Protein Alignment Myo95E and myo1eb

DIOPT Version :10

• Sequence 1: NP_001027208.1
• Gene: Myo95E / 2768680
• FlyBaseID: FBgn0039157
• Length: 1288
• Species: Drosophila melanogaster
• Sequence 2: NP_956930.1
• Gene: myo1eb / 393609
• ZFINID: ZDB-GENE-040426-1347
• Length: 1096
• Species: Danio rerio
• Alignment Length: 1340
• Identity: 292/1340 - (21%)
• Similarity: 504/1340 - (37%)
• Gaps: 488/1340 - (36%)

  Fly     6 GTWDSVLLENLSEDSFINNIHQRYKRDHIYTYIGTSVVALNPYHHISEHSLDNVRNYGDKGIFQL 70
            |..|.|||..::||:..:|:.:||..|:|:||||..::::||:..:...:...:..|.....::.
Zfish    18 GVDDMVLLSKITEDAITDNLKKRYMDDYIFTYIGPVLISVNPFKQLPYFTDREIELYQGAAQYEN 82

  Fly    71 PPHIYGLTNLAYQSLKDQSEDQCVLLTGESGAGKTETFKMIVNFLTHIQDRSHCPPTPNVLRKQS 135
            |||||.|.:..|:::...||:|||:::||||||||...|.|:::::
Zfish    83 PPHIYALADNMYRNMMIDSENQCVIISGESGAGKTVAAKYIMSYIS------------------- 128

  Fly   136 STSSASGLVMHAHRRASSSCSGTANFIICKNRAENPSGSVSRRQSPSPGPSQRSRTRAESIERQS 200
                                                                             
Zfish   129 ----------------------------------------------------------------- 128

  Fly   201 RRHMREKIVDFDFSHHKSSENISGLPESHAHHMHPTKSCFKHQQTQVSACTAMPAAAKGSPKYAV 265
                                .:||                                  |.||
Zfish   129 --------------------KVSG----------------------------------GGPK--- 136

  Fly   266 PTVYGGCRQCGHSKCVRAQSLEKEERDDLRGSNCRLSTIATATTNPAHPHRGSCSNLMRQHSTES 330
                                                                             
Zfish   137 ----------------------------------------------------------------- 136

  Fly   331 QPERERDRSSLMGSTQRISLYDAHKLSKVLGDLPPPPPSSVSPTPSASSSLHRRHKSPTQRMREC 395
                                                                      .|.:::.
Zfish   137 ----------------------------------------------------------VQHVKDI 143

  Fly   396 VTCADVFLEAMGNACTLKNNNSSRYGKLFDIEIDFKGDPMGVHITHYMLEKTRITDPIIGERNFH 460
            :..::..|||.|||.|::||||||:||.|:|:....|:|.|..|::::|||:|:.....||||||
Zfish   144 ILQSNPLLEAFGNAKTVRNNNSSRFGKYFEIQFSRGGEPDGGKISNFLLEKSRVVSQNNGERNFH 208

  Fly   461 IFYQLLLGADLQLLKSLKL-------YRNVEKYELLRNTTAMEE--DRMNFHYTKRSLDVLGLSC 516
            |:||||.||..:..::|.:       |.|..      :|..:|:  |:..|..|..::.|:|||.
Zfish   209 IYYQLLKGATKEQRENLGVTTPDYYFYLNQS------DTYTVEDVNDKKEFEDTMNAMSVVGLSM 267

  Fly   517 EESNSIFRVIAVVLKLGNFIFVPITNIDGTEGCQVSNVYEVQETAQLLNMEAQIL---------- 571
            :..:|:.:::|.:|.|||..|....|            |.|.|:...|...:.:|
Zfish   268 DAQDSVLQIVAGILHLGNIAFREEGN------------YAVVESEDFLAFPSYLLGINQDGLKSK 320

  Fly   572 INCLTRANSTNSAQEDVGCEMDARQAATNRNTLCRTLYSRLFTWLVNKINESLKSTQREKNLALL 636
            :......:......|.:...::..||:..|:.|.:.||||||.:||:.||::::..:.|.|:.:|
Zfish   321 LTSRIMDSKWGGKTETISVTLNTEQASFTRDALSKALYSRLFDYLVDAINKAMQKDREELNIGVL 385

  Fly   637 DFYGFEALDHNSFEQFAINYSAEKIHQNFVFHVLRSEQELYIREGLEWSRIDYFDNESICELID- 700
            |.||||....|.||||.||:..||:.|.|:...|::|||.|::||:.|:.|:||:|:.:|:||:
Zfish   386 DIYGFEIFQKNGFEQFCINFVNEKLQQIFIELTLKAEQEEYVQEGISWTPIEYFNNKVVCDLIES 450

  Fly   701 --KPSYGILSLINE----PHLNSNDA---LLLRVQQCCAGHPNFMTTGSNSMCFQIRHYASVVNY 756
              .|. ||:|::::    .|.....|   ||.::|.....|.:|   .|.:..|.:.|||..|:|
Zfish   451 KLNPP-GIMSILDDVCATMHAKGEGADQTLLQKLQSQIGTHEHF---NSWNKGFVVHHYAGKVSY 511

  Fly   757 SIHRFLEKNSDMLPKYISAAFYQSKLSLVQSLFPEGNPRRQVTKKPSTLSSNIRTQLQTLLAIVK 821
            .:..|.|:|.|:|...|......|:.:.::.|||| |...:...:|:|..|.|:.|..||:..:.
Zfish   512 DVSGFCERNRDVLFSDIIELMQSSEFAFIKGLFPE-NIEAEKRGRPTTAGSKIKKQANTLVQTLM 575

  Fly   822 HRRSHYVFCIKPNEGKQPHQFDMALVQHQVRYMSLMPLVHLCRTGHCYHLLHVKFFHRYKLLNSL 886
            ....||:.||||||.|:...::.:.|:|||.|:.|...:.:.|.|:.:..:..||.|||.:|...
Zfish   576 KCTPHYIRCIKPNETKKSRDWEESRVKHQVEYLGLRENIRVRRAGYAFRRIFKKFLHRYAILTRE 640

  Fly   887 TWPHFHGGSQVEGIALIIRNLPLPSAEFTIGTKNVFVRSPRTVYELEQFRRLRISELAVLIQTMF 951
            |||.:. |.:.:|:..:::::.:.|.::.:|...:|:::|.:::.||:.|.
Zfish   641 TWPQWR-GDEKQGVLHLLKSVNMDSDQYQLGKTKIFIKAPESLFLLEEMRE-------------- 690

  Fly   952 RMYHARKRFQRMRHSQMIISSAWRTWRECRFGIPFTGRRHLWSLYRVAREEYRSLKYKRQVRWAI 1016
            |.|:...|         :|..||              |:|:
Zfish   691 RKYNGYAR---------VIQQAW--------------RKHI------------------------ 708

  Fly  1017 DIIGRYYRQWKIRQFLLTIPLRLPPNTLSPLSTEWPVAPAFLADASRHLRSIYHRWKCYIYRNSF 1081
                      .:|:::
Zfish   709 ----------AVRKYV------------------------------------------------- 714

  Fly  1082 DQTARNRMREKVTASIIFKDRKASYGRSVGHPFVGDYVRLRHNQQWKKICAETNDQYVVFADIIN 1146
                  ||||:  ||.:..::|.....|:...|||||:...::.:.::.....  :.:.|||::.
Zfish   715 ------RMREE--ASDLLLNKKERRKNSLNRNFVGDYIGTDNHPEIRQFVGRR--ERIDFADVVV 769

  Fly  1147 KIARSSGKFVPILLVLSTSSLLLLDQRTLQ-----------IKYRVPASEIYRMSLSPYLDDIAV 1200
            |..|.. |.|...|:|:...|.|:.:..::           :|.::...:|..:|||...|||.:
Zfish   770 KYDRRF-KSVKRDLILTPKFLYLIGREKVKQGPEKGQIREVLKRKIEVEKIQSVSLSTLQDDIFI 833

  Fly  1201 FHVKASEFGRKKGDFVFQTGHVIEIVTKMFLVIQNATGK--PPEIHISTEFE---------ANFG 1254
            .|       ..:.|.|.|:....|.::.::...:..|.|  |.:.:...||:         |:.|
Zfish   834 LH-------EDQYDSVLQSVFKTEFLSLLYKRFEEKTKKKLPLKFNNLLEFKVKKGGWGPFASAG 891

  Fly  1255 QQTVIFSFKYGGMS-----------DLAQGPPKVTRKANR 1283
            .:.:.|....|..:           .:..|.||.||...|
Zfish   892 SRQIQFQMGQGDDAVLKPSSKILTVSIGSGLPKNTRPTRR 931

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Myo95E	NP_001027208.1	Motor_domain	3..>123	CDD:473979	41/116 (35%)
		Motor_domain	<403..937	CDD:473979	183/562 (33%)
		Myosin_TH1	1092..1288	CDD:461801	48/225 (21%)
myo1eb	NP_956930.1	MYSc_Myo1	31..677	CDD:276829	221/933 (24%)
		Myosin_TH1	717..918	CDD:461801	44/212 (21%)
		SH3_MyoIe_If_like	1043..1095	CDD:212761