DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Myo95E and ATM1

DIOPT Version :9

Sequence 1:	NP_001027208.1	Gene:	Myo95E / 2768680	FlyBaseID:	FBgn0039157	Length:	1288	Species:	Drosophila melanogaster
Sequence 2:	NP_001154628.2	Gene:	ATM1 / 821534	AraportID:	AT3G19960	Length:	1176	Species:	Arabidopsis thaliana

Alignment Length:	1061	Identity:	242/1061 - (22%)
Similarity:	387/1061 - (36%)	Gaps:	372/1061 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 GTWDSVLLENLSEDSFINNIHQRYKRDHIYTYIGTSVVALNPYHHISEHSLDNVRNYGDKGIFQL 70
            |..|.:.|..|:|.|.:.|::.||.:|.|||..|..:||:||:..:..:....:..|..|.  ..
plant   166 GVDDLMQLSYLNEPSVLYNLNYRYNQDMIYTKAGPVLVAVNPFKEVPLYGNRYIEAYRKKS--NE 228

  Fly    71 PPHIYGLTNLAYQSLKDQSEDQCVLL----------------TGESGAGKTETFKMIVNFLTHIQ 119
            .||:|.:.:.|.:.:.....:|.:::                :||||||||||.|:.:.:|
plant   229 SPHVYAIADTAIREMIRDEVNQSIIIRCICIHESMTYSISSSSGESGAGKTETAKIAMQYL---- 289

  Fly   120 DRSHCPPTPNVLRKQSSTSSASGLVMHAHRRASSSCSGTANFIICKNRAENPSGSVSRRQSPSPG 184

plant   290 ----------------------------------------------------------------- 289

  Fly   185 PSQRSRTRAESIERQSRRHMREKIVDFDFSHHKSSENISGLPESHAHHMHPTKSCFKHQQTQVSA 249

plant   290 ----------------------------------------------------------------- 289

  Fly   250 CTAMPAAAKGSPKYAVPTVYGGCRQCGHSKCVRAQSLEKEERDDLRGSNCRLSTIATATTNPAHP 314
                  ||.|          ||            ..:|.|                ...|||
plant   290 ------AALG----------GG------------SGIEYE----------------ILKTNP--- 307

  Fly   315 HRGSCSNLMRQHSTESQPERERDRSSLMGSTQRISLYDAHKLSKVLGDLPPPPPSSVSPTPSASS 379

plant   308 ----------------------------------------------------------------- 307

  Fly   380 SLHRRHKSPTQRMRECVTCADVFLEAMGNACTLKNNNSSRYGKLFDIEIDFKGDPMGVHITHYML 444
                                  .|||.|||.||:|:||||:|||.:|.....|...|..|..::|
plant   308 ----------------------ILEAFGNAKTLRNDNSSRFGKLIEIHFSESGKISGAQIQTFLL 350

  Fly   445 EKTRITDPIIGERNFHIFYQLLLGADLQLLKSLKLYRNVEKYELLRNTTAME----EDRMNFHYT 505
            ||:|:.....|||::||||||..||...|.:.|.| .:..:|:.|..:....    :|...||..
plant   351 EKSRVVQCAEGERSYHIFYQLCAGASPALREKLNL-TSAHEYKYLGQSNCYSINGVDDAERFHTV 414

  Fly   506 KRSLDVLGLSCEESNSIFRVIAVVLKLGNFIFVPITNIDGTE-------------------GCQV 551
            |.:||::.:|.|:..|:|.::|.||.|||..|..|.|.:..|                   .|.:
plant   415 KEALDIVHVSKEDQESVFAMLAAVLWLGNVSFTVIDNENHVEPVADESFLFHSLGSWCWKQECLL 479

  Fly   552 SNVYEVQETAQLLNMEAQILINCLTRANSTNSAQEDVGCEMDARQAATNRNTLCRTLYSRLFTWL 616
            .|:. :...|:|:......|...|::.| .....:.:..::...||...|:.|.:::||.||.||
plant   480 HNMC-LSTVAKLIGCNINELTLTLSKRN-MRVRNDTIVQKLTLPQAIDARDALAKSIYSCLFDWL 542

  Fly   617 VNKINESLKSTQRE--KNLALLDFYGFEALDHNSFEQFAINYSAEKIHQNFVFHVLRSEQELYIR 679
            |.:||:||...:|.  :::::||.||||:.|.||||||.|||:.|::.|:|..|:.:.|||.||:
plant   543 VEQINKSLAVGKRRTGRSISILDIYGFESFDKNSFEQFCINYANERLQQHFNRHLFKLEQEEYIQ 607

  Fly   680 EGLEWSRIDYFDNESICELIDKPSYGILSLINEPHL--NSNDALLL-RVQQCCAGHPNFMTTGSN 741
            :|::|:|:|:.||::...|.:|...|:|||::|...  |..|..|. :::|....:..|  .|..
plant   608 DGIDWTRVDFEDNQNCLSLFEKKPLGLLSLLDEESTFPNGTDLTLANKLKQHLQSNSCF--RGDK 670

  Fly   742 SMCFQIRHYASVVNYSIHRFLEKNSD---------------MLPK-YISAAFYQSKLSLVQSLFP 790
            ...|.:.|||..|.|....|||||.|               :||: :.|:...||:..:|..|:.
plant   671 GKLFTVVHYAGEVTYETTGFLEKNRDLLHSDSIQLLSSCSCLLPQAFASSMLIQSEKPVVGPLYK 735

  Fly   791 EGNPRRQVTKKPSTLSSNIRTQLQTLLAIVKHRRSHYVFCIKPNEGKQPHQFDMALVQHQVRYMS 855
            .|....|    ..::::..::||..|:..:.:...|::.|||||..:.|..::..||..|:|...
plant   736 AGGADSQ----RLSVATKFKSQLFQLMQRLGNTTPHFIRCIKPNNIQSPGVYEQGLVLQQLRCCG 796

  Fly   856 LMPLVHLCRTGHCYHLLHVKFFHRYKLLNSL-----TWPHFHGGSQVEGIALIIRNLPL-----P 910
            ::.:  ||: |.......:...|::.:|..:     |...|..| |: |:....||..|     .
plant   797 VLEV--LCK-GPYKRFFIIAILHQFNILPEMYQVGYTKLFFRTG-QI-GVLEDTRNRTLHGILRV 856

  Fly   911 SAEFT--------------IGTKNVFVRSPRTVYELEQFRRLRISELAVLIQTMFRMYHARKRFQ 961
            .:.|.              |.....|||..:...|..:.||..  :.|..||:..:...||.:::
plant   857 QSSFRGYQARCLLKELKRGISILQSFVRGEKIRKEFAELRRRH--KAAATIQSQVKSKIARIQYK 919

  Fly   962 RMRHSQMIISSAWRTW--REC 980
            .:..:.::|.||.|.|  |.|
plant   920 GIADASVVIQSAIRGWLVRRC 940

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Myo95E	NP_001027208.1	Motor_domain	19..>118	CDD:277568	32/114 (28%)
		Motor_domain	403..924	CDD:277568	178/588 (30%)
		Myosin_TH1	1092..1267	CDD:283635
ATM1	NP_001154628.2	MYSc	160..847	CDD:214580	219/964 (23%)
ATM1	NP_001154628.2	MYSc_Myo8	179..835	CDD:276834	210/937 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	3	2.870