DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment mld and Zfp605

DIOPT Version :9

Sequence 1:	NP_001247289.1	Gene:	mld / 2768685	FlyBaseID:	FBgn0263490	Length:	1965	Species:	Drosophila melanogaster
Sequence 2:	XP_017454057.1	Gene:	Zfp605 / 100365779	RGDID:	2318406	Length:	756	Species:	Rattus norvegicus

Alignment Length:	696	Identity:	147/696 - (21%)
Similarity:	221/696 - (31%)	Gaps:	212/696 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly  1220 SNESYVI-EQVNHQQ----QHCQQQIQMSQQ--QHQRQHQQQQAQQ--------QQQPIMILIQQ 1269
            ||||.:: .|:.|..    ..|.:......|  .|||.|..::..|        .|:.::.|.|:
  Rat   185 SNESQLVTNQMTHSGIYLCMECGRIFNKKSQLTVHQRNHTGEKPYQCNGCGKTFAQKSLLALHQK 249

  Fly  1270 PEIQQPVASASNPQQAPLHIYNAATSNDVHQMQHTQRQQIRQQYQHQQYQRL--------QQPQQ 1326
            ....:|                  ...|..|...:.:..:.||.:....|:|        ::.||
  Rat   250 SHSVEP------------------DGCDERQKAFSGKSLVIQQQRTHAGQKLCTHGKAYSRKSQQ 296

  Fly  1327 TRVVQSHPVLGMPGATSISTKVTPIPVTAARGRPLTLKCRFCHNGPRFSSSLEYSRHIIDLHPAV 1391
            .|....|.:                      |:|  .:|..|  |..||..|:...| ...|...
  Rat   297 NRQEMIHTM----------------------GKP--YRCSDC--GKAFSQKLKLIIH-RRTHTGE 334

  Fly  1392 APFNCPHCPMAFAGRTKRSQHILSHHVVQQYQCGQCSHVFPAQKALDVHIQRFHMTLKTDPSGAV 1456
            .|:.|..|..||...::...|..||...:.|.|.:|...|.....|..| ||.|...|...|
  Rat   335 KPYKCSECRKAFFWNSQLITHQRSHRGKKPYVCSKCKKAFRRNSLLIRH-QRIHAVEKPQRS--- 395

  Fly  1457 KVEDVQLQITSERRPRGRPYKPRLQLQQHQLQPQQKLQVQQHQQQQKALQQLPQAQHHQQQQQPQ 1521
                         |..|..:..:.||.:|::....:...|.:..:: |..:..|...||:....:
  Rat   396 -------------RECGEAFIRKAQLTKHRMTHTGEKSYQCYDCEE-AFFKKSQLMRHQKSHLGE 446

  Fly  1522 LQQEVLQQVQQLQVQVQPQQHQQHQQVLQVQQPQQQPLMQPQSPHPSTVEMQASPTTPRKILCCP 1586
                            :|.:..:..:..    |::..|:..|..|     ::..|      |.|.
  Rat   447 ----------------RPLRCTECGKTF----PEKSQLLTHQKSH-----LEERP------LRCT 480

  Fly  1587 DCEDCTSGHSHANEQF-EELQTLQAPPTVLTPPSTIVSVPSPQPMVYSQHITMPSPEQSEPDSTT 1650
            :|          .:.| |:||.|
  Rat   481 EC----------GKTFPEKLQLL------------------------------------------ 493

  Fly  1651 TLRQYRKRGVIVGPQGPLHLATPVASPSPSSSPSSSTVDHIPPASPATPASPAPPPSPAVASTVQ 1715
               .::|..:...|    |..|......|..                           ....|.|
  Rat   494 ---THQKSHLGERP----HRCTECGKTFPEK---------------------------LQLLTHQ 524

  Fly  1716 VSEL-RTSHHCLYCEERFTNEISLKKHHQLAHGALTTMPYVCTICKRGYRMRTALHRHMESHDVE 1779
            .|.| ...|.|..|.:.|.....|..|.:...|   ..||.|:.|.||:..|:::..|..:|..|
  Rat   525 KSHLGERPHRCAECGKSFPGRSQLLTHQRTHTG---EKPYKCSECGRGFSQRSSVVSHQRTHTGE 586

  Fly  1780 GRPYECNICRVRFPRPSQLTLHKITVHLLSKPHTCDECGKQFGTESALKTHIKFH-GELGYQCDG 1843
             :||:|..|...|...|.|..||.| |...||..|.:|||.|..:..|..|.:.| ||..::|..
  Rat   587 -KPYKCGDCGKAFTEKSSLLHHKRT-HTGEKPFECSDCGKAFAWKPQLLRHQRIHTGEKPFECSE 649

  Fly  1844 CDRTFEYLKELRKHRRTHS-EMFYKCKFCPSSFMRFTNFRAHMKTH 1888
            |.:.|....:|.||:|.|: |..|||..|..:|...|....|.|.|
  Rat   650 CGKAFVQKVQLIKHQRHHTGEKTYKCNGCEKAFFEKTQLMIHQKIH 695

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mld	NP_001247289.1	zf-AD	186..255	CDD:214871
		C2H2 Zn finger	1365..1388	CDD:275368	7/22 (32%)
		C2H2 Zn finger	1396..1416	CDD:275368	5/19 (26%)
		C2H2 Zn finger	1424..1445	CDD:275368	7/20 (35%)
		C2H2 Zn finger	1725..1746	CDD:275368	5/20 (25%)
		C2H2 Zn finger	1756..1776	CDD:275368	6/19 (32%)
		C2H2 Zn finger	1785..1806	CDD:275368	8/20 (40%)
		C2H2 Zn finger	1814..1834	CDD:275368	7/19 (37%)
		zf-C2H2	1839..1861	CDD:278523	7/21 (33%)
		C2H2 Zn finger	1841..1861	CDD:275368	7/19 (37%)
		C2H2 Zn finger	1868..1888	CDD:275368	6/19 (32%)
Zfp605	XP_017454057.1	KRAB	8..63	CDD:214630
		KRAB	8..46	CDD:279668
		C2H2 Zn finger	177..197	CDD:275368	5/11 (45%)
		COG5048	<200..355	CDD:227381	36/199 (18%)
		C2H2 Zn finger	203..223	CDD:275368	5/19 (26%)
		zf-H2C2_2	216..240	CDD:290200	5/23 (22%)
		C2H2 Zn finger	231..251	CDD:275368	3/19 (16%)
		C2H2 Zn finger	287..303	CDD:275368	3/15 (20%)
		C2H2 Zn finger	311..331	CDD:275368	7/22 (32%)
		zf-H2C2_2	324..346	CDD:290200	5/22 (23%)
		C2H2 Zn finger	339..359	CDD:275368	5/19 (26%)
		COG5048	362..750	CDD:227381	102/474 (22%)
		C2H2 Zn finger	367..387	CDD:275368	7/20 (35%)
		C2H2 Zn finger	395..415	CDD:275368	6/35 (17%)
		C2H2 Zn finger	423..443	CDD:275368	4/20 (20%)
		C2H2 Zn finger	451..471	CDD:275368	3/23 (13%)
		C2H2 Zn finger	479..499	CDD:275368	8/74 (11%)
		C2H2 Zn finger	507..527	CDD:275368	4/46 (9%)
		C2H2 Zn finger	535..555	CDD:275368	5/19 (26%)
		zf-H2C2_2	548..572	CDD:290200	9/26 (35%)
		C2H2 Zn finger	563..583	CDD:275368	6/19 (32%)
		zf-H2C2_2	578..599	CDD:290200	7/21 (33%)
		C2H2 Zn finger	591..611	CDD:275368	8/20 (40%)
		zf-H2C2_2	603..627	CDD:290200	11/24 (46%)
		C2H2 Zn finger	619..639	CDD:275368	7/19 (37%)
		zf-H2C2_2	632..656	CDD:290200	8/23 (35%)
		C2H2 Zn finger	647..667	CDD:275368	7/19 (37%)
		C2H2 Zn finger	675..695	CDD:275368	6/19 (32%)
		zf-H2C2_2	688..712	CDD:290200	3/8 (38%)
		C2H2 Zn finger	703..723	CDD:275368
		C2H2 Zn finger	731..751	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24376
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.100