Protein Alignment Myo95E and MYO1A

DIOPT Version :9

• Sequence 1: NP_001027208.1
• Gene: Myo95E / 2768680
• FlyBaseID: FBgn0039157
• Length: 1288
• Species: Drosophila melanogaster
• Sequence 2: NP_001242970.1
• Gene: MYO1A / 4640
• HGNCID: 7595
• Length: 1043
• Species: Homo sapiens
• Alignment Length: 1306
• Identity: 375/1306 - (28%)
• Similarity: 606/1306 - (46%)
• Gaps: 321/1306 - (24%)

  Fly     1 MEQEIGTWDSVLLENLSEDSFINNIHQRYKRDHIYTYIGTSVVALNPYHHISEHSLDNVRNYGDK 65
            :|..:|..|.||||.|.|:|.:.|:..||:...||||||..|:::|||..:..:..:.:..|.|.
Human     4 LEGSVGVEDLVLLEPLVEESLLKNLQLRYENKEIYTYIGNVVISVNPYQQLPIYGPEFIAKYQDY 68

  Fly    66 GIFQLPPHIYGLTNLAYQSLKDQSEDQCVLLTGESGAGKTETFKMIVNFLTHIQDRSHCPPTPNV 130
            ..::|.||||.|.|:|||||:|:..|||:|:|||||:||||..|::::::..:
Human    69 TFYELKPHIYALANVAYQSLRDRDRDQCILITGESGSGKTEASKLVMSYVAAV------------ 121

  Fly   131 LRKQSSTSSASGLVMHAHRRASSSCSGTANFIICKNRAENPSGSVSRRQSPSPGPSQRSRTRAES 195
                                                                             
Human   122 ----------------------------------------------------------------- 121

  Fly   196 IERQSRRHMREKIVDFDFSHHKSSENISGLPESHAHHMHPTKSCFKHQQTQVSACTAMPAAAKGS 260
                                                                             
Human   122 ----------------------------------------------------------------- 121

  Fly   261 PKYAVPTVYGGCRQCGHSKCVRAQSLEKEERDDLRGSNCRLSTIATATTNPAHPHRGSCSNLMRQ 325
                          ||                                       :|...|.:::
Human   122 --------------CG---------------------------------------KGEQVNSVKE 133

  Fly   326 HSTESQPERERDRSSLMGSTQRISLYDAHKLSKVLGDLPPPPPSSVSPTPSASSSLHRRHKSPTQ 390
            ...:|.|
Human   134 QLLQSNP---------------------------------------------------------- 140

  Fly   391 RMRECVTCADVFLEAMGNACTLKNNNSSRYGKLFDIEIDFKGDPMGVHITHYMLEKTRITDPIIG 455
                       .|||.|||.|::||||||:||..|||.||||.|:|..||:|:|||:|:...:.|
Human   141 -----------VLEAFGNAKTIRNNNSSRFGKYMDIEFDFKGSPLGGVITNYLLEKSRLVKQLKG 194

  Fly   456 ERNFHIFYQLLLGADLQLLKSLKLYRNVEKYELLRNTTAM---EEDRMNFHYTKRSLDVLGLSCE 517
            |||||||||||.|||.||||:|||.|:...|..|.:..:.   .:|..:|...:.::.|:|.|.|
Human   195 ERNFHIFYQLLAGADEQLLKALKLERDTTGYAYLNHEVSRVDGMDDASSFRAVQSAMAVIGFSEE 259

  Fly   518 ESNSIFRVIAVVLKLGNFIFVPITNIDGTEGCQVSNVYEVQETAQLLNMEAQILINCLTRANSTN 582
            |...:..|.::||||||.:........|.....:.:...|:|..:::.:.::.:...|. :.:..
Human   260 EIRQVLEVTSMVLKLGNVLVADEFQASGIPASGIRDGRGVREIGEMVGLNSEEVERALC-SRTME 323

  Fly   583 SAQEDVGCEMDARQAATNRNTLCRTLYSRLFTWLVNKINESLK--STQREKNLALLDFYGFEALD 645
            :|:|.|...::..||...|:.|.:.:|||||.|:||:||||:|  ..:::|.:.:||.||||.|:
Human   324 TAKEKVVTALNVMQAQYARDALAKNIYSRLFDWIVNRINESIKVGIGEKKKVMGVLDIYGFEILE 388

  Fly   646 HNSFEQFAINYSAEKIHQNFVFHVLRSEQELYIREGLEWSRIDYFDNESICELIDKPSYGILSLI 710
            .||||||.|||..||:.|.|:...|:.|||.|.|||:.|:::|||||..||:||:....|||:::
Human   389 DNSFEQFVINYCNEKLQQVFIEMTLKEEQEEYKREGIPWTKVDYFDNGIICKLIEHNQRGILAML 453

  Fly   711 NE----PHLNSNDALLLRVQQCCAGHPNFMTTGSNS-----------MCFQIRHYASVVNYSIHR 760
            :|    |.:.|:...|.::.|..:.|.::.:..:.:           .||:|.|||..|.|::..
Human   454 DEECLRPGVVSDSTFLAKLNQLFSKHGHYESKVTQNAQRQYDHTMGLSCFRICHYAGKVTYNVTS 518

  Fly   761 FLEKNSDMLPKYISAAFYQSKLSLVQSLFPEGNPRRQVTKKPSTLSSNIRTQLQTLLAIVKHRRS 825
            |::||:|:|.:.:..|.::::..|::||||||||::...|:|.|..:..::.:..|:..:..:..
Human   519 FIDKNNDLLFRDLLQAMWKAQHPLLRSLFPEGNPKQASLKRPPTAGAQFKSSVAILMKNLYSKSP 583

  Fly   826 HYVFCIKPNEGKQPHQFDMALVQHQVRYMSLMPLVHLCRTGHCYHLLHVKFFHRYKLLNSLTWPH 890
            :|:.||||||.:|..||...||..|.||:.|:..|.:.|.|:.:...:..|..||:||:..||||
Human   584 NYIRCIKPNEHQQRGQFSSDLVATQARYLGLLENVRVRRAGYAHRQGYGPFLERYRLLSRSTWPH 648

  Fly   891 FHGGSQVEGIALIIRNLPLPSAEFTIGTKNVFVRSPRTVYELEQFRRLRISELAVLIQTMFRMYH 955
            ::||.: ||:..::..|.:.|.|...|...:|:|||:|::.||:.||||:.:||.|||.::|.:.
Human   649 WNGGDR-EGVEKVLGELSMSSGELAFGKTKIFIRSPKTLFYLEEQRRLRLQQLATLIQKIYRGWR 712

  Fly   956 ARKRFQRMRHSQMIISSAWR--TWRECRFGIPFT---------GRRHLWSLYRVAREEYRSLKYK 1009
            .|..:|.||.||::|||.:|  ..::|...|..:         |    |.    ||:.||  ||.
Human   713 CRTHYQLMRKSQILISSWFRGNMQKKCYGKIKASVLLIQAFVRG----WK----ARKNYR--KYF 767

  Fly  1010 RQVRWAIDIIGRYYRQWKIRQFLLTIPLRLPPNTLSPLSTEWPVAP-AFLADASRHLRSIYHRWK 1073
            |. ..|:.:....|:. .:::|||.:...||...:  |...||.|| ..|:.|::.|:.::::||
Human   768 RS-EAALTLADFIYKS-MVQKFLLGLKNNLPSTNV--LDKTWPAAPYKCLSTANQELQQLFYQWK 828

  Fly  1074 CYIYRNSFDQTARNRMREKVTASIIFKDRKASYGRSVGHPFVGDYVRLRHNQQWKKICAETNDQY 1138
            |..:|:.........:|||:.||.:||.:||||.:||..||.|||:.|:.|.:.:|: ....:..
Human   829 CKRFRDQLSPKQVEILREKLCASELFKGKKASYPQSVPIPFCGDYIGLQGNPKLQKL-KGGEEGP 892

  Fly  1139 VVFADIINKIARSSGKFVPILLVLSTSSLLLLDQRTLQIKYRVPASEIYRMSLSPYLDDIAVFHV 1203
            |:.|:.:.|:.|.:||....:|:|:...::|.|.:..|.|..:....:..:|::...|.:...|:
Human   893 VLMAEAVKKVNRGNGKTSSRILLLTKGHVILTDTKKSQAKIVIGLDNVAGVSVTSLKDGLFSLHL 957

  Fly  1204 KASEFGRKKGDFVFQTGHVIEIVTKMFLVIQNATGKPPEIHISTEFEANFGQQTVIFSFKYGGMS 1268
            ........||||:..:.||||::|||:..:.:||.:...:.::.:|...|.:.:|...
Human   958 SEMSSVGSKGDFLLVSEHVIELLTKMYRAVLDATQRQLTVTVTEKFSVRFKENSVAVK------- 1015

  Fly  1269 DLAQGP 1274
             :.|||
Human  1016 -VVQGP 1020

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Myo95E	NP_001027208.1	Motor_domain	19..>118	CDD:277568	43/98 (44%)
		Motor_domain	403..924	CDD:277568	206/540 (38%)
		Myosin_TH1	1092..1267	CDD:283635	50/174 (29%)
MYO1A	NP_001242970.1	MYSc	8..694	CDD:214580	269/951 (28%)
		MYSc_Myo1	22..681	CDD:276829	255/924 (28%)
		Actin-binding. /evidence=ECO:0000255	571..593		6/21 (29%)
		IQ	742..764	CDD:197470	5/29 (17%)
		Myosin_TH1	847..1021	CDD:283635	53/183 (29%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	117	1.000	Domainoid score	I5923
eggNOG	1	0.900	-	-		E2759_KOG0164
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D105718at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100187
Panther	1	1.100	-	-	LDO	PTHR13140
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	7	6.820