Protein Alignment Myo95E and MYO9A

DIOPT Version :10

• Sequence 1: NP_001027208.1
• Gene: Myo95E / 2768680
• FlyBaseID: FBgn0039157
• Length: 1288
• Species: Drosophila melanogaster
• Sequence 2: XP_011519915.1
• Gene: MYO9A / 4649
• HGNCID: 7608
• Length: 2638
• Species: Homo sapiens
• Alignment Length: 1319
• Identity: 247/1319 - (18%)
• Similarity: 408/1319 - (30%)
• Gaps: 591/1319 - (44%)

  Fly     9 DSVLLENLSEDSFINNIHQRYKRDHIYTYIGTSVVALNPYHHISEHSLDNVRNYGDKGIFQLPPH 73
            |...|.:|:|.:.:.|:..|:|.:.||||:|:.::.:||:..:..::...|:.|.:..:.:|.||
Human   150 DLCSLPDLNEKTLLENLRNRFKHEKIYTYVGSILIVINPFKFLPIYNPKYVKMYDNHQLGKLEPH 214

  Fly    74 IYGLTNLAYQSLKDQSEDQCVLLTGESGAGKTETFKMIVNFLTHIQDRSHCPPTPNVLRKQSSTS 138
            ||.:.::||.::..:.::||::::||||:|||::    .|||.|     |       |...|...
Human   215 IYAVADVAYHAMLQRKKNQCIVISGESGSGKTQS----TNFLIH-----H-------LTALSQKG 263

  Fly   139 SASGLVMHAHRRASSSCSGTANFIICKNRAENPSGSVSRRQSPSPGPSQRSRTRAESIERQSRRH 203
            .|||:
Human   264 FASGV------------------------------------------------------------ 268

  Fly   204 MREKIVDFDFSHHKSSENISGLPESHAHHMHPTKSCFKHQQTQVSACTAMPAAAKGSPKYAVPTV 268
              |:|
Human   269 --EQI------------------------------------------------------------ 271

  Fly   269 YGGCRQCGHSKCVRAQSLEKEERDDLRGSNCRLSTIATATTNPAHPHRGSCSNLMRQHSTESQPE 333
                                                                             
Human   272 ----------------------------------------------------------------- 271

  Fly   334 RERDRSSLMGSTQRISLYDAHKLSKVLGDLPPPPPSSVSPTPSASSSLHRRHKSPTQRMRECVTC 398
                                     :||
Human   272 -------------------------ILG------------------------------------- 274

  Fly   399 ADVFLEAMGNACTLKNNNSSRYGKLFDIEIDFKGDPMGVHITHYMLEKTRITDPIIGERNFHIFY 463
            |...|||.|||.|..||||||:||...:.....|..:|.::..|:|||:|:......|||:|:||
Human   275 AGPVLEAFGNAKTAHNNNSSRFGKFIQVNYQETGTVLGAYVEKYLLEKSRLVYQEHNERNYHVFY 339

  Fly   464 QLLLGADLQLLKSLKLYRNVEKYELLRNTTAM----------------------EEDRMNFHYTK 506
            .||.||......:..| :..|:|..|...|..                      |:.|.:|...:
Human   340 YLLAGASEDERSAFHL-KQPEEYHYLNQITKKPLRQSWDDYCYDSEPDCFTVEGEDLRHDFERLQ 403

  Fly   507 RSLDVLGLSCEESNSIFRVIAVVLKLGNFIFVPITNIDGTEGCQVSNVYEVQETAQLLNMEAQIL 571
            .:::::|...:....||.:::.:|.|||..:...|..|  :...:.|...:...::||.::.::|
Human   404 LAMEMVGFLPKTRRQIFSLLSAILHLGNICYKKKTYRD--DSIDICNPEVLPIVSELLEVKEEML 466

  Fly   572 INCLTRANSTNSAQEDVGCEMDARQAATNRNTLCRTLYSRLFTWLVNKINES-LKSTQREKN--- 632
            ...|. ...|.:..|.:.......:|.|.||::.::|||.||.|:|.:||.: |.|...|.|
Human   467 FEALV-TRKTVTVGEKLILPYKLAEAVTVRNSMAKSLYSALFDWIVFRINHALLNSKDLEHNTKT 530

  Fly   633 --LALLDFYGFEALDHNSFEQFAINYSAEKIHQNFVFHVLRSEQELYIREGLEWSRIDYFDNESI 695
              :.:||.:|||..::||||||.||::.|::...|..|:.:.|||.|..||:.|..|||.||...
Human   531 LSIGVLDIFGFEDYENNSFEQFCINFANERLQHYFNQHIFKLEQEEYRTEGISWHNIDYIDNTCC 595

  Fly   696 CELIDKPSYGILSLINE----PHLNSNDALLLRVQQCCAGHPNFMTTGSNSMCFQIRHYASVVNY 756
            ..||.|...|:|.|::|    |.. :|..||.:.:.....:............|.|:|||..|.|
Human   596 INLISKKPTGLLHLLDEESNFPQA-TNQTLLDKFKHQHEDNSYIEFPAVMEPAFIIKHYAGKVKY 659

  Fly   757 SIHRFLEKNSD-MLPKYIS---------------------------AAFY--------------- 778
            .:..|.|||:| |.|..::                           .||:
Human   660 GVKDFREKNTDHMRPDIVALLRSSKNAFISGMIGIDPVAVFRWAILRAFFRAMVAFREAGKRNIH 724

  Fly   779 ----------------------------------------------------------------- 778
                                                                             
Human   725 RKTGHDDTAPCAILKSMDSFSFLQHPVHQRSLEILQRCKEEKYSITRKNPRTPLSDLQGMNALNE 789

  Fly   779 ------------------QSKLSLVQSLFP----------------------------------- 790
                              ||:||...||..
Human   790 KNQHDTFDIAWNGRTGIRQSRLSSGTSLLDKDGIFANSTSSKLLERAHGILTRNKNFKSKPALPK 854

  Fly   791 ---EGNPRRQVT------------------KKPSTLSSNIRTQLQTLLAIVKHRRSHYVFCIKPN 834
               |.|..:.:|                  |||.::|:..:..|..|:..:.....::|.||:.|
Human   855 HLLEVNSLKHLTRLTLQDRITKSLLHLHKKKKPPSISAQFQASLSKLMETLGQAEPYFVKCIRSN 919

  Fly   835 EGKQPHQFDMALVQHQVRYMSLMPLVHLCRTGHCYHLLHVKFFHRYKLLNSLTWPHFHGGSQVEG 899
            ..|.|.:|...||..|:||..::..|.:.::|         :..:|...:.::  |||
Human   920 AEKLPLRFSDVLVLRQLRYTGMLETVRIRQSG---------YSSKYSFQDFVS--HFH------- 966

  Fly   900 IALIIRNLPLPSA---------------EFTIGTKNVFVRSPRTVYELEQFRRLRISELAVLIQT 949
             .|:.||: :||.               .:.:|...||::.....: |:......:....:|:|.
Human   967 -VLLPRNI-IPSKFNIQDFFRKINLNPDNYQVGKTMVFLKEQERQH-LQDLLHQEVLRRIILLQR 1028

  Fly   950 MFRMYHARKRFQRMRHSQMIISSAWRTW---RECRFG---------------IPFTGRRHLWSLY 996
            .||:...|:.|..:|.:.:||...||.:   ::.|..               :..:.|.||
Human  1029 WFRVLLCRQHFLHLRQASVIIQRFWRNYLNQKQVRDAAVQKDAFVMASAAALLQASWRAHL---- 1089

  Fly   997 RVAREEYRSLKYKR---QVRWAIDIIGRYYRQWKIRQFLLTIPLRLPPNTLSPLSTEWPVAPAFL 1058
              .|:.|..|:...   |.:|.     .|||:
Human  1090 --ERQRYLELRAAAIVIQQKWR-----DYYRR--------------------------------- 1114

  Fly  1059 ADASRHLRS--IYHRWKCY 1075
                ||:.:  |..|||.|
Human  1115 ----RHMAAICIQARWKAY 1129

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Myo95E	NP_001027208.1	Motor_domain	3..>123	CDD:473979	36/113 (32%)
		Motor_domain	<403..937	CDD:473979	170/762 (22%)
		Myosin_TH1	1092..1288	CDD:461801
MYO9A	XP_011519915.1	RA_Myosin-IXa	15..110	CDD:340736
		MYSc_Myo9	160..1004	CDD:276836	212/1133 (19%)
		C1_Myosin-IXa	2067..2124	CDD:410433
		RhoGAP_myosin_IX	2133..2318	CDD:239842