DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment mld and LOC100365363

DIOPT Version :9

Sequence 1:	NP_001247289.1	Gene:	mld / 2768685	FlyBaseID:	FBgn0263490	Length:	1965	Species:	Drosophila melanogaster
Sequence 2:	XP_006228060.2	Gene:	LOC100365363 / 100365363	RGDID:	2319215	Length:	670	Species:	Rattus norvegicus

Alignment Length:	646	Identity:	137/646 - (21%)
Similarity:	204/646 - (31%)	Gaps:	207/646 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly  1357 RGRPLTLK-----CRFCHNGPRFSSSLEYSRHIIDLHPAVAPFNCPHCPMAFAGRTKRSQHILSH 1416
            :|:...:|     |..|....|::|||.|.|.|   |.....:.|..|..||..|:....|...|
  Rat   135 KGQKAAIKEKPYQCNECDKVFRYTSSLAYHRQI---HTGEKLYKCVECGKAFFRRSYLLVHERHH 196

  Fly  1417 HVVQQYQCGQCSHVFPAQKALDVHIQRFHMTLKTDPSGAVKVEDVQLQITSERRPRGRPYKPRLQ 1481
            ...:.|:|.:|..||.....|..| :|.|                    |.|     :|||
  Rat   197 SGAKPYKCNECGKVFSQNSHLKSH-RRIH--------------------TGE-----KPYK---- 231

  Fly  1482 LQQHQLQPQQKLQVQQHQQQQKALQQLPQAQHH---QQQQQPQLQQE---VLQQVQQLQVQVQPQ 1540
                            .....||........||   ....:|....|   |..|...|.:
  Rat   232 ----------------CNDCGKAFSVRSNLTHHLVIHTGDKPYKCNECGKVFSQTSSLTI----- 275

  Fly  1541 QHQQHQQVLQVQQPQQQPLMQPQSPHPSTVEMQASPTTPRKILCCPDCEDCTSGHSHANEQFEEL 1605
                |::....::|.:                            |.:|....|.||:.|.. :.:
  Rat   276 ----HRRTHTGEKPYR----------------------------CNECGKVFSSHSNLNTH-QAI 307

  Fly  1606 QTLQAP------PTVLTPPSTIVSVPSPQPMVYSQHITMPSPEQ-----------SEPDSTTTLR 1653
            .|.:.|      ..|.|..|.:           :.|....:.|:           |...|.||
  Rat   308 HTGEKPYKCSECGKVFTQNSHL-----------ANHWRTHTGEKPYKCNECGKAFSVYSSLTT-- 359

  Fly  1654 QYRKRGVIVGPQGPLHLATPVASPSPSS--------SPSSSTVDHIPPASPATPASPAPPPSPAV 1710
                           |||..... .|..        :.:|...:|....|...|
  Rat   360 ---------------HLAIHTGE-KPYKCEECGKVFTQNSHLANHRGIHSGEKP----------- 397

  Fly  1711 ASTVQVSELRTSHHCLYCEERFTNEISLKKHHQLAHGALTTMPYVCTICKRGYRMRTALHRHMES 1775
                        :.|..|.:.|....:|.:|.::..|   ..||.|:.|.:.:.:|::|..|...
  Rat   398 ------------YKCEECGKHFNQTSNLARHWRVHTG---EKPYKCSECGKAFSVRSSLTSHQVI 447

  Fly  1776 HDVEGRPYECNICRVRFPRPSQLTLHKITVHLLSKPHTCDECGKQFGTESALKTHIKFH-GELGY 1839
            |..| :||:|..|...|.:.|.|::|: .:|...||:.|:||||.|.:.|.|.||...| |:..|
  Rat   448 HTGE-KPYKCAECGKVFSQTSSLSIHQ-RIHTGEKPYRCNECGKAFNSHSNLNTHQVIHTGQKPY 510

  Fly  1840 QCDGCDRTFEYLKELRKHRRTHS-EMFYKCKFCPSSFMRFTNFRAHMKTHLPLGVFRNEDAASKS 1903
            :|..|.:.|.....|..|.|||: |..|||..|..:|..:::...|...|.....|:..:..  .
  Rat   511 KCLECGKVFTQNSHLANHHRTHTGEKPYKCNECGKAFSVYSSLTTHQAIHTGEKPFKCNECG--K 573

  Fly  1904 PSNNNSHASSDKLENPATPIEETPLTPMSSGGHLYHSPDEYPNSVESCAGNSVALESYATT 1964
            ....|||.:|                      |......|.|.....| |.:.::.|..||
  Rat   574 VFTQNSHLAS----------------------HRRTHTGEKPYKCSKC-GKAFSVRSSLTT 611

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mld	NP_001247289.1	zf-AD	186..255	CDD:214871
		C2H2 Zn finger	1365..1388	CDD:275368	9/22 (41%)
		C2H2 Zn finger	1396..1416	CDD:275368	6/19 (32%)
		C2H2 Zn finger	1424..1445	CDD:275368	7/20 (35%)
		C2H2 Zn finger	1725..1746	CDD:275368	5/20 (25%)
		C2H2 Zn finger	1756..1776	CDD:275368	5/19 (26%)
		C2H2 Zn finger	1785..1806	CDD:275368	6/20 (30%)
		C2H2 Zn finger	1814..1834	CDD:275368	10/19 (53%)
		zf-C2H2	1839..1861	CDD:278523	7/21 (33%)
		C2H2 Zn finger	1841..1861	CDD:275368	6/19 (32%)
		C2H2 Zn finger	1868..1888	CDD:275368	4/19 (21%)
LOC100365363	XP_006228060.2	KRAB	8..68	CDD:214630
		SFP1	<143..221	CDD:227516	24/81 (30%)
		C2H2 Zn finger	148..168	CDD:275368	9/22 (41%)
		C2H2 Zn finger	176..196	CDD:275368	6/19 (32%)
		COG5048	200..575	CDD:227381	106/517 (21%)
		C2H2 Zn finger	204..224	CDD:275368	7/20 (35%)
		C2H2 Zn finger	232..252	CDD:275368	4/19 (21%)
		C2H2 Zn finger	260..280	CDD:275368	5/28 (18%)
		C2H2 Zn finger	288..308	CDD:275368	6/20 (30%)
		C2H2 Zn finger	316..336	CDD:275368	4/30 (13%)
		C2H2 Zn finger	344..364	CDD:275368	7/36 (19%)
		C2H2 Zn finger	372..392	CDD:275368	2/19 (11%)
		C2H2 Zn finger	400..420	CDD:275368	5/19 (26%)
		C2H2 Zn finger	428..448	CDD:275368	5/19 (26%)
		C2H2 Zn finger	456..476	CDD:275368	6/20 (30%)
		C2H2 Zn finger	484..504	CDD:275368	10/19 (53%)
		C2H2 Zn finger	512..532	CDD:275368	6/19 (32%)
		C2H2 Zn finger	540..560	CDD:275368	4/19 (21%)
		C2H2 Zn finger	568..588	CDD:275368	5/43 (12%)
		zf-H2C2_2	580..604	CDD:404364	7/46 (15%)
		C2H2 Zn finger	596..615	CDD:275368	5/17 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166335924
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.930