Protein Alignment Myo95E and MYH10

DIOPT Version :10

• Sequence 1: NP_001027208.1
• Gene: Myo95E / 2768680
• FlyBaseID: FBgn0039157
• Length: 1288
• Species: Drosophila melanogaster
• Sequence 2: NP_001242941.1
• Gene: MYH10 / 4628
• HGNCID: 7568
• Length: 2007
• Species: Homo sapiens
• Alignment Length: 1268
• Identity: 297/1268 - (23%)
• Similarity: 459/1268 - (36%)
• Gaps: 406/1268 - (32%)

  Fly     9 DSVLLENLSEDSFINNIHQRYKRDHIYTYIGTSVVALNPYHHISEHSLDNVRNYGDKGIFQLPPH 73
            |...|..|:|.|.::|:..||....||||.|...|.:|||.::..:|.:.:..|..|...::|||
Human    89 DMAELTCLNEASVLHNLKDRYYSGLIYTYSGLFCVVINPYKNLPIYSENIIEMYRGKKRHEMPPH 153

  Fly    74 IYGLTNLAYQSLKDQSEDQCVLLTGESGAGKTETFKMIVNFLTHIQDRSHCPPTPNVLRKQSSTS 138
            ||.::..||:.:....|||.:|.||||||||||..|.::.:|.|:
Human   154 IYAISESAYRCMLQDREDQSILCTGESGAGKTENTKKVIQYLAHV-------------------- 198

  Fly   139 SASGLVMHAHRRASSSCSGTANFIICKNRAENPSGSVSRRQSPSPGPSQRSRTRAESIERQSRRH 203
                        |||
Human   199 ------------ASS-------------------------------------------------- 201

  Fly   204 MREKIVDFDFSHHKSSENISGLPESHAHHMHPTKSCFKHQQTQVSACTAMPAAAKGSPKYAVPTV 268
                        ||..::          |..|.:|               |...|
Human   202 ------------HKGRKD----------HNIPQES---------------PKPVK---------- 219

  Fly   269 YGGCRQCGHSKCVRAQSLEKEERDDLRGSNCRLSTIATATTNPAHPHRGSCSNLMRQHSTESQPE 333
                                                          |:|
Human   220 ----------------------------------------------HQG---------------- 222

  Fly   334 RERDRSSLMGSTQRISLYDAHKLSKVLGDLPPPPPSSVSPTPSASSSLHRRHKSPTQRMRECVTC 398
             |.:|..|.
Human   223 -ELERQLLQ-------------------------------------------------------- 230

  Fly   399 ADVFLEAMGNACTLKNNNSSRYGKLFDIEIDFKGDPMGVHITHYMLEKTRITDPIIGERNFHIFY 463
            |:..||:.|||.|:||:||||:||...|..|..|..:|.:|..|:|||:|.......||.|||||
Human   231 ANPILESFGNAKTVKNDNSSRFGKFIRINFDVTGYIVGANIETYLLEKSRAVRQAKDERTFHIFY 295

  Fly   464 QLLLGADLQLLKSLKLYRNVEKYELLRN---TTAMEEDRMNFHYTKRSLDVLGLSCEESNSIFRV 525
            |||.||. :.|||..|......|..|.|   ....::|:.||..|..::.::|.|.||..|:.:|
Human   296 QLLSGAG-EHLKSDLLLEGFNNYRFLSNGYIPIPGQQDKDNFQETMEAMHIMGFSHEEILSMLKV 359

  Fly   526 IAVVLKLGNFIFVPITNIDGTEGCQVSNVYEVQETAQLLNMEAQILINCLTRANST---NSAQED 587
            ::.||:.||..|....|.|  :.....|.. .|:...||.|.    :...|||..|   ...::.
Human   360 VSSVLQFGNISFKKERNTD--QASMPENTV-AQKLCHLLGMN----VMEFTRAILTPRIKVGRDY 417

  Fly   588 VGCEMDARQAATNRNTLCRTLYSRLFTWLVNKINESLKSTQRE--KNLALLDFYGFEALDHNSFE 650
            |.......||......|.:..|.|||.|||::||::|..|:|:  ..:.:||..|||..:.||||
Human   418 VQKAQTKEQADFAVEALAKATYERLFRWLVHRINKALDRTKRQGASFIGILDIAGFEIFELNSFE 482

  Fly   651 QFAINYSAEKIHQNFVFHVLRSEQELYIREGLEWSRIDY-FDNESICELIDKPSY--GILSLINE 712
            |..|||:.||:.|.|...:...|||.|.|||:||:.||: .|.:...:||::|:.  |:|:|::|
Human   483 QLCINYTNEKLQQLFNHTMFILEQEEYQREGIEWNFIDFGLDLQPCIDLIERPANPPGVLALLDE 547

  Fly   713 ----PHLNSNDALLLRVQQCCAGHPNFMTTG--SNSMCFQIRHYASVVNYSIHRFLEKNSDMLPK 771
                |.......:...||: ...|..|....  .:...|.|.|||..|:|....:|.||.|.|..
Human   548 ECWFPKATDKTFVEKLVQE-QGSHSKFQKPRQLKDKADFCIIHYAGKVDYKADEWLMKNMDPLND 611

  Fly   772 YISAAFYQSKLSLVQSLFPE--GNPRR----------------------QV-------------T 799
            .::...:||....|..|:.:  .|.:|                      ||             |
Human   612 NVATLLHQSSDRFVAELWKDEIQNIQRASFYDSVSGLHEPPVDRIVGLDQVTGMTETAFGSAYKT 676

  Fly   800 KKP--STLSSNIRTQLQTLLAIVKHRRSHYVFCIKPNEGKQPHQFDMALVQHQVRYMSLMPLVHL 862
            ||.  .|:....:..|..|:|.:::...::|.||.||..|:..:.|..||..|:|...::..:.:
Human   677 KKGMFRTVGQLYKESLTKLMATLRNTNPNFVRCIIPNHEKRAGKLDPHLVLDQLRCNGVLEGIRI 741

  Fly   863 CRTGHCYHLLHVKFFHRYKLLNSLTWPH-FHGGSQVEGIALIIRNLPLPSAEFTIGTKNVFVRSP 926
            ||.|....::..:|..||::|.....|. |..|.|  ....:||.|.|....:.||...:|.|:
Human   742 CRQGFPNRIVFQEFRQRYEILTPNAIPKGFMDGKQ--ACERMIRALELDPNLYRIGQSKIFFRA- 803

  Fly   927 RTVYELEQFRRLRISELAVLIQTMFRMYHARKRFQ--------------------RMRHSQMIIS 971
            ..:..||:.|.|:|:::.:..|.:.|.|.|||.|.                    ::||
Human   804 GVLAHLEEERDLKITDIIIFFQAVCRGYLARKAFAKKQQQLSALKVLQRNCAAYLKLRH------ 862

  Fly   972 SAWRTWRECRFGIPFTGRRHLWSLYR------VAREEYRSLKYKR-QVRWAIDIIGRYYRQWKIR 1029
              |:.||      .||..:.|..:.|      ...||...:|.|: :|...::.:.|.::|....
Human   863 --WQWWR------VFTKVKPLLQVTRQEEELQAKDEELLKVKEKQTKVEGELEEMERKHQQLLEE 919

  Fly  1030 QFLLTIPLRLPPNTLSPLSTEWPVAPAFLADASRHLRSIYHRWKCYI----YRNSFDQTARNRMR 1090
            :.:|...|:..    :.|..|.....|.||...:.|..|.|..:..:    .||...|..:.:|:
Human   920 KNILAEQLQAE----TELFAEAEEMRARLAAKKQELEEILHDLESRVEEEEERNQILQNEKKKMQ 980

  Fly  1091 ----------------------EKVTAS----------IIFKDRKASYGRSVGHPFVGDYVR--- 1120
                                  |||||.          ::.:|:.:.:.:.  ...:.|.:.
Human   981 AHIQDLEEQLDEEEGARQKLQLEKVTAEAKIKKMEEEILLLEDQNSKFIKE--KKLMEDRIAECS 1043

  Fly  1121 ---LRHNQQWKKICAETNDQYVVFADIINKIAR 1150
               ....::.|.:....|.|.|:.:|:..::.:
Human  1044 SQLAEEEEKAKNLAKIRNKQEVMISDLEERLKK 1076

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Myo95E	NP_001027208.1	Motor_domain	3..>123	CDD:473979	44/113 (39%)
		Motor_domain	<403..937	CDD:473979	185/590 (31%)
		Myosin_TH1	1092..1288	CDD:461801	11/75 (15%)
MYH10	NP_001242941.1	Myosin_N	31..76	CDD:460670
		MYSc_Myh10	99..802	CDD:276952	238/961 (25%)
		Actin-binding. /evidence=ECO:0000255|PROSITE-ProRule:PRU00782	692..714		7/21 (33%)
		Myosin_tail_1	879..1959	CDD:460256	34/204 (17%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1158..1178
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1728..1759
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1903..2007