Protein Alignment Myo95E and MYO3

DIOPT Version :10

• Sequence 1: NP_001027208.1
• Gene: Myo95E / 2768680
• FlyBaseID: FBgn0039157
• Length: 1288
• Species: Drosophila melanogaster
• Sequence 2: NP_012793.2
• Gene: MYO3 / 853729
• SGDID: S000001612
• Length: 1272
• Species: Saccharomyces cerevisiae
• Alignment Length: 1264
• Identity: 288/1264 - (22%)
• Similarity: 474/1264 - (37%)
• Gaps: 426/1264 - (33%)

  Fly     2 EQEIGTWDSVLLENLSEDSFINNIHQRYKRDHIYTYIGTSVVALNPYHHISEHSLDNVRNYGDKG 66
            ::|:|..|..||..:|::|...|:.:|:|...||||||..::::||:..:..::...:.:|..|.
Yeast    33 KKEVGISDLTLLSKISDESINENLKKRFKNGIIYTYIGHVLISVNPFRDLGIYTNAVLESYKGKN 97

  Fly    67 IFQLPPHIYGLTNLAYQSLKDQSEDQCVLLTGESGAGKTETFKMIVNFLTHIQDRSHCPPTPNVL 131
            ..::|||::.:....|.:||..:|:|||:::|||||||||..|.|:.::
Yeast    98 RLEVPPHVFAIAESMYYNLKSYNENQCVIISGESGAGKTEAAKRIMQYI---------------- 146

  Fly   132 RKQSSTSSASGLVMHAHRRASSSCSGTANFIICKNRAENPSGSVSRRQSPSPGPSQRSRTRAESI 196
                                                                             
Yeast   147 ----------------------------------------------------------------- 146

  Fly   197 ERQSRRHMREKIVDFDFSHHKSSENISGLPESHAHHMHPTKSCFKHQQTQVSACTAMPAAAKGSP 261
                                                                      |||..|
Yeast   147 ----------------------------------------------------------AAASNS- 152

  Fly   262 KYAVPTVYGGCRQCGHSKCVRAQSLEKEERDDLRGSNCRLSTIATATTNPAHPHRGSCSNLMRQH 326
                                                                             
Yeast   153 ----------------------------------------------------------------- 152

  Fly   327 STESQPERERDRSSLMGSTQRISLYDAHKLSKVLGDLPPPPPSSVSPTPSASSSLHRRHKSPTQR 391
                                                                      |.....:
Yeast   153 ----------------------------------------------------------HSESIGK 159

  Fly   392 MRECVTCADVFLEAMGNACTLKNNNSSRYGKLFDIEIDFKGDPMGVHITHYMLEKTRITDPIIGE 456
            :::.|...:..||:.|.|.||:||||||:||..:|:.:.:.:|...:||:|:|||.|:...|..|
Yeast   160 IKDMVLATNPLLESFGCAKTLRNNNSSRHGKYLEIKFNSQFEPCAGNITNYLLEKQRVVGQIKNE 224

  Fly   457 RNFHIFYQLLLGADLQLLKSLKLYRNVEKYELLR----NTTAMEEDRMNFHYTKRSLDVLGLSCE 517
            ||||||||...||. ...|.:...:..|:|....    .|....:|..::..|..::..:||..|
Yeast   225 RNFHIFYQFTKGAS-DTYKQMFGVQMPEQYIYTAAAGCTTADTIDDVKDYEGTLEAMRTIGLVQE 288

  Fly   518 ESNSIFRVIAVVLKLGNFIFVPITNIDGTEG-CQVSNVYEVQETAQLLNMEAQILINCLTRANST 581
            |.:.|||::|.:|.:||..|     |:..|| .||.:.......|.||.::|.:|:.||......
Yeast   289 EQDQIFRMLAAILWIGNISF-----IENEEGNAQVGDTSVTDFVAYLLQVDASLLVKCLVERIMQ 348

  Fly   582 NSAQEDVG----CEMDARQAATNRNTLCRTLYSRLFTWLVNKINESLKS-TQREKNLALLDFYGF 641
            .|.....|    ..::..||...|:.|.:.:|:.||.|:|:::|.||:: ...:|::.:||.|||
Yeast   349 TSHGMKRGSVYHVPLNPVQATAVRDALAKAIYNNLFDWIVDRVNVSLQAFPGADKSIGILDIYGF 413

  Fly   642 EALDHNSFEQFAINYSAEKIHQNFVFHVLRSEQELYIREGLEWSRIDYFDNESICELID-KPSYG 705
            |..:||||||..|||..||:.|.|:...|::|||.|.||.::|:.|.||||:.:|:||: |...|
Yeast   414 EIFEHNSFEQICINYVNEKLQQIFIQLTLKAEQETYEREKIKWTPIKYFDNKVVCDLIEAKNPPG 478

  Fly   706 ILSLINE----PHLNSNDALLLRVQQCCAGHPNFMTTG------SNSMCFQIRHYASVVNYSIHR 760
            ||:.:|:    .|.:||.|     .|..|...|...:.      :|.  |.|:|||..|.|.|:.
Yeast   479 ILAAMNDSIATAHADSNAA-----DQAFAQRLNLFNSNPYFELRANK--FVIKHYAGDVTYDING 536

  Fly   761 FLEKNSDMLPKYISAAFYQSKLSLVQSLFPEGNPRRQVTKKPSTLSSNIRTQLQTLLAIVKHRRS 825
            ..:||.|.|.|.:......:..:.:.::||: :..:...::|.|....|......|:..:.....
Yeast   537 ITDKNKDQLQKDLIELIGTTTNTFLSTIFPD-DVDKDSKRRPPTAGDKIIKSANELVETLSKAEP 600

  Fly   826 HYVFCIKPNEGKQPHQFDMALVQHQVRYMSLMPLVHLCRTGHCYHLLHVKFFHRYKLLN------ 884
            .|:..||||:.|.|:.:|...|.|||:|:.|...|.:.|.|..|.....||..|:.||:
Yeast   601 SYIRTIKPNQTKSPNDYDDHQVLHQVKYLGLQENVRIRRAGFAYRQTFEKFVERFYLLSPDCSYA 665

  Fly   885 -SLTWPHFHGGSQVEGIALIIRNLPLPSAEFTIGTKNVFVRSPRTVYELEQFRRLRISELAVLIQ 948
             ..||    .|..:|.:.||:|:..:|..||.:|..:||:::|.:::.||..|......:|..||
Yeast   666 GDYTW----DGDTLEAVKLILRDAMIPEKEFQLGVTSVFIKTPESLFALEDMRDKYWYNMAARIQ 726

  Fly   949 TMFRMYHARKRFQRMRHSQMIISSAWRTWRECRFGIPFTGRRHLWSLYRVAREEYRSLKYKRQVR 1013
            ..:|      ||.:.|....|  ...||.||.:.|..:...|...:.....::|.||:
Yeast   727 RAWR------RFLQRRIDAAI--KIQRTIREKKGGNKYVKLRDYGTKLLAGKKERRSM------- 776

  Fly  1014 WAIDIIGRYYRQWKIRQFLLTIPLRLPPNTLSPLSTEWPVAPAFLADASRHLRSIYHRWK-CYIY 1077
               .::|  ||                               ||:.|   :|.....:.| .||.
Yeast   777 ---SLLG--YR-------------------------------AFMGD---YLSCNESKTKGSYIR 802

  Fly  1078 RNSFDQTARNRMREKVTASIIFKDRKASYGRSVGHPFVGDYVRLRHNQQWKKICAETNDQYVVFA 1142
            |       :..:::||..||..:...:.:|||.              |:.||:
Yeast   803 R-------QVGIKDKVVFSIKGECLHSKFGRSA--------------QRLKKV------------ 834

  Fly  1143 DIINKIARSSGKFVPILLVLSTSSLLLLDQRTLQ--IK----YRVPASEIYRMSLSPYLDD-IAV 1200
                             .:|:..:..::.|...|  :|    |::...:|.::||:...|| :.|
Yeast   835 -----------------FILTKKTFYIIGQTREQNAMKYTQDYKIDVGKIKQVSLTNLQDDWMGV 882

  Fly  1201 FHVKASEFGRKKGDFVFQTGHVIEIVTKM 1229
            ..|.:::     .|.:..|....|::|::
Yeast   883 ILVNSTQ-----SDPLINTPFKTELMTRL 906

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Myo95E	NP_001027208.1	Motor_domain	3..>123	CDD:473979	41/119 (34%)
		Motor_domain	<403..937	CDD:473979	186/561 (33%)
		Myosin_TH1	1092..1288	CDD:461801	26/145 (18%)
MYO3	NP_012793.2	COG5022	1..1258	CDD:227355	288/1264 (23%)