Protein Alignment mld and Ctcfl1

DIOPT Version :10

• Sequence 1: NP_001247289.1
• Gene: mld / 2768685
• FlyBaseID: FBgn0263490
• Length: 1965
• Species: Drosophila melanogaster
• Sequence 2: NP_001309415.1
• Gene: Ctcfl1 / 100360757
• RGDID: 2321501
• Length: 645
• Species: Rattus norvegicus
• Alignment Length: 594
• Identity: 123/594 - (20%)
• Similarity: 194/594 - (32%)
• Gaps: 195/594 - (32%)

  Fly  1504 ALQQLPQAQHHQQQQQPQLQQEVLQQVQQLQVQVQPQQHQQHQQVLQVQQPQ-QQPLMQPQSPHP 1567
            |..::|.|..|..|.:.|              :::|...::.::...||:.: |:..::.....|
  Rat     2 AAAEVPVASGHFTQIKEQ--------------KLKPGDLEEEKEEGGVQRGEAQEGAVEEAEAEP 52

  Fly  1568 STVEMQASPTTPRKILCCPDCEDCTSGHSHANEQFEELQTL------QAPPTVLTPP--STIVSV 1624
            ..:..:|...:.|:||        |....|...|...||.|      .:....:|.|  .:|:.:
  Rat    53 QELPSRAPVESDRRIL--------TLQTLHLTSQDVHLQGLGWLSVPHSEELSMTVPQAESILQL 109

  Fly  1625 PS-----PQPMVYSQH-ITMPSPEQSEPDSTTTLRQYR--KRGVIVGPQGPLHLATPVASPSPSS 1681
            ||     |:|.:..|| :|:..||:..|.....||.:.  :..|   |:.........::...|:
  Rat   110 PSVLWLDPEPPLSLQHCVTVSIPEELYPPEMLELRHFHLLRENV---PEDDEENQESTSNLEEST 171

  Fly  1682 SPSSS-------------------------------------TVDHI-------PPASPAT--PA 1700
            :|...                                     |:.|:       |||:..|  |.
  Rat   172 APKKPEEDEKDQLLPQGGTDKKEERFLFVEMKPREGKDEIVLTISHLSLEEQQDPPAAKHTSAPG 236

  Fly  1701 SPAPPPSPAVASTVQVSELRTSHHCLYCEERFT-NEISLKKHHQLAHGALTTMPYVCTICKRGYR 1764
            :.|..|.|    ..|......:..|..|.  || :::|....|...|.  ...|::|.:|.:.:|
  Rat   237 AKAAKPKP----QRQTKGRPRTFQCDTCP--FTSSKLSTFNRHIKIHS--DERPHLCHLCLKSFR 293

  Fly  1765 MRTALHRHMESHDVEGRPYECNICRVRFPRPSQLTLHKITVHLLSKPHTCDECGKQFGTESALKT 1829
            ..|.|..|:.:| ...|||:|..|.:.|....:|..|:...|...||..|..|.......|.||.
  Rat   294 TVTLLRNHVNTH-TGTRPYKCGDCDMAFVTSGELVRHRRYKHTHEKPFKCSLCKYASVEASKLKR 357

  Fly  1830 HIKFH-GELGYQCDGCDRTFEYLKELRKHRRTHS-EMFY-------------------------- 1866
            ||:.| ||..:||..|....:...:|::|.|||| |..|
  Rat   358 HIRSHTGERPFQCSQCAYASKDTYKLKRHMRTHSGEKPYECPTCHARFTQSGTMKIHIAQKHGEN 422

  Fly  1867 ----------------------------------KCKFCPSSFMRFTNFRAHMKTHLPLGVFRNE 1897
                                              ||::||::|........|.:||      :||
  Rat   423 VPKHECPHCATIIARKSDLRVHLRNLHGHSPEEIKCRYCPAAFHERYALLQHQRTH------KNE 481

  Fly  1898 --------DAASKSPSNNNSHASSDKLENPATPIEETPLTPMSSGGHL------------YHSPD 1942
                    |.|.|......:|.        .|...|.|.:.::...|.            ||.|.
  Rat   482 KKFKCKQCDYACKQERCLTAHM--------RTHTGERPFSCLTCNKHFRQKQLLTVHLRKYHDPS 538

  Fly  1943 EYPNSVESC 1951
            ..| ||..|
  Rat   539 FVP-SVHLC 546

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
mld	NP_001247289.1	zf-AD	186..255	CDD:214871
		PAT1	<959..>1109	CDD:401645
		C2H2 Zn finger	1365..1388	CDD:275368
		C2H2 Zn finger	1396..1416	CDD:275368
		C2H2 Zn finger	1424..1445	CDD:275368
		C2H2 Zn finger	1725..1746	CDD:275368	6/21 (29%)
		C2H2 Zn finger	1756..1776	CDD:275368	6/19 (32%)
		C2H2 Zn finger	1785..1806	CDD:275368	5/20 (25%)
		zf-C2H2	1812..1834	CDD:395048	7/21 (33%)
		C2H2 Zn finger	1814..1834	CDD:275368	7/19 (37%)
		zf-C2H2	1839..1861	CDD:395048	6/21 (29%)
		C2H2 Zn finger	1841..1861	CDD:275368	5/19 (26%)
		zf-C2H2	1866..1888	CDD:395048	7/81 (9%)
		C2H2 Zn finger	1868..1888	CDD:275368	5/19 (26%)
Ctcfl1	NP_001309415.1	C2H2 Zn finger	257..277	CDD:275368	6/21 (29%)
		C2H2 Zn finger	285..305	CDD:275368	6/19 (32%)
		zf-H2C2_2	298..322	CDD:463886	9/24 (38%)
		C2H2 Zn finger	313..334	CDD:275368	5/20 (25%)
		COG5048	336..>398	CDD:227381	23/61 (38%)
		C2H2 Zn finger	342..362	CDD:275368	7/19 (37%)
		C2H2 Zn finger	370..390	CDD:275368	5/19 (26%)
		zf-H2C2_2	383..407	CDD:463886	8/23 (35%)
		C2H2 Zn finger	398..415	CDD:275370	0/16 (0%)
		C2H2 Zn finger	428..451	CDD:275368	0/22 (0%)
		C2H2 Zn finger	458..478	CDD:275368	5/19 (26%)
		zf-H2C2_2	470..495	CDD:463886	7/30 (23%)
		zf-H2C2_5	484..508	CDD:404746	5/31 (16%)
		C2H2 Zn finger	486..506	CDD:275368	4/27 (15%)
		C2H2 Zn finger	514..532	CDD:275368	1/17 (6%)