Protein Alignment Myo95E and MYO1D

DIOPT Version :10

• Sequence 1: NP_001027208.1
• Gene: Myo95E / 2768680
• FlyBaseID: FBgn0039157
• Length: 1288
• Species: Drosophila melanogaster
• Sequence 2: NP_056009.1
• Gene: MYO1D / 4642
• HGNCID: 7598
• Length: 1006
• Species: Homo sapiens
• Alignment Length: 1246
• Identity: 299/1246 - (23%)
• Similarity: 510/1246 - (40%)
• Gaps: 376/1246 - (30%)

  Fly     4 EIGTWDSVLLENLSEDSFINNIHQRYKRDHIYTYIGTSVVALNPYHHISEHSLDNVRNYGDKGIF 68
            |.|..|.||::.:|...|:.|:..|:::..|||:||..||::|||..::.:..|.:..|..:.::
Human     8 EFGKADFVLMDTVSMPEFMANLRLRFEKGRIYTFIGEVVVSVNPYKLLNIYGRDTIEQYKGRELY 72

  Fly    69 QLPPHIYGLTNLAYQSLKDQSEDQCVLLTGESGAGKTETFKMIVNFLTHIQDRSHCPPTPNVLRK 133
            :.|||::.:.:.||:::|.:|:|.|::::|||||||||..|.|:.::..|.:
Human    73 ERPPHLFAIADAAYKAMKRRSKDTCIVISGESGAGKTEASKYIMQYIAAITN------------- 124

  Fly   134 QSSTSSASGLVMHAHRRASSSCSGTANFIICKNRAENPSGSVSRRQSPSPGPSQRSRTRAESIER 198
                                                               ||||:
Human   125 ---------------------------------------------------PSQRA--------- 129

  Fly   199 QSRRHMREKIVDFDFSHHKSSENISGLPESHAHHMHPTKSCFKHQQTQVSACTAMPAAAKGSPKY 263
                                                                             
Human   130 ----------------------------------------------------------------- 129

  Fly   264 AVPTVYGGCRQCGHSKCVRAQSLEKEERDDLRGSNCRLSTIATATTNPAHPHRGSCSNLMRQHST 328
                                                                             
Human   130 ----------------------------------------------------------------- 129

  Fly   329 ESQPERERDRSSLMGSTQRISLYDAHKLSKVLGDLPPPPPSSVSPTPSASSSLHRRHKSPTQRMR 393
                |.||.::.|:.|
Human   130 ----EVERVKNMLLKS------------------------------------------------- 141

  Fly   394 ECVTCADVFLEAMGNACTLKNNNSSRYGKLFDIEIDFKGDPMGVHITHYMLEKTRITDPIIGERN 458
            .||      |||.|||.|.:|:||||:||..||..||||||:|.||.:|:|||:|:.....|||:
Human   142 NCV------LEAFGNAKTNRNDNSSRFGKYMDINFDFKGDPIGGHINNYLLEKSRVIVQQPGERS 200

  Fly   459 FHIFYQLLLGADLQLLKSLKLYRNVEKYELLRNTTAME---EDRMNFHYTKRSLDVLGLSCEESN 520
            ||.|||||.|...|:|:||.|.:::..|..:.....::   .|...|.....::.|:|...||..
Human   201 FHSFYQLLQGGSEQMLRSLHLQKSLSSYNYIHVGAQLKSSINDAAEFRVVADAMKVIGFKPEEIQ 265

  Fly   521 SIFRVIAVVLKLGNFIFVPITNIDGTEGCQVSNVYEVQETAQLLNMEAQILINCLTRANSTNSAQ 585
            ::::::|.:|.|||..||    :|| :...:.|...|...|:||:.:..::...|. ..:..:.:
Human   266 TVYKILAAILHLGNLKFV----VDG-DTPLIENGKVVSIIAELLSTKTDMVEKALL-YRTVATGR 324

  Fly   586 EDVGCEMDARQAATNRNTLCRTLYSRLFTWLVNKINESLK-----STQREKN--LALLDFYGFEA 643
            :.:..:...::|:..|:...:.:|.|||.|:|.:||:.::     :|...||  :.:||.||||.
Human   325 DIIDKQHTEQEASYGRDAFAKAIYERLFCWIVTRINDIIEVKNYDTTIHGKNTVIGVLDIYGFEI 389

  Fly   644 LDHNSFEQFAINYSAEKIHQNFVFHVLRSEQELYIREGLEWSRIDYFDNESICELIDKPSYGILS 708
            .|:||||||.|||..||:.|.|:..||:.|||.|.|||:.|..||||:|:.|.:|:::...||::
Human   390 FDNNSFEQFCINYCNEKLQQLFIQLVLKQEQEEYQREGIPWKHIDYFNNQIIVDLVEQQHKGIIA 454

  Fly   709 LINEPHLN---SNDALLLRVQQCCAG-HPNFMTTGSNSMC-----------FQIRHYASVVNYSI 758
            ::::..:|   ..|.:.|.......| |.:|   .|..:|           |:|||||..|.||:
Human   455 ILDDACMNVGKVTDEMFLEALNSKLGKHAHF---SSRKLCASDKILEFDRDFRIRHYAGDVVYSV 516

  Fly   759 HRFLEKNSDMLPKYISAAFYQSKLSLVQSLFPEGN-PRRQVTKKPSTLSSNIRTQLQTLLAIVKH 822
            ..|::||.|.|.:......|.|...::::::|||. ...:|||:|.|.::..:..:..|:..:..
Human   517 IGFIDKNKDTLFQDFKRLMYNSSNPVLKNMWPEGKLSITEVTKRPLTAATLFKNSMIALVDNLAS 581

  Fly   823 RRSHYVFCIKPNEGKQPHQFDMALVQHQVRYMSLMPLVHLCRTGHCYHLLHVKFFHRYKLLNSLT 887
            :..:||.|||||:.|.|..||....:|||.|:.|:..|.:.|.|..:...:.||.||||:::..|
Human   582 KEPYYVRCIKPNDKKSPQIFDDERCRHQVEYLGLLENVRVRRAGFAFRQTYEKFLHRYKMISEFT 646

  Fly   888 WPHFHGGSQVEGIALIIRNLPLPSAEFTIGTKNVFVRSPRTVYELEQFRRLRISELAVLIQTMFR 952
            ||:....|..|.:..:|....... :...|...:|:|:|||::.||:.|...:..:.:.:|.::|
Human   647 WPNHDLPSDKEAVKKLIERCGFQD-DVAYGKTKIFIRTPRTLFTLEELRAQMLIRIVLFLQKVWR 710

  Fly   953 MYHARKRFQRMRHSQMIISSAWRTWRECRFGIPFTGRRHLWSLYRVAREEYRSLKYKRQVRWAID 1017
            ...||.|::|.:.:..||
Human   711 GTLARMRYKRTKAALTII----------------------------------------------- 728

  Fly  1018 IIGRYYRQWKIRQFLLTIPLRL-PPNTLSPLS--TEWPVAPAFLADASRHLRSIYHRWKCYIYRN 1079
               ||||::|::.::..:..|. ...|:....  .:||..|..|......|::|::||:......
Human   729 ---RYYRRYKVKSYIHEVARRFHGVKTMRDYGKHVKWPSPPKVLRRFEEALQTIFNRWRASQLIK 790

  Fly  1080 SFDQTARNRMREKVTASIIFKDRKASYGRSVGHPFVGDYVRLR-------------HNQQWKKIC 1131
            |...:...::|.||.|..:.|.::|..|  :...:.|:|:..:             .|:..:|
Human   791 SIPASDLPQVRAKVAAVEMLKGQRADLG--LQRAWEGNYLASKPDTPQTSGTFVPVANELKRK-- 851

  Fly  1132 AETNDQY--VVFADIINKIARSSGKFVPILLVLSTSSLLLLD-QRTLQIKYRVPASEIYRMSLSP 1193
                |:|  |:|:..:.|:.|.| |.....:.::...|..:| .:..::...:|...:..:|:|.
Human   852 ----DKYMNVLFSCHVRKVNRFS-KVEDRAIFVTDRHLYKMDPTKQYKVMKTIPLYNLTGLSVSN 911

  Fly  1194 YLDDIAVFHVK 1204
            ..|.:.|||.|
Human   912 GKDQLVVFHTK 922

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Myo95E	NP_001027208.1	Motor_domain	3..>123	CDD:473979	42/118 (36%)
		Motor_domain	<403..937	CDD:473979	192/559 (34%)
		Myosin_TH1	1092..1288	CDD:461801	28/129 (22%)
MYO1D	NP_056009.1	MYSc_Myo1	24..682	CDD:276829	233/929 (25%)
		Actin-binding. /evidence=ECO:0000255|PROSITE-ProRule:PRU00782	572..594		7/21 (33%)
		Myosin_TH1	803..996	CDD:461801	28/129 (22%)