Protein Alignment Myo95E and Myo61F

DIOPT Version :10

• Sequence 1: NP_001027208.1
• Gene: Myo95E / 2768680
• FlyBaseID: FBgn0039157
• Length: 1288
• Species: Drosophila melanogaster
• Sequence 2: NP_476934.2
• Gene: Myo61F / 38153
• FlyBaseID: FBgn0010246
• Length: 1052
• Species: Drosophila melanogaster
• Alignment Length: 1326
• Identity: 346/1326 - (26%)
• Similarity: 563/1326 - (42%)
• Gaps: 358/1326 - (26%)

  Fly     6 GTWDSVLLENL-SEDSFINNIHQRYKRDHIYTYIGTSVVALNPYHHISEHSLDNVRNYGDKGIFQ 69
            |..|.|||||. ||::||.|:.:|::.|.||||||..::::|||..:..::.|:|:.|.:|..::
  Fly    38 GVQDFVLLENYQSEEAFIGNLKKRFQEDLIYTYIGQVLISVNPYKQLPIYTDDHVKAYRNKHFYE 102

  Fly    70 LPPHIYGLTNLAYQSLKDQSEDQCVLLTGESGAGKTETFKMIVNFLTHIQDRSHCPPTPNVLRKQ 134
            :||||:.:|:.|::||.:::..||||::||||:||||..|.::.|:
  Fly   103 MPPHIFAVTDNAFRSLIEENRGQCVLISGESGSGKTEASKKVLQFI------------------- 148

  Fly   135 SSTSSASGLVMHAHRRASSSCSGTANFIICKNRAENPSGSVSRRQSPSPGPSQRSRTRAESIERQ 199
                              ::|||                               ::|..|.:
  Fly   149 ------------------AACSG-------------------------------NQTTVEGV--- 161

  Fly   200 SRRHMREKIVDFDFSHHKSSENISGLPESHAHHMHPTKSCFKHQQTQVSACTAMPAAAKGSPKYA 264
                 ::|::
  Fly   162 -----KDKLL------------------------------------------------------- 166

  Fly   265 VPTVYGGCRQCGHSKCVRAQSLEKEERDDLRGSNCRLSTIATATTNPAHPHRGSCSNLMRQHSTE 329
                                                       .:||.
  Fly   167 -------------------------------------------KSNPV----------------- 171

  Fly   330 SQPERERDRSSLMGSTQRISLYDAHKLSKVLGDLPPPPPSSVSPTPSASSSLHRRHKSPTQRMRE 394
                                                                             
  Fly   172 ----------------------------------------------------------------- 171

  Fly   395 CVTCADVFLEAMGNACTLKNNNSSRYGKLFDIEIDFKGDPMGVHITHYMLEKTRITDPIIGERNF 459
                    |||.|||.|.:|:||||:||..||:.||||.|:|.:|.:|:|||:|:...:.|||||
  Fly   172 --------LEAFGNAKTNRNDNSSRFGKYMDIQFDFKGAPIGGNILNYLLEKSRVVAQMGGERNF 228

  Fly   460 HIFYQLLLGADLQLLKSLKLYRNVEKYEL----LRNTTAMEEDRMNFHYTKRSLDVLGLSCEESN 520
            |||||||.|||..||:.|:|.|.::.|..    |..|.....|..:|...:::|.|:..:.||..
  Fly   229 HIFYQLLAGADEALLQELRLERALDTYSYLTDGLNGTVTRINDADSFKQVQQALTVIDFTKEEQR 293

  Fly   521 SIFRVIAVVLKLGNFIFVPITNIDGTEGCQVSNVYEVQETAQLLNMEAQILINCLTRANSTNSAQ 585
            .||.::|.:|.|||   |..|.::|  ..:|::...|...|:||.:.|..|...||  :.|..|:
  Fly   294 EIFGIVASILHLGN---VGFTEVEG--NAKVNSRDLVVTAARLLGVNASELEAALT--HRTIDAR 351

  Fly   586 ED-VGCEMDARQAATNRNTLCRTLYSRLFTWLVNKINESL--KSTQREKN--LALLDFYGFEALD 645
            .| |...::...|...|:.|.:.:|.|||:|||.::|.||  |.|:..:|  :.:||.||||...
  Fly   352 GDVVTSPLNQELAIYARDALAKAVYDRLFSWLVQRLNISLQAKETRASRNNVMGILDIYGFEIFQ 416

  Fly   646 HNSFEQFAINYSAEKIHQNFVFHVLRSEQELYIREGLEWSRIDYFDNESICELIDKPSYGILSLI 710
            .||||||.||:..||:.|.|:...|:|||:.|.|||:||..::||||:.||.||::...||:|::
  Fly   417 KNSFEQFCINFCNEKLQQLFIELTLKSEQDEYRREGIEWIPVEYFDNKVICNLIEEKHKGIISIL 481

  Fly   711 NE----PHLNSNDALLLRVQQCCAGHPNFMTTGSNSMC----------------FQIRHYASVVN 755
            :|    |...::...|.::.|..|.|.::       :|                |::.|||..|.
  Fly   482 DEECLRPGEPTDKTFLEKLTQKLAQHHHY-------VCHEKAPAHIKKIMLRDEFRLVHYAGEVT 539

  Fly   756 YSIHRFLEKNSDMLPKYISAAFYQSKLSLVQSLFPEGNPRRQVTKKPSTLSSNIRTQLQTLLAIV 820
            ||::.||:||:|:|.:.:.....::...:|::.|||...|.  .|:|.|..:..|..|..|:.|:
  Fly   540 YSVNGFLDKNNDLLFRDLKETLSKAGNGIVRNCFPEKELRS--LKRPETAITQFRASLNNLMDIL 602

  Fly   821 KHRRSHYVFCIKPNEGKQPHQFDMALVQHQVRYMSLMPLVHLCRTGHCYHLLHVKFFHRYKLLNS 885
            ..:...|:.|||||:.:..:.|:..||.|||:|:.||..:.:.|.|..|...:..|..|||.|:.
  Fly   603 MCKEPSYIRCIKPNDLQTANVFNDELVLHQVKYLGLMENLRVRRAGFAYRRTYELFLERYKSLSK 667

  Fly   886 LTWPHFHG-GSQVEGIALIIRNLPLPSAEFTIGTKNVFVRSPRTVYELEQFRRLRISELAVLIQT 949
            .|||::.| |....|:..::::|.....::.:|...:|:|.|||:::.|...:.:..|:|.:||.
  Fly   668 STWPNYKGPGGPKAGVQQLVKDLGWDEEKYRVGETKLFIRWPRTLFDTEDAYQEKKHEIAAIIQA 732

  Fly   950 MFRMYHARKRFQRMRHSQMIISSAWRTWRECRFGIPFTGRRHLWSLYRVAREEYRSLKYKRQVRW 1014
            .::....|:::.::| :|:||..::     |        ||.|.......|.|... |.:..::.
  Fly   733 HWKGLMQRRKYLKLR-AQVIIMQSY-----C--------RRKLAQQAAKKRREAAD-KIRAFIKG 782

  Fly  1015 AI-----------DIIGRYYRQWKIRQFLLTIPLRLPPNTLSPLSTEWPVAPAFLADASRHLRSI 1068
            .|           :.|....|.|     ||.:...||...   |...||.||....:||..|..:
  Fly   783 FITRNDAPNGFNEEFIANAKRMW-----LLRLAKELPTKV---LDKSWPHAPGHCEEASGILHRL 839

  Fly  1069 YHRWKCYIYRNSFDQTARNRMREKVTASIIFKDRKASYGRSVGHPFVGDYVRLRHNQQWKKICAE 1133
            :......|||.......:.:...||.|..:||.:|.:|..||...|..|.:...|.|:.....|.
  Fly   840 HRLHLARIYRLKLTPQQKRQFELKVLAEKVFKGKKNNYASSVSTWFQEDRIPKEHIQRVNDFVAS 904

  Fly  1134 T-NDQYVVFADIINKIARSSGKFVPILLVLSTSSLLLLDQRTLQIKYRVPASEIYRMSLSPYLDD 1197
            | ..:.:.:.....|..|...|.....::||..::.:||.:|.:.|:|:|..:| ..:|:.:.||
  Fly   905 TFGSEQLKYQSFCTKFDRHGYKSRDRFILLSNKAIYVLDGKTYKQKHRLPLDKI-DFTLTNHNDD 968

  Fly  1198 IAVFHVKASEFGRKKGDFVFQTGHVIEIVTKMFLVIQNATGKPPEIHISTEFEANFGQQTVIFSF 1262
            :.|..:.. :..:.|||.:.....:||..|.:...:..|:       |.:..:.|..:..|:..
  Fly   969 LMVIRIPL-DLKKDKGDLILIIPRIIEFSTYIIDTVGTAS-------IVSIVDRNSLEHNVVKG- 1024

  Fly  1263 KYGGMSDLAQG-PPKVTRKANRMEII 1287
             .||:.|:..| .|.|.|....:.||
  Fly  1025 -KGGVIDIQTGAEPGVVRDKGHLVII 1049

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Myo95E	NP_001027208.1	Motor_domain	3..>123	CDD:473979	49/117 (42%)
		Motor_domain	<403..937	CDD:473979	204/563 (36%)
		Myosin_TH1	1092..1288	CDD:461801	50/198 (25%)
Myo61F	NP_476934.2	MYSc_Myo1	52..707	CDD:276829	247/934 (26%)
		Myosin_TH1	863..1049	CDD:461801	48/196 (24%)