Protein Alignment Myo95E and Myo19

DIOPT Version :10

• Sequence 1: NP_001027208.1
• Gene: Myo95E / 2768680
• FlyBaseID: FBgn0039157
• Length: 1288
• Species: Drosophila melanogaster
• Sequence 2: NP_079690.2
• Gene: Myo19 / 66196
• MGIID: 1913446
• Length: 963
• Species: Mus musculus
• Alignment Length: 1158
• Identity: 270/1158 - (23%)
• Similarity: 435/1158 - (37%)
• Gaps: 405/1158 - (34%)

  Fly    13 LENLSE------DSFINNIHQRYKRDHIYTYIGTSVVALNPYHHISE----------HSLDNVRN 61
            |::|::      ::.:..:..||..|..||..|.::|||||:.|:.:          |:....:
Mouse    37 LDDLTKVNPVTLETVLRCLQARYTEDIFYTNAGCTLVALNPFKHVPQLYAPELMQEYHAAPQPQ- 100

  Fly    62 YGDKGIFQLPPHIYGLTNLAYQSLKDQSE--DQCVLLTGESGAGKTETFKMIVNFLTHIQDRSHC 124
                   :|.|||:.:....|:::|...|  :|.::::||||||||.|.:.::.|
Mouse   101 -------KLKPHIFTVGEQTYRNVKSLIEPVNQSIVVSGESGAGKTWTSRCLMKF---------- 148

  Fly   125 PPTPNVLRKQSSTSSASGLVMHAHRRASSSCSGTANFIICKNRAENPSGSVSRRQSPSPGPSQRS 189
                                                                             
Mouse   149 ----------------------------------------------------------------- 148

  Fly   190 RTRAESIERQSRRHMREKIVDFDFSHHKSSENISGLPESHAHHMHPTKSCFKHQQTQVSACTAMP 254
                                                                             
Mouse   149 ----------------------------------------------------------------- 148

  Fly   255 AAAKGSPKYAVPTVYGGCRQCGHSKCVRAQSLEKEERDDLRGSNCRLSTIATATTNPAHPHRGSC 319
                    |||                                      :|.:.|        ||
Mouse   149 --------YAV--------------------------------------VAASPT--------SC 159

  Fly   320 SNLMRQHSTESQPERERDRSSLMGSTQRISLYDAHKLSKVLGDLPPPPPSSVSPTPSASSSLHRR 384
            .|                                ||::
Mouse   160 EN--------------------------------HKIA--------------------------- 165

  Fly   385 HKSPTQRMRECVTCADVFLEAMGNACTLKNNNSSRYGKLFDIEIDFKGDPMGVHITHYMLEKTRI 449
                 :|:.:.:..::..:||.||||||:|:||||:||...::::......|..:..|:|||||:
Mouse   166 -----ERIEQRILNSNPVMEAFGNACTLRNSNSSRFGKFIQLQLNRAQQMTGAAVQTYLLEKTRV 225

  Fly   450 TDPIIGERNFHIFYQLLLGADLQLLKSLKLYRNVEK---YELLRN-TTAMEEDRMNFHYTKRSLD 510
            ......|||||||||:..||    .|..:|..::.:   :..|.| .:::|||  .|..|:.::.
Mouse   226 ACQASSERNFHIFYQICKGA----TKDERLQWHLPEGTAFSWLPNPESSLEED--CFEVTREAML 284

  Fly   511 VLGLSCEESNSIFRVIAVVLKLGNFIFVPITNIDGTEGCQV--SNVYEVQETAQLLNMEAQILIN 573
            .||:.....|:||:|:|.:|.|||..||  .:.|....|||  .....|:.:|.||.:..::|:.
Mouse   285 HLGIDTPTQNNIFKVLAGLLHLGNVHFV--DSEDEALPCQVMDDTKVSVRTSALLLQLPEKMLLE 347

  Fly   574 CLTRANSTNSAQEDVGCEMDAR-QAATNRNTLCRTLYSRLFTWLVNKINESLKSTQREKN--LAL 635
            .:.........|:.|..:..:| :..|.|:.|.:.:|:|||.|||:.||.|:.:..:...  :.|
Mouse   348 SMQIRTIKAGKQQQVFQKPCSRAECDTRRDCLAKLIYARLFDWLVSVINSSICADSKSWTAFIGL 412

  Fly   636 LDFYGFEALDHNSFEQFAINYSAEKIHQNFVFHVLRSEQELYIREGLEWSRIDYFDNESICELID 700
            ||.||||:..:||.||..|||:.||:.|:||.|.||::||.|..||||||.::|.||::..:|::
Mouse   413 LDVYGFESFPNNSLEQLCINYANEKLQQHFVAHYLRAQQEEYEVEGLEWSFVNYQDNQTCLDLLE 477

  Fly   701 KPSYGILSLINEP-HLN---SNDALLLRVQQCCAGHPNFMTTGSNSM----CFQIRHYASVVNYS 757
            .....|.|||||. .||   |...|..|::...||.|   ..|.|.:    .|.:.|:|..|.|.
Mouse   478 GSPISICSLINEECRLNRPSSAAQLQTRIESTLAGRP---CLGHNKLSREPSFVVVHFAGPVRYH 539

  Fly   758 IHRFLEKNSDMLPKYISAAFYQSKLSLVQSLFPEGNPRRQVTKKPS--------TLSSNIRTQLQ 814
            ....:|||.|.:|..::....||:..|:..||| .||..:..::.|        |:.|..:..|:
Mouse   540 TAGLVEKNKDPVPPELTELLQQSQDPLLTMLFP-ANPEEKTQEELSGQSRAPALTVVSKFKASLE 603

  Fly   815 TLLAIVKHRRSHYVFCIKPNEGKQPHQFDMALVQHQVRYMSLMPLVHLCRTGHCYHLLHVKFFHR 879
            .||.::.:...||:.|||||...||..|....|.:|:....|:..:|:...|....:.|..|..|
Mouse   604 QLLQVLHNTTPHYIRCIKPNSQSQPQTFLQEEVLNQLEACGLVETIHISAAGFPIRVSHQNFIER 668

  Fly   880 YKLLNSLTWPHFHGG----SQVEG-----------------------IALIIRNLPLPS--AEFT 915
            ||||..| .|....|    ...||                       :..:|:....||  |:.|
Mouse   669 YKLLRRL-GPRMSSGLGGLEPAEGSSEQPLCAKEATLQPLLQDILHALPALIQTAATPSDPAKNT 732

  Fly   916 -----IGTKNVFVRSPRTVYE-LEQFRRLRISELAVLIQTMFRMYHARKRFQRMRHSQMIISSAW 974
                 .|...:|:..  ::.| ||..|...:.:.|..||..:|.:..:|: ::.|.:.::|.:|:
Mouse   733 QIPLYCGRTKIFMTD--SMLELLECGRAQMLEQCARCIQCGWRRHRLQKQ-EKQRRAAVLIQAAF 794

  Fly   975 RTWRECRFGIPFTGRRHLWSLYRVAREEYRSLKYKRQVRWAIDIIGRYYRQWKIRQFLLTI---- 1035
            |:|         ..|:|:                 |::..|..:|...:.:|:||...|..
Mouse   795 RSW---------LTRKHI-----------------RRLHIAATVIKHAWHKWRIRMACLASKELD 833

  Fly  1036 -----PLRLPPNTLSPLSTEWPVAPAFLADASRHLRSIYHRWKC-YIYRNSFD 1082
                 |:...|.||..     .::||.    :|.|.:|.|.|.. .:..||.|
Mouse   834 GMEEKPMPQAPGTLRS-----SMSPAH----TRFLGAIIHLWPLGLVLANSAD 877

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Myo95E	NP_001027208.1	Motor_domain	3..>123	CDD:473979	33/127 (26%)
		Motor_domain	<403..937	CDD:473979	192/593 (32%)
		Myosin_TH1	1092..1288	CDD:461801
Myo19	NP_079690.2	MYSc_Myo19	49..746	CDD:276846	231/975 (24%)
		Actin-binding. /evidence=ECO:0000255|PROSITE-ProRule:PRU00782	602..624		9/21 (43%)
		IQCD	776..>801	CDD:467745	6/34 (18%)
		MyMOMA region. /evidence=ECO:0000250|UniProtKB:Q96H55	829..963		14/58 (24%)