DRSC/TRiP Functional Genomics Resources

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Protein Alignment mld and ZNF729

DIOPT Version :9

Sequence 1:NP_001247289.1 Gene:mld / 2768685 FlyBaseID:FBgn0263490 Length:1965 Species:Drosophila melanogaster
Sequence 2:NP_001229609.1 Gene:ZNF729 / 100287226 HGNCID:32464 Length:1252 Species:Homo sapiens


Alignment Length:785 Identity:158/785 - (20%)
Similarity:281/785 - (35%) Gaps:175/785 - (22%)


- Green bases have known domain annotations that are detailed below.


  Fly  1193 PTTTTYYISASDLYPQQTETYTMLQPASNESYVIEQVNHQ----QQHCQ--QQIQMSQQQHQRQH 1251
            |...:::  ..||:|.|: |....|.....:|.  :..|:    ::.|:  .:.:|.::.:.:.:
Human    84 PVMRSHF--TQDLWPDQS-TKDSFQEVILRTYA--RCGHKNLRLRKDCKSANEGKMHKEGYNKLN 143

  Fly  1252 QQQQAQQQQQPIMILIQQPEIQQPVASASNPQQAPLHIYNAATSNDVHQMQHTQRQQ-------- 1308
            |.:.|.|::     :.|           .|......|.|     ::.::::||:::.        
Human   144 QCRTATQRK-----IFQ-----------CNKHMKVFHKY-----SNRNKVRHTKKKTFKCIKCSK 187

  Fly  1309 --------IRQQYQHQQYQRLQQPQQTRVVQSHPVLGMPGATSISTKVTPIPVTAARGRPLTLKC 1365
                    ||.:..|.:....:..::.:..:|...|            |...:.....:|  .|.
Human   188 SFFMLSCLIRHKRIHIRQNIYKCEERGKAFKSFSTL------------TKHKIIHTEDKP--YKY 238

  Fly  1366 RFCHNGPRFSSSLEYSRHIIDLHPAVAPFNCPHCPMAFAGRTKRSQHILSHHVVQQYQCGQCSHV 1430
            :.|.|..:|||:....:.|   |....||.|..|..||...:..:.|...|...:.|:|.:|...
Human   239 KKCGNAFKFSSTFTKHKRI---HTGETPFRCEECGKAFNQSSNLTDHKRIHTGEKTYKCEECGKA 300

  Fly  1431 FPAQKALDVHIQRFHMTLKTDPSGAVKVEDVQLQITSERRPRGRPYKPRLQLQQHQLQPQQKLQV 1495
            |......:.| :..|...|     ..|.||.           |:.:.....|::|::....| :.
Human   301 FKGSSNFNAH-KVIHTAEK-----PYKCEDC-----------GKTFNHFSALRKHKIIHTGK-KP 347

  Fly  1496 QQHQQQQKALQQLPQAQHHQ---QQQQPQLQQE---VLQQVQQLQVQVQPQQHQQHQQVLQVQQP 1554
            .:.::..||..|....:.|:   ..::|...:|   ..:...:|.|         |:.|...::|
Human   348 YKREECGKAFSQSSTLRKHEIIHTGEKPYKCEECGKAFKWSSKLTV---------HKVVHTGEKP 403

  Fly  1555 QQQPLMQPQSPHPSTVEMQASPTTPRKILCCPDCEDCTSGHSHANEQFEELQTLQAPPTVLTPPS 1619
            .:...........||::......|.:|...|.:|          .:.|....||.....:.|...
Human   404 YKCEECGKAFSQFSTLKKHKIIHTGKKPYKCEEC----------GKAFNSSSTLMKHKIIHTGEK 458

  Fly  1620 TIVSVPSPQPMVYSQHITM-------PSPEQSEP-----DSTTTLRQYRKRGVIVGPQGPLHLAT 1672
            ........:....|.|:|.       ..|.:.|.     :..:.||:::   :|...:.|.....
Human   459 PYKCEECGKAFRQSSHLTRHKAIHTGEKPYKCEECGKAFNHFSDLRRHK---IIHTGKKPYKCEE 520

  Fly  1673 PVASPSPSSSPSSSTVDHIPPASPATPASPAPPPSPAVASTVQVSELRTSHHCLY-------CEE 1730
            ...:.|.||:..:..:.|         ....|..........:.|...|.|..::       |||
Human   521 CGKAFSQSSTLRNHQIIH---------TGEKPYKCEECGKAFKWSSKLTVHKVIHTGEKPCKCEE 576

  Fly  1731 ---RFTNEISLKKH---------------------------HQLAHGALTTMPYVCTICKRGYRM 1765
               .|.:..:|:||                           |::.|..  ..||.|..|.:.:|.
Human   577 CGKAFKHFSALRKHKVIHTREKLYKCEECGKAFNNSSILAKHKIIHTG--KKPYKCEECGKAFRQ 639

  Fly  1766 RTALHRHMESHDVEGRPYECNICRVRFPRPSQLTLHKITVHLLSKPHTCDECGKQFGTESALKTH 1830
            .:.|.||...|..| :||:|..|...|...|.|..||| :|...||:.|:||||.|...|||:.|
Human   640 SSHLTRHKAIHTGE-KPYKCEECGKAFSHFSALRRHKI-IHTGKKPYKCEECGKAFSHFSALRRH 702

  Fly  1831 IKFH-GELGYQCDGCDRTFEYLKELRKHRRTH-SEMFYKCKFCPSSFMRFTNFRAHMKTHLPLGV 1893
            ...| ||..|:|:.|.:.|::..:|..|:..| :|...||:.|..||..|:..|.|...|....:
Human   703 KIIHTGEKPYKCEECGKAFKWSSKLTVHKVIHTAEKPCKCEECGKSFKHFSALRKHKVIHTREKL 767

  Fly  1894 FRNED 1898
            ::.|:
Human   768 YKCEE 772

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
mldNP_001247289.1 zf-AD 186..255 CDD:214871
C2H2 Zn finger 1365..1388 CDD:275368 6/22 (27%)
C2H2 Zn finger 1396..1416 CDD:275368 5/19 (26%)
C2H2 Zn finger 1424..1445 CDD:275368 4/20 (20%)
C2H2 Zn finger 1725..1746 CDD:275368 8/57 (14%)
C2H2 Zn finger 1756..1776 CDD:275368 6/19 (32%)
C2H2 Zn finger 1785..1806 CDD:275368 8/20 (40%)
C2H2 Zn finger 1814..1834 CDD:275368 10/19 (53%)
zf-C2H2 1839..1861 CDD:278523 6/21 (29%)
C2H2 Zn finger 1841..1861 CDD:275368 5/19 (26%)
C2H2 Zn finger 1868..1888 CDD:275368 7/19 (37%)
ZNF729NP_001229609.1 KRAB 13..73 CDD:214630
KRAB 13..52 CDD:279668
C2H2 Zn finger 182..202 CDD:275368 2/19 (11%)
C2H2 Zn finger 210..230 CDD:275368 3/31 (10%)
C2H2 Zn finger 239..258 CDD:275368 6/21 (29%)
COG5048 262..666 CDD:227381 83/455 (18%)
C2H2 Zn finger 266..286 CDD:275368 5/19 (26%)
C2H2 Zn finger 294..314 CDD:275368 4/20 (20%)
C2H2 Zn finger 322..342 CDD:275368 5/30 (17%)
C2H2 Zn finger 351..370 CDD:275368 4/18 (22%)
zf-H2C2_2 363..386 CDD:290200 3/22 (14%)
C2H2 Zn finger 378..398 CDD:275368 4/28 (14%)
C2H2 Zn finger 406..426 CDD:275368 2/19 (11%)
C2H2 Zn finger 434..454 CDD:275368 5/29 (17%)
C2H2 Zn finger 462..482 CDD:275368 3/19 (16%)
zf-H2C2_2 474..499 CDD:290200 4/24 (17%)
C2H2 Zn finger 490..510 CDD:275368 3/22 (14%)
zf-H2C2_2 502..527 CDD:290200 4/27 (15%)
C2H2 Zn finger 518..538 CDD:275368 3/19 (16%)
zf-H2C2_2 531..554 CDD:290200 2/31 (6%)
C2H2 Zn finger 546..566 CDD:275368 3/19 (16%)
C2H2 Zn finger 574..594 CDD:275368 7/19 (37%)
C2H2 Zn finger 602..622 CDD:275368 1/19 (5%)
COG5048 625..1123 CDD:227381 54/150 (36%)
C2H2 Zn finger 630..650 CDD:275368 6/19 (32%)
zf-H2C2_2 642..667 CDD:290200 10/25 (40%)
C2H2 Zn finger 658..678 CDD:275368 8/20 (40%)
zf-H2C2_2 670..695 CDD:290200 13/25 (52%)
C2H2 Zn finger 686..706 CDD:275368 10/19 (53%)
zf-H2C2_2 698..722 CDD:290200 9/23 (39%)
C2H2 Zn finger 714..734 CDD:275368 5/19 (26%)
C2H2 Zn finger 742..762 CDD:275368 7/19 (37%)
C2H2 Zn finger 770..790 CDD:275368 1/3 (33%)
C2H2 Zn finger 798..818 CDD:275368
C2H2 Zn finger 826..846 CDD:275368
C2H2 Zn finger 854..874 CDD:275368
zf-H2C2_2 866..890 CDD:290200
C2H2 Zn finger 882..902 CDD:275368
C2H2 Zn finger 910..930 CDD:275368
C2H2 Zn finger 938..958 CDD:275368
C2H2 Zn finger 966..986 CDD:275368
zf-H2C2_2 978..1003 CDD:290200
C2H2 Zn finger 994..1014 CDD:275368
C2H2 Zn finger 1022..1042 CDD:275368
zf-H2C2_2 1034..1058 CDD:290200
C2H2 Zn finger 1050..1070 CDD:275368
C2H2 Zn finger 1078..1098 CDD:275368
C2H2 Zn finger 1106..1126 CDD:275368
C2H2 Zn finger 1134..1154 CDD:275368
C2H2 Zn finger 1162..1182 CDD:275368
C2H2 Zn finger 1190..1210 CDD:275368
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C165142214
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - O PTHR24376
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
22.030

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