Protein Alignment Myo95E and MYO10

DIOPT Version :10

• Sequence 1: NP_001027208.1
• Gene: Myo95E / 2768680
• FlyBaseID: FBgn0039157
• Length: 1288
• Species: Drosophila melanogaster
• Sequence 2: NP_036466.2
• Gene: MYO10 / 4651
• HGNCID: 7593
• Length: 2058
• Species: Homo sapiens
• Alignment Length: 1057
• Identity: 263/1057 - (24%)
• Similarity: 412/1057 - (38%)
• Gaps: 343/1057 - (32%)

  Fly     4 EIGTWDSVLLENLSEDSFINNIHQRYKRDHIYTYIGTSVVALNPYHHISE-HSLDNVRNYGDKGI 67
            |.|..|...|..|...|.:.|:.|||||:.||||||:.:.::|||..|:. :....:..|..:.:
Human    62 EEGVDDMASLTELHGGSIMYNLFQRYKRNQIYTYIGSILASVNPYQPIAGLYEPATMEQYSRRHL 126

  Fly    68 FQLPPHIYGLTNLAYQSLKDQSEDQCVLLTGESGAGKTETFKMIVNFLTHIQDRSHCPPTPNVLR 132
            .:|||||:.:.|..|:.|..:.::||:|::|||||||||:.|:|:.||             :|:.
Human   127 GELPPHIFAIANECYRCLWKRHDNQCILISGESGAGKTESTKLILKFL-------------SVIS 178

  Fly   133 KQSSTSSASGLVMHAHRRASSSCSGTANFIICKNRAENPSGSVSRRQSPSPGPSQRSRTRAESIE 197
            :||...|
Human   179 QQSLELS---------------------------------------------------------- 185

  Fly   198 RQSRRHMREKIVDFDFSHHKSSENISGLPESHAHHMHPTKSCFKHQQTQVSACTAMPAAAKGSPK 262
                  ::||
Human   186 ------LKEK------------------------------------------------------- 189

  Fly   263 YAVPTVYGGCRQCGHSKCVRAQSLEKEERDDLRGSNCRLSTIATATTNPAHPHRGSCSNLMRQHS 327
                           :.||....||
Human   190 ---------------TSCVERAILE---------------------------------------- 199

  Fly   328 TESQPERERDRSSLMGSTQRISLYDAHKLSKVLGDLPPPPPSSVSPTPSASSSLHRRHKSPTQRM 392
                                                                      .||
Human   200 ----------------------------------------------------------SSP---- 202

  Fly   393 RECVTCADVFLEAMGNACTLKNNNSSRYGKLFDIEIDFKGDPMGVHITHYMLEKTRITDPIIGER 457
                     .:||.|||.|:.||||||:||...:.|..||:..|..|..|:|||.|:.....|||
Human   203 ---------IMEAFGNAKTVYNNNSSRFGKFVQLNICQKGNIQGGRIVDYLLEKNRVVRQNPGER 258

  Fly   458 NFHIFYQLLLGADLQLLKSLKLYRNVEKYELLRNTTAMEE----DRMNFHYTKRSLDVLGLSCEE 518
            |:||||.||.|.:.:..:...| ...|.|..|..:..:|:    |:.:|.....::||:..|.||
Human   259 NYHIFYALLAGLEHEEREEFYL-STPENYHYLNQSGCVEDKTISDQESFREVITAMDVMQFSKEE 322

  Fly   519 SNSIFRVIAVVLKLGNFIFVPITNIDGTEGCQVSNVYEVQETAQLLNMEAQILINCLTRANSTNS 583
            ...:.|::|.:|.|||..|:.      ..|.|||....:..:|:||.::...|.:.||: .|...
Human   323 VREVSRLLAGILHLGNIEFIT------AGGAQVSFKTALGRSAELLGLDPTQLTDALTQ-RSMFL 380

  Fly   584 AQEDVGCEMDARQAATNRNTLCRTLYSRLFTWLVNKINESLKSTQREKNLALLDFYGFEALDHNS 648
            ..|::...::.:||..:|::|...||:..|.|::.|||..:|..:..|::.:||.:|||..:.|.
Human   381 RGEEILTPLNVQQAVDSRDSLAMALYACCFEWVIKKINSRIKGNEDFKSIGILDIFGFENFEVNH 445

  Fly   649 FEQFAINYSAEKIHQNFVFHVLRSEQELYIREGLEWSRIDYFDNESICELIDKPSYGILSLIN-E 712
            ||||.|||:.||:.:.|..|:...||..|.||||.|..||:.||....:||:| ..|:|:||| |
Human   446 FEQFNINYANEKLQEYFNKHIFSLEQLEYSREGLVWEDIDWIDNGECLDLIEK-KLGLLALINEE 509

  Fly   713 PHL-NSNDALLLRVQQCCAGHPN---FMTTGSNSMCFQIRHYASVVNYSIHRFLEKNSDMLPKYI 773
            .|. .:.|:.||  ::..:.|.|   ::........|.::|||..|.|.:...||||.|.....:
Human   510 SHFPQATDSTLL--EKLHSQHANNHFYVKPRVAVNNFGVKHYAGEVQYDVRGILEKNRDTFRDDL 572

  Fly   774 SAAFYQSKLSLVQSLFPEGNPR-RQVT-------KKPSTLSSNIRTQLQTLLAIVKHRRSHYVFC 830
            .....:|:...:..||...:.| .|.|       ::| |:||..:..|.:|:|.:......:|.|
Human   573 LNLLRESRFDFIYDLFEHVSSRNNQDTLKCGSKHRRP-TVSSQFKDSLHSLMATLSSSNPFFVRC 636

  Fly   831 IKPNEGKQPHQFDMALVQHQVRYMSLMPLVHLCRTGHCYHLLHVKFFHRYKLLNSLTWPHFHGGS 895
            ||||..|.|.|||.|:|.:|:||..::..|.:.:.|:........|:.|||:|
Human   637 IKPNMQKMPDQFDQAVVLNQLRYSGMLETVRIRKAGYAVRRPFQDFYKRYKVL------------ 689

  Fly   896 QVEGIALIIRNLPLP-----------------SAEFTIGTKNVFVRSPRTVYELEQFRRLRISEL 943
                    :|||.||                 ::|:.:|...||:|. ....:||:.|...:|..
Human   690 --------MRNLALPEDVRGKCTSLLQLYDASNSEWQLGKTKVFLRE-SLEQKLEKRREEEVSHA 745

  Fly   944 AVLIQTMFRMYHARKRFQRMRHSQMIISSAWRTWRECRFGIPFTGRRHLWSLYRVAREEYRSLKY 1008
            |::|:.....:.|||:::::.:..:||...:|.         |..||....|.:.|      :.:
Human   746 AMVIRAHVLGFLARKQYRKVLYCVVIIQKNYRA---------FLLRRRFLHLKKAA------IVF 795

  Fly  1009 KRQVRWAIDIIGRYYRQ 1025
            ::|:|.  .|..|.|||
Human   796 QKQLRG--QIARRVYRQ 810

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Myo95E	NP_001027208.1	Motor_domain	3..>123	CDD:473979	47/119 (39%)
		Motor_domain	<403..937	CDD:473979	182/567 (32%)
		Myosin_TH1	1092..1288	CDD:461801
MYO10	NP_036466.2	SH3_19	7..58	CDD:465815
		MYSc_Myo10	77..727	CDD:276840	233/939 (25%)
		Actin-binding. /evidence=ECO:0000255|PROSITE-ProRule:PRU00782	619..641		8/21 (38%)
		SMC_N	727..>958	CDD:481474	25/102 (25%)
		SAH. /evidence=ECO:0000269|PubMed:23012428	814..883
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	819..840
		PTZ00108	<846..1161	CDD:240271
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	847..866
		DUF5401	<848..967	CDD:375164
		MYO10_CC	883..933	CDD:465249
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	964..1090
		PH-like	1181..>1223	CDD:473070
		PH2_MyoX	1215..1316	CDD:270108
		PH3_MyoX-like	1381..1506	CDD:270109
		MyTH4	1549..1695	CDD:214535
		FERM_F1_Myosin-X	1697..1792	CDD:340726
		B41	1704..1958	CDD:214604
		FERM_C_MyoX	1954..2042	CDD:270023