DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Myo95E and myo6

DIOPT Version :9

Sequence 1:	NP_001027208.1	Gene:	Myo95E / 2768680	FlyBaseID:	FBgn0039157	Length:	1288	Species:	Drosophila melanogaster
Sequence 2:	XP_031758531.1	Gene:	myo6 / 493193	XenbaseID:	XB-GENE-1012303	Length:	1300	Species:	Xenopus tropicalis

Alignment Length:	1040	Identity:	233/1040 - (22%)
Similarity:	376/1040 - (36%)	Gaps:	367/1040 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 DSVLLENLSEDSFINNIHQRYKRDHIYTYIGTSVVALNPYHHISE-HSLDNVRNYGDKGIFQLPP 72
            |:..|..|:|.:.::||..||.:|.||||:...::|:|||..:.: ::.:.::.|..|.:..|||
Frog    61 DNCSLMYLNEATLLHNIQVRYSKDKIYTYVANILIAVNPYFDVPKLYTSEQIKQYHGKSLGTLPP 125

  Fly    73 HIYGLTNLAYQSLKDQSEDQCVLLTGESGAGKTETFKMIVNFLTHIQDRSHCPPTPNVLRKQSST 137
            |:|.:.:.|::.:|.....|.::::|||||||||..|.::.:||.
Frog   126 HVYAIADKAFRDMKVLKMSQSIIVSGESGAGKTENTKFVLRYLTE-------------------- 170

  Fly   138 SSASGLVMHAHRRASSSCSGTANFIICKNRAENPSGSVSRRQSPSPGPSQRSRTRAESIERQSRR 202
            |..||                                                           :
Frog   171 SYGSG-----------------------------------------------------------Q 176

  Fly   203 HMREKIVDFDFSHHKSSENISGLPESHAHHMHPTKSCFKHQQTQVSACTAMPAAAKGSPKYAVPT 267
            .:.|:||:
Frog   177 DIDERIVE--------------------------------------------------------- 184

  Fly   268 VYGGCRQCGHSKCVRAQSLEKEERDDLRGSNCRLSTIATATTNPAHPHRGSCSNLMRQHSTESQP 332
                                                     .||
Frog   185 -----------------------------------------ANP--------------------- 187

  Fly   333 ERERDRSSLMGSTQRISLYDAHKLSKVLGDLPPPPPSSVSPTPSASSSLHRRHKSPTQRMRECVT 397

Frog   188 ----------------------------------------------------------------- 187

  Fly   398 CADVFLEAMGNACTLKNNNSSRYGKLFDIEIDFKGDPMGVHITHYMLEKTRITDPIIGERNFHIF 462
                .|||.|||.|::||||||:||..:|..:.|...:|..::||:|||:||......|||:|||
Frog   188 ----LLEAFGNAKTVRNNNSSRFGKFVEIHFNEKNSVVGGFVSHYLLEKSRICVQGQDERNYHIF 248

  Fly   463 YQLLLGADLQLLKSL---------KLYRNVEKY--------ELLRNTTAMEEDRM---------- 500
            |:|..||...:.:.|         .|.|...:|        ::|:|..:.|||..
Frog   249 YRLCAGAPEDIRQKLFLCSPDTFRYLNRGCTRYFASKDTDKQILQNRKSPEEDEYLKHGALKDPL 313

  Fly   501 -----NFHYTKRSLDVLGLSCEESNSIFRVIAVVLKLGNFIFVPITNIDGTEGCQV--SNVYEVQ 558
                 :|:....::..:||...|...:|||:|.||.|||..|....:..|  ||.:  .:...:|
Frog   314 LDDHGDFNRMCIAMKKIGLDDTEKLDLFRVVAGVLHLGNIDFEEAGSTSG--GCTLRKKSSESLQ 376

  Fly   559 ETAQLLNM---EAQILIN---CLTRANSTNSAQEDVGCEMDARQAATNRNTLCRTLYSRLFTWLV 617
            ..|:||.:   :.|:.:.   .||.|..|....  :...:..:||...|:.|.:.:||.||..:|
Frog   377 CCAKLLGLDQDDLQVSLTSRVMLTTAGGTKGTV--IKVPLKVQQAENARDALAKAIYSHLFDHVV 439

  Fly   618 NKINESLKSTQREKNLALLDFYGFEALDHNSFEQFAINYSAEKIHQNFVFHVLRSEQELYIREGL 682
            |::|:.....:....:.:||..|||..:|||||||.|||..||:.|.|...:|:.|||||.:|||
Frog   440 NRVNQCFPFERSSFFIGVLDIAGFEYFEHNSFEQFCINYCNEKLQQFFNERILKEEQELYQKEGL 504

  Fly   683 EWSRIDYFDNESICELIDKPSYGILSLINE---------PHLNS--------NDALLLRVQQCCA 730
            ..:.:.|.||:...:||:....|||.:::|         .|..|        :..|.:..:...|
Frog   505 GVNEVHYVDNQDCIDLIEAKLVGILDILDEENRLPQPTDQHFTSAVHQKHKNHFRLTIPRKSKLA 569

  Fly   731 GHPNFMTTGSNSMCFQIRHYASVVNYSIHRFLEKNSDMLPKYISAAFYQSKLSLVQSLFPEGNPR 795
            .|.|.    .:...|.:||:|..|.|...:|:|||:|.|...:.:...:||...|:.||...|..
Frog   570 VHRNI----RDDEGFIVRHFAGAVCYETTQFVEKNNDALHMSLESLICESKDKFVRELFESANNH 630

  Fly   796 RQVTKKPSTLS-----SNIRTQLQTLLAIVKHRRSHYVFCIKPNEGKQPHQFDMALVQHQVRYMS 855
            :.:.:|...||     :..:|||..||..::...|.::.|||||.....|||:.|.:..|::...
Frog   631 KDLKQKTGKLSFISVGNKFKTQLNLLLEKLRSTGSSFIRCIKPNLKMTSHQFEGAQILSQLQCSG 695

  Fly   856 LMPLVHLCRTGHCYHLLHVKFFHRYK-----LLNSLTWPHFHGGSQVEGIALIIRNLPLPSAEFT 915
            ::.::.|.:.|........:.::.||     .::.|....|        ...:.:.|.|...::.
Frog   696 MVSVLDLMQGGFPSRASFHELYNMYKKYMPAKMSRLDPRLF--------CKALFKALGLNENDYK 752

  Fly   916 IGTKNVFVRSPRTVYELEQFRRLRISELAVLIQTMFRMYHARKRFQRMRHSQMIISSAWRTWREC 980
            .|...||.| |....|.:|..:.....||.||             :|:.|  .:|.|.|:..:.|
Frog   753 FGLTKVFFR-PGKFAEFDQIMKSDPDHLAELI-------------RRVNH--WLICSRWKKVQWC 801

Fly 981 980
Frog 802 801

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Myo95E	NP_001027208.1	Motor_domain	19..>118	CDD:277568	35/99 (35%)
		Motor_domain	403..924	CDD:277568	172/587 (29%)
		Myosin_TH1	1092..1267	CDD:283635
myo6	XP_031758531.1	Myosin_N	4..40	CDD:397036
		MYSc_Myo6	71..761	CDD:276833	215/972 (22%)
		CBD_MYO6-like	772..916	CDD:409646	10/45 (22%)
		MYO6_MIU_linker	1001..1074	CDD:412090
		Myosin-VI_CBD	1183..1273	CDD:406827
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D122881at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.920