DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Myo95E and myo6b

DIOPT Version :9

Sequence 1:	NP_001027208.1	Gene:	Myo95E / 2768680	FlyBaseID:	FBgn0039157	Length:	1288	Species:	Drosophila melanogaster
Sequence 2:	NP_001004110.1	Gene:	myo6b / 445472	ZFINID:	ZDB-GENE-030318-3	Length:	1267	Species:	Danio rerio

Alignment Length:	1041	Identity:	228/1041 - (21%)
Similarity:	377/1041 - (36%)	Gaps:	361/1041 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 DSVLLENLSEDSFINNIHQRYKRDHIYTYIGTSVVALNPYHHISE-HSLDNVRNYGDKGIFQLPP 72
            |:..|..|:|.:.:|||..||.:|.|||::...::|:|||..|.: :|.:::::|..:.:..|||
Zfish    61 DNCSLMYLNEATLLNNIRIRYSKDMIYTFVANILIAVNPYFDIPKLYSPESIKSYQGRSLGTLPP 125

  Fly    73 HIYGLTNLAYQSLKDQSEDQCVLLTGESGAGKTETFKMIVNFLTHIQDRSHCPPTPNVLRKQSST 137
            |:|.:.:.||:.::.....|.::::|||||||||..|.::.:||                    |
Zfish   126 HVYAIADKAYRDMRVLKMSQSIIVSGESGAGKTENTKFVLRYLT--------------------T 170

  Fly   138 SSASGLVMHAHRRASSSCSGTANFIICKNRAENPSGSVSRRQSPSPGPSQRSRTRAESIERQSRR 202
            |..:|                                                           :
Zfish   171 SYGTG-----------------------------------------------------------Q 176

  Fly   203 HMREKIVDFDFSHHKSSENISGLPESHAHHMHPTKSCFKHQQTQVSACTAMPAAAKGSPKYAVPT 267
            .:.|:||:
Zfish   177 DIDERIVE--------------------------------------------------------- 184

  Fly   268 VYGGCRQCGHSKCVRAQSLEKEERDDLRGSNCRLSTIATATTNPAHPHRGSCSNLMRQHSTESQP 332
                                                     .||
Zfish   185 -----------------------------------------ANP--------------------- 187

  Fly   333 ERERDRSSLMGSTQRISLYDAHKLSKVLGDLPPPPPSSVSPTPSASSSLHRRHKSPTQRMRECVT 397

Zfish   188 ----------------------------------------------------------------- 187

  Fly   398 CADVFLEAMGNACTLKNNNSSRYGKLFDIEIDFKGDPMGVHITHYMLEKTRITDPIIGERNFHIF 462
                .|||.|||.|::||||||:||..:|..:.|...:|..::||:|||:||......|||:|||
Zfish   188 ----LLEAFGNAKTVRNNNSSRFGKFVEIHFNEKNAVVGGFVSHYLLEKSRICMQSQEERNYHIF 248

  Fly   463 YQLLLGA--DLQLLKSLK-------LYRNVEKY--------ELLRNTTAME-------------- 496
            |:|..||  |::.:..|.       |.|...:|        ::::| .:.|
Zfish   249 YRLCAGASEDIRNMLHLNSPDSFRYLNRGCTRYFANKDSDKQIMQNXKSPEDHKHGKVGALKDPL 313

  Fly   497 -EDRMNFHYTKRSLDVLGLSCEESNSIFRVIAVVLKLGNFIFVPITNIDGTEGCQVSN--VYEVQ 558
             :|..:|:....::..:||...|..::|||:|.||.|||..|....:..|  ||.:.|  ...::
Zfish   314 LDDLGDFNRMVVAMKKIGLDDTEKLNLFRVVAGVLHLGNIDFEETGSTSG--GCILKNQSSQTLE 376

  Fly   559 ETAQLLNMEAQIL-INCLTRANSTNSAQED---VGCEMDARQAATNRNTLCRTLYSRLFTWLVNK 619
            ..|.||.::...| ::..||...|.:....   :...:...||...|:.|.:.:|||||..:|.:
Zfish   377 YCADLLGLDQDDLRVSLTTRVMLTTAGGAKGTVIKVPLKVEQANNARDALAKAVYSRLFDHVVKR 441

  Fly   620 INESLKSTQREKNLALLDFYGFEALDHNSFEQFAINYSAEKIHQNFVFHVLRSEQELYIREGLEW 684
            :|:..........:.:.|..|||..:|||||||.|||..||:.|.|...:|:.|||||.||||..
Zfish   442 VNQCFPFDTSSNFIGVPDIAGFEYFEHNSFEQFCINYCNEKLQQFFNERILKEEQELYQREGLGV 506

  Fly   685 SRIDYFDNESICELIDKPSYGILSLINEP---------------HLNSNDALLLRV--QQCCAGH 732
            :.:.|.||:...:|::....|:|.:::|.               |....|...|.|  :.....|
Zfish   507 NEVHYVDNQDCIDLVEAKLVGVLDILDEENRLPQPSDQHFAEAVHSKHKDHFRLTVPRKSKLTIH 571

  Fly   733 PNFMTTGSNSMCFQIRHYASVVNYSIHRFLEKNSDMLPKYISAAFYQSKLSLVQSLFPEGNPRRQ 797
            .|.    .:...|.|||:|..|.|...:|:|||:|.|...:.:...:||...|:.||...:..:.
Zfish   572 RNL----RDDEGFIIRHFAGAVCYETTQFVEKNNDALHMSLESLVCESKDKFVRDLFENNSNSKD 632

  Fly   798 VTKKPSTLS-----SNIRTQLQTLLAIVKHRRSHYVFCIKPNEGKQPHQFDMALVQHQVRYMSLM 857
            ..:|...||     :..:|||..||..::...|.::.|:|||.....|||:.|.:..|::...::
Zfish   633 SKQKAGKLSFISVGNKFKTQLNLLLEKLRSTGSSFIRCVKPNLKMVSHQFEGAQILSQLQCSGMV 697

  Fly   858 PLVHLCRTGHCYHLLHVKFFHRYK--LLNSLTW--PHFHGGSQVEGIALIIRNLPLPSAEFTIGT 918
            .::.|.:.|........:.::.||  :.|.||.  |...       ...:.:.|.|...::..|.
Zfish   698 SVLDLMQGGFPSRAPFHELYNMYKQYMPNKLTRLDPRLF-------CKALFKALGLNENDYKFGL 755

  Fly   919 KNVFVRSPRTVYELEQFRRLRISELAVLIQTMFRMYHARKRFQRMRHSQMIISSAWRTWRECRFG 983
            ..||.| |....|.:|..:.....||.|::               |.::.::.|.|:..:.|...
Zfish   756 TRVFFR-PGKFAEFDQIMKSDPDHLAELVK---------------RVNKWLVCSRWKKVQWCTLS 804

  Fly   984 I 984
            :
Zfish   805 V 805

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Myo95E	NP_001027208.1	Motor_domain	19..>118	CDD:277568	36/99 (36%)
		Motor_domain	403..924	CDD:277568	169/584 (29%)
		Myosin_TH1	1092..1267	CDD:283635
myo6b	NP_001004110.1	MYSc	59..773	CDD:214580	221/992 (22%)
		MYSc_Myo6	71..761	CDD:276833	213/969 (22%)
		Ax_dynein_light	<847..930	CDD:287215
		Myosin-VI_CBD	1150..1240	CDD:293129
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D122881at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	2.010