Protein Alignment Myo95E and myo5c

DIOPT Version :10

• Sequence 1: NP_001027208.1
• Gene: Myo95E / 2768680
• FlyBaseID: FBgn0039157
• Length: 1288
• Species: Drosophila melanogaster
• Sequence 2: XP_691143.2
• Gene: myo5c / 562676
• ZFINID: ZDB-GENE-131127-196
• Length: 1746
• Species: Danio rerio
• Alignment Length: 1142
• Identity: 246/1142 - (21%)
• Similarity: 419/1142 - (36%)
• Gaps: 366/1142 - (32%)

  Fly     5 IGTWDSVLLENLSEDSFINNIHQRYKRDH-IYTYIGTSVVALNPYHHISEHSLDNVRNYGDKGIF 68
            :|..|...|..|.|.:.::|:..|:.... ||||.|..:||:|||..:..:....:..|..:.:.
Zfish    68 VGENDLTALSYLHEPAVLHNLKVRFVESKIIYTYCGIILVAVNPYKQLPIYGDAVIHAYSGQNMG 132

  Fly    69 QLPPHIYGLTNLAYQSLKDQSEDQCVLLTGESGAGKTETFKMIVNFLTHIQDRSHCPPTPNVLRK 133
            .|.|||:.:...||:.:...:::|.::::||||||||.:.:..:.:...:
Zfish   133 DLDPHIFAVAEEAYKQMARNNKNQSIIVSGESGAGKTVSARYAMRYFAMV--------------- 182

  Fly   134 QSSTSSASGLVMHAHRRASSSCSGTANFIICKNRAENPSGSVSRRQSPSPGPSQRSRTRAESIER 198
                 |.||                                              |:||.|
Zfish   183 -----SKSG----------------------------------------------SKTRVE---- 192

  Fly   199 QSRRHMREKIVDFDFSHHKSSENISGLPESHAHHMHPTKSCFKHQQTQVSACTAMPAAAKGSPKY 263
                                                                             
Zfish   193 ----------------------------------------------------------------- 192

  Fly   264 AVPTVYGGCRQCGHSKCVRAQSLEKEERDDLRGSNCRLSTIATATTNPAHPHRGSCSNLMRQHST 328
                                                                             
Zfish   193 ----------------------------------------------------------------- 192

  Fly   329 ESQPERERDRSSLMGSTQRISLYDAHKLSKVLGDLPPPPPSSVSPTPSASSSLHRRHKSPTQRMR 393
                                        .|||...|
Zfish   193 ----------------------------DKVLASNP----------------------------- 200

  Fly   394 ECVTCADVFLEAMGNACTLKNNNSSRYGKLFDIEIDFKGDPMGVHITHYMLEKTRITDPIIGERN 458
                    ..||:|||.|.:|:||||:||..:|..|.:...:|.::..|:|||:|:......|||
Zfish   201 --------ITEAIGNAKTTRNDNSSRFGKYTEISFDKRYQIIGANMRTYLLEKSRVVFQSENERN 257

  Fly   459 FHIFYQLLLGADLQLLKSLKLYRNVEKYELLRNTTAME----EDRMNFHYTKRSLDVLGLSCEES 519
            :|||||:...|:....|.|:|. ..||:...|....:|    :||.:...|:|:.::|||.....
Zfish   258 YHIFYQMCACANQPEFKGLRLL-GAEKFNYTRLGGEIEIEGVDDRADMAETRRTFNLLGLKENFQ 321

  Fly   520 NSIFRVIAVVLKLGNFIFV---PITNIDGTEGCQVSNVYEVQETAQLLNMEAQILINCLTRANST 581
            ..:|:|:|.:|.|||.|..   |..:..|:....:: ::     ..|:.:..:.:...|......
Zfish   322 TDVFKVLAAILHLGNVIIKAKDPEKSFIGSRDPHLA-IF-----CDLMGVSTENMSRWLCHRRIV 380

  Fly   582 NSAQEDVGCEMDARQAATN-RNTLCRTLYSRLFTWLVNKINESLKSTQREKN-LALLDFYGFEAL 644
            .|.:..|  :...|:.|.| |:.|.:.:|:.||.|:::|||.:|....::.: :.:||.||||..
Zfish   381 LSTETVV--KPQPRERAVNARDALAKHIYAHLFNWVIHKINHALMVPGKQHSFIGVLDIYGFETF 443

  Fly   645 DHNSFEQFAINYSAEKIHQNFVFHVLRSEQELYIREGLEWSRIDYFDNESICELIDKPSYGILSL 709
            :.||||||.|||:.||:.|.|..||.:.|||.|::|.:.|:.||::||:.:.:||: ...|||.|
Zfish   444 EINSFEQFCINYANEKLQQQFNLHVFKLEQEEYMKEDIPWTLIDFYDNQPVIDLIE-AKMGILDL 507

  Fly   710 INEPHL---NSNDALLLRVQQCCAGHPNFMTTGSNSMCFQIRHYASVVNYSIHRFLEKNSDMLPK 771
            ::|..|   .::...|.::.......|.|.....::..|.|:|:|..|.|....|||||.|.|.:
Zfish   508 LDEECLFPQGTDKNWLQKLYNFLGSKPLFEKPRLSNDSFMIQHFADKVEYQCKGFLEKNRDTLYE 572

  Fly   772 YISAAFYQSKLSLVQSLFPE--------------GNPRRQVTKKP--STLSSNIRTQLQTLLAIV 820
            .:......|:.:|:...|.|              ..||.:.:.|.  ||:....|:.|..|:..:
Zfish   573 ELVDIMRASQFALLAGFFKEEEADSGHKIIKVTPAQPRVKASNKQLRSTVGDKFRSSLYLLMETL 637

  Fly   821 KHRRSHYVFCIKPNEGKQPHQFDMALVQHQVRYMSLMPLVHLCRTGHCYHLLHVKFFHRYKLLNS 885
            .....|||.||||||.|.|.::|...|..|:|...::..:.:....:.....:|:|:.||.:|.|
Zfish   638 NATTPHYVRCIKPNEEKLPFEYDSRRVVQQLRACGVLETIRISAQSYPSRWTYVEFYSRYSILMS 702

  Fly   886 LTWPHFHGGSQVEGIALIIRNLPLPSAEFTIGTKNVFVRSPRTVYELEQFRRLRISELAVLIQTM 950
            .:  ....|.:.:....:::.|...|.::..|...:|.|:.:..| ||:.|...:....|.||..
Zfish   703 QS--ELKLGEKKQTCRTVLQRLIPDSNQYKFGRTKIFFRAGQVAY-LEKLRLDHLRAACVTIQKH 764

  Fly   951 FRMYHARKRFQRMRHSQMIISSAWRTWRECRFGIPFTGRRHLWSLYRVAREEYRSLKYKRQVR-- 1013
            .|.:..|:.|..:|.:.:||                       .||         ::.|:|:|
Zfish   765 VRGWRQRRSFLNIRQAALII-----------------------QLY---------VRGKKQIRCT 797

  Fly  1014 ---------WAIDIIGRYYRQWKIRQFLLTIPLRLPPNTLSPLSTEWPVAPAFLADASRHLRSIY 1069
                     ||..:|.|:.|.:.:|: :..:.||... |:...:..|.....:....:.|...:.
Zfish   798 VTAQALKQGWAAIVIQRHCRGFLVRR-IYQLVLRAAV-TIQAFTRGWMARKRYKKMVAEHKALVL 860

  Fly  1070 HRW-KCYIYRNSFDQTAR------------NRMREKV 1093
            .:: :.::.|..| ||.|            .::|:||
Zfish   861 QKYARAWLVRRRF-QTMRRLVINVQLSYRVQQLRKKV 896

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Myo95E	NP_001027208.1	Motor_domain	3..>123	CDD:473979	33/118 (28%)
		Motor_domain	<403..937	CDD:473979	168/561 (30%)
		Myosin_TH1	1092..1288	CDD:461801	2/2 (100%)
myo5c	XP_691143.2	COG5022	12..1333	CDD:227355	246/1142 (22%)
		MYSc_Myo5	82..739	CDD:276831	203/933 (22%)
		Myo5c_CBD	1366..1740	CDD:271260