Protein Alignment Myo95E and MYO1G

DIOPT Version :9

• Sequence 1: NP_001027208.1
• Gene: Myo95E / 2768680
• FlyBaseID: FBgn0039157
• Length: 1288
• Species: Drosophila melanogaster
• Sequence 2: NP_149043.2
• Gene: MYO1G / 64005
• HGNCID: 13880
• Length: 1018
• Species: Homo sapiens
• Alignment Length: 1259
• Identity: 307/1259 - (24%)
• Similarity: 490/1259 - (38%)
• Gaps: 384/1259 - (30%)

  Fly     4 EIGTWDSVLLENLSEDSFINNIHQRYKRDHIYTYIGTSVVALNPYHHISEHSLDNVRNYGDKGIF 68
            |.|..|.|||:.::.:.|:.|:..|:::..||||||..:|::|||..:..:..:.:..|..:.::
Human     8 EYGKPDFVLLDQVTMEDFMRNLQLRFEKGRIYTYIGEVLVSVNPYQELPLYGPEAIARYQGRELY 72

  Fly    69 QLPPHIYGLTNLAYQSLKDQSEDQCVLLTGESGAGKTETFKMIVNFLTHIQDRSHCPPTPNVLRK 133
            :.|||:|.:.|.||:::|.:|.|.|::::|||||||||..|.|:.::
Human    73 ERPPHLYAVANAAYKAMKHRSRDTCIVISGESGAGKTEASKHIMQYI------------------ 119

  Fly   134 QSSTSSASGLVMHAHRRASSSCSGTANFIICKNRAENPSGSVSRRQSPSPGPSQRSRTRAESIER 198
                                                                             
Human   120 ----------------------------------------------------------------- 119

  Fly   199 QSRRHMREKIVDFDFSHHKSSENISGLPESHAHHMHPTKSCFKHQQTQVSACTAMPAAAKGSPKY 263
                                                                             
Human   120 ----------------------------------------------------------------- 119

  Fly   264 AVPTVYGGCRQCGHSKCVRAQSLEKEERDDLRGSNCRLSTIATATTNPAHPHRGSCSNLMRQHST 328
                                                      .|.|||:
Human   120 ------------------------------------------AAVTNPS---------------- 126

  Fly   329 ESQPERERDRSSLMGSTQRISLYDAHKLSKVLGDLPPPPPSSVSPTPSASSSLHRRHKSPTQRMR 393
             .:.|.||.:..|:.||
Human   127 -QRAEVERVKDVLLKST------------------------------------------------ 142

  Fly   394 ECVTCADVFLEAMGNACTLKNNNSSRYGKLFDIEIDFKGDPMGVHITHYMLEKTRITDPIIGERN 458
             ||      |||.|||.|.:|:||||:||..||..||||||:|.||..|:|||:|:....:||||
Human   143 -CV------LEAFGNARTNRNHNSSRFGKYMDINFDFKGDPIGGHIHSYLLEKSRVLKQHVGERN 200

  Fly   459 FHIFYQLLLGADLQLLKSLKLYRNVEKYELLR-----NTT---AMEEDRMNFHYTKRSLDVLGLS 515
            ||.|||||.|::.:.|..|.|.||...|....     |.|   |::.|..:......::.|:|.|
Human   201 FHAFYQLLRGSEDKQLHELHLERNPAVYNFTHQGAGLNMTVHSALDSDEQSHQAVTEAMRVIGFS 265

  Fly   516 CEESNSIFRVIAVVLKLGNFIFVPITNIDG--TEGCQVSNVYEVQETAQLLNMEAQILINCLTRA 578
            .||..|:.|::|.:|.|||..||. |...|  .||..|:....|...|:|......:::..|...
Human   266 PEEVESVHRILAAILHLGNIEFVE-TEEGGLQKEGLAVAEEALVDHVAELTATPRDLVLRSLLAR 329

  Fly   579 NSTNSAQEDVGCEMDARQAATNRNTLCRTLYSRLFTWLVNKINESLKSTQREKN-------LALL 636
            ...:..:|.:.....|.:|:..|:...:.:|.|||.|:||:||..::...|:..       :.:|
Human   330 TVASGGRELIEKGHTAAEASYARDACAKAVYQRLFEWVVNRINSVMEPRGRDPRRDGKDTVIGVL 394

  Fly   637 DFYGFEALDHNSFEQFAINYSAEKIHQNFVFHVLRSEQELYIREGLEWSRIDYFDNESICELIDK 701
            |.||||....||||||.|||..||:.|.|:..:|:.|||.|.|||:.|..::||:|.:|.:|:::
Human   395 DIYGFEVFPVNSFEQFCINYCNEKLQQLFIQLILKQEQEEYEREGITWQSVEYFNNATIVDLVER 459

  Fly   702 PSYGILSLINEPHLNS---NDALLLRVQQCCAGHPNFMTTGSNSMC-----------FQIRHYAS 752
            |..|||::::|...::   .|.:.|  |.....|.:.:...|..:|           |:|:|||.
Human   460 PHRGILAVLDEACSSAGTITDRIFL--QTLDMHHRHHLHYTSRQLCPTDKTMEFGRDFRIKHYAG 522

  Fly   753 VVNYSIHRFLEKNSDMLPKYISAAFYQSKLSLVQSLFPEGNPR-RQVTKKPSTLSSNIRTQLQTL 816
            .|.||:..|::||.|.|.:......|.|....:::::|:|... .:|||:|.|..:..:..:..|
Human   523 DVTYSVEGFIDKNRDFLFQDFKRLLYNSTDPTLRAMWPDGQQDITEVTKRPLTAGTLFKNSMVAL 587

  Fly   817 LAIVKHRRSHYVFCIKPNEGKQPHQFDMALVQHQVRYMSLMPLVHLCRTGHCYHLLHVKFFHRYK 881
            :..:..:...||.||||||.|...:.|....:|||.|:.|:..|.:.|.|......:.:|..|||
Human   588 VENLASKEPFYVRCIKPNEDKVAGKLDENHCRHQVAYLGLLENVRVRRAGFASRQPYSRFLLRYK 652

  Fly   882 LLNSLTWPHFHGGSQVEGIALIIRNLPLPSAEFTIGTKNVFVRSPRTVYELEQFRRLRISELAVL 946
            :....|||:...||....::.::....| ..:...|...:|:|||||:..|||.|...|..:.:|
Human   653 MTCEYTWPNHLLGSDKAAVSALLEQHGL-QGDVAFGHSKLFIRSPRTLVTLEQSRARLIPIIVLL 716

  Fly   947 IQTMFRMYHARKRFQRMRHSQMIISSAWRTWRECRFGIPFTGRRHLWSLYRVAREEYRSLKYKRQ 1011
            :|..:|...||.|.:|:|    .|.:..|.:|..:.      |.||..|.|..:...:...|.|.
Human   717 LQKAWRGTLARWRCRRLR----AIYTIMRWFRRHKV------RAHLAELQRRFQAARQPPLYGRD 771

  Fly  1012 VRWAI---------DIIGRYYRQWKIRQFLLTIPLRLPPNTLSPLSTEWPVAPAFLADASRHLRS 1067
            :.|.:         |.....:.:|:.||.:..||           .::.|...|.:| |...|:.
Human   772 LVWPLPPAVLQPFQDTCHALFCRWRARQLVKNIP-----------PSDMPQIKAKVA-AMGALQG 824

  Fly  1068 IYHRWKCYIYRNSFDQTARNRMREKVTASIIFKDR------KASYGRSVGHPFVGDYVRLRHNQQ 1126
            :...|.|   |.::.:...:...:..|||.:|..|      |..:|.
Human   825 LRQDWGC---RRAWARDYLSSATDNPTASSLFAQRLKTLQDKDGFGA------------------ 868

  Fly  1127 WKKICAETNDQYVVFADIINKIARSSGKFVPILLVLSTSSLLLLDQRTLQI----KYR----VPA 1183
                        |:|:..:.|:.|        ...:...:|||.||...::    :||    ||.
Human   869 ------------VLFSSHVRKVNR--------FHKIRNRALLLTDQHLYKLDPDRQYRVMRAVPL 913

  Fly  1184 SEIYRMSLSPYLDDIAVFHVKASE 1207
            ..:..:|::...|.:.|.|.:..:
Human   914 EAVTGLSVTSGGDQLVVLHARGQD 937

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Myo95E	NP_001027208.1	Motor_domain	19..>118	CDD:277568	36/98 (37%)
		Motor_domain	403..924	CDD:277568	186/552 (34%)
		Myosin_TH1	1092..1267	CDD:283635	24/130 (18%)
MYO1G	NP_149043.2	MYSc	4..706	CDD:214580	248/963 (26%)
		MYSc_Myo1	23..694	CDD:276829	234/936 (25%)
		Actin-binding. /evidence=ECO:0000255|PROSITE-ProRule:PRU00782	584..606		7/21 (33%)
		Myosin_TH1	815..980	CDD:283635	30/165 (18%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0164
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D122881at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100187
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.720