger	1868..1888	CDD:275368	6/19 (32%)
ZNF197	NP_001310222.1	SCAN	38..150	CDD:128708	18/80 (23%)
		KRAB	216..256	CDD:307490	7/42 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	262..290		4/28 (14%)
		C2H2 Zn finger	372..392	CDD:275368	2/19 (11%)
		zf-H2C2_2	384..409	CDD:316026	3/24 (13%)
		C2H2 Zn finger	400..420	CDD:275368	5/19 (26%)
		COG5048	424..853	CDD:227381	89/582 (15%)
		C2H2 Zn finger	428..448	CDD:275368	2/19 (11%)
		C2H2 Zn finger	456..476	CDD:275368	3/26 (12%)
		C2H2 Zn finger	484..504	CDD:275368	2/19 (11%)
		C2H2 Zn finger	512..532	CDD:275368	5/22 (23%)
		C2H2 Zn finger	540..560	CDD:275368	6/19 (32%)
		C2H2 Zn finger	568..588	CDD:275368	9/20 (45%)
		C2H2 Zn finger	596..616	CDD:275368	3/42 (7%)
		C2H2 Zn finger	624..644	CDD:275368	5/19 (26%)
		C2H2 Zn finger	652..672	CDD:275368	2/19 (11%)
		C2H2 Zn finger	680..700	CDD:275368	1/19 (5%)
		C2H2 Zn finger	708..728	CDD:275368	2/19 (11%)
		C2H2 Zn finger	736..756	CDD:275368	5/19 (26%)
		COG5048	760..>1026	CDD:227381	67/292 (23%)
		C2H2 Zn finger	764..784	CDD:275368	3/34 (9%)
		C2H2 Zn finger	792..812	CDD:275368	4/70 (6%)
		C2H2 Zn finger	820..840	CDD:275368	5/19 (26%)
		C2H2 Zn finger	848..868	CDD:275368	5/19 (26%)
		C2H2 Zn finger	876..896	CDD:275368	5/20 (25%)
		C2H2 Zn finger	904..924	CDD:275368	8/19 (42%)
		C2H2 Zn finger	932..952	CDD:275368	7/19 (37%)
		C2H2 Zn finger	960..980	CDD:275368	6/19 (32%)
		C2H2 Zn finger	988..1008	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24376
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.100