Protein Alignment Myo95E and MYO1

DIOPT Version :10

• Sequence 1: NP_001027208.1
• Gene: Myo95E / 2768680
• FlyBaseID: FBgn0039157
• Length: 1288
• Species: Drosophila melanogaster
• Sequence 2: NP_011888.1
• Gene: MYO1 / 856418
• SGDID: S000001065
• Length: 1928
• Species: Saccharomyces cerevisiae
• Alignment Length: 1025
• Identity: 255/1025 - (24%)
• Similarity: 400/1025 - (39%)
• Gaps: 332/1025 - (32%)

  Fly     7 TWDSVLLENLSEDSFIN------NIHQRYKRDHIYTYIGTSVVALNPYHHISEHSLDNVRNYGDK 65
            |:|.|  ||:||.:.:|      |:.:||..|.||||.|..:||:||||:::.:|.|::..|.:|
Yeast    73 TFDKV--ENMSELTHLNEPSVLYNLEKRYDCDLIYTYSGLFLVAINPYHNLNLYSEDHINLYHNK 135

  Fly    66 ------------GIFQLPPHIYGLTNLAYQSLKDQSEDQCVLLTGESGAGKTETFKMIVNFLTHI 118
                        ...:|||||:.:...||::|..:.:||.:|:||||||||||..|.|:.:|..|
Yeast   136 HNRLSKSRLDENSHEKLPPHIFAIAEEAYENLLSEGKDQSILVTGESGAGKTENTKKILQYLASI 200

  Fly   119 QDRSHCPPTPNVLRKQSSTSSASGLVMHAHRRASSSCSGTANFIICKNRAENPSGSVSRRQSPSP 183
                                                                             
Yeast   201 ----------------------------------------------------------------- 200

  Fly   184 GPSQRSRTRAESIERQSRRHMREKIVDFDFSHHKSSENISGLPESHAHHMHPTKSCFKHQQTQVS 248
                                                                             
Yeast   201 ----------------------------------------------------------------- 200

  Fly   249 ACTAMPAAAKGSPKYAVPTVYGGCRQCGHSKCVRAQSLEKEERDDLRGSNCRLSTIATATTNPAH 313
                    ..|||                                        |.||
Yeast   201 --------TSGSP----------------------------------------SNIA-------- 209

  Fly   314 PHRGSCSNLMRQHSTESQPERERDRSSLMGSTQRISLYDAHKLSKVLGDLPPPPPSSVSPTPSAS 378
            |..||                              |:.::.:: |:|...|
Yeast   210 PVSGS------------------------------SIVESFEM-KILQSNP-------------- 229

  Fly   379 SSLHRRHKSPTQRMRECVTCADVFLEAMGNACTLKNNNSSRYGKLFDIEIDFKGDPMGVHITHYM 443
                                   .||:.|||.|::||||||:||...||.:..|...|.||..|:
Yeast   230 -----------------------ILESFGNAQTVRNNNSSRFGKFIKIEFNEHGMINGAHIEWYL 271

  Fly   444 LEKTRITDPIIGERNFHIFYQLLLGADLQLLKSLKL-YRNVEKYELLRNTT----AMEEDRMNFH 503
            |||:||......|||:|||||||.|.|...||:|:| .|||:.|::|.|:.    ....|..||.
Yeast   272 LEKSRIVHQNSKERNYHIFYQLLSGLDDSELKNLRLKSRNVKDYKILSNSNQDIIPGINDVENFK 336

  Fly   504 YTKRSLDVLGLSCEESNSIFRVIAVVLKLGNFIFVPITNIDGTEGCQVSNVYEVQETAQLLNMEA 568
            ....:|:::|.|.::...||:|:|::|.:||..||.    |..|.....|  :|......|.::.
Yeast   337 ELLSALNIIGFSKDQIRWIFQVVAIILLIGNIEFVS----DRAEQASFKN--DVSAICSNLGVDE 395

  Fly   569 QILINCLTRANSTNSAQEDVGCEMDARQAATNRNTLCRTLYSRLFTWLVNKINESLKSTQREKN- 632
            :.....:.|..| .:.:|.|....:::||....|.|.|.||.|||.::|:.||::|.......|
Yeast   396 KDFQTAILRPRS-KAGKEWVSQSKNSQQAKFILNALSRNLYERLFGYIVDMINKNLDHGSATLNY 459

  Fly   633 LALLDFYGFEALDHNSFEQFAINYSAEKIHQNFVFHVLRSEQELYIREGLEWSRIDY-FDNESIC 696
            :.|||..|||..::|||||..|||:.||:.|.|..|:...||..|::|.::|..||| .|.:...
Yeast   460 IGLLDIAGFEIFENNSFEQLCINYTNEKLQQFFNNHMFVLEQSEYLKENIQWDYIDYGKDLQLTI 524

  Fly   697 ELIDK--PSYGILSLINEPHLNSNDALLLRVQQCCAGHPNFMTTGSNSMCFQ---------IRHY 750
            :||:.  |..|:|.|::|      :|:|.:............|...||..|:         ::||
Yeast   525 DLIESKGPPTGVLPLLDE------EAVLPKSTDESFYSKLISTWDQNSSKFKRSRLKNGFILKHY 583

  Fly   751 ASVVNYSIHRFLEKNSDMLPKYISAAFYQSKLSLVQSLF-PEG----------NPRRQVTKKPS- 803
            |..|.|::..:|.||.|.|...:.:....|:..::..|| |||          |...|..||.:
Yeast   584 AGDVEYTVEGWLSKNKDPLNDNLLSLLSSSQNDIISKLFQPEGEKSSSAGVEANISNQEVKKSAR 648

  Fly   804 -----TLSSNIRTQLQTLLAIVKHRRSHYVFCIKPNEGKQPHQFDMALVQHQVRYMSLMPLVHLC 863
                 |.||..|.|..|||..:.....|:|.||.||..|:...|:..|:..|:|...::..:.|.
Yeast   649 TSTFKTTSSRHREQQITLLNQLASTHPHFVRCIIPNNVKKVKTFNRRLILDQLRCNGVLEGIRLA 713

  Fly   864 RTGHCYHLLHVKFFHRYKLL-----NSLTWPHFHGGSQVEGIALIIRNLPLPSAEFTIGTKNVFV 923
            |.|:...:...:||.||::|     .:.|:......|..:....::.:|.|.:..:.||...:|.
Yeast   714 REGYPNRIAFQEFFQRYRILYPENSTTTTFSSKLKASTKQNCEFLLTSLQLDTKVYKIGNTKLFF 778

  Fly   924 RSPRTVYELEQFRRLRISELAVLIQTMFRMYHARK----RFQRMRHSQMI 969
            :: ..:.:||:.:.::::.:.:.:....|.|..||    ..|:::.:::|
Yeast   779 KA-GVLADLEKQKDVKLNNIMIKLTATIRGYTVRKEITYHLQKLKKTRVI 827

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Myo95E	NP_001027208.1	Motor_domain	3..>123	CDD:473979	52/133 (39%)
		Motor_domain	<403..937	CDD:473979	184/573 (32%)
		Myosin_TH1	1092..1288	CDD:461801
MYO1	NP_011888.1	COG5022	2..1691	CDD:227355	255/1025 (25%)
		Smc	1607..>1901	CDD:440809