DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Myo95E and myo1e.2

DIOPT Version :9

Sequence 1:	NP_001027208.1	Gene:	Myo95E / 2768680	FlyBaseID:	FBgn0039157	Length:	1288	Species:	Drosophila melanogaster
Sequence 2:	NP_001011082.1	Gene:	myo1e.2 / 496494	XenbaseID:	XB-GENE-5913944	Length:	1093	Species:	Xenopus tropicalis

Alignment Length:	1341	Identity:	296/1341 - (22%)
Similarity:	501/1341 - (37%)	Gaps:	481/1341 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 QEIGTWDSVLLENLSEDSFINNIHQRYKRDHIYTYIGTSVVALNPYHHISEHSLDNVRNYGDKGI 67
            ::.|..|.|||..::|::.:.|:.:||..|:|:||||..::::||:..:...:...:..|.....
Frog    15 RQSGVDDMVLLSKITEEAIMENLKKRYMDDYIFTYIGPVLISVNPFKQLPYFTDREIEMYQGAAQ 79

  Fly    68 FQLPPHIYGLTNLAYQSLKDQSEDQCVLLTGESGAGKTETFKMIVNFLTHIQDRSHCPPTPNVLR 132
            ::.|||||.|.:..|:::....|:|||:::||||||||...|.|:.:::
Frog    80 YENPPHIYALADTMYRNMLIDGENQCVIISGESGAGKTVAAKYIMGYVS---------------- 128

  Fly   133 KQSSTSSASGLVMHAHRRASSSCSGTANFIICKNRAENPSGSVSRRQSPSPGPSQRSRTRAESIE 197

Frog   129 ----------------------------------------------------------------- 128

  Fly   198 RQSRRHMREKIVDFDFSHHKSSENISGLPESHAHHMHPTKSCFKHQQTQVSACTAMPAAAKGSPK 262
                                   .:||                                  |.||
Frog   129 -----------------------KVSG----------------------------------GGPK 136

  Fly   263 YAVPTVYGGCRQCGHSKCVRAQSLEKEERDDLRGSNCRLSTIATATTNPAHPHRGSCSNLMRQHS 327

Frog   137 ----------------------------------------------------------------- 136

  Fly   328 TESQPERERDRSSLMGSTQRISLYDAHKLSKVLGDLPPPPPSSVSPTPSASSSLHRRHKSPTQRM 392
                                                                         .|.:
Frog   137 -------------------------------------------------------------VQHV 140

  Fly   393 RECVTCADVFLEAMGNACTLKNNNSSRYGKLFDIEIDFKGDPMGVHITHYMLEKTRITDPIIGER 457
            ::.:..::..|||.|||.|::||||||:||.|:|:....|:|.|..|::::|||:|:.....|||
Frog   141 KDIILKSNPLLEAFGNAKTVRNNNSSRFGKYFEIQFSRGGEPDGGKISNFLLEKSRVVSQNSGER 205

  Fly   458 NFHIFYQLLLGADLQLLKSLKLYRNVEKYELLRNTTAM-----EEDRMNFHYTKRSLDVLGLSCE 517
            :||||||||.||..:..::|.:  ....|....|.:|:     ..|:..|..|..::||:||..:
Frog   206 SFHIFYQLLEGASAEDKENLGV--TSPDYYFYLNQSAVYHVDDVSDKKEFAETMLAMDVVGLGPD 268

  Fly   518 ESNSIFRVIAVVLKLGNFIFVPITNIDGTEGCQVSNVYEVQE----TAQLLNMEAQILINCLTRA 578
            ...|:.:::|.:|.|||..|....|         ..|.|.|:    .|.||.::...|.:.||..
Frog   269 TQTSVLQIVAGILHLGNVAFTESGN---------HAVVESQDFLAFPAYLLGIDQARLQDKLTSR 324

  Fly   579 ---NSTNSAQEDVGCEMDARQAATNRNTLCRTLYSRLFTWLVNKINESLKSTQREKNLALLDFYG 640
               :......|.:...::|.||...|:.|.:.||:|||.:||..||::::....|.|:.:||.||
Frog   325 KMDSKWGGKSEVIDVTLNAEQACFTRDALAKALYTRLFDFLVEAINKAMRKDTEEYNIGVLDIYG 389

  Fly   641 FEALDHNSFEQFAINYSAEKIHQNFVFHVLRSEQELYIREGLEWSRIDYFDNESICELID---KP 702
            ||....|.||||.||:..||:.|.|:...|::|||.|::||:.|:.|:||:|:.:|:||:   .|
Frog   390 FEIFQKNGFEQFCINFVNEKLQQIFIELTLKAEQEEYVQEGIHWNPIEYFNNKVVCDLIESKVSP 454

  Fly   703 SYGILSLINE----PHLNSNDA---LLLRVQQCCAGHPNFMTTGSNSMCFQIRHYASVVNYSIHR 760
            . |::|::::    .|.....|   ||.::|.....|.:|   .|.:..|.|.|||..|:|.:..
Frog   455 P-GVMSILDDVCATMHAKGEGADQTLLQKLQSAIGSHEHF---NSWNRGFIIHHYAGKVSYDVSG 515

  Fly   761 FLEKNSDMLPKYISAAFYQSKLSLVQSLFPEGNPRRQVTKKPSTLSSNIRTQLQTLLAIVKHRRS 825
            |.|:|.|:|...:......|::..::..||| |...:...:|||..|.|:.|...|:..:.....
Frog   516 FCERNRDVLFVDLIELMQSSEIPFIRERFPE-NLNAEKKGRPSTAGSKIKKQANDLVQTLMKCTP 579

  Fly   826 HYVFCIKPNEGKQPHQFDMALVQHQVRYMSLMPLVHLCRTGHCYHLLHVKFFHRYKLLNSLTWPH 890
            ||:.||||||.|:|..::.:.|:|||.|:.|...:.:.|.|:.|..:..||.|||.:|...|||.
Frog   580 HYIRCIKPNETKKPRDWEDSRVKHQVEYLGLRENIRVRRAGYAYRRVFQKFLHRYAILTRETWPQ 644

  Fly   891 FHGGSQVEGIALIIRNLPLPSAEFTIGTKNVFVRSPRTVYELEQFRRLRISELAVLIQTMFRMYH 955
            :. |.:.:|:..::|::.:.|.::.:|...||:::|.:::.||:.|..:....|.:||
Frog   645 WR-GDEKKGVMHLLRSVNMDSDQYQLGRTKVFIKAPESLFLLEEMRERKYDNYARVIQ------- 701

  Fly   956 ARKRFQRMRHSQMIISSAWRTWRECRFGIPFTGRRHLWSLYRVAREEYRSLKYKRQVRWAIDIIG 1020
                            .|||
Frog   702 ----------------KAWR--------------------------------------------- 705

  Fly  1021 RYYRQWKIRQFLLTIPLRLPPNTLSPLSTEWPVAPAFLADASRHLRSIYHRWKCYIYRNSFDQTA 1085
               :...:|:::
Frog   706 ---KHTAVRKYI----------------------------------------------------- 714

  Fly  1086 RNRMREKVTASIIFKDRKASYGRSVGHPFVGDYVRLRHNQQWKKICAETNDQYVVFADIINKIAR 1150
              ||||:  ||.|..::|.....|:...|||||:.:....:.::.....  :.:.|||::.|..|
Frog   715 --RMREE--ASSIVLNQKERRRNSINRNFVGDYIGMDGRPELRQFVGRR--ERIDFADVVTKYDR 773

  Fly  1151 SSGKFVPIL--LVLSTSSLLLLDQRTLQ-----------IKYRVPASEIYRMSLSPYLDDIAVFH 1202
               :|..:.  |||:...|.|:.:..::           :|.::....|..:|||...||..:.|
Frog   774 ---RFKTLKRDLVLTPKFLYLIGREKVKQGPDKGQIKEVLKRKIELENIQSVSLSKLQDDFIILH 835

  Fly  1203 VKASEFGRKKGDFVFQTGHVIEIVTKMFLVIQNATGK--PPEIHISTEFEAN---------FGQQ 1256
            ..|.:...   :.||:|    |.::.::...:..|.:  |.:..:..||:..         .|.:
Frog   836 EGAYDSAL---EGVFKT----EFLSLLYKRYEEKTHRKLPIKFGLQLEFKVKKEGWAPWGAAGTR 893

  Fly  1257 TVIFSFKYGGMS-DLAQG-----------PP--KVTRKANR 1283
            .:.|....|.|: ..|.|           ||  :.|||.||
Frog   894 QIQFQTGIGDMALTKANGKVLIVTIGPGLPPNSRPTRKDNR 934

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Myo95E	NP_001027208.1	Motor_domain	19..>118	CDD:277568	33/98 (34%)
		Motor_domain	403..924	CDD:277568	185/542 (34%)
		Myosin_TH1	1092..1267	CDD:283635	41/198 (21%)
myo1e.2	NP_001011082.1	MYSc_Myo1	31..677	CDD:276829	224/926 (24%)
		Myosin_TH1	717..918	CDD:368706	46/214 (21%)
		SH3_MyoIe_If_like	1040..1092	CDD:212761
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D122881at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.010