DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Myo95E and MYO6

DIOPT Version :9

Sequence 1:	NP_001027208.1	Gene:	Myo95E / 2768680	FlyBaseID:	FBgn0039157	Length:	1288	Species:	Drosophila melanogaster
Sequence 2:	NP_001355794.1	Gene:	MYO6 / 4646	HGNCID:	7605	Length:	1294	Species:	Homo sapiens

Alignment Length:	1085	Identity:	231/1085 - (21%)
Similarity:	383/1085 - (35%)	Gaps:	385/1085 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 DSVLLENLSEDSFINNIHQRYKRDHIYTYIGTSVVALNPYHHISE-HSLDNVRNYGDKGIFQLPP 72
            |:..|..|:|.:.::||..||.:|.||||:...::|:|||..|.: :|.:.:::|..|.:...||
Human    61 DNCSLMYLNEATLLHNIKVRYSKDRIYTYVANILIAVNPYFDIPKIYSSEAIKSYQGKSLGTRPP 125

  Fly    73 HIYGLTNLAYQSLKDQSEDQCVLLTGESGAGKTETFKMIVNFLTHIQDRSHCPPTPNVLRKQSST 137
            |::.:.:.|::.:|.....|.::::|||||||||..|.::.:||.
Human   126 HVFAIADKAFRDMKVLKMSQSIIVSGESGAGKTENTKFVLRYLTE-------------------- 170

  Fly   138 SSASGLVMHAHRRASSSCSGTANFIICKNRAENPSGSVSRRQSPSPGPSQRSRTRAESIERQSRR 202
                                                        |.|..|
Human   171 --------------------------------------------SYGTGQ--------------- 176

  Fly   203 HMREKIVDFDFSHHKSSENISGLPESHAHHMHPTKSCFKHQQTQVSACTAMPAAAKGSPKYAVPT 267
                   |.|
Human   177 -------DID------------------------------------------------------- 179

  Fly   268 VYGGCRQCGHSKCVRAQSLEKEERDDLRGSNCRLSTIATATTNPAHPHRGSCSNLMRQHSTESQP 332

Human   180 ----------------------------------------------------------------- 179

  Fly   333 ERERDRSSLMGSTQRISLYDAHKLSKVLGDLPPPPPSSVSPTPSASSSLHRRHKSPTQRMRECVT 397
                ||                                                         :.
Human   180 ----DR---------------------------------------------------------IV 183

  Fly   398 CADVFLEAMGNACTLKNNNSSRYGKLFDIEIDFKGDPMGVHITHYMLEKTRITDPIIGERNFHIF 462
            .|:..|||.|||.|::||||||:||..:|..:.|...:|..::||:|||:||......|||:|||
Human   184 EANPLLEAFGNAKTVRNNNSSRFGKFVEIHFNEKSSVVGGFVSHYLLEKSRICVQGKEERNYHIF 248

  Fly   463 YQLLLGADLQLLKSLK---------LYRNVEKY--------ELLRNTTAME------------ED 498
            |:|..||...:.:.|.         |.|...:|        ::|:|..:.|            :|
Human   249 YRLCAGASEDIREKLHLSSPDNFRYLNRGCTRYFANKETDKQILQNRKSPEYLKAGSMKDPLLDD 313

  Fly   499 RMNFHYTKRSLDVLGLSCEESNSIFRVIAVVLKLGNFIFVPITNIDGTEGCQVSN--VYEVQETA 561
            ..:|.....::..:||..||...:|||:|.||.|||..|....:..|  ||.:.|  ...::..|
Human   314 HGDFIRMCTAMKKIGLDDEEKLDLFRVVAGVLHLGNIDFEEAGSTSG--GCNLKNKSAQSLEYCA 376

  Fly   562 QLLNMEAQIL-INCLTRANSTNSAQED---VGCEMDARQAATNRNTLCRTLYSRLFTWLVNKINE 622
            :||.::...| ::..||...|.:....   :...:...||...|:.|.:|:||.||..:||::|:
Human   377 ELLGLDQDDLRVSLTTRVMLTTAGGTKGTVIKVPLKVEQANNARDALAKTVYSHLFDHVVNRVNQ 441

  Fly   623 SLKSTQREKNLALLDFYGFEALDHNSFEQFAINYSAEKIHQNFVFHVLRSEQELYIREGLEWSRI 687
            ..........:.:||..|||..:|||||||.|||..||:.|.|...:|:.|||||.:|||..:.:
Human   442 CFPFETSSYFIGVLDIAGFEYFEHNSFEQFCINYCNEKLQQFFNERILKEEQELYQKEGLGVNEV 506

  Fly   688 DYFDNESICELIDKPSYGILSLINEP---------------HLNSNDALLLRV--QQCCAGHPNF 735
            .|.||:...:||:....|||.:::|.               |....|...|.:  :...|.|.|.
Human   507 HYVDNQDCIDLIEAKLVGILDILDEENRLPQPSDQHFTSAVHQKHKDHFRLTIPRKSKLAVHRNI 571

  Fly   736 MTTGSNSMCFQIRHYASVVNYSIHRFLEKNSDMLPKYISAAFYQSKLSLVQSLFPEGNPRRQVTK 800
                .:...|.|||:|..|.|...:|:|||:|.|...:.:...:|:...::.||.......:.||
Human   572 ----RDDEGFIIRHFAGAVCYETTQFVEKNNDALHMSLESLICESRDKFIRELFESSTNNNKDTK 632

  Fly   801 KPS------TLSSNIRTQLQTLLAIVKHRRSHYVFCIKPNEGKQPHQFDMALVQHQVRYMSLMPL 859
            :.:      ::.:..:|||..||..::...:.::.|||||.....|.|:.|.:..|::...::.:
Human   633 QKAGKLSFISVGNKFKTQLNLLLDKLRSTGASFIRCIKPNLKMTSHHFEGAQILSQLQCSGMVSV 697

  Fly   860 VHLCRTGHCYHLLHVKFFHRYK-----LLNSLTWPHFHGGSQVEGIALIIRNLPLPSAEFTIGTK 919
            :.|.:.|:.......:.::.||     .|..|....|        ...:.:.|.|...::..|..
Human   698 LDLMQGGYPSRASFHELYNMYKKYMPDKLARLDPRLF--------CKALFKALGLNENDYKFGLT 754

  Fly   920 NVFVRSPRTVYELEQFRRLRISELAVLIQTMFRMYHARKRFQRMRHSQMIISSAWRTWRECRFGI 984
            .||.| |....|.:|..:.....||.|:             :|:.|  .:..|.|:..:.|...:
Human   755 KVFFR-PGKFAEFDQIMKSDPDHLAELV-------------KRVNH--WLTCSRWKKVQWCSLSV 803

  Fly   985 PFTGRRHLWSLYRVAREEYRSLKYKRQVRWAIDI---IGRYYRQW 1026
                                 :|.|.::::..:.   :.:..|.|
Human   804 ---------------------IKLKNKIKYRAEACIKMQKTIRMW 827

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Myo95E	NP_001027208.1	Motor_domain	19..>118	CDD:277568	35/99 (35%)
		Motor_domain	403..924	CDD:277568	168/583 (29%)
		Myosin_TH1	1092..1267	CDD:283635
MYO6	NP_001355794.1	MYSc_Myo6	71..759	CDD:276833	211/968 (22%)
		Responsible for slow ATPase activity. /evidence=ECO:0000250\|UniProtKB:Q29122	273..317		7/43 (16%)
		Actin-binding. /evidence=ECO:0000255	665..672		3/6 (50%)
		Required for binding calmodulin. /evidence=ECO:0000250\|UniProtKB:Q29122	782..810		7/50 (14%)
		SMC_prok_B	<800..>1039	CDD:274008	4/49 (8%)
		Three-helix bundle. /evidence=ECO:0000250\|UniProtKB:Q29122	835..916
		SAH. /evidence=ECO:0000269\|PubMed:18511944	917..984
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	934..955
		Interaction with OPTN. /evidence=ECO:0000250\|UniProtKB:Q9I8D1	1116..1118
		Myosin-VI_CBD	1177..1267	CDD:339762
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D122881at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.920