Protein Alignment Myo95E and myo6

DIOPT Version :10

• Sequence 1: NP_001027208.1
• Gene: Myo95E / 2768680
• FlyBaseID: FBgn0039157
• Length: 1288
• Species: Drosophila melanogaster
• Sequence 2: XP_031758531.1
• Gene: myo6 / 493193
• XenbaseID: XB-GENE-1012303
• Length: 1300
• Species: Xenopus tropicalis
• Alignment Length: 1040
• Identity: 233/1040 - (22%)
• Similarity: 376/1040 - (36%)
• Gaps: 367/1040 - (35%)

  Fly     9 DSVLLENLSEDSFINNIHQRYKRDHIYTYIGTSVVALNPYHHISE-HSLDNVRNYGDKGIFQLPP 72
            |:..|..|:|.:.::||..||.:|.||||:...::|:|||..:.: ::.:.::.|..|.:..|||
 Frog    61 DNCSLMYLNEATLLHNIQVRYSKDKIYTYVANILIAVNPYFDVPKLYTSEQIKQYHGKSLGTLPP 125

  Fly    73 HIYGLTNLAYQSLKDQSEDQCVLLTGESGAGKTETFKMIVNFLTHIQDRSHCPPTPNVLRKQSST 137
            |:|.:.:.|::.:|.....|.::::|||||||||..|.::.:||.
 Frog   126 HVYAIADKAFRDMKVLKMSQSIIVSGESGAGKTENTKFVLRYLTE-------------------- 170

  Fly   138 SSASGLVMHAHRRASSSCSGTANFIICKNRAENPSGSVSRRQSPSPGPSQRSRTRAESIERQSRR 202
            |..||                                                           :
 Frog   171 SYGSG-----------------------------------------------------------Q 176

  Fly   203 HMREKIVDFDFSHHKSSENISGLPESHAHHMHPTKSCFKHQQTQVSACTAMPAAAKGSPKYAVPT 267
            .:.|:||:
 Frog   177 DIDERIVE--------------------------------------------------------- 184

  Fly   268 VYGGCRQCGHSKCVRAQSLEKEERDDLRGSNCRLSTIATATTNPAHPHRGSCSNLMRQHSTESQP 332
                                                     .||
 Frog   185 -----------------------------------------ANP--------------------- 187

  Fly   333 ERERDRSSLMGSTQRISLYDAHKLSKVLGDLPPPPPSSVSPTPSASSSLHRRHKSPTQRMRECVT 397
                                                                             
 Frog   188 ----------------------------------------------------------------- 187

  Fly   398 CADVFLEAMGNACTLKNNNSSRYGKLFDIEIDFKGDPMGVHITHYMLEKTRITDPIIGERNFHIF 462
                .|||.|||.|::||||||:||..:|..:.|...:|..::||:|||:||......|||:|||
 Frog   188 ----LLEAFGNAKTVRNNNSSRFGKFVEIHFNEKNSVVGGFVSHYLLEKSRICVQGQDERNYHIF 248

  Fly   463 YQLLLGADLQLLKSL---------KLYRNVEKY--------ELLRNTTAMEEDRM---------- 500
            |:|..||...:.:.|         .|.|...:|        ::|:|..:.|||..
 Frog   249 YRLCAGAPEDIRQKLFLCSPDTFRYLNRGCTRYFASKDTDKQILQNRKSPEEDEYLKHGALKDPL 313

  Fly   501 -----NFHYTKRSLDVLGLSCEESNSIFRVIAVVLKLGNFIFVPITNIDGTEGCQV--SNVYEVQ 558
                 :|:....::..:||...|...:|||:|.||.|||..|....:..|  ||.:  .:...:|
 Frog   314 LDDHGDFNRMCIAMKKIGLDDTEKLDLFRVVAGVLHLGNIDFEEAGSTSG--GCTLRKKSSESLQ 376

  Fly   559 ETAQLLNM---EAQILIN---CLTRANSTNSAQEDVGCEMDARQAATNRNTLCRTLYSRLFTWLV 617
            ..|:||.:   :.|:.:.   .||.|..|....  :...:..:||...|:.|.:.:||.||..:|
 Frog   377 CCAKLLGLDQDDLQVSLTSRVMLTTAGGTKGTV--IKVPLKVQQAENARDALAKAIYSHLFDHVV 439

  Fly   618 NKINESLKSTQREKNLALLDFYGFEALDHNSFEQFAINYSAEKIHQNFVFHVLRSEQELYIREGL 682
            |::|:.....:....:.:||..|||..:|||||||.|||..||:.|.|...:|:.|||||.:|||
 Frog   440 NRVNQCFPFERSSFFIGVLDIAGFEYFEHNSFEQFCINYCNEKLQQFFNERILKEEQELYQKEGL 504

  Fly   683 EWSRIDYFDNESICELIDKPSYGILSLINE---------PHLNS--------NDALLLRVQQCCA 730
            ..:.:.|.||:...:||:....|||.:::|         .|..|        :..|.:..:...|
 Frog   505 GVNEVHYVDNQDCIDLIEAKLVGILDILDEENRLPQPTDQHFTSAVHQKHKNHFRLTIPRKSKLA 569

  Fly   731 GHPNFMTTGSNSMCFQIRHYASVVNYSIHRFLEKNSDMLPKYISAAFYQSKLSLVQSLFPEGNPR 795
            .|.|.    .:...|.:||:|..|.|...:|:|||:|.|...:.:...:||...|:.||...|..
 Frog   570 VHRNI----RDDEGFIVRHFAGAVCYETTQFVEKNNDALHMSLESLICESKDKFVRELFESANNH 630

  Fly   796 RQVTKKPSTLS-----SNIRTQLQTLLAIVKHRRSHYVFCIKPNEGKQPHQFDMALVQHQVRYMS 855
            :.:.:|...||     :..:|||..||..::...|.::.|||||.....|||:.|.:..|::...
 Frog   631 KDLKQKTGKLSFISVGNKFKTQLNLLLEKLRSTGSSFIRCIKPNLKMTSHQFEGAQILSQLQCSG 695

  Fly   856 LMPLVHLCRTGHCYHLLHVKFFHRYK-----LLNSLTWPHFHGGSQVEGIALIIRNLPLPSAEFT 915
            ::.::.|.:.|........:.::.||     .::.|....|        ...:.:.|.|...::.
 Frog   696 MVSVLDLMQGGFPSRASFHELYNMYKKYMPAKMSRLDPRLF--------CKALFKALGLNENDYK 752

  Fly   916 IGTKNVFVRSPRTVYELEQFRRLRISELAVLIQTMFRMYHARKRFQRMRHSQMIISSAWRTWREC 980
            .|...||.| |....|.:|..:.....||.||             :|:.|  .:|.|.|:..:.|
 Frog   753 FGLTKVFFR-PGKFAEFDQIMKSDPDHLAELI-------------RRVNH--WLICSRWKKVQWC 801

  Fly   981  980
             Frog   802  801

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Myo95E	NP_001027208.1	Motor_domain	3..>123	CDD:473979	39/114 (34%)
		Motor_domain	<403..937	CDD:473979	176/600 (29%)
		Myosin_TH1	1092..1288	CDD:461801
myo6	XP_031758531.1	Myosin_N	2..40	CDD:460670
		MYSc_Myo6	71..761	CDD:276833	215/972 (22%)
		CBD_MYO6-like	772..916	CDD:409646	10/45 (22%)
		MYO6_MIU_linker	1001..1074	CDD:412090
		MyUb_Myo6	1088..1128	CDD:439319
		Myosin-VI_CBD	1183..1273	CDD:465157