Protein Alignment Myo95E and Myo1a

DIOPT Version :10

• Sequence 1: NP_001027208.1
• Gene: Myo95E / 2768680
• FlyBaseID: FBgn0039157
• Length: 1288
• Species: Drosophila melanogaster
• Sequence 2: NP_001074688.1
• Gene: Myo1a / 432516
• MGIID: 107732
• Length: 1043
• Species: Mus musculus
• Alignment Length: 1344
• Identity: 376/1344 - (27%)
• Similarity: 603/1344 - (44%)
• Gaps: 361/1344 - (26%)

  Fly     1 MEQEIGTWDSVLLENLSEDSFINNIHQRYKRDHIYTYIGTSVVALNPYHHISEHSLDNVRNYGDK 65
            :|..:|..|.:|||.|.|:|.|.|:..||:...||||||..|:::|||..:..:..:.:..|.|.
Mouse     4 LEGPVGVEDLILLEPLDEESLIKNLQLRYENKEIYTYIGNVVISMNPYEQLPIYGPEFIAKYRDY 68

  Fly    66 GIFQLPPHIYGLTNLAYQSLKDQSEDQCVLLTGESGAGKTETFKMIVNFLTHIQDRSHCPPTPNV 130
            ..::|.||||.|.|:|||||||:..|||:|:||||||||||..|::::::..:
Mouse    69 TFYELKPHIYALANVAYQSLKDRDRDQCILITGESGAGKTEASKLVMSYVAAV------------ 121

  Fly   131 LRKQSSTSSASGLVMHAHRRASSSCSGTANFIICKNRAENPSGSVSRRQSPSPGPSQRSRTRAES 195
                                                                             
Mouse   122 ----------------------------------------------------------------- 121

  Fly   196 IERQSRRHMREKIVDFDFSHHKSSENISGLPESHAHHMHPTKSCFKHQQTQVSACTAMPAAAKGS 260
                                                                             
Mouse   122 ----------------------------------------------------------------- 121

  Fly   261 PKYAVPTVYGGCRQCGHSKCVRAQSLEKEERDDLRGSNCRLSTIATATTNPAHPHRGSCSNLMRQ 325
                          ||                                       :|...|.:::
Mouse   122 --------------CG---------------------------------------KGEQVNSVKE 133

  Fly   326 HSTESQPERERDRSSLMGSTQRISLYDAHKLSKVLGDLPPPPPSSVSPTPSASSSLHRRHKSPTQ 390
            ...:|.|
Mouse   134 QLLQSNP---------------------------------------------------------- 140

  Fly   391 RMRECVTCADVFLEAMGNACTLKNNNSSRYGKLFDIEIDFKGDPMGVHITHYMLEKTRITDPIIG 455
                       .|||.|||.|::||||||:||..|||.||||.|:|..||:|:|||:|:...:.|
Mouse   141 -----------VLEAFGNAKTIRNNNSSRFGKYMDIEFDFKGSPLGGVITNYLLEKSRVVKQLKG 194

  Fly   456 ERNFHIFYQLLLGADLQLLKSLKLYRNVEKYELLRNTTAM---EEDRMNFHYTKRSLDVLGLSCE 517
            |||||||||||.|||.||||:|||..:...|..|....:.   .:|..||...:.::.|:|.|.|
Mouse   195 ERNFHIFYQLLAGADAQLLKALKLEEDTSVYGYLNGEVSKVNGMDDASNFRAVQHAMSVIGFSEE 259

  Fly   518 ESNSIFRVIAVVLKLGNFIFVPITNIDGTEGCQVSNVYE---VQETAQLLNMEAQILINCLTRAN 579
            |...:..|.|:||||||   |.:|:.....|...|.:.:   :||..:::.:.:..|...|. :.
Mouse   260 EIRQVLEVTALVLKLGN---VKLTDEFQANGIPASGICDGKGIQEIGEMMGLNSTELERALC-SR 320

  Fly   580 STNSAQEDVGCEMDARQAATNRNTLCRTLYSRLFTWLVNKINESLK--STQREKNLALLDFYGFE 642
            :..:.:|.|...::..||...|:.|.:.:|||||.|:|.:||||:|  :.:::|.:.:||.||||
Mouse   321 TMETGKEKVVTVLNVTQAQYARDALAKNIYSRLFDWIVKRINESIKVGTGEKKKVMGVLDIYGFE 385

  Fly   643 ALDHNSFEQFAINYSAEKIHQNFVFHVLRSEQELYIREGLEWSRIDYFDNESICELIDKPSYGIL 707
            .|:.||||||.|||..|::.|.|:...|:.|||.|.|||:.|::::||||..||.||:....|||
Mouse   386 ILEDNSFEQFVINYCNERLQQVFIELTLKEEQEEYKREGIPWTKVEYFDNGIICNLIEHSQRGIL 450

  Fly   708 SLINE----PHLNSNDALLLRVQQCCAGHPNFMTTGSNS-----------MCFQIRHYASVVNYS 757
            ::::|    |.:.|:...|.::.|..:.|.::.:..|.:           .||:|.|||..|.|:
Mouse   451 AMLDEECLRPGVVSDSTFLAKLNQLFSKHSHYESKVSQNAQRQYDRTMGLSCFRISHYAGKVTYN 515

  Fly   758 IHRFLEKNSDMLPKYISAAFYQSKLSLVQSLFPEGNPRRQVTKKPSTLSSNIRTQLQTLLAIVKH 822
            :..|::||:|:|.:.:|...::::..|::||||||||:....|:|.|..:..:..:..|:..:..
Mouse   516 VTGFIDKNNDLLFRDLSQTMWKAQHPLLKSLFPEGNPKEASLKRPPTAGTQFKNSVAVLMKNLYS 580

  Fly   823 RRSHYVFCIKPNEGKQPHQFDMALVQHQVRYMSLMPLVHLCRTGHCYHLLHVKFFHRYKLLNSLT 887
            :..:|:.|||||:.:|..:|...:|..|.||:.|:..|.:.|.|:.:...:..|..||:||:..|
Mouse   581 KNPNYIRCIKPNDQQQKGRFTSEMVMVQARYLGLLENVRVRRAGYAFRQGYKPFLERYRLLSRST 645

  Fly   888 WPHFHGGSQVEGIALIIRNLPLPSAEFTIGTKNVFVRSPRTVYELEQFRRLRISELAVLIQTMFR 952
            ||.::|..: ||:..::.:|.|.|.|...|...:|:|||:|::.||:.||||:.:||.|||.::|
Mouse   646 WPRWNGDDR-EGVEKVLGSLTLSSEELAYGKTKIFIRSPKTLFYLEEQRRLRLQQLATLIQKVYR 709

  Fly   953 MYHARKRFQRMRHSQMIISSAW------------------------RTWRECRFGIPFTGRRHLW 993
            .:..|..:|:||.||::| |||                        |.||
Mouse   710 GWRCRTHYQQMRKSQILI-SAWFRGNKQKKHYGKIRSSVLLIQAFVRGWR--------------- 758

  Fly   994 SLYRVAREEYRSLKYKRQVRWAIDIIGRYYRQWKIRQFLLTIPLRLPPNTLSPLSTEWPVAP-AF 1057
                 ||:.||  ||.|.  .|...:..:..|...::|||.:...||...:  |...||.|| ..
Mouse   759 -----ARKNYR--KYFRS--GAALTLANFIYQSMAQKFLLNLKKNLPSTKV--LDNTWPAAPYRC 812

  Fly  1058 LADASRHLRSIYHRWKCYIYRNSFDQTARNRMREKVTASIIFKDRKASYGRSVGHPFVGDYVRLR 1122
            ...|::.|:.::::|||..:|:.........:|||:.||.:||.:||||.:||..||.|||:.|:
Mouse   813 FNTANQELQRLFYQWKCKKFRDQLSPKQVQTLREKLCASELFKGKKASYPQSVPIPFRGDYIGLQ 877

  Fly  1123 HNQQWKKICAETNDQYVVFADIINKIARSSGKFVPILLVLSTSSLLLLDQRTLQIKYRVPASEIY 1187
            .|.:.:::... .:..|:.||.:.|:.|.:||....:|:|:...::|.|.:..|.:..:...::.
Mouse   878 GNPKLQRLKGR-EEGPVLVADTVKKVNRGNGKTSARILLLTKGHVILTDAKKSQAQIVIGLEDVA 941

  Fly  1188 RMSLSPYLDDIAVFHVKASEFGRKKGDFVFQTGHVIEIVTKMFLVIQNATGKPPEIHISTEFEAN 1252
            .:|:|...|.:...|:........|||.:..:.||:|::|||:..:.:||.:...:.::.:|...
Mouse   942 GVSVSSLQDGLFSLHLSEMSSAVSKGDILLVSDHVVELLTKMYQAVLDATQRQLSVTVTEKFSVR 1006

  Fly  1253 FGQQTVIFSFKYGGMSDLAQGP------PKVTRK--ANRMEIIV 1288
            |.:.:|...        :.|||      ..:.:|  :|.||:.|
Mouse  1007 FKEGSVAVK--------VIQGPEGGGNRKLICKKKGSNAMEVTV 1042

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Myo95E	NP_001027208.1	Motor_domain	3..>123	CDD:473979	53/119 (45%)
		Motor_domain	<403..937	CDD:473979	210/556 (38%)
		Myosin_TH1	1092..1288	CDD:461801	55/203 (27%)
Myo1a	NP_001074688.1	MYSc_Myo1	22..681	CDD:276829	256/927 (28%)
		Actin-binding. /evidence=ECO:0000255	571..593		6/21 (29%)
		IQ	742..764	CDD:197470	5/41 (12%)
		Myosin_TH1	847..1042	CDD:461801	55/203 (27%)