DRSC/TRiP Functional Genomics Resources

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Protein Alignment Myo95E and MYO1C

DIOPT Version :9

Sequence 1:NP_001027208.1 Gene:Myo95E / 2768680 FlyBaseID:FBgn0039157 Length:1288 Species:Drosophila melanogaster
Sequence 2:NP_001074248.1 Gene:MYO1C / 4641 HGNCID:7597 Length:1063 Species:Homo sapiens


Alignment Length:1335 Identity:352/1335 - (26%)
Similarity:557/1335 - (41%) Gaps:376/1335 - (28%)


- Green bases have known domain annotations that are detailed below.


  Fly     5 IGTWDSVLLENL-SEDSFINNIHQRYKRDHIYTYIGTSVVALNPYHHISEHSLDNVRNYGDKGIF 68
            :|..|.|||||. ||.:||.|:.:|::.:.||||||..:|::|||..:..:|..::..|.....:
Human    46 VGVQDFVLLENFTSEAAFIENLRRRFRENLIYTYIGPVLVSVNPYRDLQIYSRQHMERYRGVSFY 110

  Fly    69 QLPPHIYGLTNLAYQSLKDQSEDQCVLLTGESGAGKTETFKMIVNFLTHIQDRSHCPPTPNVLRK 133
            ::|||::.:.:..|::|:.:..||.|:::|||||||||..|.::.|.                  
Human   111 EVPPHLFAVADTVYRALRTERRDQAVMISGESGAGKTEATKRLLQFY------------------ 157

  Fly   134 QSSTSSASGLVMHAHRRASSSCSGTANFIICKNRAENPSGSVSRRQSPSPGPSQRSRTRAESIER 198
                                                                             
Human   158 ----------------------------------------------------------------- 157

  Fly   199 QSRRHMREKIVDFDFSHHKSSENISGLPESHAHHMHPTKSCFKHQQTQVSACTAMPAAAKGSPKY 263
                                                                             
Human   158 ----------------------------------------------------------------- 157

  Fly   264 AVPTVYGGCRQCGHSKCVRAQSLEKEERDDLRGSNCRLSTIATATTNPAHPHRGSCSNLMRQHST 328
                                                       |.|.|| |.||..   :|....
Human   158 -------------------------------------------AETCPA-PERGGA---VRDRLL 175

  Fly   329 ESQPERERDRSSLMGSTQRISLYDAHKLSKVLGDLPPPPPSSVSPTPSASSSLHRRHKSPTQRMR 393
            :|.|                                                             
Human   176 QSNP------------------------------------------------------------- 179

  Fly   394 ECVTCADVFLEAMGNACTLKNNNSSRYGKLFDIEIDFKGDPMGVHITHYMLEKTRITDPIIGERN 458
                    .|||.|||.||:|:||||:||..|::.||||.|:|.||..|:|||:|:.....||||
Human   180 --------VLEAFGNAKTLRNDNSSRFGKYMDVQFDFKGAPVGGHILSYLLEKSRVVHQNHGERN 236

  Fly   459 FHIFYQLLLGADLQLLKSLKLYRNVEKY-ELLRNTTAME---EDRMNFHYTKRSLDVLGLSCEES 519
            ||||||||.|.:.:.|:.|.|.||.:.| .|::...|..   .|:.::...:::|.|:..:.:|.
Human   237 FHIFYQLLEGGEEETLRRLGLERNPQSYLYLVKGQCAKVSSINDKSDWKVVRKALTVIDFTEDEV 301

  Fly   520 NSIFRVIAVVLKLGNFIFVPITNIDGTEGCQVSNVYEVQETAQLLNMEAQILINCLTRANSTNSA 584
            ..:..::|.||.|||..|.    .:.....||:...:::...:||::|...|...||........
Human   302 EDLLSIVASVLHLGNIHFA----ANEESNAQVTTENQLKYLTRLLSVEGSTLREALTHRKIIAKG 362

  Fly   585 QEDVGCEMDARQAATNRNTLCRTLYSRLFTWLVNKINESLKSTQREKN-------LALLDFYGFE 642
            :|.:. .::..|||..|:.|.:.:|||.|||||.|||.||.|...|..       |.|||.||||
Human   363 EELLS-PLNLEQAAYARDALAKAVYSRTFTWLVGKINRSLASKDVESPSWRSTTVLGLLDIYGFE 426

  Fly   643 ALDHNSFEQFAINYSAEKIHQNFVFHVLRSEQELYIREGLEWSRIDYFDNESICELIDKPSYGIL 707
            ...|||||||.|||..||:.|.|:...|:||||.|..||:.|..:.||:|:.||:|:::...||:
Human   427 VFQHNSFEQFCINYCNEKLQQLFIELTLKSEQEEYEAEGIAWEPVQYFNNKIICDLVEEKFKGII 491

  Fly   708 SLINEPHLNSNDA----LLLRVQQCCAGHPNFMT-----------TGSNSMCFQIRHYASVVNYS 757
            |:::|..|...:|    .|.:::.....||:|:|           .|...  |::.|||..|.||
Human   492 SILDEECLRPGEATDLTFLEKLEDTVKHHPHFLTHKLADQRTRKSLGRGE--FRLLHYAGEVTYS 554

  Fly   758 IHRFLEKNSDMLPKYISAAFYQSKLSLVQSLFPEGNPRRQVT--KKPSTLSSNIRTQLQTLLAIV 820
            :..||:||:|:|.:.:......||..::...|    .|.:::  |:|.|:::..:..|..|:.|:
Human   555 VTGFLDKNNDLLFRNLKETMCSSKNPIMSQCF----DRSELSDKKRPETVATQFKMSLLQLVEIL 615

  Fly   821 KHRRSHYVFCIKPNEGKQPHQFDMALVQHQVRYMSLMPLVHLCRTGHCYHLLHVKFFHRYKLLNS 885
            :.:...||.|||||:.|||.:||..|::|||:|:.|:..:.:.|.|..|...:..|..|||.|..
Human   616 QSKEPAYVRCIKPNDAKQPGRFDEVLIRHQVKYLGLLENLRVRRAGFAYRRKYEAFLQRYKSLCP 680

  Fly   886 LTWPHFHGGSQVEGIALIIRNLPLPSAEFTIGTKNVFVRSPRTVYELEQFRRLRISELAVLIQTM 950
            .|||.:.|..| :|:|:::|:|.....|:.:|...:|:|.|:|::..|....:|...||..||..
Human   681 ETWPTWAGRPQ-DGVAVLVRHLGYKPEEYKMGRTKIFIRFPKTLFATEDALEVRRQSLATKIQAA 744

  Fly   951 FRMYHARKRFQRMRHSQMIISSAWRTWRECRFGIPFTGRRHLWSLYRVAREEYRSLKYKRQVRWA 1015
            :|.:|.|::|.|::.|.:.|.|.||         ...|||      :.|:.           :||
Human   745 WRGFHWRQKFLRVKRSAICIQSWWR---------GTLGRR------KAAKR-----------KWA 783

  Fly  1016 IDIIGRYYRQWKIR-----------------QFLLTIPLRLPPNTLSPLSTEWPVAPAFLADASR 1063
            ...|.|..|.:.:|                 .|||.:..:||.|.   |.|.||..|..|.:||.
Human   784 AQTIRRLIRGFVLRHAPRCPENAFFLDHVRTSFLLNLRRQLPQNV---LDTSWPTPPPALREASE 845

  Fly  1064 HLRSIYHR---WKCYIYRNSFDQTARNRMREKVTASIIFKDRKASYGRSVGHPFVGDYVRLRHNQ 1125
            .||.:..:   ||   |..|.....:.::::|..||.|||.:|.:|.:||...|:.  .||..::
Human   846 LLRELCIKNMVWK---YCRSISPEWKQQLQQKAVASEIFKGKKDNYPQSVPRLFIS--TRLGTDE 905

  Fly  1126 QWKKICAETNDQYVVFADIINKIARSSGKFVPILLVLSTSSLLLLDQRTLQIKYRVPASEIYRMS 1190
            ...::......:.:.:|..:.|..|...|.....|:|:.:::::::.  .::|.|:..:.:..:|
Human   906 ISPRVLQALGSEPIQYAVPVVKYDRKGYKPRSRQLLLTPNAVVIVED--AKVKQRIDYANLTGIS 968

  Fly  1191 LSPYLDDIAVFHVKASEFGRKKGDFVFQTGHVIEIVTKMFLVIQNATGKPPEIHISTEFEANFGQ 1255
            :|...|.:.|.||:.:: .::|||.|.|:.||||.:||..|......            ..|..|
Human   969 VSSLSDSLFVLHVQRAD-NKQKGDVVLQSDHVIETLTKTALSANRVN------------SININQ 1020

  Fly  1256 QTVIFSFKYG--GMSDLAQGPPKVTRKANRMEIIV 1288
            .::.|:...|  |..|...|...:..||....:.|
Human  1021 GSITFAGGPGRDGTIDFTPGSELLITKAKNGHLAV 1055

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Myo95ENP_001027208.1 Motor_domain 19..>118 CDD:277568 35/98 (36%)
Motor_domain 403..924 CDD:277568 200/548 (36%)
Myosin_TH1 1092..1267 CDD:283635 43/176 (24%)
MYO1CNP_001074248.1 MYSc 43..731 CDD:214580 258/960 (27%)
MYSc_Myo1 62..718 CDD:276829 245/931 (26%)
Actin-binding. /evidence=ECO:0000255|PROSITE-ProRule:PRU00782 608..630 9/21 (43%)
IQ 756..776 CDD:197470 9/34 (26%)
Myosin_TH1 874..1041 CDD:283635 45/183 (25%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D105718at33208
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_100187
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
32.820

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