DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Myo95E and myo1eb

DIOPT Version :9

Sequence 1:	NP_001027208.1	Gene:	Myo95E / 2768680	FlyBaseID:	FBgn0039157	Length:	1288	Species:	Drosophila melanogaster
Sequence 2:	NP_956930.1	Gene:	myo1eb / 393609	ZFINID:	ZDB-GENE-040426-1347	Length:	1096	Species:	Danio rerio

Alignment Length:	1335	Identity:	292/1335 - (21%)
Similarity:	505/1335 - (37%)	Gaps:	478/1335 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 GTWDSVLLENLSEDSFINNIHQRYKRDHIYTYIGTSVVALNPYHHISEHSLDNVRNYGDKGIFQL 70
            |..|.|||..::||:..:|:.:||..|:|:||||..::::||:..:...:...:..|.....::.
Zfish    18 GVDDMVLLSKITEDAITDNLKKRYMDDYIFTYIGPVLISVNPFKQLPYFTDREIELYQGAAQYEN 82

  Fly    71 PPHIYGLTNLAYQSLKDQSEDQCVLLTGESGAGKTETFKMIVNFLTHIQDRSHCPPTPNVLRKQS 135
            |||||.|.:..|:::...||:|||:::||||||||...|.|:::::
Zfish    83 PPHIYALADNMYRNMMIDSENQCVIISGESGAGKTVAAKYIMSYIS------------------- 128

  Fly   136 STSSASGLVMHAHRRASSSCSGTANFIICKNRAENPSGSVSRRQSPSPGPSQRSRTRAESIERQS 200

Zfish   129 ----------------------------------------------------------------- 128

  Fly   201 RRHMREKIVDFDFSHHKSSENISGLPESHAHHMHPTKSCFKHQQTQVSACTAMPAAAKGSPKYAV 265
                                .:||                                  |.||
Zfish   129 --------------------KVSG----------------------------------GGPK--- 136

  Fly   266 PTVYGGCRQCGHSKCVRAQSLEKEERDDLRGSNCRLSTIATATTNPAHPHRGSCSNLMRQHSTES 330

Zfish   137 ----------------------------------------------------------------- 136

  Fly   331 QPERERDRSSLMGSTQRISLYDAHKLSKVLGDLPPPPPSSVSPTPSASSSLHRRHKSPTQRMREC 395
                                                                      .|.:::.
Zfish   137 ----------------------------------------------------------VQHVKDI 143

  Fly   396 VTCADVFLEAMGNACTLKNNNSSRYGKLFDIEIDFKGDPMGVHITHYMLEKTRITDPIIGERNFH 460
            :..::..|||.|||.|::||||||:||.|:|:....|:|.|..|::::|||:|:.....||||||
Zfish   144 ILQSNPLLEAFGNAKTVRNNNSSRFGKYFEIQFSRGGEPDGGKISNFLLEKSRVVSQNNGERNFH 208

  Fly   461 IFYQLLLGADLQLLKSLKLYRNVEKYELLR--NTTAMEE--DRMNFHYTKRSLDVLGLSCEESNS 521
            |:||||.||..:..::|.: ...:.|..|.  :|..:|:  |:..|..|..::.|:|||.:..:|
Zfish   209 IYYQLLKGATKEQRENLGV-TTPDYYFYLNQSDTYTVEDVNDKKEFEDTMNAMSVVGLSMDAQDS 272

  Fly   522 IFRVIAVVLKLGNFIFVPITNIDGTEGCQVSNVYEVQETAQLLNMEAQIL----------INCLT 576
            :.:::|.:|.|||..|....|            |.|.|:...|...:.:|          :....
Zfish   273 VLQIVAGILHLGNIAFREEGN------------YAVVESEDFLAFPSYLLGINQDGLKSKLTSRI 325

  Fly   577 RANSTNSAQEDVGCEMDARQAATNRNTLCRTLYSRLFTWLVNKINESLKSTQREKNLALLDFYGF 641
            ..:......|.:...::..||:..|:.|.:.||||||.:||:.||::::..:.|.|:.:||.|||
Zfish   326 MDSKWGGKTETISVTLNTEQASFTRDALSKALYSRLFDYLVDAINKAMQKDREELNIGVLDIYGF 390

  Fly   642 EALDHNSFEQFAINYSAEKIHQNFVFHVLRSEQELYIREGLEWSRIDYFDNESICELID---KPS 703
            |....|.||||.||:..||:.|.|:...|::|||.|::||:.|:.|:||:|:.:|:||:   .|.
Zfish   391 EIFQKNGFEQFCINFVNEKLQQIFIELTLKAEQEEYVQEGISWTPIEYFNNKVVCDLIESKLNPP 455

  Fly   704 YGILSLINE----PHLNSNDA---LLLRVQQCCAGHPNFMTTGSNSMCFQIRHYASVVNYSIHRF 761
             ||:|::::    .|.....|   ||.::|.....|.:|   .|.:..|.:.|||..|:|.:..|
Zfish   456 -GIMSILDDVCATMHAKGEGADQTLLQKLQSQIGTHEHF---NSWNKGFVVHHYAGKVSYDVSGF 516

  Fly   762 LEKNSDMLPKYISAAFYQSKLSLVQSLFPEGNPRRQVTKKPSTLSSNIRTQLQTLLAIVKHRRSH 826
            .|:|.|:|...|......|:.:.::.|||| |...:...:|:|..|.|:.|..||:..:.....|
Zfish   517 CERNRDVLFSDIIELMQSSEFAFIKGLFPE-NIEAEKRGRPTTAGSKIKKQANTLVQTLMKCTPH 580

  Fly   827 YVFCIKPNEGKQPHQFDMALVQHQVRYMSLMPLVHLCRTGHCYHLLHVKFFHRYKLLNSLTWPHF 891
            |:.||||||.|:...::.:.|:|||.|:.|...:.:.|.|:.:..:..||.|||.:|...|||.:
Zfish   581 YIRCIKPNETKKSRDWEESRVKHQVEYLGLRENIRVRRAGYAFRRIFKKFLHRYAILTRETWPQW 645

  Fly   892 HGGSQVEGIALIIRNLPLPSAEFTIGTKNVFVRSPRTVYELEQFRRLRISELAVLIQTMFRMYHA 956
            . |.:.:|:..:::::.:.|.::.:|...:|:::|.:::.||:.|.              |.|:.
Zfish   646 R-GDEKQGVLHLLKSVNMDSDQYQLGKTKIFIKAPESLFLLEEMRE--------------RKYNG 695

  Fly   957 RKRFQRMRHSQMIISSAWRTWRECRFGIPFTGRRHLWSLYRVAREEYRSLKYKRQVRWAIDIIGR 1021
            ..|         :|..||              |:|:
Zfish   696 YAR---------VIQQAW--------------RKHI----------------------------- 708

  Fly  1022 YYRQWKIRQFLLTIPLRLPPNTLSPLSTEWPVAPAFLADASRHLRSIYHRWKCYIYRNSFDQTAR 1086
                 .:|:::
Zfish   709 -----AVRKYV------------------------------------------------------ 714

  Fly  1087 NRMREKVTASIIFKDRKASYGRSVGHPFVGDYVRLRHNQQWKKICAETNDQYVVFADIINKIARS 1151
             ||||:  ||.:..::|.....|:...|||||:...::.:.::.....  :.:.|||::.|..|.
Zfish   715 -RMREE--ASDLLLNKKERRKNSLNRNFVGDYIGTDNHPEIRQFVGRR--ERIDFADVVVKYDRR 774

  Fly  1152 SGKFVPILLVLSTSSLLLLDQRTLQ-----------IKYRVPASEIYRMSLSPYLDDIAVFHVKA 1205
            . |.|...|:|:...|.|:.:..::           :|.::...:|..:|||...|||.:.|
Zfish   775 F-KSVKRDLILTPKFLYLIGREKVKQGPEKGQIREVLKRKIEVEKIQSVSLSTLQDDIFILH--- 835

  Fly  1206 SEFGRKKGDFVFQTGHVIEIVTKMFLVIQNATGK--PPEIHISTEFE---------ANFGQQTVI 1259
                ..:.|.|.|:....|.::.::...:..|.|  |.:.:...||:         |:.|.:.:.
Zfish   836 ----EDQYDSVLQSVFKTEFLSLLYKRFEEKTKKKLPLKFNNLLEFKVKKGGWGPFASAGSRQIQ 896

  Fly  1260 FSFKYGGMS-----------DLAQGPPKVTRKANR 1283
            |....|..:           .:..|.||.||...|
Zfish   897 FQMGQGDDAVLKPSSKILTVSIGSGLPKNTRPTRR 931

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Myo95E	NP_001027208.1	Motor_domain	19..>118	CDD:277568	35/98 (36%)
		Motor_domain	403..924	CDD:277568	180/544 (33%)
		Myosin_TH1	1092..1267	CDD:283635	42/196 (21%)
myo1eb	NP_956930.1	MYSc	12..690	CDD:214580	230/954 (24%)
		MYSc_Myo1	31..677	CDD:276829	221/928 (24%)
		Myosin_TH1	717..902	CDD:283635	43/196 (22%)
		SH3_MyoIe_If_like	1043..1095	CDD:212761
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D122881at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100187
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.820