DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment mld and LOC100910046

DIOPT Version :9

Sequence 1:	NP_001247289.1	Gene:	mld / 2768685	FlyBaseID:	FBgn0263490	Length:	1965	Species:	Drosophila melanogaster
Sequence 2:	XP_038956767.1	Gene:	LOC100910046 / 100910046	RGDID:	6500398	Length:	668	Species:	Rattus norvegicus

Alignment Length:	873	Identity:	165/873 - (18%)
Similarity:	280/873 - (32%)	Gaps:	295/873 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly  1096 AQHQVVPHVQLQSQLVPHVQTQGTTTTVTYEQIYQ-------QHIVQQTVQQSSNKMQVISLPSA 1153
            :||.|...|..:...|...|.:......|.:.:|:       .|:| ..|.:..:|..:|:|
  Rat     6 SQHTVCGSVTFRDVAVDFSQEEWACLDATQKVLYRDTMLETYSHLV-SVVGRCISKPHLITL--- 66

  Fly  1154 GSETTRQWQTQQSQQQQQVQWSSVGGLEAIKSAPVESVAPTTTTYYISASDLYPQQTETYTMLQP 1218
                         .:|::..|.:|       ....:..:|...|.:                  .
  Rat    67 -------------LEQEKEPWMAV-------KEESDRPSPGVKTCF------------------K 93

  Fly  1219 ASNESYVIEQVNHQQ-QHCQQQIQMSQQQHQ----------RQHQQQQAQQQQQPIMILIQQPEI 1272
            |.|.|.:  .||.|. :|..:...:.:....          .|..|..|.|:
  Rat    94 AENVSDI--NVNKQSIKHLSKTFDLKESTFSDGPNYRTLSGLQGCQGDADQK------------- 143

  Fly  1273 QQPVASASNPQQAPLHIYNAATSNDVHQMQHTQRQQIRQQYQHQQY-QRLQQPQQ-TRVVQSH-- 1333
                  ::|....|.:...|...|            :.:.|:.::. :..:.||| ||..:||
  Rat   144 ------SNNKDGTPPYTCQALAHN------------VERAYECKECGKAFRLPQQLTRHQKSHSG 190

  Fly  1334 ----------PVLGMPGA----TSISTKVTPIPVTAARGRPLTLKCRFCHNGPRFSSSLEYSRHI 1384
                      ....:||.    .:|.|...|            .:|..|      ..|.....|:
  Rat   191 EKPFKCNECGKAFHLPGLLKYHKTIHTGEKP------------FECEEC------GKSFNCVSHL 237

  Fly  1385 ID---LHPAVAPFNCPHCPMAFAGRTKRSQHILSHHVV----QQYQCGQCSHVFPAQKALDVHIQ 1442
            ::   :|..|.|:.|..|..||    ||..:::.|..:    :.:||.:|...|.....|..| |
  Rat   238 VEHRTIHAGVKPYECNDCGKAF----KRHSYLMQHQKIHSGDKPFQCKECGKAFTVLPQLTQH-Q 297

  Fly  1443 RFHMTLKTDP-------SGAVKVEDVQLQITSER----RPRGRPYKPRLQLQQHQLQPQQKLQVQ 1496
            ..|.:.|.:.       ||...:...|...|.|:    ...|:.::.::.|.:||         :
  Rat   298 NTHTSEKFECKQCGKIFSGGFYLVRHQSIHTGEKPFECNVCGKAFRLQVYLNEHQ---------K 353

  Fly  1497 QHQQQQKALQQLPQAQHHQQQQQPQLQQEVLQQVQQLQVQVQPQQ-------------HQQHQQV 1548
            .|..::....:|.::...::.|        |.:.|::...|:|.|             ..:||.:
  Rat   354 THTDEKPFKCKLCESAFRRKYQ--------LSEHQKIHTNVKPYQCKDCGKFFRRRSNFTEHQSI 410

  Fly  1549 LQVQQPQQQP-----------LMQPQSPHPSTVEMQASPTTPRKILCCPDCEDCTSGHSHANEQF 1602
            ...::|.:..           |::.||.|        |...|.      :|.:|..|. |.:.|.
  Rat   411 HTGKKPFECKQCGKVFRLNIHLIRHQSFH--------SGKRPF------ECNECGKGF-HFSSQL 460

  Fly  1603 EELQTLQAPPTVLTPPSTIVSVPSPQPMVYSQHITMPSPEQSEPDSTTTLRQYRKRGVIVGPQGP 1667
            ...:|:.                           |..:|.:.|           |.|
  Rat   461 NYHKTIH---------------------------TGQTPFECE-----------KCG-------- 479

  Fly  1668 LHLATPVASPSPSSSPSSSTVDHIPPASPATPASPAPPPSPAVASTVQVSELRTSHHCLYCEERF 1732
                       .|.....|.::|....:...|                       :.|..|.:.|
  Rat   480 -----------KSFKRVCSLLEHRVIHAAVKP-----------------------YECSECGKTF 510

  Fly  1733 TNEISLKKHHQLAHGALTTMPYVCTICKRGYRMRTALHRHMESHDVEGRPYECNICRVRFPRPSQ 1797
            ....:|.:|.::..|   ..|:.|..|.:|:.:...|.||...|..| :.:||..|...|....|
  Rat   511 NRRSNLVQHQKIHSG---ERPFECKECGKGFTVLAQLTRHQTIHTGE-KSFECEQCGSAFRLQYQ 571

  Fly  1798 LTLHKITVHLLSKPHTCDECGKQFGTESALKTHIKFH-GELGYQCDGCDRTFEYLKELRKHRRTH 1861
            ||.|: .:|...||..|.||||.|...:||:.|.:.| ||..:||..|...|:|..:...|.|||
  Rat   572 LTQHQ-RIHNDVKPFECKECGKGFVRGTALRIHERIHTGERPFQCKECGEGFQYHYQFLGHSRTH 635

  Fly  1862 S-EMFYKCKFCPSSFMRFTNFRAHMKTH 1888
            : :..|:|..|...|.|..:.:.|.:.|
  Rat   636 TGKKPYECNECGKYFARDGDLKVHQRIH 663

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mld	NP_001247289.1	zf-AD	186..255	CDD:214871
		C2H2 Zn finger	1365..1388	CDD:275368	4/25 (16%)
		C2H2 Zn finger	1396..1416	CDD:275368	6/19 (32%)
		C2H2 Zn finger	1424..1445	CDD:275368	6/20 (30%)
		C2H2 Zn finger	1725..1746	CDD:275368	5/20 (25%)
		C2H2 Zn finger	1756..1776	CDD:275368	6/19 (32%)
		C2H2 Zn finger	1785..1806	CDD:275368	7/20 (35%)
		C2H2 Zn finger	1814..1834	CDD:275368	9/19 (47%)
		zf-C2H2	1839..1861	CDD:278523	7/21 (33%)
		C2H2 Zn finger	1841..1861	CDD:275368	6/19 (32%)
		C2H2 Zn finger	1868..1888	CDD:275368	5/19 (26%)
LOC100910046	XP_038956767.1	KRAB	14..75	CDD:214630	12/77 (16%)
		COG5048	<168..323	CDD:227381	37/177 (21%)
		C2H2 Zn finger	168..188	CDD:275368	5/19 (26%)
		C2H2 Zn finger	196..216	CDD:275368	2/19 (11%)
		C2H2 Zn finger	224..244	CDD:275368	4/25 (16%)
		COG5048	248..653	CDD:227381	109/526 (21%)
		C2H2 Zn finger	252..272	CDD:275368	7/23 (30%)
		C2H2 Zn finger	280..300	CDD:275368	6/20 (30%)
		C2H2 Zn finger	307..327	CDD:275368	3/19 (16%)
		C2H2 Zn finger	335..355	CDD:275368	4/28 (14%)
		C2H2 Zn finger	363..383	CDD:275368	4/27 (15%)
		C2H2 Zn finger	391..411	CDD:275368	2/19 (11%)
		C2H2 Zn finger	419..439	CDD:275368	3/19 (16%)
		C2H2 Zn finger	447..467	CDD:275368	6/20 (30%)
		C2H2 Zn finger	475..495	CDD:275368	6/49 (12%)
		C2H2 Zn finger	503..523	CDD:275368	5/19 (26%)
		C2H2 Zn finger	531..551	CDD:275368	6/19 (32%)
		C2H2 Zn finger	559..579	CDD:275368	7/20 (35%)
		C2H2 Zn finger	587..607	CDD:275368	9/19 (47%)
		C2H2 Zn finger	615..635	CDD:275368	6/19 (32%)
		C2H2 Zn finger	643..663	CDD:275368	5/19 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24376
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.100