DRSC/TRiP Functional Genomics Resources

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Protein Alignment mld and ZNF729

DIOPT Version :10

Sequence 1:NP_001247289.1 Gene:mld / 2768685 FlyBaseID:FBgn0263490 Length:1965 Species:Drosophila melanogaster
Sequence 2:NP_001229609.1 Gene:ZNF729 / 100287226 HGNCID:32464 Length:1252 Species:Homo sapiens


Alignment Length:785 Identity:158/785 - (20%)
Similarity:281/785 - (35%) Gaps:175/785 - (22%)


- Green bases have known domain annotations that are detailed below.


  Fly  1193 PTTTTYYISASDLYPQQTETYTMLQPASNESYVIEQVNHQ----QQHCQ--QQIQMSQQQHQRQH 1251
            |...:::  ..||:|.|: |....|.....:|.  :..|:    ::.|:  .:.:|.::.:.:.:
Human    84 PVMRSHF--TQDLWPDQS-TKDSFQEVILRTYA--RCGHKNLRLRKDCKSANEGKMHKEGYNKLN 143

  Fly  1252 QQQQAQQQQQPIMILIQQPEIQQPVASASNPQQAPLHIYNAATSNDVHQMQHTQRQQ-------- 1308
            |.:.|.|::     :.|           .|......|.|     ::.::::||:::.        
Human   144 QCRTATQRK-----IFQ-----------CNKHMKVFHKY-----SNRNKVRHTKKKTFKCIKCSK 187

  Fly  1309 --------IRQQYQHQQYQRLQQPQQTRVVQSHPVLGMPGATSISTKVTPIPVTAARGRPLTLKC 1365
                    ||.:..|.:....:..::.:..:|...|            |...:.....:|  .|.
Human   188 SFFMLSCLIRHKRIHIRQNIYKCEERGKAFKSFSTL------------TKHKIIHTEDKP--YKY 238

  Fly  1366 RFCHNGPRFSSSLEYSRHIIDLHPAVAPFNCPHCPMAFAGRTKRSQHILSHHVVQQYQCGQCSHV 1430
            :.|.|..:|||:....:.|   |....||.|..|..||...:..:.|...|...:.|:|.:|...
Human   239 KKCGNAFKFSSTFTKHKRI---HTGETPFRCEECGKAFNQSSNLTDHKRIHTGEKTYKCEECGKA 300

  Fly  1431 FPAQKALDVHIQRFHMTLKTDPSGAVKVEDVQLQITSERRPRGRPYKPRLQLQQHQLQPQQKLQV 1495
            |......:.| :..|...|     ..|.||.           |:.:.....|::|::....| :.
Human   301 FKGSSNFNAH-KVIHTAEK-----PYKCEDC-----------GKTFNHFSALRKHKIIHTGK-KP 347

  Fly  1496 QQHQQQQKALQQLPQAQHHQ---QQQQPQLQQE---VLQQVQQLQVQVQPQQHQQHQQVLQVQQP 1554
            .:.::..||..|....:.|:   ..::|...:|   ..:...:|.|         |:.|...::|
Human   348 YKREECGKAFSQSSTLRKHEIIHTGEKPYKCEECGKAFKWSSKLTV---------HKVVHTGEKP 403

  Fly  1555 QQQPLMQPQSPHPSTVEMQASPTTPRKILCCPDCEDCTSGHSHANEQFEELQTLQAPPTVLTPPS 1619
            .:...........||::......|.:|...|.:|          .:.|....||.....:.|...
Human   404 YKCEECGKAFSQFSTLKKHKIIHTGKKPYKCEEC----------GKAFNSSSTLMKHKIIHTGEK 458

  Fly  1620 TIVSVPSPQPMVYSQHITM-------PSPEQSEP-----DSTTTLRQYRKRGVIVGPQGPLHLAT 1672
            ........:....|.|:|.       ..|.:.|.     :..:.||:::   :|...:.|.....
Human   459 PYKCEECGKAFRQSSHLTRHKAIHTGEKPYKCEECGKAFNHFSDLRRHK---IIHTGKKPYKCEE 520

  Fly  1673 PVASPSPSSSPSSSTVDHIPPASPATPASPAPPPSPAVASTVQVSELRTSHHCLY-------CEE 1730
            ...:.|.||:..:..:.|         ....|..........:.|...|.|..::       |||
Human   521 CGKAFSQSSTLRNHQIIH---------TGEKPYKCEECGKAFKWSSKLTVHKVIHTGEKPCKCEE 576

  Fly  1731 ---RFTNEISLKKH---------------------------HQLAHGALTTMPYVCTICKRGYRM 1765
               .|.:..:|:||                           |::.|..  ..||.|..|.:.:|.
Human   577 CGKAFKHFSALRKHKVIHTREKLYKCEECGKAFNNSSILAKHKIIHTG--KKPYKCEECGKAFRQ 639

  Fly  1766 RTALHRHMESHDVEGRPYECNICRVRFPRPSQLTLHKITVHLLSKPHTCDECGKQFGTESALKTH 1830
            .:.|.||...|..| :||:|..|...|...|.|..||| :|...||:.|:||||.|...|||:.|
Human   640 SSHLTRHKAIHTGE-KPYKCEECGKAFSHFSALRRHKI-IHTGKKPYKCEECGKAFSHFSALRRH 702

  Fly  1831 IKFH-GELGYQCDGCDRTFEYLKELRKHRRTH-SEMFYKCKFCPSSFMRFTNFRAHMKTHLPLGV 1893
            ...| ||..|:|:.|.:.|::..:|..|:..| :|...||:.|..||..|:..|.|...|....:
Human   703 KIIHTGEKPYKCEECGKAFKWSSKLTVHKVIHTAEKPCKCEECGKSFKHFSALRKHKVIHTREKL 767

  Fly  1894 FRNED 1898
            ::.|:
Human   768 YKCEE 772

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
mldNP_001247289.1 zf-AD 186..255 CDD:214871
PAT1 <959..>1109 CDD:401645
C2H2 Zn finger 1365..1388 CDD:275368 6/22 (27%)
C2H2 Zn finger 1396..1416 CDD:275368 5/19 (26%)
C2H2 Zn finger 1424..1445 CDD:275368 4/20 (20%)
C2H2 Zn finger 1725..1746 CDD:275368 8/57 (14%)
C2H2 Zn finger 1756..1776 CDD:275368 6/19 (32%)
C2H2 Zn finger 1785..1806 CDD:275368 8/20 (40%)
zf-C2H2 1812..1834 CDD:395048 10/21 (48%)
C2H2 Zn finger 1814..1834 CDD:275368 10/19 (53%)
zf-C2H2 1839..1861 CDD:395048 6/21 (29%)
C2H2 Zn finger 1841..1861 CDD:275368 5/19 (26%)
zf-C2H2 1866..1888 CDD:395048 8/21 (38%)
C2H2 Zn finger 1868..1888 CDD:275368 7/19 (37%)
ZNF729NP_001229609.1 KRAB 13..73 CDD:214630
C2H2 Zn finger 182..202 CDD:275368 2/19 (11%)
C2H2 Zn finger 210..230 CDD:275368 3/31 (10%)
C2H2 Zn finger 239..258 CDD:275368 6/21 (29%)
COG5048 262..666 CDD:227381 83/455 (18%)
C2H2 Zn finger 266..286 CDD:275368 5/19 (26%)
C2H2 Zn finger 294..314 CDD:275368 4/20 (20%)
C2H2 Zn finger 322..342 CDD:275368 5/30 (17%)
C2H2 Zn finger 351..370 CDD:275368 4/18 (22%)
C2H2 Zn finger 378..398 CDD:275368 4/28 (14%)
C2H2 Zn finger 406..426 CDD:275368 2/19 (11%)
C2H2 Zn finger 434..454 CDD:275368 5/29 (17%)
C2H2 Zn finger 462..482 CDD:275368 3/19 (16%)
C2H2 Zn finger 490..510 CDD:275368 3/22 (14%)
C2H2 Zn finger 518..538 CDD:275368 3/19 (16%)
C2H2 Zn finger 546..566 CDD:275368 3/19 (16%)
C2H2 Zn finger 574..594 CDD:275368 7/19 (37%)
C2H2 Zn finger 602..622 CDD:275368 1/19 (5%)
COG5048 625..1123 CDD:227381 54/150 (36%)
C2H2 Zn finger 630..650 CDD:275368 6/19 (32%)
C2H2 Zn finger 658..678 CDD:275368 8/20 (40%)
C2H2 Zn finger 686..706 CDD:275368 10/19 (53%)
C2H2 Zn finger 714..734 CDD:275368 5/19 (26%)
C2H2 Zn finger 742..762 CDD:275368 7/19 (37%)
C2H2 Zn finger 770..790 CDD:275368 1/3 (33%)
C2H2 Zn finger 798..818 CDD:275368
C2H2 Zn finger 826..846 CDD:275368
C2H2 Zn finger 854..874 CDD:275368
C2H2 Zn finger 882..902 CDD:275368
C2H2 Zn finger 910..930 CDD:275368
C2H2 Zn finger 938..958 CDD:275368
C2H2 Zn finger 966..986 CDD:275368
C2H2 Zn finger 994..1014 CDD:275368
C2H2 Zn finger 1022..1042 CDD:275368
C2H2 Zn finger 1050..1070 CDD:275368
C2H2 Zn finger 1078..1098 CDD:275368
C2H2 Zn finger 1106..1126 CDD:275368
zf-H2C2_2 1119..1143 CDD:463886
C2H2 Zn finger 1134..1154 CDD:275368
C2H2 Zn finger 1162..1182 CDD:275368
zf-H2C2_2 1174..1199 CDD:463886
C2H2 Zn finger 1190..1210 CDD:275368
Blue background indicates that the domain is not in the aligned region.

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