Protein Alignment Myo95E and MYO1B

DIOPT Version :10

• Sequence 1: NP_001027208.1
• Gene: Myo95E / 2768680
• FlyBaseID: FBgn0039157
• Length: 1288
• Species: Drosophila melanogaster
• Sequence 2: XP_047300366.1
• Gene: MYO1B / 4430
• HGNCID: 7596
• Length: 1156
• Species: Homo sapiens
• Alignment Length: 1396
• Identity: 399/1396 - (28%)
• Similarity: 639/1396 - (45%)
• Gaps: 379/1396 - (27%)

  Fly     1 MEQEIGTWDSVLLENLSEDSFINNIHQRYKRDHIYTYIGTSVVALNPYHHISEHSLDNVRNYGDK 65
            ::..||..|.||||.|:|::||||:.:|:....||||||:.|:::|||..:..:|.:.|..|.::
Human    31 LDNMIGVGDMVLLEPLNEETFINNLKKRFDHSEIYTYIGSVVISVNPYRSLPIYSPEKVEEYRNR 95

  Fly    66 GIFQLPPHIYGLTNLAYQSLKDQSEDQCVLLTGESGAGKTETFKMIVNFLTHIQDRSHCPPTPNV 130
            ..::|.|||:.|::.||:||:||.:|||:|:||||||||||..|::::::..:
Human    96 NFYELSPHIFALSDEAYRSLRDQDKDQCILITGESGAGKTEASKLVMSYVAAV------------ 148

  Fly   131 LRKQSSTSSASGLVMHAHRRASSSCSGTANFIICKNRAENPSGSVSRRQSPSPGPSQRSRTRAES 195
                                                                             
Human   149 ----------------------------------------------------------------- 148

  Fly   196 IERQSRRHMREKIVDFDFSHHKSSENISGLPESHAHHMHPTKSCFKHQQTQVSACTAMPAAAKGS 260
                                                                             
Human   149 ----------------------------------------------------------------- 148

  Fly   261 PKYAVPTVYGGCRQCGHSKCVRAQSLEKEERDDLRGSNCRLSTIATATTNPAHPHRGSCSNLMRQ 325
                          ||                                       :|:..|.:::
Human   149 --------------CG---------------------------------------KGAEVNQVKE 160

  Fly   326 HSTESQPERERDRSSLMGSTQRISLYDAHKLSKVLGDLPPPPPSSVSPTPSASSSLHRRHKSPTQ 390
            ...:|.|
Human   161 QLLQSNP---------------------------------------------------------- 167

  Fly   391 RMRECVTCADVFLEAMGNACTLKNNNSSRYGKLFDIEIDFKGDPMGVHITHYMLEKTRITDPIIG 455
                       .|||.|||.|::|:||||:||..|||.||||||:|..|::|:|||:|:.....|
Human   168 -----------VLEAFGNAKTVRNDNSSRFGKYMDIEFDFKGDPLGGVISNYLLEKSRVVKQPRG 221

  Fly   456 ERNFHIFYQLLLGADLQLLKSLKLYRNVEKYELLRNTTAM---EEDRMNFHYTKRSLDVLGLSCE 517
            |||||:|||||.||..:||..|||.|:..:|..|...:|.   .:|..||...:.::.::|....
Human   222 ERNFHVFYQLLSGASEELLNKLKLERDFSRYNYLSLDSAKVNGVDDAANFRTVRNAMQIVGFMDH 286

  Fly   518 ESNSIFRVIAVVLKLGNFIFVPITNIDGTEGCQVSNVYEVQETAQLLNMEAQILINCLTRANSTN 582
            |:.|:..|:|.||||||..|.|.:.::|.:..::.:..|::|..:|..::..:|....: ..:..
Human   287 EAESVLAVVAAVLKLGNIEFKPESRVNGLDESKIKDKNELKEICELTGIDQSVLERAFS-FRTVE 350

  Fly   583 SAQEDVGCEMDARQAATNRNTLCRTLYSRLFTWLVNKINESLKSTQ--REKNLALLDFYGFEALD 645
            :.||.|...::..||...|:.|.:.||||||:||||:||||:|:..  |:|.:.:||.||||..:
Human   351 AKQEKVSTTLNVAQAYYARDALAKNLYSRLFSWLVNRINESIKAQTKVRKKVMGVLDIYGFEIFE 415

  Fly   646 HNSFEQFAINYSAEKIHQNFVFHVLRSEQELYIREGLEWSRIDYFDNESICELIDKPSYGILSLI 710
            .||||||.|||..||:.|.|:...|:.|||.||||.:||:.||||:|..||:||:..:.|||:::
Human   416 DNSFEQFIINYCNEKLQQIFIELTLKEEQEEYIREDIEWTHIDYFNNAIICDLIENNTNGILAML 480

  Fly   711 NE----PHLNSNDALLLRVQQCCAGHPNFMT-----------TGSNSMCFQIRHYASVVNYSIHR 760
            :|    |...:::..|.::.|.||.|.:|.:           |.....||:|:|||..|.|.:..
Human   481 DEECLRPGTVTDETFLEKLNQVCATHQHFESRMSKCSRFLNDTSLPHSCFRIQHYAGKVLYQVEG 545

  Fly   761 FLEKNSDMLPKYISAAFYQSKLSLVQSLFPEGNPRRQVTKKPSTLSSNIRTQLQTLLAIVKHRRS 825
            |::||:|:|.:.:|.|.:::..:|::||||||||.:...|:|.|..|..:..:.||:..::.:..
Human   546 FVDKNNDLLYRDLSQAMWKASHALIKSLFPEGNPAKINLKRPPTAGSQFKASVATLMKNLQTKNP 610

  Fly   826 HYVFCIKPNEGKQPHQFDMALVQHQVRYMSLMPLVHLCRTGHCYHLLHVKFFHRYKLLNSLTWPH 890
            :|:.|||||:.|..|.|:.|||.||:||:.|:..|.:.|.|:.:...:.....|||:|...||||
Human   611 NYIRCIKPNDKKAAHIFNEALVCHQIRYLGLLENVRVRRAGYAFRQAYEPCLERYKMLCKQTWPH 675

  Fly   891 FHGGSQVEGIALIIRNLPLPSAEFTIGTKNVFVRSPRTVYELEQFRRLRISELAVLIQTM----- 950
            :.|.:: .|:.::...|.:|..|::.|...:|:|:|||:::||..|:.|:.:||.|||.:
Human   676 WKGPAR-SGVEVLFNELEIPVEEYSFGRSKIFIRNPRTLFKLEDLRKQRLEDLATLIQKIYRGWK 739

  Fly   951 ------------------FRMYHARKRFQRMRHSQMIISSAWRTW------------RECRFGIP 985
                              :|.|..:||:|:.:.|.::|.|..|.|            :.|:..:.
Human   740 CRTHFLLMKKSQIVIAAWYRRYAQQKRYQQTKSSALVIQSYIRGWKARKILRELKHQKRCKEAVT 804

  Fly   986 --------FTGRRHL----------------WS--LYRVAREEYRSLKYKRQVRWAIDIIGRYYR 1024
                    ...||.|                |:  |...||.|.:.||.:.:.:.|:.:|..|:.
Human   805 TIAAYWHGTQARRELRRLKEEARNKHAIAVIWAYWLGSKARRELKRLKEEARRKHAVAVIWAYWL 869

  Fly  1025 QWKIR-------------------------QFLLTIPLRLPPNTLSPLSTEWPVAP-AFLADASR 1063
            ..|:|                         ::.|.:..::|  :|||:...||..| .||....:
Human   870 GLKVRREYRKFFRANAGKKIYEFTLQRIVQKYFLEMKNKMP--SLSPIDKNWPSRPYLFLDSTHK 932

  Fly  1064 HLRSIYHRWKCYIYRNSFDQTARNRMREKVTASIIFKDRKASYGRSVGHPFVGDYVRLRHNQQWK 1128
            .|:.|:|.|:|..||:.|....:....||:.||.:|||:||.|..|||.||.|.|:.:..|.::|
Human   933 ELKRIFHLWRCKKYRDQFTDQQKLIYEEKLEASELFKDKKALYPSSVGQPFQGAYLEINKNPKYK 997

  Fly  1129 KICAETNDQYVVFADIINKIARSSGKFVPILLVLSTSSLLLLDQRTLQIKYRVPASEIYRMSLSP 1193
            |: .:..::.::.|:::|||.|::||....:.:|:.::|||.||::.|||..||..::.::|:|.
Human   998 KL-KDAIEEKIIIAEVVNKINRANGKSTSRIFLLTNNNLLLADQKSGQIKSEVPLVDVTKVSMSS 1061

  Fly  1194 YLDDIAVFHVKASEFGRKKGDFVFQTGHVIEIVTKMFLVIQNATGKPPEIHISTEFEANFGQQTV 1258
            ..|.....|:|.......||||:|.:.|:||:.||::....:.|.:...|.||.||...|.|..|
Human  1062 QNDGFFAVHLKEGSEAASKGDFLFSSDHLIEMATKLYRTTLSQTKQKLNIEISDEFLVQFRQDKV 1126

  Fly  1259 IFSFKYGGMSDLAQGPPKVTRKANR-MEIIV 1288
            ...|..|...:  ...|...||.|| :|:.|
Human  1127 CVKFIQGNQKN--GSVPTCKRKNNRLLEVAV 1155

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Myo95E	NP_001027208.1	Motor_domain	3..>123	CDD:473979	53/119 (45%)
		Motor_domain	<403..937	CDD:473979	218/553 (39%)
		Myosin_TH1	1092..1288	CDD:461801	69/196 (35%)
MYO1B	XP_047300366.1	MYSc_Myo1	49..708	CDD:276829	262/924 (28%)
		IQ	769..791	CDD:197470	5/21 (24%)
		Myosin_TH1	961..1138	CDD:461801	63/179 (35%)