DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Myo95E and myo1ea

DIOPT Version :9

Sequence 1:	NP_001027208.1	Gene:	Myo95E / 2768680	FlyBaseID:	FBgn0039157	Length:	1288	Species:	Drosophila melanogaster
Sequence 2:	XP_005168983.1	Gene:	myo1ea / 555285	ZFINID:	ZDB-GENE-030131-5127	Length:	1117	Species:	Danio rerio

Alignment Length:	1323	Identity:	283/1323 - (21%)
Similarity:	499/1323 - (37%)	Gaps:	465/1323 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 QEIGTWDSVLLENLSEDSFINNIHQRYKRDHIYTYIGTSVVALNPYHHISEHSLDNVRNYGDKGI 67
            ::.|..|.|||..::||:.:.|:.:||..|:|:||||..::::||:..:.......:..|.....
Zfish    17 KQSGVDDMVLLSKINEDAIVENLKKRYMDDYIFTYIGPVLISVNPFKQMPYFGEKEIEMYQGAAQ 81

  Fly    68 FQLPPHIYGLTNLAYQSLKDQSEDQCVLLTGESGAGKTETFKMIVNFLTHIQDRSHCPPTPNVLR 132
            ::.|||||.|.:..|:::....|:|||:::||||||||...|.|:.:::
Zfish    82 YENPPHIYALADNMYRNMMIDRENQCVIISGESGAGKTVAAKYIMGYIS---------------- 130

  Fly   133 KQSSTSSASGLVMHAHRRASSSCSGTANFIICKNRAENPSGSVSRRQSPSPGPSQRSRTRAESIE 197

Zfish   131 ----------------------------------------------------------------- 130

  Fly   198 RQSRRHMREKIVDFDFSHHKSSENISGLPESHAHHMHPTKSCFKHQQTQVSACTAMPAAAKGSPK 262
                                   .:||                                  |.|:
Zfish   131 -----------------------KVSG----------------------------------GGPR 138

  Fly   263 YAVPTVYGGCRQCGHSKCVRAQSLEKEERDDLRGSNCRLSTIATATTNPAHPHRGSCSNLMRQHS 327

Zfish   139 ----------------------------------------------------------------- 138

  Fly   328 TESQPERERDRSSLMGSTQRISLYDAHKLSKVLGDLPPPPPSSVSPTPSASSSLHRRHKSPTQRM 392
                                                                         .|.:
Zfish   139 -------------------------------------------------------------VQHV 142

  Fly   393 RECVTCADVFLEAMGNACTLKNNNSSRYGKLFDIEIDFKGDPMGVHITHYMLEKTRITDPIIGER 457
            ::.:..::..|||.|||.|::||||||:||.|:|:....|:|.|..|::::|||:|:.....|||
Zfish   143 KDIILQSNPLLEAFGNAKTVRNNNSSRFGKYFEIQFSSGGEPDGGKISNFLLEKSRVVMRNPGER 207

  Fly   458 NFHIFYQLLLGADLQLLKSLKLYRNVEKYELLRNTTAMEEDRMN----FHYTKRSLDVLGLSCEE 518
            :|||||||:.||......||.: .:::.|..|..:.:.:.|.:|    |..|..::||:|:|..:
Zfish   208 SFHIFYQLIEGASGDQKSSLGI-TSLDYYTYLNQSGSYKVDDINDKHDFQETLHAMDVIGISGID 271

  Fly   519 SNSIFRVIAVVLKLGNFIFVPITNIDGTEGCQVSNVYEVQETAQLLNMEAQILINCLTRA---NS 580
            ...:.:::|.:|.|||..|....|.     ..|.|...:...|.||.::.:.|...||..   ..
Zfish   272 RTMVLQIVAGILHLGNINFREAGNY-----AAVENDEFLAFPAFLLGIDQERLKEKLTSRKMDGK 331

  Fly   581 TNSAQEDVGCEMDARQAATNRNTLCRTLYSRLFTWLVNKINESLKSTQREKNLALLDFYGFEALD 645
            .....|.:...::..||...|:.|.:.|:||:|.:||..||:::....:|.|:.:||.||||...
Zfish   332 WGGKSESIDVTLNVEQACFTRDALSKALHSRVFDYLVESINKAMVKEHQELNIGVLDIYGFEIFQ 396

  Fly   646 HNSFEQFAINYSAEKIHQNFVFHVLRSEQELYIREGLEWSRIDYFDNESICELID---KPSYGIL 707
            .|.||||.||:..||:.|.|:...|::||:.|::||:.|::|:||:|:.:|:||:   .|. ||:
Zfish   397 KNGFEQFCINFVNEKLQQIFIELTLKAEQDEYVQEGIRWTQIEYFNNKIVCDLIESKINPP-GIM 460

  Fly   708 SLINE----PHLNSNDA---LLLRVQQCCAGHPNFMTTGSNSMCFQIRHYASVVNYSIHRFLEKN 765
            |::::    .|.....|   :|.:::.....|.:|   .|.:..|.|.|||..|:|....|.|:|
Zfish   461 SILDDVCATMHAKGEGADQTMLQKLRMQINNHEHF---NSWNQGFIIHHYAGKVSYDAEGFCERN 522

  Fly   766 SDMLPKYISAAFYQSKLSLVQSLFPEGNPRRQVTKKPSTLSSNIRTQLQTLLAIVKHRRSHYVFC 830
            .|:|...:......|:::.:::|||| |...:...:|:|..|.|:.|...|::.:.....||:.|
Zfish   523 RDVLFTDLIELMQSSEIAFIRALFPE-NLNAEKKGRPTTAGSKIKKQANDLVSTLMKCTPHYIRC 586

  Fly   831 IKPNEGKQPHQFDMALVQHQVRYMSLMPLVHLCRTGHCYHLLHVKFFHRYKLLNSLTWPHFHGGS 895
            |||||.|:|..::.:.|:|||.|:.|...:.:.|.|:.|..:..||.:||.:|...:||.:. |.
Zfish   587 IKPNETKKPKDWEESRVKHQVEYLGLKENIRVRRAGYAYRRIFRKFLNRYAILTKESWPTWR-GD 650

  Fly   896 QVEGIALIIRNLPLPSAEFTIGTKNVFVRSPRTVYELEQFRRLRISELAVLIQTMFRMYHARKRF 960
            :.:|:..::|::.:...::.:|...:|:::|.:::.||:.|..:....|..|||.:|.|.|||::
Zfish   651 EKQGVLHLLRSVNMDQDQYQLGHTKIFIKAPESLFLLEETRERKFDGYARTIQTAWRKYCARKKY 715

  Fly   961 QRMRH--SQMIISSAWRTWRECRFGIPFTGRRHLWSLYRVAREEYRSLKYKRQVRWAIDIIGRYY 1023
            .:||.  |.::::...|             |||
Zfish   716 VQMREEASDLLLNKKER-------------RRH-------------------------------- 735

  Fly  1024 RQWKIRQFLLTIPLRLPPNTLSPLSTEWPVAPAFLADASRHLRSIYHRWKCYIYRNSFDQTARNR 1088

Zfish   736 ----------------------------------------------------------------- 735

  Fly  1089 MREKVTASIIFKDRKASYGRSVGHPFVGDYVRLRHNQQWKKICAETNDQYVVFADIINKIARSSG 1153
                                |:...|||||:.:....:.::...:.  :.:.|||.:||..|
Zfish   736 --------------------SLNRNFVGDYLGMDDRPELRQFMGKR--EKIDFADKVNKFDR--- 775

  Fly  1154 KFVPIL--LVLSTSSLLLLDQRTLQ-----------IKYRVPASEIYRMSLSPYLDDIAVFHVKA 1205
            :|..|.  |:|:..|:.|:.:..::           :|.::...:|..:|||...||..:.|  .
Zfish   776 RFKSIKRDLILTPKSVYLIGREKVKQGPEKGLVKEVLKRKIDVEKILAVSLSTLQDDFMILH--E 838

  Fly  1206 SEFGRKKGDFVFQTGHVIEIVTKMFLVIQNATGKPPEIHISTEFEANFGQQTVIFSFKY-----G 1265
            .|:.... :.||:|    |.::.:....:..|.:...:..|...|....::      |:     |
Zfish   839 DEYDSLL-ECVFKT----EFISLLARRYEERTQRKLPLKYSNTMEMKLKKE------KWGPWNAG 892

  Fly  1266 GMSDL----AQGPPKVTRKANRM 1284
            |...:    .||...|.|.:|:|
Zfish   893 GSRQVQFMQGQGDVAVLRPSNKM 915

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Myo95E	NP_001027208.1	Motor_domain	19..>118	CDD:277568	34/98 (35%)
		Motor_domain	403..924	CDD:277568	175/537 (33%)
		Myosin_TH1	1092..1267	CDD:283635	36/192 (19%)
myo1ea	XP_005168983.1	MYSc	14..692	CDD:214580	223/950 (23%)
		MYSc_Myo1	33..679	CDD:276829	214/921 (23%)
		Myosin_TH1	719..904	CDD:283635	43/332 (13%)
		SH3_MyoIe_If_like	1064..1116	CDD:212761
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D122881at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100187
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.820