Protein Alignment Myo95E and MYH7

DIOPT Version :10

• Sequence 1: NP_001027208.1
• Gene: Myo95E / 2768680
• FlyBaseID: FBgn0039157
• Length: 1288
• Species: Drosophila melanogaster
• Sequence 2: NP_000248.2
• Gene: MYH7 / 4625
• HGNCID: 7577
• Length: 1935
• Species: Homo sapiens
• Alignment Length: 1064
• Identity: 244/1064 - (22%)
• Similarity: 381/1064 - (35%)
• Gaps: 357/1064 - (33%)

  Fly     9 DSVLLENLSEDSFINNIHQRYKRDHIYTYIGTSVVALNPYHHISEHSLDNVRNYGDKGIFQLPPH 73
            |..:|..|.|.:.:.|:..||....||||.|...|.:|||..:..::.:.|..|..|...:.|||
Human    89 DMAMLTFLHEPAVLYNLKDRYGSWMIYTYSGLFCVTVNPYKWLPVYTPEVVAAYRGKKRSEAPPH 153

  Fly    74 IYGLTNLAYQSLKDQSEDQCVLLTGESGAGKTETFKMIVNF---LTHIQDRSHCPPTPNVLRKQS 135
            |:.:::.|||.:....|:|.:|:|||||||||...|.::.:   :..|.|||
Human   154 IFSISDNAYQYMLTDRENQSILITGESGAGKTVNTKRVIQYFAVIAAIGDRS------------- 205

  Fly   136 STSSASGLVMHAHRRASSSCSGTANFIICKNRAENPSGSVSRRQSPSPGPSQRSRTRAESIERQS 200
                                                    .:.|||..|.
Human   206 ----------------------------------------KKDQSPGKGT--------------- 215

  Fly   201 RRHMREKIVDFDFSHHKSSENISGLPESHAHHMHPTKSCFKHQQTQVSACTAMPAAAKGSPKYAV 265
               :.::|:.
Human   216 ---LEDQIIQ------------------------------------------------------- 222

  Fly   266 PTVYGGCRQCGHSKCVRAQSLEKEERDDLRGSNCRLSTIATATTNPAHPHRGSCSNLMRQHSTES 330
                                                       .|||
Human   223 -------------------------------------------ANPA------------------ 226

  Fly   331 QPERERDRSSLMGSTQRISLYDAHKLSKVLGDLPPPPPSSVSPTPSASSSLHRRHKSPTQRMREC 395
                                                                             
Human   227 ----------------------------------------------------------------- 226

  Fly   396 VTCADVFLEAMGNACTLKNNNSSRYGKLFDIEIDFKGDPMGVHITHYMLEKTRITDPIIGERNFH 460
                   |||.|||.|::|:||||:||...|.....|......|..|:|||:|:...:..||::|
Human   227 -------LEAFGNAKTVRNDNSSRFGKFIRIHFGATGKLASADIETYLLEKSRVIFQLKAERDYH 284

  Fly   461 IFYQLLLGADLQLLKSLKLYRNVEKYELL---RNTTAMEEDRMNFHYTKRSLDVLGLSCEESNSI 522
            ||||:|.....:||..|.:..|...|..:   ..|.|..:|......|..:.||||.:.||.||:
Human   285 IFYQILSNKKPELLDMLLITNNPYDYAFISQGETTVASIDDAEELMATDNAFDVLGFTSEEKNSM 349

  Fly   523 FRVIAVVLKLGNFIF---------VPITNIDGTEGCQVSNVYEVQETAQLLNMEAQILIN--CLT 576
            :::...::..||..|         .|    ||||        |..::|.|:.:.:..|:.  |..
Human   350 YKLTGAIMHFGNMKFKLKQREEQAEP----DGTE--------EADKSAYLMGLNSADLLKGLCHP 402

  Fly   577 RANSTNSAQEDVGCEMDARQAATNRNTLCRTLYSRLFTWLVNKINESLKSTQ-REKNLALLDFYG 640
            |....|   |.|....:.:|.......|.:.:|.|:|.|:|.:||.:|::.| |:..:.:||..|
Human   403 RVKVGN---EYVTKGQNVQQVIYATGALAKAVYERMFNWMVTRINATLETKQPRQYFIGVLDIAG 464

  Fly   641 FEALDHNSFEQFAINYSAEKIHQNFVFHVLRSEQELYIREGLEWSRIDY-FDNESICELIDKPSY 704
            ||..|.|||||..||::.||:.|.|..|:...|||.|.:||:||:.||: .|.::..:||:|| .
Human   465 FEIFDFNSFEQLCINFTNEKLQQFFNHHMFVLEQEEYKKEGIEWTFIDFGMDLQACIDLIEKP-M 528

  Fly   705 GILSLINEP------------------HLNSNDALLLRVQQCCAGHPNFM----TTGSNSMCFQI 747
            ||:|::.|.                  ||..:              .||.    ..|.....|.:
Human   529 GIMSILEEECMFPKATDMTFKAKLFDNHLGKS--------------ANFQKPRNIKGKPEAHFSL 579

  Fly   748 RHYASVVNYSIHRFLEKNSDMLPKYISAAFYQSKLSLVQSLF----------PEGNPRRQVTKKP 802
            .|||.:|:|:|..:|:||.|.|.:.:...:.:|.|.|:.:||          .:|..:.:.....
Human   580 IHYAGIVDYNIIGWLQKNKDPLNETVVGLYQKSSLKLLSTLFANYAGADAPIEKGKGKAKKGSSF 644

  Fly   803 STLSSNIRTQLQTLLAIVKHRRSHYVFCIKPNEGKQPHQFDMALVQHQVRYMSLMPLVHLCRTGH 867
            .|:|:..|..|..|:..::....|:|.||.|||.|.|...|..||.||:|...::..:.:||.|.
Human   645 QTVSALHRENLNKLMTNLRSTHPHFVRCIIPNETKSPGVMDNPLVMHQLRCNGVLEGIRICRKGF 709

  Fly   868 CYHLLHVKFFHRYKLLNSLTWPHFHGGSQVEGIALIIRNLPLPSAEFTIGTKNVFVRSPRTVYEL 932
            ...:|:..|..||::||....|........:|...::.:|.:...::..|...||.:: ..:..|
Human   710 PNRILYGDFRQRYRILNPAAIPEGQFIDSRKGAEKLLSSLDIDHNQYKFGHTKVFFKA-GLLGLL 773

  Fly   933 EQFRRLRISELAVLIQTMFRMYHARKRFQRM---RHSQMIISSAWR----------TWRECRFGI 984
            |:.|..|:|.:...||...|...||..::::   |.|.::|.  |.          .|.:..|.|
Human   774 EEMRDERLSRIITRIQAQSRGVLARMEYKKLLERRDSLLVIQ--WNIRAFMGVKNWPWMKLYFKI 836

  Fly   985 -PFTGRRHLWSLYRVAREEYRSLK 1007
             |..............:||:..||
Human   837 KPLLKSAEREKEMASMKEEFTRLK 860

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Myo95E	NP_001027208.1	Motor_domain	3..>123	CDD:473979	42/116 (36%)
		Motor_domain	<403..937	CDD:473979	173/581 (30%)
		Myosin_TH1	1092..1288	CDD:461801
MYH7	NP_000248.2	COG5022	37..1432	CDD:227355	244/1064 (23%)
		MYSc_Myh7	99..766	CDD:276881	218/955 (23%)
		Actin-binding	655..677		7/21 (33%)
		Actin-binding	757..771		3/14 (21%)
		SMC_prok_B	1173..1930	CDD:274008
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1907..1935