Protein Alignment Myo95E and MYO5

DIOPT Version :10

• Sequence 1: NP_001027208.1
• Gene: Myo95E / 2768680
• FlyBaseID: FBgn0039157
• Length: 1288
• Species: Drosophila melanogaster
• Sequence 2: NP_013827.1
• Gene: MYO5 / 855136
• SGDID: S000004715
• Length: 1219
• Species: Saccharomyces cerevisiae
• Alignment Length: 1334
• Identity: 318/1334 - (23%)
• Similarity: 507/1334 - (38%)
• Gaps: 457/1334 - (34%)

  Fly     2 EQEIGTWDSVLLENLSEDSFINNIHQRYKRDHIYTYIGTSVVALNPYHHISEHSLDNVRN-YGDK 65
            ::|:|..|..||..:|:::...|:.:|:....||||||..::::||:..:..:: |.|.| |..|
Yeast    33 KKEVGVSDLTLLSKISDEAINENLKKRFLNATIYTYIGHVLISVNPFRDLGIYT-DAVMNEYKGK 96

  Fly    66 GIFQLPPHIYGLTNLAYQSLKDQSEDQCVLLTGESGAGKTETFKMIVNFLTHIQDRSHCPPTPNV 130
            ...::|||::.:....|.::|..:|:|||:::|||||||||..|.|:.::.
Yeast    97 NRLEVPPHVFAIAESMYYNMKSYNENQCVIISGESGAGKTEAAKRIMQYIA-------------- 147

  Fly   131 LRKQSSTSSASGLVMHAHRRASSSCSGTANFIICKNRAENPSGSVSRRQSPSPGPSQRSRTRAES 195
                                |:||                                    |..||
Yeast   148 --------------------AASS------------------------------------THTES 156

  Fly   196 IERQSRRHMREKIVDFDFSHHKSSENISGLPESHAHHMHPTKSCFKHQQTQVSACTAMPAAAKGS 260
            |         .||.|.
Yeast   157 I---------GKIKDM------------------------------------------------- 163

  Fly   261 PKYAVPTVYGGCRQCGHSKCVRAQSLEKEERDDLRGSNCRLSTIATATTNPAHPHRGSCSNLMRQ 325
                                                         ...|||
Yeast   164 ---------------------------------------------VLATNP-------------- 169

  Fly   326 HSTESQPERERDRSSLMGSTQRISLYDAHKLSKVLGDLPPPPPSSVSPTPSASSSLHRRHKSPTQ 390
                                                                             
Yeast   170 ----------------------------------------------------------------- 169

  Fly   391 RMRECVTCADVFLEAMGNACTLKNNNSSRYGKLFDIEIDFKGDPMGVHITHYMLEKTRITDPIIG 455
                       .||:.|.|.||:||||||:||..:|:.:.:.:|...:||:|:|||.|:...|..
Yeast   170 -----------LLESFGCAKTLRNNNSSRHGKYLEIKFNNQFEPCAGNITNYLLEKQRVVSQIKN 223

  Fly   456 ERNFHIFYQLLLGADLQLLKSLKLYR---NVEKYELLRNTTAME-------EDRMNFHYTKRSLD 510
            |||||||||...||.       ..||   .|:|.|....|.|..       :|..::..|.:::.
Yeast   224 ERNFHIFYQFTKGAS-------DAYRQTFGVQKPEQYVYTAAAGCISAETIDDLQDYQETLKAMR 281

  Fly   511 VLGLSCEESNSIFRVIAVVLKLGNFIFVPITNIDGTEG-CQVSNVYEVQETAQLLNMEAQILINC 574
            |:||..||.:.|||::|.:|.:||..|     |:..|| .||.:.......|.||.:::|:||..
Yeast   282 VIGLGQEEQDQIFRMLAAILWIGNVSF-----IENEEGNAQVRDTSVTDFVAYLLQIDSQLLIKS 341

  Fly   575 LT-RANSTNSAQED---VGCEMDARQAATNRNTLCRTLYSRLFTWLVNKINESLKS-TQREKNLA 634
            |. |...||...:.   ....::..||...|:.|.:.:|:.||.|:|:::|:||:: ...||::.
Yeast   342 LVERIMETNHGMKRGSVYHVPLNIVQADAVRDALAKAIYNNLFDWIVSRVNKSLQAFPGAEKSIG 406

  Fly   635 LLDFYGFEALDHNSFEQFAINYSAEKIHQNFVFHVLRSEQELYIREGLEWSRIDYFDNESICELI 699
            :||.||||..:||||||..|||..||:.|.|:...|:||||.|.||.::|:.|.||||:.:|:||
Yeast   407 ILDIYGFEIFEHNSFEQICINYVNEKLQQIFIQLTLKSEQETYEREKIQWTPIKYFDNKVVCDLI 471

  Fly   700 D--KPSYGILSLINE----PHLNSNDALLLRVQQCCAGHPNFMTTGSN----SMCFQIRHYASVV 754
            :  :|. ||.:.:|:    .|.:||.|     .|..|...|..||..:    |..|.|:|||..|
Yeast   472 EARRPP-GIFAAMNDSVATAHADSNAA-----DQAFAQRLNLFTTNPHFDLRSNKFVIKHYAGDV 530

  Fly   755 NYSIHRFLEKNSDMLPKYISAAFYQSKLSLVQSLFPEGNPRRQVTKKPSTLSSNIRTQLQTLLAI 819
            .|.|....:||.|.|.|.:......:..:.:.::||: ...|:..::|.|....|......|:..
Yeast   531 TYDIDGITDKNKDQLQKDLVELIGTTTNTFLATIFPD-TVDRESKRRPPTAGDKIIKSANDLVET 594

  Fly   820 VKHRRSHYVFCIKPNEGKQPHQFDMALVQHQVRYMSLMPLVHLCRTGHCYHLLHVKFFHRYKLLN 884
            :...:..|:..|||||.|.|:.:|...|.||::|:.|...|.:.|.|..|..:..||..|:.||:
Yeast   595 LSKAQPSYIRTIKPNETKSPNDYDDRQVLHQIKYLGLQENVRIRRAGFAYRQVFEKFVERFYLLS 659

  Fly   885 -------SLTWPHFHGGSQVEGIALIIRNLPLPSAEFTIGTKNVFVRSPRTVYELEQFRRLRISE 942
                   ..||.    |..::.:..|:::..:|..|:.:|..:||:::|.|::.||..|......
Yeast   660 PHCSYAGDYTWQ----GDTLDAVKYILQDSSIPQQEYQLGVTSVFIKTPETLFALEHMRDRYWHN 720

  Fly   943 LAVLIQTMFRMYHARKRFQRMRHSQMIISSA---WRTWRECRFGIPFTGRRHLWSLYRVAREEYR 1004
            :|..||..:|.:..|:           |.:|   .||.||.:.|..:...|...:.....|:|.|
Yeast   721 MAARIQRAWRRFLQRR-----------IDAATKIQRTIRERKEGNKYEKLRDYGTKVLGGRKERR 774

  Fly  1005 SLKYKRQVRWAIDIIGRYYRQWKIRQFLLTIPLRLPPNTLSPLSTEWPVAPAFLADASRHLRSIY 1069
            |:          .::|  ||                               ||:.|   :|....
Yeast   775 SM----------SLLG--YR-------------------------------AFMGD---YLSCNE 793

  Fly  1070 HRWK-CYIYRNSFDQTARNRMREKVTASIIFKDRKASYGRS-----------------VGHPFVG 1116
            .:.| .||.|       :..::|||..||..:.....:|||                 ||...|.
Yeast   794 SKSKGAYIKR-------QVSIKEKVIFSIHGEALHTKFGRSAQRLKKTFLLTPTTLYIVGQTLVQ 851

  Fly  1117 DYVRLRHNQQWK------KICAETN--DQYVVFADIINKIARSSGKFVPILLVLSTSSLLLLDQR 1173
            :  .:.:.|.:|      :..:.||  |.:|..     |:| |||:..|::.....:.|:
Yeast   852 N--AMTYTQDYKIDVRNIQAVSLTNLQDDWVAI-----KLA-SSGQPDPLINTYFKTELI----- 903

  Fly  1174 TLQIKYRVPASEIYRMSLSPYLDDIAVFHVKASEFGRKKGDFVFQTGHVIEIVTKMFLVIQNAT- 1237
                      :.:.|::     |.|.:....|.|:.:|.|........:.|...|...:.:::|
Yeast   904 ----------THLKRLN-----DKIQIKIGSAIEYQKKPGKLHSVKCQINESAPKYGDIYKSSTI 953

  Fly  1238 ----GKPP--EIH--------ISTEFEANFGQQT 1257
                |.||  ::|        ||:.:.|:..|.|
Yeast   954 SVRRGNPPNSQVHKKPRKKSSISSGYHASSSQAT 987

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Myo95E	NP_001027208.1	Motor_domain	3..>123	CDD:473979	41/120 (34%)
		Motor_domain	<403..937	CDD:473979	192/566 (34%)
		Myosin_TH1	1092..1288	CDD:461801	42/206 (20%)
MYO5	NP_013827.1	COG5022	1..1186	CDD:227355	318/1334 (24%)