DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Myo95E and MYO1E

DIOPT Version :9

Sequence 1:	NP_001027208.1	Gene:	Myo95E / 2768680	FlyBaseID:	FBgn0039157	Length:	1288	Species:	Drosophila melanogaster
Sequence 2:	NP_004989.2	Gene:	MYO1E / 4643	HGNCID:	7599	Length:	1108	Species:	Homo sapiens

Alignment Length:	1340	Identity:	295/1340 - (22%)
Similarity:	498/1340 - (37%)	Gaps:	488/1340 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 GTWDSVLLENLSEDSFINNIHQRYKRDHIYTYIGTSVVALNPYHHISEHSLDNVRNYGDKGIFQL 70
            |..|.|||..::|:|.:.|:.:||..|:|:||||:.::::||:..:.......:..|.....::.
Human    20 GVDDMVLLSKITENSIVENLKKRYMDDYIFTYIGSVLISVNPFKQMPYFGEKEIEMYQGAAQYEN 84

  Fly    71 PPHIYGLTNLAYQSLKDQSEDQCVLLTGESGAGKTETFKMIVNFLTHIQDRSHCPPTPNVLRKQS 135
            |||||.|.:..|:::....|:|||:::||||||||...|.|:::::.:.
Human    85 PPHIYALADNMYRNMIIDRENQCVIISGESGAGKTVAAKYIMSYISRVS---------------- 133

  Fly   136 STSSASGLVMHAHRRASSSCSGTANFIICKNRAENPSGSVSRRQSPSPGPSQRSRTRAESIERQS 200

Human   134 ----------------------------------------------------------------- 133

  Fly   201 RRHMREKIVDFDFSHHKSSENISGLPESHAHHMHPTKSCFKHQQTQVSACTAMPAAAKGSPKYAV 265

Human   134 ----------------------------------------------------------------- 133

  Fly   266 PTVYGGCRQCGHSKCVRAQSLEKEERDDLRGSNCRLSTIATATTNPAHPHRGSCSNLMRQHSTES 330
                ||..:..|.|.:..||                        ||
Human   134 ----GGGTKVQHVKDIILQS------------------------NP------------------- 151

  Fly   331 QPERERDRSSLMGSTQRISLYDAHKLSKVLGDLPPPPPSSVSPTPSASSSLHRRHKSPTQRMREC 395

Human   152 ----------------------------------------------------------------- 151

  Fly   396 VTCADVFLEAMGNACTLKNNNSSRYGKLFDIEIDFKGDPMGVHITHYMLEKTRITDPIIGERNFH 460
                  .|||.|||.|::||||||:||.|:|:....|:|.|..|::::|||:|:.....|||:||
Human   152 ------LLEAFGNAKTVRNNNSSRFGKYFEIQFSPGGEPDGGKISNFLLEKSRVVMRNPGERSFH 210

  Fly   461 IFYQLLLGADLQLLKSLKLYRNVEKYELLRNTTAME----EDRMNFHYTKRSLDVLGLSCEESNS 521
            |||||:.||..:...||.: .:::.|..|..:.:.:    :||..|..|..:::|:|:..||...
Human   211 IFYQLIEGASAEQKHSLGI-TSMDYYYYLSLSGSYKVDDIDDRREFQETLHAMNVIGIFAEEQTL 274

  Fly   522 IFRVIAVVLKLGNFIFVPITNIDGTEGCQVSNVYEVQETAQLLNMEAQIL-INCLTRANSTNSAQ 585
            :.:::|.:|.|||..|..:.|            |...|:.:.|...|.:| ||.........|.|
Human   275 VLQIVAGILHLGNISFKEVGN------------YAAVESEEFLAFPAYLLGINQDRLKEKLTSRQ 327

  Fly   586 ---------EDVGCEMDARQAATNRNTLCRTLYSRLFTWLVNKINESLKSTQREKNLALLDFYGF 641
                     |.:...::..||...|:.|.:.|::|:|.:||:.||::::....|.|:.:||.|||
Human   328 MDSKWGGKSESIHVTLNVEQACYTRDALAKALHARVFDFLVDSINKAMEKDHEEYNIGVLDIYGF 392

  Fly   642 EALDHNSFEQFAINYSAEKIHQNFVFHVLRSEQELYIREGLEWSRIDYFDNESICELID---KPS 703
            |....|.||||.||:..||:.|.|:...|::|||.|::||:.|:.|:||:|:.:|:||:   .|.
Human   393 EIFQKNGFEQFCINFVNEKLQQIFIELTLKAEQEEYVQEGIRWTPIEYFNNKIVCDLIENKVNPP 457

  Fly   704 YGILSLINE----PHL---NSNDALLLRVQQCCAGHPNFMTTGSNSMCFQIRHYASVVNYSIHRF 761
             ||:|::::    .|.   .::..||.::|.....|.:|   .|.:..|.|.|||..|:|.:..|
Human   458 -GIMSILDDVCATMHAVGEGADQTLLQKLQMQIGSHEHF---NSWNQGFIIHHYAGKVSYDMDGF 518

  Fly   762 LEKNSDMLPKYISAAFYQSKLSLVQSLFPEGNPRRQVTKK--PSTLSSNIRTQLQTLLAIVKHRR 824
            .|:|.|:|...:......|:|..::|||||   ..|..||  |:|..|.|:.|...|::.:....
Human   519 CERNRDVLFMDLIELMQSSELPFIKSLFPE---NLQADKKGRPTTAGSKIKKQANDLVSTLMKCT 580

  Fly   825 SHYVFCIKPNEGKQPHQFDMALVQHQVRYMSLMPLVHLCRTGHCYHLLHVKFFHRYKLLNSLTWP 889
            .||:.||||||.|:|..::.:.|:|||.|:.|...:.:.|.|:.|..:..||..||.:|...|||
Human   581 PHYIRCIKPNETKKPRDWEESRVKHQVEYLGLKENIRVRRAGYAYRRIFQKFLQRYAILTKATWP 645

  Fly   890 HFHGGSQVEGIALIIRNLPLPSAEFTIGTKNVFVRSPRTVYELEQFRRLRISELAVLIQTMFRMY 954
            .:. |.:.:|:..:::::.:.|.:|.:|...||:::|.:::.||:.|..:....|.:||..:|.:
Human   646 SWQ-GEEKQGVLHLLQSVNMDSDQFQLGRSKVFIKAPESLFLLEEMRERKYDGYARVIQKSWRKF 709

  Fly   955 HARKRFQRMRHSQMIISSAWRTWRECRFGIPFTGRRHLWSLYRVAREEYRSLKYKRQVRWAIDII 1019
            .|||::.:|                                    |||
Human   710 VARKKYVQM------------------------------------REE----------------- 721

  Fly  1020 GRYYRQWKIRQFLLTIPLRLPPNTLSPLSTEWPVAPAFLADASRHLRSIYHRWKCYIYRNSFDQT 1084

Human   722 ----------------------------------------------------------------- 721

  Fly  1085 ARNRMREKVTASIIFKDRKASYGRSVGHPFVGDYVRLRHNQQWKKICAETNDQYVVFADIINKIA 1149
                      ||.:..::|.....|:...|:|||:.:..:.:.::...:.  :.:.|||.:.|..
Human   722 ----------ASDLLLNKKERRRNSINRNFIGDYIGMEEHPELQQFVGKR--EKIDFADTVTKYD 774

  Fly  1150 RSSGKFVPILLVLSTSSLLLLDQRTLQ-----------IKYRVPASEIYRMSLSPYLDDIAVFHV 1203
            |.. |.|...|:|:...|.|:.:..::           :|.::....|..:|||...|||.:.|.
Human   775 RRF-KGVKRDLLLTPKCLYLIGREKVKQGPDKGLVKEVLKRKIEIERILSVSLSTMQDDIFILHE 838

  Fly  1204 KASEFGRKKGDFVFQTGHVIEIVTKMFLVIQNATGKPPEIHISTEFEANF-----------GQQT 1257
            :..:   ...:.||:| ..:.::.|.:   :..|.|...:..|...|...           |.:.
Human   839 QEYD---SLLESVFKT-EFLSLLAKRY---EEKTQKQLPLKFSNTLELKLKKENWGPWSAGGSRQ 896

  Fly  1258 VIFSFKYGGMSDLA--------------QGPPKVTRKANR 1283
            |.|   :.|..|||              .|.||.:|...|
Human   897 VQF---HQGFGDLAVLKPSNKVLQVSIGPGLPKNSRPTRR 933

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Myo95E	NP_001027208.1	Motor_domain	19..>118	CDD:277568	34/98 (35%)
		Motor_domain	403..924	CDD:277568	184/546 (34%)
		Myosin_TH1	1092..1267	CDD:283635	39/196 (20%)
MYO1E	NP_004989.2	MYSc	14..692	CDD:214580	235/956 (25%)
		MYSc_Myo1	33..679	CDD:276829	226/930 (24%)
		Actin-binding. /evidence=ECO:0000255	581..591		6/9 (67%)
		Myosin_TH1	719..902	CDD:283635	42/287 (15%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	919..966		5/15 (33%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	993..1053
		SH3_MyoIe_If_like	1056..1107	CDD:212761
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D122881at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100187
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.820