Protein Alignment Myo95E and myo1b

DIOPT Version :9

• Sequence 1: NP_001027208.1
• Gene: Myo95E / 2768680
• FlyBaseID: FBgn0039157
• Length: 1288
• Species: Drosophila melanogaster
• Sequence 2: XP_005168005.1
• Gene: myo1b / 541515
• ZFINID: ZDB-GENE-030131-695
• Length: 1167
• Species: Danio rerio
• Alignment Length: 1432
• Identity: 406/1432 - (28%)
• Similarity: 630/1432 - (43%)
• Gaps: 428/1432 - (29%)

  Fly     1 MEQEIGTWDSVLLENLSEDSFINNIHQRYKRDHIYTYIGTSVVALNPYHHISEHSLDNVRNYGDK 65
            ::..||..|.||||.|||:|||.|:.:|:..:.||||||:.|:::|||..:|.:|.:.|..|.::
Zfish     8 LDNMIGVGDMVLLEPLSEESFIENLKKRFDHNEIYTYIGSVVISMNPYKSLSIYSAEKVEEYRNR 72

  Fly    66 GIFQLPPHIYGLTNLAYQSLKDQSEDQCVLLTGESGAGKTETFKMIVNFLTHIQDRSHCPPTPNV 130
            ..::|.||||.|.:.||:||:.|.:|||:|:||||||||||..|.:::::..:
Zfish    73 NFYELSPHIYALADEAYRSLRHQDKDQCILITGESGAGKTEASKFVMSYVAAV------------ 125

  Fly   131 LRKQSSTSSASGLVMHAHRRASSSCSGTANFIICKNRAENPSGSVSRRQSPSPGPSQRSRTRAES 195
                                                                             
Zfish   126 ----------------------------------------------------------------- 125

  Fly   196 IERQSRRHMREKIVDFDFSHHKSSENISGLPESHAHHMHPTKSCFKHQQTQVSACTAMPAAAKGS 260
                                                                             
Zfish   126 ----------------------------------------------------------------- 125

  Fly   261 PKYAVPTVYGGCRQCGHSKCVRAQSLEKEERDDLRGSNCRLSTIATATTNPAHPHRGSCSNLMRQ 325
                          ||                                       :|...|.:::
Zfish   126 --------------CG---------------------------------------KGQEVNKVKE 137

  Fly   326 HSTESQPERERDRSSLMGSTQRISLYDAHKLSKVLGDLPPPPPSSVSPTPSASSSLHRRHKSPTQ 390
            ...:|.|
Zfish   138 QLLQSNP---------------------------------------------------------- 144

  Fly   391 RMRECVTCADVFLEAMGNACTLKNNNSSRYGKLFDIEIDFKGDPMGVHITHYMLEKTRITDPIIG 455
                       .|||.|||.|::|:||||:||..|||.||||||:|..|::|:|||:|:.....|
Zfish   145 -----------VLEAFGNAKTVRNDNSSRFGKYMDIEFDFKGDPLGGVISNYLLEKSRVVKQPRG 198

  Fly   456 ERNFHIFYQLLLGADLQLLKSLKLYRNVEKYELLRNTTAME---EDRMNFHYTKRSLDVLGLSCE 517
            |||||||||||.||...:||.|||.|:..||..|...:|..   :|..:|...:.::.::|...:
Zfish   199 ERNFHIFYQLLSGASDDMLKKLKLDRDFSKYNYLSLDSATVNGLDDAASFRTVRNAMQIVGFMED 263

  Fly   518 ESNSIFRVIAVVLKLGNFIFVPITNIDGTEGCQVSNVYEVQETAQLLNMEAQILINCLTRANSTN 582
            |..||..:||.||||||..|.|.:.::|.:..:|.:..:::|..:||.:|..:    |.||.|..
Zfish   264 EVQSILELIAAVLKLGNIEFKPESRVNGFDESRVKDKNDLKEMCELLGIEQSV----LERAFSFR 324

  Fly   583 SAQ---EDVGCEMDARQAATNRNTLCRTLYSRLFTWLVNKINESLK--STQREKNLALLDFYGFE 642
            :.:   |.|...::..||...|:.|.:.|||||||||||:||||:|  :..|:|.:.:||.||||
Zfish   325 TVEAKMEKVSTTLNVAQAYYARDALAKNLYSRLFTWLVNRINESIKAQTKTRKKVMGVLDIYGFE 389

  Fly   643 ALDH--NSFEQFAINYSAEKIHQNFVFHVLRSEQELYIREGLEWSRIDYFDNESICELIDKPSYG 705
            ..::  ||||||.|||..||:.|.|:...||.|||.|||||:||:.|:||:|..||:||:....|
Zfish   390 IFENGDNSFEQFIINYCNEKLQQIFIELTLREEQEEYIREGIEWTNIEYFNNAIICDLIENNKNG 454

  Fly   706 ILSLINE----PHLNSNDALLLRVQQCCAGHPNFMTTGSNSM-----------CFQIRHYASVVN 755
            ||::::|    |...:::..|.::...||.|.:|.:..|.:.           ||:|:|||..|.
Zfish   455 ILAMLDEECLRPGTVTDETFLDKLNTVCAEHQHFESRLSKNSKFLTDHSLPHNCFRIQHYAGKVL 519

  Fly   756 YSIHRFLEKNSDMLPKYISAAFYQSKLSLVQSLFPEGNPRRQVTKKPSTLSSNIRTQLQTLLAIV 820
            |.:..|::||:|:|.:.:|.|.|::..:|::.|||||||.:...|:|.|.....|..:.||:..:
Zfish   520 YRVEGFVDKNNDLLYRDLSQAMYKANHNLIKLLFPEGNPAKVNLKRPPTAGFQFRASVGTLMKNL 584

  Fly   821 KHRRSHYVFCIKPNEGKQPHQFDMALVQHQVRYMSLMPLVHLCRTGHCYHLLHVKFFHRYKLLNS 885
            ..:..:|:.|||||:.|..|.|..:||.|||||:.||..|.:.|.|:.:...:.....|||:|..
Zfish   585 LTKNPNYIRCIKPNDKKAAHIFTDSLVCHQVRYLGLMENVRVRRAGYAFRQAYEPCLERYKMLCK 649

  Fly   886 LTWPHFHGGSQVEGIALIIRNLPLPSAEFTIGTKNVFVRSPRTVYELEQFRRLRISELAVLIQTM 950
            .||||:.|.:: ||:.:::.:|.:|:.||..|...:|:|:|||::.||:.||..:.:||.|||.:
Zfish   650 QTWPHWKGPAR-EGVEVLLSDLQVPAEEFAYGRSKIFIRNPRTLFFLEEKRRQCLEDLAALIQKI 713

  Fly   951 FRMYHAR-----------------------KRFQRMRHSQMIISSAWRTW------------REC 980
            :|.:..|                       |::|::|.|.:::.|..|.|            :.|
Zfish   714 YRGWKCRTHFLLLKKSQVVVAAWYRRFAQQKKYQKIRCSALVVQSFIRGWKARKLLRELKHKKRC 778

  Fly   981 RFGIP-----FTGRRHLWSLYRV------------------------------------------ 998
            ...:.     :.|.:..|.|.|:
Zfish   779 EEAVTTISAYWHGTQARWELRRLKKEAWNKHAVSVIWAAWLGTKARRELQKLKHEACSKQAVSVI 843

  Fly   999 --------AREEYRSLKYKRQVRWAIDIIGRYYRQWKIR-------------------------Q 1030
                    ||.|.:.||.:.:.:.||.:|..|:...|:|                         :
Zfish   844 WACWQGTKARRELKRLKEEARRKHAIAVIWAYWLGLKVRREYRKFFRANAGKKIYDFTIQRIIQK 908

  Fly  1031 FLLTIPLRLPPNTLSPLSTEWPVAP-AFLADASRHLRSIYHRWKCYIYRNSFDQTARNRMREKVT 1094
            :.|.:...:|  ::||:...|...| .||....:.||.|:|.|:|..||:.|.:..:....||:.
Zfish   909 YYLGLKKTMP--SMSPIDKSWSTCPYGFLDGTHQELRRIFHLWRCKKYRSQFTEEKKATYEEKLA 971

  Fly  1095 ASIIFKDRKASYGRSVGHPFVGDYVRLRHNQQWKKICAETNDQYVVFADIINKIARSSGKFVPIL 1159
            ||.:|||:||.|..||..||.||||.:..|.:::|:.:...|: |:.||:::||.|::||..|.:
Zfish   972 ASELFKDKKALYPSSVSQPFKGDYVEITKNPKYQKLNSLVEDK-VLLADVVSKINRANGKGTPRI 1035

  Fly  1160 LVLSTSSLLLLDQRTLQIKYRVPASEIYRMSLSPYLDDIAVFHVKASEFGRKKGDFVFQTGHVIE 1224
            .:|:...|:|.||:|.|:|..||..::..:.:|...|......::.......|||::..:..:||
Zfish  1036 FLLTKKCLVLADQKTGQVKASVPLPDLSSVFVSTQNDGFFALKLREGATSAAKGDYLLSSDRLIE 1100

  Fly  1225 IVTKMFLV-IQNATGKPPEIHISTEFEANFGQQTVIFSFKYGGMSDLAQGPPK------VTRKAN 1282
            |:||::.. ..:|.....:|.||.||...|.|..|...|        .||.||      ..||.|
Zfish  1101 IITKLYCTGAASAERNQIKIDISDEFLVQFKQDKVCVKF--------IQGTPKNSNSVSCKRKNN 1157

  Fly  1283 RM 1284
            |:
Zfish  1158 RL 1159

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Myo95E	NP_001027208.1	Motor_domain	19..>118	CDD:277568	45/98 (46%)
		Motor_domain	403..924	CDD:277568	222/545 (41%)
		Myosin_TH1	1092..1267	CDD:283635	59/175 (34%)
myo1b	XP_005168005.1	MYSc	13..700	CDD:214580	288/955 (30%)
		MYSc_Myo1	26..687	CDD:276829	273/929 (29%)
		Myosin_TH1	969..1142	CDD:283635	59/181 (33%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	101	1.000	Domainoid score	I6934
eggNOG	1	0.900	-	-		E2759_KOG0164
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H7856
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D105718at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100187
Panther	1	1.100	-	-	LDO	PTHR13140
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	8	7.820