Protein Alignment Myo95E and didum

DIOPT Version :10

• Sequence 1: NP_001027208.1
• Gene: Myo95E / 2768680
• FlyBaseID: FBgn0039157
• Length: 1288
• Species: Drosophila melanogaster
• Sequence 2: NP_724569.1
• Gene: didum / 35680
• FlyBaseID: FBgn0261397
• Length: 1800
• Species: Drosophila melanogaster
• Alignment Length: 1156
• Identity: 265/1156 - (22%)
• Similarity: 428/1156 - (37%)
• Gaps: 437/1156 - (37%)

  Fly     5 IGTWDSVLLENLSEDSFINNIHQRY-KRDHIYTYIGTSVVALNPYHHISEHSLDNVRNYGDKGIF 68
            :|..|...|..|.|...::|:..|: :|..||||.|..:||:|||..:..:....:|.|....:.
  Fly    70 VGQNDLTTLSYLHEPGVLHNLRVRFCERQIIYTYCGIILVAINPYAEMPLYGPSIIRAYRGHAMG 134

  Fly    69 QLPPHIYGLTNLAYQSLKDQSEDQCVLLTGESGAGKTETFKMIVNFLTHIQDRSHCPPTPNVLRK 133
            .|.|||:.|...||..|:.::.:..::::||||||||.:.|..:.:.
  Fly   135 DLEPHIFALAEEAYTKLERENCNLSIIVSGESGAGKTVSAKYAMRYF------------------ 181

  Fly   134 QSSTSSASGLVMHAHRRASSSCSGTANFIICKNRAENPSGSVSRRQSPSPGPSQRSRTRAESIER 198
                                                                             
  Fly   182 ----------------------------------------------------------------- 181

  Fly   199 QSRRHMREKIVDFDFSHHKSSENISGLPESHAHHMHPTKSCFKHQQTQVSACTAMPAAAKGSPKY 263
                                                                    ||..||
  Fly   182 --------------------------------------------------------AAVGGS--- 187

  Fly   264 AVPTVYGGCRQCGHSKCVRAQSLEKEERDDLRGSNCRLSTIATATTNPAHPHRGSCSNLMRQHST 328
                                                                           .:
  Fly   188 ---------------------------------------------------------------ES 189

  Fly   329 ESQPERERDRSSLMGSTQRISLYDAHKLSKVLGDLPPPPPSSVSPTPSASSSLHRRHKSPTQRMR 393
            |:|.||                       |||...|
  Fly   190 ETQVER-----------------------KVLASSP----------------------------- 202

  Fly   394 ECVTCADVFLEAMGNACTLKNNNSSRYGKLFDIEIDFKGDPMGVHITH------YMLEKTRITDP 452
                    .:||.|||.|.:|:||||:||.  .::.|: :.|||....      |:|||:|:...
  Fly   203 --------IMEAFGNAKTTRNDNSSRFGKF--TKLLFR-NQMGVMFLQGATMHTYLLEKSRVVYQ 256

  Fly   453 IIGERNFHIFYQLL--------LGADLQLLKSLKLYRNVEKYELLRNTTAMEEDRMN----FHYT 505
            ..||||:||||||.        |..|.|           :|::.|....|.|.:|::    |:.|
  Fly   257 AQGERNYHIFYQLCAARSKYPELVLDHQ-----------DKFQFLNMGGAPEIERVSDAEQFNET 310

  Fly   506 KRSLDVLGLSCEESNSIFRVIAVVLKLGNFIFVPITNIDGTE-----GCQV-SNVYEVQETAQLL 564
            .:::.|||.|.::...|.:::|.:|.||| |.|.....:|:|     .|.: .|...:|.||.||
  Fly   311 VQAMTVLGFSIQQIADIVKILAGILHLGN-IQVSKKFNEGSEEEDSDSCDIFHNDIHLQITADLL 374

  Fly   565 NMEAQ-----ILINCLTRANS----TNSAQEDVGCEMDARQAATNRNTLCRTLYSRLFTWLVNKI 620
            .:.|.     :|:..:...|.    .||        ::|.|||  |:.|.:.:|::||.::|..:
  Fly   375 RVSADDLRRWLLMRKIESVNEYVLIPNS--------IEAAQAA--RDALAKHIYAKLFQYIVGVL 429

  Fly   621 NESLKSTQREKN-LALLDFYGFEALDHNSFEQFAINYSAEKIHQNFVFHVLRSEQELYIREGLEW 684
            |:||.:..::.: :.:||.||||..:.||||||.|||:.||:.|.|..||.:.|||.|::||:.|
  Fly   430 NKSLNNGSKQCSFIGVLDIYGFETFEVNSFEQFCINYANEKLQQQFNQHVFKLEQEEYLKEGITW 494

  Fly   685 SRIDYFDNESICELIDKPSYGILSLINE----PHLNSNDALLLRVQQCCAGHPNFMTTGSNSMCF 745
            :.||::||:...:||:. ..|:|.|::|    |. .|:::...::...|...|:|......:..|
  Fly   495 TMIDFYDNQPCIDLIES-RLGVLDLLDEECRMPK-GSDESWAGKLIGKCNKFPHFEKPRFGTTSF 557

  Fly   746 QIRHYASVVNYSIHRFLEKNSDMLPKYISAAFYQSKLSLVQSLF--------------------- 789
            .|:|::..|.|.::.|||||.|.:.|.::....:|.:||.:.:.
  Fly   558 FIKHFSDTVEYDVNGFLEKNRDTVSKELTQVLSESNMSLAKQVMTLEEIDTLCVDSAKSSTLGGR 622

  Fly   790 --------PEGNP--RRQVTKKP--STLSSNIRTQLQTLLAIVKHRRSHYVFCIKPNEGKQPHQF 842
                    .:||.  ||.|..|.  .|:.|..:..|.:|::.:.....|||.|||||:.|...::
  Fly   623 VVISAGRKQQGNDTRRRVVPSKQHRKTVGSQFQESLASLISTLHATTPHYVRCIKPNDDKVAFKW 687

  Fly   843 DMALVQHQVRYMSLMPLVHLCRTGHCYHLLHVKFFHRYKLLNSLTWPHFHGGSQVEGIALIIRNL 907
            :.|.:..|:|...::..|.:...|.....|:..|:.||:||      .:........:.|..||:
  Fly   688 ETAKIIQQLRACGVLETVRISAAGFPSRWLYPDFYMRYQLL------VYRSKLDKNDMKLSCRNI 746

  Fly   908 PL----PSAEFTIGTKNVFVRSPRTVYELEQ---------------------FRR--LRISELAV 945
            .:    ...::..|...:|.|:.:..: |||                     :||  |||.::..
  Fly   747 VMKWIQDEDKYRFGNTQIFFRAGQVAF-LEQVRANLRKKYITIVQSVVRRFVYRRQFLRIQKVIN 810

  Fly   946 LIQTMFRMYHARKRFQRMRHSQ--MIISSAWRTWRECRFGIPFTGRRHL---------------- 992
            .||...|.|.||:|.|:||.::  :|:|...|.|. ||       ||:|
  Fly   811 GIQKHARGYLARERTQKMREARAGLILSKYARGWL-CR-------RRYLRLRHSISGIQTYARGM 867

  Fly   993 --WSLYRVAREEYRSLKYKRQVRWAIDIIGRYYR---------QWKIRQFL 1032
              .:.:...|:.||:::.:|.||.|  :..|.|:         |..||:||
  Fly   868 LARNKFHAMRDHYRAVQIQRFVRGA--LARRAYQKRRRNIIICQAAIRRFL 916

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Myo95E	NP_001027208.1	Motor_domain	3..>123	CDD:473979	37/118 (31%)
		Motor_domain	<403..937	CDD:473979	178/629 (28%)
		Myosin_TH1	1092..1288	CDD:461801
didum	NP_724569.1	MYSc_Myo5	84..767	CDD:276831	218/980 (22%)
		IQ	900..922	CDD:197470	5/17 (29%)
		SMC_prok_B	<942..1365	CDD:274008
		Myo5_CBD	1424..1792	CDD:271254