DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment mld and ZNF717

DIOPT Version :9

Sequence 1:	NP_001247289.1	Gene:	mld / 2768685	FlyBaseID:	FBgn0263490	Length:	1965	Species:	Drosophila melanogaster
Sequence 2:	XP_011531546.1	Gene:	ZNF717 / 100131827	HGNCID:	29448	Length:	948	Species:	Homo sapiens

Alignment Length:	1097	Identity:	205/1097 - (18%)
Similarity:	359/1097 - (32%)	Gaps:	346/1097 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly   920 NFTNELIGFQNDIPCFENIETPEEGQNLHLELTQFLRD--LQPSQSDPPAG------EQVEKIEM 976
            |.:.||:.|:.....|    |.||.|:|........||  |:...|....|      |.:.|:|.
Human    50 NKSLELVSFEEVAVHF----TWEEWQDLDDAQRTLYRDVMLETYSSLVSLGHYITKPEMIFKLEQ 110

  Fly   977 ETQPSTVQMDVQSNL-PVQAADTQPQNESANHSPFESPI----SSPQVQSQIELQMEPQIETQMQ 1036
            ..:|..|:......| .||..|...:....:|..|...|    |:...|.::||.....:.:
Human   111 GAEPWIVEETPNLRLSAVQIIDDLIERSHESHDRFFWQIVITNSNTSTQERVELGKTFNLNS--- 172

  Fly  1037 PQIETRMQHDVLSVQSPQNHQPQVQSHDQSQMQHQIPPQIEPQIEVQNQEQNTLQLVPQAQHQVV 1101
                    :.||::.....:...::....:..|:.:.| |:|. |.|:.|:
Human   173 --------NHVLNLIINNGNSSGMKPGQFNDCQNMLFP-IKPG-ETQSGEK-------------- 213

  Fly  1102 PHVQLQSQLVPHVQTQGTTTTVTYEQIYQQHIVQQTVQQSSNKMQVISLPSAGSETTRQWQTQQS 1166
                      |||......:...:|.:.|.|.:|..:                       ||.|.
Human   214 ----------PHVCDITRRSHRHHEHLTQHHKIQTLL-----------------------QTFQC 245

  Fly  1167 QQQQQVQWSSVGGLEAIKSAPVESVAPTTTTYYISASDLYPQQTETYTMLQPASNESYVIEQVNH 1231
            .:|.:                   ...|...::|.......|....|...:.|.|.|.||.||..
Human   246 NEQGK-------------------TFNTEAMFFIHKRVHIVQTFGKYNEYEKACNNSAVIVQVIT 291

  Fly  1232 Q--QQHCQQQIQMSQQQHQRQHQQQQAQQ---------QQQPIMILIQQPEIQQPVASASNPQQA 1285
            |  |..|.::...:  :||:.|..::..:         .:..:|:..:.|..::|.|.....:
Human   292 QVGQPTCCRKSDFT--KHQQTHTGEKPYECVECEKPSISKSDLMLQCKMPTEEKPYACNWCEK-- 352

  Fly  1286 PLHIYNAATSNDVHQMQHTQRQ-----QIRQQYQHQQYQRLQQPQQT-----RVVQSHPVLGMPG 1340
               :::..:|..:||..||..:     :..:.::.:.:..|.:...|     :.::.........
Human   353 ---LFSYKSSLIIHQRIHTGEKPYGCNECGKTFRRKSFLTLHERTHTGDKPYKCIECGKTFHCKS 414

  Fly  1341 ATSISTKVTPIPVTAARGRPLTLKCRFCHNGPRFSSSLEYSRHIIDLHPAVAPFNCPHCPMAFAG 1405
            ..::..:      |.:..:|  .:|..|  |..||.....:.| ...|....|:.|.||..||:.
Human   415 LLTLHHR------THSGEKP--YQCSEC--GKTFSQKSYLTIH-HRTHTGEKPYACDHCEEAFSH 468

  Fly  1406 RTKRSQHILSHHVVQQYQCGQCSHVFPAQKALDVHIQRFHMTLKTDPSGAVKVEDVQLQITSER- 1469
            :::.:.|..:|...:.|:|.:|...|..:..|.:| ||.|                    |.|:
Human   469 KSRLTVHQRTHTGEKPYECNECGKPFINKSNLRLH-QRTH--------------------TGEKP 512

  Fly  1470 ---RPRGRPYKPRLQLQQHQL-----QPQQ----------KLQVQQHQQQQKALQQLPQA----- 1511
               ...|:.:..:..|..||.     :|.:          |..:..||:....  :.|.|
Human   513 YECNECGKTFHRKSFLTIHQWTHTGEKPYECNECGKTFRCKSFLTVHQRTHAG--EKPYACNECG 575

  Fly  1512 ----------QHHQQQ--QQPQLQQE---------VLQQVQQLQVQVQPQQHQQ----------- 1544
                      .||:..  ::|....|         .|...|:.....:|.:..:
Human   576 KTYSHKSYLTVHHRTHTGEKPYECNECGKSFHCKSFLTIHQRTHAGKKPYECNECEKTFINKLNL 640

  Fly  1545 --HQQVLQVQQP-----------QQQPLMQPQSPHPSTVEMQASPTTPRKILCCPDC------ED 1590
              |::....::|           |:..|...|..|           |..|...|.:|      :.
Human   641 GIHKRTHTGERPYECNECGKTFRQKSNLSTHQGTH-----------TGEKPYVCNECGKTFHRKS 694

  Fly  1591 CTSGHSHANEQFEELQTLQAPPTV-----------LTP---PSTIVSVPSPQPMVYSQHITMPSP 1641
            ..:.|...:.....:..:......           |||   |..:::|.:|
Human   695 FLTIHQRTHTGKNRMDVMNVEKLFVRNHTLLYIRELTPGKSPMNVMNVENP-------------- 745

  Fly  1642 EQSEPDSTTTLRQYRKRGVIVGPQG--PLHLATPVASPSPSSSPSSSTVDHIPPASPATPASPAP 1704
                     .:|:...|.:.|..:|  |:::|. |..|...|
Human   746 ---------FIRRQIFRSIKVFTRGRNPMNVAN-VEKPCQKS----------------------- 777

  Fly  1705 PPSPAVASTVQVSELRTSHHCLYCEERFTNEISLKKHHQLAHGALTTMPYVCTICKRGYRMRTAL 1769
                          :.|.||..:..|:                     ||.|..|.:.:..::.|
Human   778 --------------VLTVHHRTHTGEK---------------------PYECNECGKTFCHKSNL 807

  Fly  1770 HRHMESHDVEGRPYECNICRVRFPRPSQLTLHKITVHLLSKPHTCDECGKQFGTESALKTHIKFH 1834
            ..|..:|..| :||||:.||..|...:.||:|:.| |...||..|.||.|.|..:|.|..|.:.|
Human   808 STHQGTHSGE-KPYECDECRKTFYDKTVLTIHQRT-HTGEKPFECKECRKTFSQKSKLFVHHRTH 870

  Fly  1835 -GELGYQCDGCDRTFEYLKELRKHRRTHS-EMFYKCKFCPSSFMRFTNFRAHMKTHL 1889
             ||..::|:.|.:||.....|..|:|||: |..|:||.|..:|.:.::...|.:||:
Human   871 TGEKPFRCNECRKTFSQKSGLSIHQRTHTGEKPYECKECGKTFCQKSHLSRHQQTHI 927

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mld	NP_001247289.1	zf-AD	186..255	CDD:214871
		C2H2 Zn finger	1365..1388	CDD:275368	6/22 (27%)
		C2H2 Zn finger	1396..1416	CDD:275368	6/19 (32%)
		C2H2 Zn finger	1424..1445	CDD:275368	7/20 (35%)
		C2H2 Zn finger	1725..1746	CDD:275368	1/20 (5%)
		C2H2 Zn finger	1756..1776	CDD:275368	4/19 (21%)
		C2H2 Zn finger	1785..1806	CDD:275368	8/20 (40%)
		C2H2 Zn finger	1814..1834	CDD:275368	8/19 (42%)
		zf-C2H2	1839..1861	CDD:278523	7/21 (33%)
		C2H2 Zn finger	1841..1861	CDD:275368	7/19 (37%)
		C2H2 Zn finger	1868..1888	CDD:275368	5/19 (26%)
ZNF717	XP_011531546.1	KRAB	56..116	CDD:214630	16/63 (25%)
		KRAB	56..95	CDD:279668	11/42 (26%)
		C2H2 Zn finger	217..237	CDD:275368	3/19 (16%)
		COG5048	343..723	CDD:227381	65/429 (15%)
		C2H2 Zn finger	347..367	CDD:275368	3/24 (13%)
		C2H2 Zn finger	375..395	CDD:275368	1/19 (5%)
		zf-H2C2_2	388..412	CDD:290200	2/23 (9%)
		C2H2 Zn finger	403..423	CDD:275368	0/25 (0%)
		zf-H2C2_2	416..440	CDD:290200	6/33 (18%)
		zf-C2H2	429..451	CDD:278523	6/24 (25%)
		C2H2 Zn finger	431..451	CDD:275368	6/22 (27%)
		zf-H2C2_2	443..468	CDD:290200	8/25 (32%)
		C2H2 Zn finger	459..479	CDD:275368	6/19 (32%)
		zf-H2C2_2	472..494	CDD:290200	5/21 (24%)
		C2H2 Zn finger	487..507	CDD:275368	7/20 (35%)
		zf-H2C2_2	499..524	CDD:290200	8/45 (18%)
		C2H2 Zn finger	515..535	CDD:275368	4/19 (21%)
		zf-H2C2_2	528..552	CDD:290200	4/23 (17%)
		C2H2 Zn finger	543..563	CDD:275368	3/19 (16%)
		C2H2 Zn finger	571..591	CDD:275368	2/19 (11%)
		zf-H2C2_2	583..608	CDD:290200	4/24 (17%)
		COG5048	595..932	CDD:227381	86/428 (20%)
		C2H2 Zn finger	599..619	CDD:275368	3/19 (16%)
		C2H2 Zn finger	627..647	CDD:275368	1/19 (5%)
		zf-H2C2_2	639..664	CDD:290200	2/24 (8%)
		C2H2 Zn finger	655..675	CDD:275368	3/19 (16%)
		zf-H2C2_2	667..692	CDD:290200	7/35 (20%)
		C2H2 Zn finger	683..703	CDD:275368	3/19 (16%)
		zf-H2C2_2	779..801	CDD:290200	8/42 (19%)
		C2H2 Zn finger	794..814	CDD:275368	4/19 (21%)
		C2H2 Zn finger	822..842	CDD:275368	8/20 (40%)
		zf-H2C2_2	835..859	CDD:290200	12/24 (50%)
		C2H2 Zn finger	850..870	CDD:275368	8/19 (42%)
		zf-H2C2_2	863..887	CDD:290200	9/23 (39%)
		C2H2 Zn finger	878..898	CDD:275368	7/19 (37%)
		zf-H2C2_2	891..913	CDD:290200	10/21 (48%)
		zf-C2H2	904..926	CDD:278523	6/21 (29%)
		C2H2 Zn finger	906..926	CDD:275368	5/19 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24376
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.100