Protein Alignment Myo95E and Myo19

DIOPT Version :10

• Sequence 1: NP_001027208.1
• Gene: Myo95E / 2768680
• FlyBaseID: FBgn0039157
• Length: 1288
• Species: Drosophila melanogaster
• Sequence 2: NP_001157208.1
• Gene: Myo19 / 497974
• RGDID: 1559961
• Length: 964
• Species: Rattus norvegicus
• Alignment Length: 1156
• Identity: 269/1156 - (23%)
• Similarity: 430/1156 - (37%)
• Gaps: 401/1156 - (34%)

  Fly    13 LENLSE------DSFINNIHQRYKRDHIYTYIGTSVVALNPYHHISE----------HSLDNVRN 61
            |::|::      ::.:..:..||..|..||..|.::|||||:.||.:          |:....:
  Rat    37 LDDLTKVNPVTLETVLRCLQARYTEDIFYTNAGCTLVALNPFKHIPQLYAPELMQEYHAAPQPQ- 100

  Fly    62 YGDKGIFQLPPHIYGLTNLAYQSLKDQSE--DQCVLLTGESGAGKTETFKMIVNFLTHIQDRSHC 124
                   :|.|||:.:....|:::|...|  :|.::::||||||||.|.:.::.|
  Rat   101 -------KLKPHIFTVGEQTYRNVKSLIEPINQSIVVSGESGAGKTWTSRCLMKF---------- 148

  Fly   125 PPTPNVLRKQSSTSSASGLVMHAHRRASSSCSGTANFIICKNRAENPSGSVSRRQSPSPGPSQRS 189
                                                                             
  Rat   149 ----------------------------------------------------------------- 148

  Fly   190 RTRAESIERQSRRHMREKIVDFDFSHHKSSENISGLPESHAHHMHPTKSCFKHQQTQVSACTAMP 254
                                                                             
  Rat   149 ----------------------------------------------------------------- 148

  Fly   255 AAAKGSPKYAVPTVYGGCRQCGHSKCVRAQSLEKEERDDLRGSNCRLSTIATATTNPAHPHRGSC 319
                    |||                                      :|.:.|        ||
  Rat   149 --------YAV--------------------------------------VAASPT--------SC 159

  Fly   320 SNLMRQHSTESQPERERDRSSLMGSTQRISLYDAHKLSKVLGDLPPPPPSSVSPTPSASSSLHRR 384
            .|                                ||::
  Rat   160 EN--------------------------------HKMA--------------------------- 165

  Fly   385 HKSPTQRMRECVTCADVFLEAMGNACTLKNNNSSRYGKLFDIEIDFKGDPMGVHITHYMLEKTRI 449
                 :|:.|.:..::..:||.||||||:||||||:||...::::......|..:..|:|||||:
  Rat   166 -----ERIEERILNSNPVMEAFGNACTLRNNNSSRFGKFIQLQLNRAQQMTGAAVQTYLLEKTRV 225

  Fly   450 TDPIIGERNFHIFYQLLLGADLQLLKSLKLYRNVEKYELLRNTTAMEEDRMNFHYTKRSLDVLGL 514
            ......|||||||||:..||..:......|........|....:::|||  .|..|:.::..||:
  Rat   226 ACQAASERNFHIFYQICKGATKEERLQWCLPEGTAFSWLPNPESSLEED--CFEVTREAMLHLGI 288

  Fly   515 SCEESNSIFRVIAVVLKLGNFIFV-------PITNIDGTEGCQVSNVYEVQETAQLLNMEAQILI 572
            .....|:||:|:|.:|.|||..||       |...:|||:|       .|:.:|.||.:...:|:
  Rat   289 DTPTQNNIFKVLAGLLHLGNVHFVDSEDEAQPCQLMDGTKG-------SVRTSALLLQLPDNMLL 346

  Fly   573 NCLTRANSTNSAQEDVGCEMDAR-QAATNRNTLCRTLYSRLFTWLVNKINESLKS--TQREKNLA 634
            ..:.........|:.|..:..:| :..|.|:.|.:.:|:|||.|||:.||.|:.:  :.....:.
  Rat   347 ESMQIRTIKAGKQQQVFQKPCSRAECDTRRDCLAKLIYARLFDWLVSVINSSICADFSSWTAFIG 411

  Fly   635 LLDFYGFEALDHNSFEQFAINYSAEKIHQNFVFHVLRSEQELYIREGLEWSRIDYFDNESICELI 699
            |||.||||:...||.||..|||:.||:.|:||.|.||::||.|..||||||.::|.||::..:|:
  Rat   412 LLDVYGFESFPDNSLEQLCINYANEKLQQHFVAHYLRAQQEEYEVEGLEWSFVNYQDNQTCLDLL 476

  Fly   700 DKPSYGILSLINEP-HLN---SNDALLLRVQQCCAGHPNFMTTGSNSM----CFQIRHYASVVNY 756
            :.....|.|||||. .||   |...|..|::...||.|   ..|.|.:    .|.:.|:|..|.|
  Rat   477 EGSPISICSLINEECRLNRPSSAAQLQTRIESTLAGRP---CLGHNKLSREPSFVVMHFAGPVRY 538

  Fly   757 SIHRFLEKNSDMLPKYISAAFYQSKLSLVQSLFPEGNPRRQVTKKPS--------TLSSNIRTQL 813
            .....:|||.|.:|..::....||:..|:..||| .||..:..::.|        |:.|..:..|
  Rat   539 CTAGLVEKNKDPVPPELTGLLQQSQDPLLMMLFP-ANPEEKTQEELSGQSRAPALTVVSKFKASL 602

  Fly   814 QTLLAIVKHRRSHYVFCIKPNEGKQPHQFDMALVQHQVRYMSLMPLVHLCRTGHCYHLLHVKFFH 878
            :.||.::.....||:.|||||...||..|....|.:|:....|:..:|:...|....:.|..|..
  Rat   603 EQLLQVLHKTTPHYIRCIKPNSQSQPQTFLQEEVLNQLEACGLVETIHISAAGFPIRVSHQNFME 667

  Fly   879 RYKLLNSLTWPHFHGGSQ---------------------------VEGIALIIRNLPLPS----- 911
            |||||..|. |....|.:                           :..:..:|:....||
  Rat   668 RYKLLTRLR-PRTSSGLRSLCPAKGSSEQPLCAKEATLQPLLQDILHALPALIQTATTPSDPAKT 731

  Fly   912 AEFTI--GTKNVFVRSPRTVYE-LEQFRRLRISELAVLIQTMFRMYHARKRFQRMRHSQMIISSA 973
            |:..:  |...:|:..  ::.| ||..|...:.:.|..||..:|.:..:|: ::.|.:.:||.:|
  Rat   732 AQIPLYCGRTKIFMTD--SMLELLECGRAQMLEQCARCIQCGWRRHRLQKQ-EKQRRAAVIIQAA 793

  Fly   974 WRTWRECRFGIPFTGRRHLWSLYRVAREEYRSLKYKRQVRWAIDIIGRYYRQWKIRQFLLT---- 1034
            :|:|         ..|:|:                 |::..|..:|...:.:|:||...|.
  Rat   794 FRSW---------LTRKHI-----------------RRLHIAATVIKHAWHKWRIRMACLASKEL 832

  Fly  1035 --IPLRLPPNTLSPLSTEWPVAPAFLADASRHLRSIYHRWKC-YIYRNSFD 1082
              :..:|.|.  :|.:....::||.    :|.|.:|.|.|.. .:..||.|
  Rat   833 DGMEEKLMPQ--APGTLRSSLSPAH----TRFLGAIIHLWPLGLVLANSAD 877

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Myo95E	NP_001027208.1	Motor_domain	3..>123	CDD:473979	34/127 (27%)
		Motor_domain	<403..937	CDD:473979	189/594 (32%)
		Myosin_TH1	1092..1288	CDD:461801
Myo19	NP_001157208.1	MYSc_Myo19	49..746	CDD:276846	230/976 (24%)
		IQCD	776..>801	CDD:467745	7/34 (21%)