Protein Alignment Myo95E and ck

DIOPT Version :10

• Sequence 1: NP_001027208.1
• Gene: Myo95E / 2768680
• FlyBaseID: FBgn0039157
• Length: 1288
• Species: Drosophila melanogaster
• Sequence 2: NP_523571.1
• Gene: ck / 34882
• FlyBaseID: FBgn0000317
• Length: 2167
• Species: Drosophila melanogaster
• Alignment Length: 1155
• Identity: 270/1155 - (23%)
• Similarity: 429/1155 - (37%)
• Gaps: 363/1155 - (31%)

  Fly     6 GTWDSVLLENLSEDSFINNIHQRYKRDHIYTYIGTSVVALNPYHHISEHSLDNVRNYGDKGIFQL 70
            |..|.:.|.:|.|...:.|:..|||.:.||||.|:.:||:|||..:..::.|.::.|.::.|.:|
  Fly    64 GVEDMISLGDLHEAGILRNLLIRYKENLIYTYTGSILVAVNPYQILPIYTGDQIKLYKERKIGEL 128

  Fly    71 PPHIYGLTNLAYQSLKDQSEDQCVLLTGESGAGKTETFKMIVNFLTHIQDRSHCPPTPNVLRKQS 135
            ||||:.:.:.||..:|...:|||::::|||||||||:.|:|:.:|..|.
  Fly   129 PPHIFAIGDNAYAHMKRYRQDQCIVISGESGAGKTESTKLILQYLAAIS---------------- 177

  Fly   136 STSSASGLVMHAHRRASSSCSGTANFIICKNRAENPSGSVSRRQSPSPGPSQRSRTRAESIERQS 200
                                                                             
  Fly   178 ----------------------------------------------------------------- 177

  Fly   201 RRHMREKIVDFDFSHHKSSENISGLPESHAHHMHPTKSCFKHQQTQVSACTAMPAAAKGSPKYAV 265
                                                                             
  Fly   178 ----------------------------------------------------------------- 177

  Fly   266 PTVYGGCRQCGHSKCVRAQSLEKEERDDLRGSNCRLSTIATATTNPAHPHRGSCSNLMRQHSTES 330
                      |....:..|.||                     .||
  Fly   178 ----------GKHSWIEQQILE---------------------ANP------------------- 192

  Fly   331 QPERERDRSSLMGSTQRISLYDAHKLSKVLGDLPPPPPSSVSPTPSASSSLHRRHKSPTQRMREC 395
                                                                             
  Fly   193 ----------------------------------------------------------------- 192

  Fly   396 VTCADVFLEAMGNACTLKNNNSSRYGKLFDIEIDFKGDPMGVHITHYMLEKTRITDPIIGERNFH 460
                  .|||.|||.|::|:||||:||..||.....|...|..|..|:|||:||......|||:|
  Fly   193 ------ILEAFGNAKTIRNDNSSRFGKYIDIHFSANGVIEGAKIEQYLLEKSRIVSQNHSERNYH 251

  Fly   461 IFYQLLLGADLQLLKSLKLYRNVE-KYELLRNTTAME--EDRMNFHYTKRSLDVLGLSCEESNSI 522
            :||.:|.|........|.|....: ||....|:...|  :|...|...:.::.||..|.:|...|
  Fly   252 VFYCILAGLSADEKSRLDLGMAADYKYLTGGNSITCEGRDDAAEFSDIRSAMKVLLFSDQEIWEI 316

  Fly   523 FRVIAVVLKLGNFIF--VPITNIDGTEGCQVSNVYEVQETAQLLNMEAQILINCLTRANSTNSAQ 585
            .:::|.:|..||..:  ..:.|:|.||   :.....|:..|.||.:..|.||:.||| .:..:..
  Fly   317 IKLLAALLHCGNIKYKATVVDNLDATE---IPEHINVERVAGLLGLPIQPLIDALTR-RTLFAHG 377

  Fly   586 EDVGCEMDARQAATNRNTLCRTLYSRLFTWLVNKINESL---KSTQREKNLALLDFYGFEALDHN 647
            |.|...:...|:...|:...:.:|.|:|..:|.|||.::   :.|.|.. :.:||.:|||..|.|
  Fly   378 ETVVSTLSRDQSVDVRDAFVKGIYGRMFVHIVRKINTAIFKPRGTSRNA-IGVLDIFGFENFDQN 441

  Fly   648 SFEQFAINYSAEKIHQNFVFHVLRSEQELYIREGLEWSRIDYFDNESICELIDKPSYGILSLINE 712
            |||||.|||:.|.:.|.||.|:.:.|||.|..|.:.|..|::.||:...:||......|::||:|
  Fly   442 SFEQFCINYANENLQQFFVQHIFKLEQEEYNHEAINWQHIEFVDNQDALDLIAIKQLNIMALIDE 506

  Fly   713 ----PHLNSNDALLLRVQQCCAGHPNFMTTGSN-SMCFQIRHYASVVNYSIHRFLEKNSDMLPKY 772
                |. .::..:|.::.:....|.|::...|: :..|.:.|:|.||.|....||:||.|.....
  Fly   507 EARFPK-GTDQTMLAKLHKTHGSHKNYLKPKSDINTSFGLNHFAGVVFYDTRGFLDKNRDTFSPD 570

  Fly   773 ISAAFYQSKLSLVQSLFPEG-NPRRQVTKKPSTLSSNIRTQLQTLLAIVKHRRSHYVFCIKPNEG 836
            :.....||....::.:|.:. ....:..|:..|||:..|..|..|:..:...:..::.||||||.
  Fly   571 LLHLVSQSTNKFLRQIFAQDIEMGAETRKRTPTLSTQFRKSLDALMKTLSSCQPFFIRCIKPNEL 635

  Fly   837 KQPHQFDMALVQHQVRYMSLMPLVHLCRTGHCYHLLH--VKFFHRYKLLNSLTWPHFHGGSQ--V 897
            |:|..||..|...|:||..:|..:.:.|.|  |.:.|  .:|..||:.|.....|......|  .
  Fly   636 KKPMMFDRGLCCRQLRYSGMMETIRIRRAG--YPIRHGFREFVERYRFLIPGVPPAHRTDCQAAT 698

  Fly   898 EGIALIIRNLPLPSAEFTIGTKNVFVRSPRTVYELEQ---------------------FRR--LR 939
            ..|..::    |..:::.:|...||::....:: |||                     :||  ||
  Fly   699 SRICAVV----LGKSDYQLGHTKVFLKDAHDLF-LEQERDRVLTRKILILQRSIRGWVYRRRFLR 758

  Fly   940 ISELAVLIQTMFRMYHARKRFQRMRHSQM---------IISSAWRTWRECRFGIPFTGRRHLWSL 995
            :...|:.:|..::.|..|||::.||...|         ::|..:|..|....|:....|.:|
  Fly   759 LRAAAITVQRFWKGYAQRKRYRNMRVGYMRLQALIRSRVLSHRFRHLRGHIVGLQAHARGYL--- 820

  Fly   996 YRVAREEY-----RSLKYKRQVRWAIDIIGRYYRQWKI--RQFLLTIPLR-LPPNTLSPLSTEWP 1052
               .|.||     ..:|.:..||..|.:  |.||:.::  :||...:.|| |....|
  Fly   821 ---VRREYGHKMWAVIKIQSHVRRMIAM--RRYRKLRLEHKQFAEVLQLRKLEEQEL-------- 872

  Fly  1053 VAPAFLADASRHLRSI---YHRWKCY-IYRNSFDQTARNRMREKVTASII 1098
                 |...::|.|.|   ::|.:.: :.|....:...||.|.:|..:||
  Fly   873 -----LHRGNKHAREIAEQHYRDRLHELERREIQEQLENRRRVEVNMNII 917

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Myo95E	NP_001027208.1	Motor_domain	3..>123	CDD:473979	46/116 (40%)
		Motor_domain	<403..937	CDD:473979	171/572 (30%)
		Myosin_TH1	1092..1288	CDD:461801	3/7 (43%)
ck	NP_523571.1	MYSc_Myo7	77..721	CDD:276832	215/922 (23%)
		MyTH4	<1138..1245	CDD:214535
		FERM1_F1_Myosin-VII	1249..1347	CDD:340612
		B41	1251..1467	CDD:214604
		FERM_C1_MyoVII	1461..1559	CDD:270019
		SH3	1560..1624	CDD:473055
		MyTH4	1701..1849	CDD:214535
		FERM2_F1_Myosin-VII	1854..1951	CDD:340613
		B41	1856..2068	CDD:214604
		FERM_C2_MyoVII	2064..2159	CDD:270020